Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.3
USERS' SCORE
Good
Based on 67 Reviews
8
Supplement Facts
Serving Size: Two (2) softgels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Total Carbohydrate
<1 g
<1%**
Vitamin C (as ascorbic acid)
120 mg
133%
Pacran® Whole Fruit Cranberry (Vaccinium macrocarpon)
500 mg
†
Top Medical Research Studies
7
We explored the impact of vaccinium macrocarpon, commonly known as cranberry, on preventing urinary tract infections (UTIs) in aged care residents. The current evidence suggests that cranberry products may help reduce the frequency of UTIs among this demographic, particularly for those who are at heightened risk. However, we noted that the findings are somewhat mixed and incomplete, largely due to insufficient understanding of the active components in cranberries, specifically proanthocyanins.
This analysis highlights the potential benefits of cranberry products for UTI prevention, while also acknowledging the need for further research and education. By better understanding these preventive measures, we could lower antibiotic usage and decrease UTI occurrences in residential aged care settings.
This analysis highlights the potential benefits of cranberry products for UTI prevention, while also acknowledging the need for further research and education. By better understanding these preventive measures, we could lower antibiotic usage and decrease UTI occurrences in residential aged care settings.
Read More
We conducted a 6-month study to understand whether whole cranberry fruit powder could help prevent urinary tract infections (UTIs) in women with a history of recurrent UTIs. Our focus was on 150 healthy females between the ages of 18 and 65 who had experienced either three or more UTIs in the past year or two in the past six months. Participants were randomly assigned to either take 500 mg of cranberry powder daily or a placebo.
Throughout the study, we monitored participants for culture-confirmed UTIs by checking for specific symptoms and conducting tests at various intervals. Unfortunately, our findings showed that the cranberry powder did not significantly impact the incidence of culture-confirmed UTIs, nor did it change safety markers or other related outcomes in the women we studied.
While we hoped to see a positive effect from the cranberry supplement, it's important to report that this study concluded there was no meaningful benefit. Our research provides valuable insights for those considering cranberry as a preventative approach against UTIs, highlighting the need for continued exploration of effective alternatives.
Throughout the study, we monitored participants for culture-confirmed UTIs by checking for specific symptoms and conducting tests at various intervals. Unfortunately, our findings showed that the cranberry powder did not significantly impact the incidence of culture-confirmed UTIs, nor did it change safety markers or other related outcomes in the women we studied.
While we hoped to see a positive effect from the cranberry supplement, it's important to report that this study concluded there was no meaningful benefit. Our research provides valuable insights for those considering cranberry as a preventative approach against UTIs, highlighting the need for continued exploration of effective alternatives.
Read More
9
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
Most Useful Reviews
9
Effective treatment
8 people found this helpful
Every winter, I suffer from urinary tract infection, often affecting my kidneys. I drink a course of antibiotics monthly. However, taking two cranberry tablets daily from the start of winter resolves this issue, as proven over several years. I opt for different brands based on discounts, and this budget option has worked just as well. As long as the concentration is no less than 500, I'm satisfied.
Read More
9
Emotional peace
8 people found this helpful
For two years, I dealt with a urinary tract infection despite consultations with several specialists. After trying many antibiotics with little success, I found this product, which is reputed to combat E-coli. It has significantly eased my distress and gave me a sense of emotional peace. I highly recommend it.
Read More
9
Pain relief
7 people found this helpful
After suffering from cystitis for five years, I would wake in pain throughout the night. Taking two pills before bed has really helped; within a week, I felt more relaxed, and the bacteria disappeared. For those with prolonged urinary tract infections, this is highly recommended.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.3
- All Researches
9.5
We explored the potential of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli (UPEC), which is a major contributor to urinary tract infections (UTIs). This research was motivated by the growing concern over antibiotic resistance, highlighting the need for safer alternatives in UTI treatments.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
Read More
9
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
9
Supplement reduces recurrent UTIs
We investigated the effectiveness of a food supplement containing proanthocyanidin A-rich cranberry extracts (vaccinium macrocarpon) and cinnamon in reducing urinary tract infections (UTIs), particularly recurrent cystitis in women.
