5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
40 mg (10 billion CFUs)
**
Inulin (Chicory Root Extract)
200 mg
**
Top Medical Research Studies
9
We investigated the effectiveness of a combined probiotic treatment for young children suffering from food allergies that affected their skin and digestive systems. In a randomized controlled study involving 92 children, those taking the probiotics saw a notable decrease in allergy symptoms and a significant drop in immunoglobulin E levels—an antibody linked with allergic reactions.
After 21 days of treatment, skin issues improved, while gastrointestinal symptoms like bloating and discomfort were also reduced. Although some symptoms returned over the next five months, the overall health of the group remained significantly better compared to those who didn’t receive the treatment.
After 21 days of treatment, skin issues improved, while gastrointestinal symptoms like bloating and discomfort were also reduced. Although some symptoms returned over the next five months, the overall health of the group remained significantly better compared to those who didn’t receive the treatment.
Read More
9
We investigated how Probio-M9, a probiotic found in human milk, affects food allergies in mice sensitized to ovalbumin (OVA). Our study showed that administering live Probio-M9 significantly lowered levels of allergy markers like specific IgE and histamine, which are key in allergic reactions.
Importantly, Probio-M9 also shifted immune responses towards a more balanced state, reducing allergy-related inflammation. The analysis revealed beneficial changes in gut bacteria and an increase in short-chain fatty acids, which play a role in maintaining health.
Overall, our results suggest that Probio-M9 could be a promising approach to prevent food allergies.
Importantly, Probio-M9 also shifted immune responses towards a more balanced state, reducing allergy-related inflammation. The analysis revealed beneficial changes in gut bacteria and an increase in short-chain fatty acids, which play a role in maintaining health.
Overall, our results suggest that Probio-M9 could be a promising approach to prevent food allergies.
Read More
9
We explored how Lactobacillus rhamnosus DNA might affect allergic responses linked to Th2 polarization. Using a specific protocol in mice, we administered LR-DNA daily for five days and observed its impact on intestinal cells. The results showed that LR-DNA increased PD-L1 expression in these cells, which then helped trigger the death of Th2 cells.
Importantly, while we found promising effects, the study suggests that just the DNA from the probiotic—not the live bacteria—was effective in reducing allergic responses.
Importantly, while we found promising effects, the study suggests that just the DNA from the probiotic—not the live bacteria—was effective in reducing allergic responses.
Read More
Most Useful Reviews
7.5
Improved sleep quality
18 people found this helpful
Good on many fronts, but caution as it may lead to weight gain. Within a week, Lactobacillus rhamnosus (LGG) has significantly improved my leaky gut and food allergies, allowing me a better tolerance of various foods. My sleep quality has enhanced, leaving me well-rested and more energetic in the morning. Additionally, it has reduced mast cell activation syndrome, along with joint inflammation and pain. While it works wonders in those respects, I would advise caution regarding potential rapid weight gain.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
- All Researches
9
We investigated how Probio-M9, a probiotic found in human milk, affects food allergies in mice sensitized to ovalbumin (OVA). Our study showed that administering live Probio-M9 significantly lowered levels of allergy markers like specific IgE and histamine, which are key in allergic reactions.
Importantly, Probio-M9 also shifted immune responses towards a more balanced state, reducing allergy-related inflammation. The analysis revealed beneficial changes in gut bacteria and an increase in short-chain fatty acids, which play a role in maintaining health.
Overall, our results suggest that Probio-M9 could be a promising approach to prevent food allergies.
Importantly, Probio-M9 also shifted immune responses towards a more balanced state, reducing allergy-related inflammation. The analysis revealed beneficial changes in gut bacteria and an increase in short-chain fatty acids, which play a role in maintaining health.
Overall, our results suggest that Probio-M9 could be a promising approach to prevent food allergies.
Read More
9
We investigated the effectiveness of a combined probiotic treatment for young children suffering from food allergies that affected their skin and digestive systems. In a randomized controlled study involving 92 children, those taking the probiotics saw a notable decrease in allergy symptoms and a significant drop in immunoglobulin E levels—an antibody linked with allergic reactions.
