Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.3
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.6
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
100 mcg
182%
Top Medical Research Studies
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
8
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
Read More
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
Most Useful Reviews
7.5
Prevents cancer development
5 people found this helpful
Selenium fortifies the immune system and acts as a potent antioxidant, shielding cells from free radicals, which can be exacerbated by factors like smoking and stress. This mineral is linked to cardiovascular disease prevention, and studies indicate that a 50% increase in blood selenium correlates with a 24% drop in coronary artery disease. Its antitumor properties against lung and breast cancer are well-documented, and selenium is essential for proper thyroid function.
Read More
9
Supports cancer patients
3 people found this helpful
Selenium's multifaceted effects are crucial for normal immune system operation. It involves metabolic processes and provides antioxidant and antiviral protection. Research has shown a deficiency of selenium in many cancer patients, highlighting its importance as an anticancer agent. After consulting with a doctor and undergoing tests, I was prescribed Selenium, completed the course, and now feel happy and healthy 😁.
Read More
9
Destroys carcinogens
Selenium serves as a potent immunomodulatory and anticancer agent, positively affecting the entire body. It acts against carcinogens to prevent malignant tumour formation, while also benefiting reproductive health in both men and women. Obtaining sufficient selenium from food is challenging, making supplements essential in one's diet. I highly recommend it🌹🌹🌹.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.3
- All Researches
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
9.5
We investigated the impact of selenium nanoparticles (SeNPs) on enhancing treatment for advanced non-small-cell lung cancer (NSCLC). Our research revealed that selenium deficiency is linked to immune dysfunction in patients, contributing to cancer progression. In experiments with mice, low selenium led to weakened immunity and faster tumor growth.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Read More
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
Read More
9
We synthesized thirty selenium-containing coumarin derivatives and tested their effectiveness against various malignant tumor cell lines. Notably, one compound, referred to as 11i, showed remarkable potency against SK-N-SH neuroblastoma cells, with a low inhibitory concentration of just 2.5 μM.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Prevents cancer development
5 people found this helpful
Selenium fortifies the immune system and acts as a potent antioxidant, shielding cells from free radicals, which can be exacerbated by factors like smoking and stress. This mineral is linked to cardiovascular disease prevention, and studies indicate that a 50% increase in blood selenium correlates with a 24% drop in coronary artery disease. Its antitumor properties against lung and breast cancer are well-documented, and selenium is essential for proper thyroid function.
Read More
9
Supports cancer patients
3 people found this helpful
Selenium's multifaceted effects are crucial for normal immune system operation. It involves metabolic processes and provides antioxidant and antiviral protection. Research has shown a deficiency of selenium in many cancer patients, highlighting its importance as an anticancer agent. After consulting with a doctor and undergoing tests, I was prescribed Selenium, completed the course, and now feel happy and healthy 😁.
Read More
9
Destroys carcinogens
Selenium serves as a potent immunomodulatory and anticancer agent, positively affecting the entire body. It acts against carcinogens to prevent malignant tumour formation, while also benefiting reproductive health in both men and women. Obtaining sufficient selenium from food is challenging, making supplements essential in one's diet. I highly recommend it🌹🌹🌹.
Read More
7.5
Reduces cancer risk
3 people found this helpful
Selenium is a trace element known for its immunomodulatory properties and regulation of thyroid hormones. Its applications include antioxidant effects, cancer risk reduction, cardiovascular protection, preservation of cognitive function, thyroid health maintenance, and immunity strengthening. The WHO recommends daily intake levels of 55 mcg for women, 70 mcg for men, and 1 mcg per kg of body weight for children.
Read More
7.5
Good cancer preventer
2 people found this helpful
Country Life Selenium offers a great price and is widely acclaimed as a strong antioxidant. Many users praise its effectiveness in preventing cancer, particularly prostate cancer. I hope to see great results!
Read More
Frequently Asked Questions
9
Supports cancer patients
3 people found this helpful
Selenium's multifaceted effects are crucial for normal immune system operation. It involves metabolic processes and provides antioxidant and antiviral protection. Research has shown a deficiency of selenium in many cancer patients, highlighting its importance as an anticancer agent. After consulting with a doctor and undergoing tests, I was prescribed Selenium, completed the course, and now feel happy and healthy 😁.
7.5
Good cancer preventer
2 people found this helpful
Country Life Selenium offers a great price and is widely acclaimed as a strong antioxidant. Many users praise its effectiveness in preventing cancer, particularly prostate cancer. I hope to see great results!
7.5
Prevents cancer development
5 people found this helpful
Selenium fortifies the immune system and acts as a potent antioxidant, shielding cells from free radicals, which can be exacerbated by factors like smoking and stress. This mineral is linked to cardiovascular disease prevention, and studies indicate that a 50% increase in blood selenium correlates with a 24% drop in coronary artery disease. Its antitumor properties against lung and breast cancer are well-documented, and selenium is essential for proper thyroid function.
6
Suppresses cancer cells
Selenium is a key amino acid component responsible for creating enzymes crucial for metabolic processes. It defends cells against oxidative stress and impacts immune system functionality. This trace element suppresses cancer cell division while protecting neurons and heart muscle cells. Additionally, it is vital for the endocrine, immune, and reproductive systems. Known for its antioxidant properties, selenium, paired with vitamin E, defends against free radicals and encourages proper cell growth.
6
Inhibits cancer cells
123 people found this helpful
Selenium is a vital amino acid component that forms enzymes essential for various metabolic processes. It helps protect cells from oxidative stress and influences immune system function. This microelement inhibits cancer cell division and safeguards neurons and heart muscle cells. It plays a crucial role in supporting the endocrine, immune, and reproductive systems. Known for its antioxidant properties, selenium, along with vitamin E, defends the body against free radicals and promotes healthy cell growth.
9
Destroys carcinogens
Selenium serves as a potent immunomodulatory and anticancer agent, positively affecting the entire body. It acts against carcinogens to prevent malignant tumour formation, while also benefiting reproductive health in both men and women. Obtaining sufficient selenium from food is challenging, making supplements essential in one's diet. I highly recommend it🌹🌹🌹.
7.5
Reduces cancer risk
3 people found this helpful
Selenium is a trace element known for its immunomodulatory properties and regulation of thyroid hormones. Its applications include antioxidant effects, cancer risk reduction, cardiovascular protection, preservation of cognitive function, thyroid health maintenance, and immunity strengthening. The WHO recommends daily intake levels of 55 mcg for women, 70 mcg for men, and 1 mcg per kg of body weight for children.
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
7
We investigated the potential of selenium nanoparticles, specifically those derived from Spirulina platensis, as a treatment for cancer. The study focused on understanding how these nanoparticles might impact cancer cells, which is an important area of research given selenium's reputation for health benefits.
Through our evaluation, we discovered that these selenium nanoparticles were effective in reducing the viability of certain cancer cell lines, including breast adenocarcinoma (MCF-7) and ovarian cancer (SKOV-3). At a concentration of 100 µg/ml, we saw a decrease in cell viability by 17.6% and 14.9%, respectively. This suggests that Spirulina-derived selenium could offer a pathway for developing new cancer treatments, although more research is needed to understand the full scope of its effects.
Besides their cancer-fighting potential, these selenium nanoparticles demonstrated a range of additional beneficial properties, such as antibacterial, antioxidant, and anti-inflammatory effects. This multifaceted effectiveness could make them valuable in various therapeutic contexts, not just for cancer.
Through our evaluation, we discovered that these selenium nanoparticles were effective in reducing the viability of certain cancer cell lines, including breast adenocarcinoma (MCF-7) and ovarian cancer (SKOV-3). At a concentration of 100 µg/ml, we saw a decrease in cell viability by 17.6% and 14.9%, respectively. This suggests that Spirulina-derived selenium could offer a pathway for developing new cancer treatments, although more research is needed to understand the full scope of its effects.
Besides their cancer-fighting potential, these selenium nanoparticles demonstrated a range of additional beneficial properties, such as antibacterial, antioxidant, and anti-inflammatory effects. This multifaceted effectiveness could make them valuable in various therapeutic contexts, not just for cancer.
9
Selenium-Axitinib Combination in Cancer
We examined the combined effects of seleno-L-methionine (SLM), a selenium form, and axitinib for treating advanced clear cell renal cell carcinoma (ccRCC). Our study focused on patients who had already undergone prior treatments, seeking to uncover if SLM could enhance the effectiveness of axitinib.
Through a structured phase I clinical trial, we treated participants with escalating doses of SLM, starting from 2500 μg to 4000 μg. These doses were administrated orally, first twice a day and then alongside axitinib. An exciting aspect of our findings was the tolerance level of patients, with no dose-limiting toxicities reported at the highest dose.
Among the 27 patients who received 4000 μg of SLM, we observed notable results: a 55.6% overall response rate, with a median duration of response extending to 18.4 months. Additionally, median progression-free survival was documented at 14.8 months, and overall survival reached 19.6 months. These results suggest that SLM might enhance the therapeutic effect of axitinib while also contributing to better tumor vasculature and drug delivery.
In summary, our findings indicate that high doses of SLM, when combined with axitinib, are well tolerated and may improve treatment outcomes for patients with advanced ccRCC. However, further research is essential to fully understand its efficacy.
Through a structured phase I clinical trial, we treated participants with escalating doses of SLM, starting from 2500 μg to 4000 μg. These doses were administrated orally, first twice a day and then alongside axitinib. An exciting aspect of our findings was the tolerance level of patients, with no dose-limiting toxicities reported at the highest dose.
Among the 27 patients who received 4000 μg of SLM, we observed notable results: a 55.6% overall response rate, with a median duration of response extending to 18.4 months. Additionally, median progression-free survival was documented at 14.8 months, and overall survival reached 19.6 months. These results suggest that SLM might enhance the therapeutic effect of axitinib while also contributing to better tumor vasculature and drug delivery.
In summary, our findings indicate that high doses of SLM, when combined with axitinib, are well tolerated and may improve treatment outcomes for patients with advanced ccRCC. However, further research is essential to fully understand its efficacy.
References
- Li X, Rui W, Shu P, Sun Y, Yang J. Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice. Probiotics Antimicrob Proteins. 2025. doi:10.1007/s12602-025-10500-x
- Raman S, Kasirajan S, Chinnapandi B, Karthikeyan K, Pandian A, et al. Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health. Luminescence. 2025;40:e70101. doi:10.1002/bio.70101
- Janakiram NB, Mohammed A, Ravillah D, Choi CI, Zhang Y, et al. [Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats. Oncol Rep. 2025;53. doi:10.3892/or.2025.8877
- Varlamova EG. Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer. J Trace Elem Med Biol. 2025;88:127620. doi:10.1016/j.jtemb.2025.127620
- Qin X, Guo J, Li H, He H, Cai F, et al. Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412062
- Yu YH, Kouame KJE, Liu X, Yu X, Jin MY, et al. Preparation, characterization, and induced human colon cancer HCT-116 and HT-29 cell apoptosis performance of selenium nanoparticles stabilized by longan polysaccharides. Int J Biol Macromol. 2025. doi:10.1016/j.ijbiomac.2025.140719
- Yassein AS, Elamary RB, Alwaleed EA. Biogenesis, characterization, and applications of Spirulina selenium nanoparticles. Microb Cell Fact. 2025;24:39. doi:10.1186/s12934-025-02656-6
- Guo K, Yang X, Wang J, Chang W, Liu S, et al. Synthesis and Bioactivity of Selenium Nanoparticles From Tussilago farfara L. Polysaccharides: Antioxidant Properties and MCF-7 Cell Inhibition. Chem Biodivers. 2025. doi:10.1002/cbdv.202402677
- Wang M, Xu H, Xiong X, Chang L, Zhang K, et al. Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights. Eur J Med Chem. 2025;286:117322. doi:10.1016/j.ejmech.2025.117322
- Zakharia Y, Reis RJ, Kroll MR, Rataan AO, Manchkanti S, et al. Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2025. doi:10.1158/1078-0432.CCR-24-3234
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. doi:10.1016/j.biomaterials.2025.123117
- Ban B, Yang H, Liu Y, Luo Z. Se-methylselenocysteine Inhibits Migration and Glycolysis in Anaplastic Thyroid Carcinoma Cells via the ERK1/2 Signaling Pathway . Ann Clin Lab Sci. 2024;54:810.
- He L, Zhang L, Peng Y, He Z. Selenium in cancer management: exploring the therapeutic potential. Front Oncol. 2024;14:1490740. doi:10.3389/fonc.2024.1490740
- Rataan AO, Xu Y, Geary SM, Zakharia Y, Kamel ES, et al. Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential. Cancer Treat Res Commun. 2024;42:100864. doi:10.1016/j.ctarc.2025.100864
- Ashraf R, Khalid Z, Qin QP, Iqbal MA, Taskin-Tok T, et al. Synthesis of N-heterocyclic carbene‑selenium complexes modulating apoptosis and autophagy in cancer cells: Probing the interactions with biomolecules and enzymes. Bioorg Chem. 2025;160:108435. doi:10.1016/j.bioorg.2025.108435
- Wei K, Yin X, Chen F, Wang X, Ding W, et al. Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers. Int J Biol Macromol. 2025. doi:10.1016/j.ijbiomac.2025.142791
- Hosseinzadeh Ranjbar M, Einafshar E, Javid H, Jafari N, Sajjadi SS, et al. Enhancing the anticancer effects of rosmarinic acid in PC3 and LNCaP prostate cancer cells using titanium oxide and selenium-doped graphene oxide nanoparticles. Sci Rep. 2025;15:11568. doi:10.1038/s41598-025-96707-y
- Doostan M, Rahmani Azar A, Maleki H. Selenium nanoparticles and paclitaxel co-delivery by a PCL based nanofibrous scaffold to enhance melanoma therapy. J Biomater Appl. 2025. doi:10.1177/08853282251330724
- Çiğ B. Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1. Front Pharmacol. 2025;16:1549190. doi:10.3389/fphar.2025.1549190
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. doi:10.1016/j.ijbiomac.2025.142352
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. doi:10.4149/gpb_2024046
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