In our study, we followed 80 women with a history of cystitis for six months. Half of the participants took the supplement daily while the other half did not. We measured the number of recurrence episodes and assessed symptoms through patient-completed questionnaires.
The results were quite promising. About two-thirds of those using the supplement had no further episodes of cystitis during the six-month period, compared to only one-third of those who didn't take the supplement. Additionally, we noted significant improvements in the frequency and severity of urinary symptoms in those taking the supplement, leading to a better quality of life.
Overall, this study suggests that incorporating vaccinium macrocarpon through supplementation may play a valuable role in managing recurrent urinary infections, providing an alternative for those seeking options beyond antibiotics. The data we've gathered supports the potential benefits of this natural treatment approach.
In our study, we followed 80 women with a history of cystitis for six months. Half of the participants took the supplement daily while the other half did not. We measured the number of recurrence episodes and assessed symptoms through patient-completed questionnaires.
The results were quite promising. About two-thirds of those using the supplement had no further episodes of cystitis during the six-month period, compared to only one-third of those who didn't take the supplement. Additionally, we noted significant improvements in the frequency and severity of urinary symptoms in those taking the supplement, leading to a better quality of life.
Overall, this study suggests that incorporating vaccinium macrocarpon through supplementation may play a valuable role in managing recurrent urinary infections, providing an alternative for those seeking options beyond antibiotics. The data we've gathered supports the potential benefits of this natural treatment approach.
Read More
9
We examined the impacts of vaccinium macrocarpon, commonly known as cranberry, on the management of urinary tract infections (UTIs). Our review focused on several studies that explored how cranberry juice, cranberry tablets, and increased liquid intake affect UTI occurrences.
We found that consuming cranberry juice led to a significantly lower rate of UTIs compared to not receiving any treatment—an impressive 54% reduction. When compared to placebo, the reduction stood at 27%. Additionally, drinking cranberry juice not only helped prevent UTIs but also contributed to a reduction in antibiotic use by 49% compared to placebo and 59% compared to no treatment.
Furthermore, the cranberry compounds also alleviated the symptoms associated with UTIs, making it a beneficial option for managing this common health issue. Overall, the evidence suggests that while increasing fluid intake is helpful in reducing UTIs, cranberry juice provides even better outcomes, offering a promising alternative to traditional antibiotic treatments.
We found that consuming cranberry juice led to a significantly lower rate of UTIs compared to not receiving any treatment—an impressive 54% reduction. When compared to placebo, the reduction stood at 27%. Additionally, drinking cranberry juice not only helped prevent UTIs but also contributed to a reduction in antibiotic use by 49% compared to placebo and 59% compared to no treatment.
Furthermore, the cranberry compounds also alleviated the symptoms associated with UTIs, making it a beneficial option for managing this common health issue. Overall, the evidence suggests that while increasing fluid intake is helpful in reducing UTIs, cranberry juice provides even better outcomes, offering a promising alternative to traditional antibiotic treatments.
Read More
9
Cranberry shows strong UTI prevention
We examined the effectiveness of vaccinium macrocarpon, commonly known as cranberry, in combating urinary tract infections (UTIs). Our study focused on the anti-adhesion activity (AAA) of a dry extract from cranberry fruit juice and D-mannose against two types of uropathogenic bacteria most often responsible for UTIs. Using a crossover design, we analyzed the AAA from both supplements through bioassays that measured their effects after consumption.
Results indicated that cranberry juice extract demonstrated a broad-spectrum AAA against the important bacterial types. However, we also uncovered some limitations in the effectiveness of D-mannose when compared to cranberry products. This suggests that while both dietary supplements may offer protection, cranberry extract has specific advantages in preventing UTIs through its unique mechanisms.
This study provides valuable insights for consumers and healthcare professionals, revealing the potential benefits of including cranberry juice extract in dietary routines for UTI prevention. Armed with this knowledge, individuals looking to enhance their urinary health can make informed choices based on the superior anti-adhesion properties of cranberry.
Results indicated that cranberry juice extract demonstrated a broad-spectrum AAA against the important bacterial types. However, we also uncovered some limitations in the effectiveness of D-mannose when compared to cranberry products. This suggests that while both dietary supplements may offer protection, cranberry extract has specific advantages in preventing UTIs through its unique mechanisms.
This study provides valuable insights for consumers and healthcare professionals, revealing the potential benefits of including cranberry juice extract in dietary routines for UTI prevention. Armed with this knowledge, individuals looking to enhance their urinary health can make informed choices based on the superior anti-adhesion properties of cranberry.
Read More
User Reviews
USERS' SCORE
Good
Based on 67 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
8 people found this helpful
Every winter, I suffer from urinary tract infection, often affecting my kidneys. I drink a course of antibiotics monthly. However, taking two cranberry tablets daily from the start of winter resolves this issue, as proven over several years. I opt for different brands based on discounts, and this budget option has worked just as well. As long as the concentration is no less than 500, I'm satisfied.
Read More
9
Emotional peace
8 people found this helpful
For two years, I dealt with a urinary tract infection despite consultations with several specialists. After trying many antibiotics with little success, I found this product, which is reputed to combat E-coli. It has significantly eased my distress and gave me a sense of emotional peace. I highly recommend it.
Read More
9
Pain relief
7 people found this helpful
After suffering from cystitis for five years, I would wake in pain throughout the night. Taking two pills before bed has really helped; within a week, I felt more relaxed, and the bacteria disappeared. For those with prolonged urinary tract infections, this is highly recommended.
Read More
9
Effective during pregnancy
7 people found this helpful
I’m six months pregnant and have struggled with severe urinary tract infections. After three courses of antibiotics with no improvement, I tried this recommendation from a friend. Within two weeks, I felt relief as the pain diminished. After finishing the course, my tests showed no issues. Trust this product!
Read More
9
Prevented infections
6 people found this helpful
This product has helped my mother, who suffers from recurrent urinary tract infections. Previously, she would have them monthly, but thanks to this, she's able to fast this year without any infections.
Read More
Frequently Asked Questions
9
Pain relief
7 people found this helpful
After suffering from cystitis for five years, I would wake in pain throughout the night. Taking two pills before bed has really helped; within a week, I felt more relaxed, and the bacteria disappeared. For those with prolonged urinary tract infections, this is highly recommended.
9
Effective during pregnancy
7 people found this helpful
I’m six months pregnant and have struggled with severe urinary tract infections. After three courses of antibiotics with no improvement, I tried this recommendation from a friend. Within two weeks, I felt relief as the pain diminished. After finishing the course, my tests showed no issues. Trust this product!
9
Relieves discomfort
4 people found this helpful
I initially took it a month ago, and since then, it has helped immensely. It alleviated urinary tract issues and discomfort during menstruation. I recommend trying it if you face similar problems—feel free to like if it helps you.
9
Effective treatment
8 people found this helpful
Every winter, I suffer from urinary tract infection, often affecting my kidneys. I drink a course of antibiotics monthly. However, taking two cranberry tablets daily from the start of winter resolves this issue, as proven over several years. I opt for different brands based on discounts, and this budget option has worked just as well. As long as the concentration is no less than 500, I'm satisfied.
9
Emotional peace
8 people found this helpful
For two years, I dealt with a urinary tract infection despite consultations with several specialists. After trying many antibiotics with little success, I found this product, which is reputed to combat E-coli. It has significantly eased my distress and gave me a sense of emotional peace. I highly recommend it.
9
Great relief
4 people found this helpful
This is excellent; I found significant relief from inflammation and urinary tract infections. After my second dosage, I noticed remarkable improvements, especially for gynecological issues and discomfort. Of course, maintaining a balanced diet helped too.
10
Cured chronic cystitis
2 people found this helpful
This supplement is perfect for chronic cystitis! After suffering for a year and several courses of antibiotics, I ordered this supplement and mannose, taking it twice daily. After two months, I feel healthier and require it less frequently. It's safer and more cost-effective than antibiotics, with added benefits for the whole body. My mother also improved significantly after five days. This supplement is now a staple in my medicine cabinet. Many thanks to the manufacturer!