After 21 days of treatment, skin issues improved, while gastrointestinal symptoms like bloating and discomfort were also reduced. Although some symptoms returned over the next five months, the overall health of the group remained significantly better compared to those who didn’t receive the treatment.
After 21 days of treatment, skin issues improved, while gastrointestinal symptoms like bloating and discomfort were also reduced. Although some symptoms returned over the next five months, the overall health of the group remained significantly better compared to those who didn’t receive the treatment.
Read More
9
We explored how Lactobacillus rhamnosus DNA might affect allergic responses linked to Th2 polarization. Using a specific protocol in mice, we administered LR-DNA daily for five days and observed its impact on intestinal cells. The results showed that LR-DNA increased PD-L1 expression in these cells, which then helped trigger the death of Th2 cells.
Importantly, while we found promising effects, the study suggests that just the DNA from the probiotic—not the live bacteria—was effective in reducing allergic responses.
Importantly, while we found promising effects, the study suggests that just the DNA from the probiotic—not the live bacteria—was effective in reducing allergic responses.
Read More
9
We examined how probiotics, especially Lactobacillus rhamnosus, can improve treatments for food allergies through allergen-specific immunotherapy (FA-AIT). These helpful bacteria promote better immune responses, leading to increased tolerance. Clinical trials revealed that combining Lactobacillus rhamnosus with peanut immunotherapy led to better desensitization rates and positive immune changes.
While FA-AIT remains under study, integrating probiotics into these treatments appears promising for achieving lasting relief from allergies and improving patient well-being.
While FA-AIT remains under study, integrating probiotics into these treatments appears promising for achieving lasting relief from allergies and improving patient well-being.
Read More
9
Lr improves lung inflammation management
We sought to understand how Lactobacillus rhamnosus (Lr) influences lung inflammation and gut health in asthma-COPD overlap syndrome (ACOS). In an experimental study with mice, we introduced Lr treatment after inducing ACOS.
Our findings indicated that Lr treatment reduced lung inflammation, bronchial hyperreactivity, and improved gut microbiota diversity. Specifically, Lr lowered the levels of pro-inflammatory cytokines and restored beneficial immune markers. This study reveals that Lr could play a role in managing symptoms of ACOS by modulating both lung inflammation and gut dysbiosis.
Our findings indicated that Lr treatment reduced lung inflammation, bronchial hyperreactivity, and improved gut microbiota diversity. Specifically, Lr lowered the levels of pro-inflammatory cytokines and restored beneficial immune markers. This study reveals that Lr could play a role in managing symptoms of ACOS by modulating both lung inflammation and gut dysbiosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved sleep quality
18 people found this helpful
Good on many fronts, but caution as it may lead to weight gain. Within a week, Lactobacillus rhamnosus (LGG) has significantly improved my leaky gut and food allergies, allowing me a better tolerance of various foods. My sleep quality has enhanced, leaving me well-rested and more energetic in the morning. Additionally, it has reduced mast cell activation syndrome, along with joint inflammation and pain. While it works wonders in those respects, I would advise caution regarding potential rapid weight gain.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Bai J, Ni Y, Zeng Q, Wu Z, Li X, et al. In vitro screening of synbiotics composed of Lactobacillus and oligosaccharides and evaluating the potential anti-allergic ability. J Food Sci. 2025;90:e70080. 10.1111/1750-3841.70080
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- Mennini M, Piccirillo M, Furio S, Valitutti F, Ferretti A, et al. Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review. Front Allergy. 2024;5:1473352. 10.3389/falgy.2024.1473352
- Malekiantaghi A, Ghanaati F, Shabani-Mirzaee H, Shariat M, Mojtahedi SY, et al. Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis. Breastfeed Med. 2025;20:59. 10.1089/bfm.2024.0185
- Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. 10.1159/000540075
- Uberos J, Garcia-Cuesta A, Carrasco-Solis M, Ruiz-López A, Fernandez-Marı N E, et al. Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants. Benef Microbes. 2023;14:433. 10.1163/18762891-20220144
- Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. 10.3389/fmicb.2023.1202858
- Vasconcelos JA, Mota AS, Olímpio F, