' 
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
100 mcg
182%
Top Medical Research Studies
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Direct evaluation of selenium's efficacy
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
8
Selenium's role in lung cancer
Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer.
Direct focus on lung cancer
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
Read More
9
Selenium improves colon cancer treatment
Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice.
Direct impact on cancer therapy
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
Most Useful Reviews
8.8
Prevents cancer development
Selenium fortifies the immune system and acts as a potent antioxidant, shielding cells from free radicals, which can be exacerbated by factors like smoking and stress. This mineral is linked to cardiovascular disease prevention, and studies indicate that a 50% increase in blood selenium correlates with a 24% drop in coronary artery disease. Its antitumor properties against lung and breast cancer are well-documented, and selenium is essential for proper thyroid function.
Read More
9.5
Supports cancer patients
Selenium's multifaceted effects are crucial for normal immune system operation. It involves metabolic processes and provides antioxidant and antiviral protection. Research has shown a deficiency of selenium in many cancer patients, highlighting its importance as an anticancer agent. After consulting with a doctor and undergoing tests, I was prescribed Selenium, completed the course, and now feel happy and healthy 😁.
Read More
9.5
Destroys carcinogens
Selenium serves as a potent immunomodulatory and anticancer agent, positively affecting the entire body. It acts against carcinogens to prevent malignant tumour formation, while also benefiting reproductive health in both men and women. Obtaining sufficient selenium from food is challenging, making supplements essential in one's diet. I highly recommend it🌹🌹🌹.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Direct evaluation of selenium's efficacy
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
9
Selenium improves colon cancer treatment
Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice.
Direct impact on cancer therapy
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
9
Selenium nanoparticles show cancer potential
Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health.
High relevance in cancer therapy
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
Read More
9
Selenium compounds show anti-cancer promise
Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights.
Relevant to selenium's cancer impact
We synthesized thirty selenium-containing coumarin derivatives and tested their effectiveness against various malignant tumor cell lines. Notably, one compound, referred to as 11i, showed remarkable potency against SK-N-SH neuroblastoma cells, with a low inhibitory concentration of just 2.5 μM.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Read More
9
Selenium-Axitinib Combination in Cancer
Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma.
Cancer treatment enhancement explored
We examined the combined effects of seleno-L-methionine (SLM), a selenium form, and axitinib for treating advanced clear cell renal cell carcinoma (ccRCC). Our study focused on patients who had already undergone prior treatments, seeking to uncover if SLM could enhance the effectiveness of axitinib.
Through a structured phase I clinical trial, we treated participants with escalating doses of SLM, starting from 2500 μg to 4000 μg. These doses were administrated orally, first twice a day and then alongside axitinib. An exciting aspect of our findings was the tolerance level of patients, with no dose-limiting toxicities reported at the highest dose.
Among the 27 patients who received 4000 μg of SLM, we observed notable results: a 55.6% overall response rate, with a median duration of response extending to 18.4 months. Additionally, median progression-free survival was documented at 14.8 months, and overall survival reached 19.6 months. These results suggest that SLM might enhance the therapeutic effect of axitinib while also contributing to better tumor vasculature and drug delivery.
In summary, our findings indicate that high doses of SLM, when combined with axitinib, are well tolerated and may improve treatment outcomes for patients with advanced ccRCC. However, further research is essential to fully understand its efficacy.
Through a structured phase I clinical trial, we treated participants with escalating doses of SLM, starting from 2500 μg to 4000 μg. These doses were administrated orally, first twice a day and then alongside axitinib. An exciting aspect of our findings was the tolerance level of patients, with no dose-limiting toxicities reported at the highest dose.
Among the 27 patients who received 4000 μg of SLM, we observed notable results: a 55.6% overall response rate, with a median duration of response extending to 18.4 months. Additionally, median progression-free survival was documented at 14.8 months, and overall survival reached 19.6 months. These results suggest that SLM might enhance the therapeutic effect of axitinib while also contributing to better tumor vasculature and drug delivery.
In summary, our findings indicate that high doses of SLM, when combined with axitinib, are well tolerated and may improve treatment outcomes for patients with advanced ccRCC. However, further research is essential to fully understand its efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
9.5
Supports cancer patients
Selenium's multifaceted effects are crucial for normal immune system operation. It involves metabolic processes and provides antioxidant and antiviral protection. Research has shown a deficiency of selenium in many cancer patients, highlighting its importance as an anticancer agent. After consulting with a doctor and undergoing tests, I was prescribed Selenium, completed the course, and now feel happy and healthy 😁.
Read More
9.5
Destroys carcinogens
Selenium serves as a potent immunomodulatory and anticancer agent, positively affecting the entire body. It acts against carcinogens to prevent malignant tumour formation, while also benefiting reproductive health in both men and women. Obtaining sufficient selenium from food is challenging, making supplements essential in one's diet. I highly recommend it🌹🌹🌹.
Read More
8.8
Prevents cancer development
Selenium fortifies the immune system and acts as a potent antioxidant, shielding cells from free radicals, which can be exacerbated by factors like smoking and stress. This mineral is linked to cardiovascular disease prevention, and studies indicate that a 50% increase in blood selenium correlates with a 24% drop in coronary artery disease. Its antitumor properties against lung and breast cancer are well-documented, and selenium is essential for proper thyroid function.
Read More
8.8
Good cancer preventer
Country Life Selenium offers a great price and is widely acclaimed as a strong antioxidant. Many users praise its effectiveness in preventing cancer, particularly prostate cancer. I hope to see great results!
8.8
Reduces cancer risk
Selenium is a trace element known for its immunomodulatory properties and regulation of thyroid hormones. Its applications include antioxidant effects, cancer risk reduction, cardiovascular protection, preservation of cognitive function, thyroid health maintenance, and immunity strengthening. The WHO recommends daily intake levels of 55 mcg for women, 70 mcg for men, and 1 mcg per kg of body weight for children.
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