9
Highly recommended
3 people found this helpful
These cranberry pills are the best! Taking two daily has relieved my urinary and vaginal infections. If they help you too, please like my review.
We conducted a study focusing on how an oral preparation that includes vitamin C, along with other compounds, might help alleviate urinary tract infection (UTI) symptoms. Through a randomized crossover trial involving participants of reproductive age with recurrent UTIs, we compared two groups: one that received a combination treatment containing vitamin C and another that received a control treatment with various other ingredients.
Over a period of six months, we evaluated participants for changes in urinary and sexual symptoms using standardized assessment tools. Our approach allowed us to observe how effective the treatment was at different intervals.
The results indicated that the combination of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C could lead to improvements in both urinary and sexual function symptoms in study participants. This suggests that vitamin C, when used alongside other compounds, may play a beneficial role in managing symptoms of UTIs.
However, it’s important to note that because vitamin C was part of a multi-ingredient approach, isolating its specific impact remains a challenge. Nonetheless, our findings encourage further exploration into vitamin C's role within such combinations for patients dealing with recurrent UTIs.
Over a period of six months, we evaluated participants for changes in urinary and sexual symptoms using standardized assessment tools. Our approach allowed us to observe how effective the treatment was at different intervals.
The results indicated that the combination of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C could lead to improvements in both urinary and sexual function symptoms in study participants. This suggests that vitamin C, when used alongside other compounds, may play a beneficial role in managing symptoms of UTIs.
However, it’s important to note that because vitamin C was part of a multi-ingredient approach, isolating its specific impact remains a challenge. Nonetheless, our findings encourage further exploration into vitamin C's role within such combinations for patients dealing with recurrent UTIs.
7
We investigated the impact of vitamin C, or ascorbate, on urinary tract infections caused by antibiotic-resistant bacteria. Our study focused on whether adding vitamin C could enhance the effectiveness of certain antibiotics when tested in synthetic human urine, which mimics the conditions in our bodies.
We found that while vitamin C on its own didn’t inhibit bacterial growth, when paired with antibiotics like nitrofurantoin and sulfamethoxazole, the combination showed stronger effects in synthetic urine than in standard media. This was promising, as the minimal inhibitory concentrations—meaning the lowest amounts needed to prevent bacterial growth—were below those typically found in urine.
For other antibiotics like ciprofloxacin and gentamicin, their effectiveness also improved with vitamin C in urine, which is encouraging for treating resistant strains. However, ampicillin wasn’t as affected. Importantly, the beneficial relationship we observed between vitamin C and antibiotics appeared to operate independently from the bacteria's sensitivity to oxygen or oxidative stress.
These findings support the potential for vitamin C to play a role in making certain antibiotic treatments more effective against resistant urinary tract infections. We believe these results open the door for clinical trials to explore how pairing vitamin C with antibiotics could help tackle these challenging infections more efficiently.
We found that while vitamin C on its own didn’t inhibit bacterial growth, when paired with antibiotics like nitrofurantoin and sulfamethoxazole, the combination showed stronger effects in synthetic urine than in standard media. This was promising, as the minimal inhibitory concentrations—meaning the lowest amounts needed to prevent bacterial growth—were below those typically found in urine.
For other antibiotics like ciprofloxacin and gentamicin, their effectiveness also improved with vitamin C in urine, which is encouraging for treating resistant strains. However, ampicillin wasn’t as affected. Importantly, the beneficial relationship we observed between vitamin C and antibiotics appeared to operate independently from the bacteria's sensitivity to oxygen or oxidative stress.
These findings support the potential for vitamin C to play a role in making certain antibiotic treatments more effective against resistant urinary tract infections. We believe these results open the door for clinical trials to explore how pairing vitamin C with antibiotics could help tackle these challenging infections more efficiently.
