Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: One (1) Tablet
Amount Per Serving
%DV
Top Medical Research Studies
8
Lactobacillus shows promise for constipation
We investigated the effects of a new microbial strain, LP-HFY11, on constipation caused by a common medication in mice. The results showed that LP-HFY11 helped maintain fecal weight and improved gut movement. Those given a high dose expelled stool faster than others treated with lactulose, although still slower than in normal mice.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Read More
9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Read More
8
We explored the impact of Lactobacillus probiotics on chronic constipation through a single-blind, randomized, placebo-controlled trial. Patients received Lactobacillus powder derived from 15 different probiotic products while a placebo was given to the control group.
Our findings showed that probiotic treatment improved gut microbiota composition, notably enhancing beneficial bacteria like Bifidobacterium and Lactobacillus, and significantly reducing constipation symptoms. However, more in-depth research is needed to fully understand the metabolic pathways involved in these improvements.
Our findings showed that probiotic treatment improved gut microbiota composition, notably enhancing beneficial bacteria like Bifidobacterium and Lactobacillus, and significantly reducing constipation symptoms. However, more in-depth research is needed to fully understand the metabolic pathways involved in these improvements.
Read More
Most Useful Reviews
10
Life-changing results
5 people found this helpful
This product has been a lifesaver for my son, who suffered severe stomach issues and extreme constipation—a diagnosis confirmed by three doctors. After trying numerous treatments, including enemas and diet modifications, I was advised to try probiotics. I purchased this multivitamin, and on the first day, he had bowel movements without pain. Since then, he has become more regular, and the agony he endured seems like a distant memory. I will continue to buy this for as long as necessary; it has transformed our lives.
Read More
9
Good for relief
4 people found this helpful
These chewable tablets are excellent for tackling constipation. They taste great, and once my child got used to them, they effectively eased his constipation.
Read More
10
Hundreds of recommendations
2 people found this helpful
This product has been invaluable for my daughter, who previously struggled with painful constipation. Having researched this product, I decided to try it, and I’m so glad I did. After nearly a month, she experiences no more issues and now goes to the toilet regularly and pain-free. It’s such a relief to see her happy and comfortable, and I highly recommend it to anyone facing similar issues with their children.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We explored the potential of the probiotic CCFM1163 to alleviate slow-transit constipation caused by prolonged laxative use, known as cathartic colon. Using a mouse model, we observed how this probiotic affects the gut's nerve and barrier functions.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
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9
Probiotics effectively relieve constipation
We explored how specific microbial agents can change the gut bacteria and help relieve constipation in mice. The study focused on two treatments, including Lactobacillus, and found they increased beneficial gut bacteria and improved peristalsis, which is the movement that helps waste pass through the intestines.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Read More
9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Read More
8
Lactobacillus shows promise for constipation
We investigated the effects of a new microbial strain, LP-HFY11, on constipation caused by a common medication in mice. The results showed that LP-HFY11 helped maintain fecal weight and improved gut movement. Those given a high dose expelled stool faster than others treated with lactulose, although still slower than in normal mice.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Read More
8
We aimed to explore how TWK10 affects constipation in rats on a high-fat diet. In our findings, administering TWK10 or its fermented soy milk notably improved bowel movements and increased the intestinal transit ratio by over 10%.
The study showed that TWK10 also boosted short-chain fatty acid production and positively altered the gut microbiota. Additionally, we observed enhanced thickness in the colon’s muscle and mucosal layers, indicating overall gut health improvement.
This suggests that TWK10 might be a promising option for addressing constipation linked to obesity.
The study showed that TWK10 also boosted short-chain fatty acid production and positively altered the gut microbiota. Additionally, we observed enhanced thickness in the colon’s muscle and mucosal layers, indicating overall gut health improvement.
This suggests that TWK10 might be a promising option for addressing constipation linked to obesity.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing results
5 people found this helpful
This product has been a lifesaver for my son, who suffered severe stomach issues and extreme constipation—a diagnosis confirmed by three doctors. After trying numerous treatments, including enemas and diet modifications, I was advised to try probiotics. I purchased this multivitamin, and on the first day, he had bowel movements without pain. Since then, he has become more regular, and the agony he endured seems like a distant memory. I will continue to buy this for as long as necessary; it has transformed our lives.
Read More
9
Good for relief
4 people found this helpful
These chewable tablets are excellent for tackling constipation. They taste great, and once my child got used to them, they effectively eased his constipation.
Read More
10
Hundreds of recommendations
2 people found this helpful
This product has been invaluable for my daughter, who previously struggled with painful constipation. Having researched this product, I decided to try it, and I’m so glad I did. After nearly a month, she experiences no more issues and now goes to the toilet regularly and pain-free. It’s such a relief to see her happy and comfortable, and I highly recommend it to anyone facing similar issues with their children.
Read More
9
Effective for constipation
I genuinely like this brand of vitamins for the children. They enjoy the taste and look forward to their "sweet" each morning. Additionally, it has resolved their constipation issues!
Read More
9
No more constipation
I love the quality and ingredients of Culturelle brand. This probiotic is excellent for my children’s digestion and has completely eliminated their constipation.
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Frequently Asked Questions
9
Noticeable improvement
These probiotics are of super high quality. They taste pleasant, and I noticed an improvement in my child's constipation from the first use.
