I have Ulcerative Colitis, SIBO, and histamine issues. I've tried probiotics in the past in an attempt to help with all of my gut issues. They've either made them worse or triggered a histamine reaction. After years of trying very expensive "clean ingredient" probiotics, I finally broke down and tried Cultrelle. It's been great! I can't say any miracles are happening, but it does help to make BM's more regular (TMI - but hey, that's what we're buying here) and no histamine reactions! I do wish this wasn't made with corn, but I'm happy that a reasonable priced probiotic is actually working for me. I recommend trying this if you have any of the same issues I have...and be sure to purchase the one without prebiotics if you have SIBO