9.5
We explored the potential of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli (UPEC), which is a major contributor to urinary tract infections (UTIs). This research was motivated by the growing concern over antibiotic resistance, highlighting the need for safer alternatives in UTI treatments.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
8
We explored the effectiveness of vaccinium macrocarpon, commonly known as cranberry, in preventing urinary tract infections (UTIs). Our analysis included data from 50 studies involving nearly 9,000 participants, focusing on various populations who are prone to UTIs.
The results showed that cranberry products can significantly reduce the risk of symptomatic, culture-verified UTIs, particularly in women with recurrent infections, children, and people undergoing specific medical interventions that increase UTI risk.
However, we found less promising outcomes for elderly individuals, pregnant women, and adults with neuromuscular bladder issues, where cranberry appeared to provide little or no benefit in preventing UTIs.
Additionally, while cranberry products may be more effective than probiotics in reducing UTIs, their efficacy compared to antibiotics was less clear and indicated minimal differences. Our findings affirm the potential of cranberry in UTI prevention, but also highlight the limitations for certain groups.
The results showed that cranberry products can significantly reduce the risk of symptomatic, culture-verified UTIs, particularly in women with recurrent infections, children, and people undergoing specific medical interventions that increase UTI risk.
However, we found less promising outcomes for elderly individuals, pregnant women, and adults with neuromuscular bladder issues, where cranberry appeared to provide little or no benefit in preventing UTIs.
Additionally, while cranberry products may be more effective than probiotics in reducing UTIs, their efficacy compared to antibiotics was less clear and indicated minimal differences. Our findings affirm the potential of cranberry in UTI prevention, but also highlight the limitations for certain groups.
References
- Boeri L, De Lorenzis E, Lucignani G, Turetti M, Silvani C, et al. Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial. J Sex Med. 2024;21:627. 10.1093/jsxmed/qdae052
- Amábile-Cuevas CF. Ascorbate and Antibiotics, at Concentrations Attainable in Urine, Can Inhibit the Growth of Resistant Strains of Cultured in Synthetic Human Urine. Antibiotics (Basel). 2023;12. 10.3390/antibiotics12060985
- Hassuna NA, Rabie EM, Mahd WKM, Refaie MMM, Yousef RKM, et al. Antibacterial effect of vitamin C against uropathogenic E. coli in vitro and in vivo. BMC Microbiol. 2023;23:112. 10.1186/s12866-023-02856-3
- Stolarek P, Bernat P, Różalski A. Combined Application of Aminoglycosides and Ascorbic Acid in the Elimination of Rods Responsible for Causing Catheter-Associated Urinary Tract Infections (CAUTIs)-A Molecular Approach. Int J Mol Sci. 2022;23. 10.3390/ijms232113069
- Przekwas J, Gębalski J, Kwiecińska-Piróg J, Wiktorczyk-Kapischke N, Wałecka-Zacharska E, et al. The effect of fluoroquinolones and antioxidans on biofilm formation by Proteus mirabilis strains. Ann Clin Microbiol Antimicrob. 2022;21:22. 10.1186/s12941-022-00515-5
- Bachow BH. Intravesical acetic acid in combination with prophylactic methenamine and ascorbic acid to decrease the incidence of recurrent urinary tract infections associated with intermittent urinary self-catherization: A case report. Urol Case Rep. 2021;35:101531. 10.1016/j.eucr.2020.101531
- Ge B, Guo C, Liang Y, Liu M, Wu K. Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C. Biofactors. 2019;45:912. 10.1002/biof.1558
- Kwiecińska-Piróg J, Skowron K, Bogiel T, Białucha A, Przekwas J, et al. Vitamin C in the Presence of Sub-Inhibitory Concentration of Aminoglycosides and Fluoroquinolones Alters Biofilm Inhibitory Rate. Antibiotics (Basel). 2019;8. 10.3390/antibiotics8030116