9
Effective for constipation
I genuinely like this brand of vitamins for the children. They enjoy the taste and look forward to their "sweet" each morning. Additionally, it has resolved their constipation issues!
9
No more constipation
I love the quality and ingredients of Culturelle brand. This probiotic is excellent for my children’s digestion and has completely eliminated their constipation.
7.5
Great for digestion
Great quality product. The package is large with a nice taste. It works well for gut health, constipation, and digestion, providing numerous benefits for mineral absorption.
9
Effective digestion support
I continually feed my child lactobacillus, and it effectively aids digestion while preventing constipation. Being a multivitamin, it simplifies their supplement needs.
7.5
Relieved constipation
I liked this product very much. While on antibiotics, there was no bowel pain, likely due to this supplement. Overall, constipation has ceased to be an issue.
9
Improves constipation
The quality, packaging, and ingredients are excellent. This probiotic with multivitamins for children enhances health and digestion while preventing constipation.
8
We explored the impact of Lactobacillus probiotics on chronic constipation through a single-blind, randomized, placebo-controlled trial. Patients received Lactobacillus powder derived from 15 different probiotic products while a placebo was given to the control group.
Our findings showed that probiotic treatment improved gut microbiota composition, notably enhancing beneficial bacteria like Bifidobacterium and Lactobacillus, and significantly reducing constipation symptoms. However, more in-depth research is needed to fully understand the metabolic pathways involved in these improvements.
Our findings showed that probiotic treatment improved gut microbiota composition, notably enhancing beneficial bacteria like Bifidobacterium and Lactobacillus, and significantly reducing constipation symptoms. However, more in-depth research is needed to fully understand the metabolic pathways involved in these improvements.
8
We evaluated the effectiveness of two Lactobacillus strains, MWLp-12 and MWLf-4, in relieving constipation through a study involving Balb/c mice. By measuring factors like fecal water content and the time to expel feces, we found that both strains and their fermented milk had significant constipation-relieving effects.
Notably, fermented milk outperformed the individual strains. Our findings indicate that these treatments may influence key gastrointestinal peptides and short-chain fatty acid levels, contributing to their effectiveness in easing constipation.
Notably, fermented milk outperformed the individual strains. Our findings indicate that these treatments may influence key gastrointestinal peptides and short-chain fatty acid levels, contributing to their effectiveness in easing constipation.
8
We conducted a decentralized clinical trial to evaluate how Lactobacillus affects constipation symptoms. Participants, who experienced functional constipation, were randomly assigned to either receive Lactobacillus with vitamin C or vitamin C alone.
Over two weeks, we observed that those taking Lactobacillus reported more frequent bowel movements and shorter time spent in the bathroom compared to the control group. While two weeks of treatment showed some promise, individual results varied, and not all participants completed their diaries consistently.
This pilot highlights the potential of using modern methods for studying health but also suggests that more research is needed to ensure reliability and access.
Over two weeks, we observed that those taking Lactobacillus reported more frequent bowel movements and shorter time spent in the bathroom compared to the control group. While two weeks of treatment showed some promise, individual results varied, and not all participants completed their diaries consistently.
This pilot highlights the potential of using modern methods for studying health but also suggests that more research is needed to ensure reliability and access.
7
We examined how lactobacillus, a type of beneficial bacteria, might help alleviate constipation and other digestive system issues. The review of existing research presented evidence that lactobacillus works through several mechanisms, like producing helpful metabolites and improving gut microbiome balance.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
References
- Tan F, Kong CS. Inhibitory Effect of HFY11 on Compound Diphenoxylate-Induced Constipation in Mice. Biomolecules. 2025;15. doi:10.3390/biom15030358
- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. doi:10.1016/j.anireprosci.2025.107785
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
- Liu TH, Chen GL, Lin CH, Tsai TY, Cheng MC. TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food Funct. 2025;16:181. doi:10.1039/d4fo02270j
- Zhao B, Wang Y, Wang S, Mu G, Wu X. Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk. J Sci Food Agric. 2025;105:2594. doi:10.1002/jsfa.14032
- Zhang X, Jia Y, Li X, Wang X, Li L, et al. Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation. Benef Microbes. 2024;16:35. doi:10.1163/18762891-bja00039
- Tanihiro R, Yuki M, Sakano K, Sasai M, Sawada D, et al. Effects of Heat-Treated CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16142191
- Yang WC, Zeng BS, Liang CS, Hsu CW, Su KP, et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr. 2024;183:3531. doi:10.1007/s00431-024-05568-6
- Han Y, Zhou Y, Xu X, Chen S, Zhang S, et al. Improvement of Post-Surgery Constipation in Patients with Fractures by JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16101505
- Zhang C, Wang L, Liu X, Wang G, Guo X, et al. Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation. Benef Microbes. 2024;15:311. doi:10.1163/18762891-bja00011
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Yang C, Hu T, Xue X, Su X, Zhang X, et al. Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety. BMC Microbiol. 2023;23:389. doi:10.1186/s12866-023-03123-1
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
- Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, et al. in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023;13:1254198. doi:10.3389/fcimb.2023.1254198
- Huh KY, Chung WK, Park J, Lee S, Kim MG, et al. Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms. Clin Transl Sci. 2023;16:2177. doi:10.1111/cts.13617