- Manzoor MAP, Duwal SR, Mujeeburahiman M, Rekha PD. Vitamin C inhibits crystallization of struvite from artificial urine in the presence of Pseudomonas aeruginosa. Int Braz J Urol. 2018;44:1234. 10.1590/S1677-5538.IBJU.2017.0656
- Montorsi F, Gandaglia G, Salonia A, Briganti A, Mirone V. Effectiveness of a Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study. Eur Urol. 2016;70:912. 10.1016/j.eururo.2016.05.042
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD. Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: A 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.01.022
- Ait Abdellah S, Leblanc A, Dauchet Q, Blondeau C, Bohbot JM. Effects of a supplement associating strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study. Investig Clin Urol. 2025;66:36. 10.4111/icu.20240092
- Carvajal-Campos A, Trebossen L, Jeusette I, Mayot G, Torre C, et al. The effect of consumption of cranberry on adherence to feline uroepithelial cells in a blind randomised cross-over trial in cats. J Vet Res. 2024;68:583. 10.2478/jvetres-2024-0055
- Bimbatti KF, Rocha RDS, Braido IZ, Lima IC, Benoso P, et al. Development and evaluation of fermented milk with Lactobacillus acidophilus added to concentrated cranberry (Vaccinium macrocarpon) juice with the potential to minimize the recurrence of urinary tract infections. Food Res Int. 2024;195:114997. 10.1016/j.foodres.2024.114997
- Ots T, Gold D, Ziller P, Kuenzer T, Dalpiaz O, et al. Segmental Acupuncture for Prevention of Recurrent Urinary Tract Infections. A Randomised Clinical Trial. Int Urogynecol J. 2024;35:1689. 10.1007/s00192-024-05872-7
- Moro C, Phelps C, Veer V, Jones M, Glasziou P, et al. Cranberry Juice, Cranberry Tablets, or Liquid Therapies for Urinary Tract Infection: A Systematic Review and Network Meta-analysis. Eur Urol Focus. 2024;10:947. 10.1016/j.euf.2024.07.002
- Rondanelli M, Mansueto F, Gasparri C, Solerte SB, Misiano P, et al. Supplementation with Highly Standardized Cranberry Extract Phytosome Achieved the Modulation of Urinary Tract Infection Episodes in Diabetic Postmenopausal Women Taking SGLT-2 Inhibitors: A RCT Study. Nutrients. 2024;16. 10.3390/nu16132113
- Howell AB, Dreyfus JF, Bosley S, Krueger CG, Birmingham A, et al. Differences in P-Type and Type 1 Uropathogenic Urinary Anti-Adhesion Activity of Cranberry Fruit Juice Dry Extract Product and D-Mannose Dietary Supplement. J Diet Suppl. 2024;21:633. 10.1080/19390211.2024.2356592
- González de Llano D, Roldán M, Taladrid D, Relaño de la Guía E, Moreno-Arribas MV, et al. Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers. J Agric Food Chem. 2024;72:10328. 10.1021/acs.jafc.3c07169
- Tsiakoulias E, Gravas S, Hadjichristodoulou C, Oikonomou KG, Kyritsi M, et al. Randomized, placebo-controlled, double-blinded study of prophylactic cranberries use in women with recurrent uncomplicated cystitis. World J Urol. 2024;42:27. 10.1007/s00345-023-04741-0
- Bosley S, Krueger CG, Birmingham A, Howell AB, Reed JD. Improved Hemagglutination Assays Utilizing P-Type and Type 1 Uropathogenic to Evaluate Bacterial Anti-Adhesion Activity of Cranberry Products. J Diet Suppl. 2024;21:327. 10.1080/19390211.2023.2276962
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, et al. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;11:CD001321. 10.1002/14651858.CD001321.pub7
- Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;4:CD001321. 10.1002/14651858.CD001321.pub6
- Hakkola M, Vehviläinen P, Muotka J, Tejesvi MV, Pokka T, et al. Cranberry-lingonberry juice affects the gut and urinary microbiome in children - a randomized controlled trial. APMIS. 2023;131:112. 10.1111/apm.13292
- Zhao S, Su Z, Liu H, Khoo C, Garrett TJ, et al. Predictive models built upon annotated and validated intake biomarkers in urine using paired or unpaired analysis helped to classify cranberry juice consumers in a randomized, double-blinded, placebo-controlled, and crossover study. Nutr Res. 2023;109:58. 10.1016/j.nutres.2022.12.002
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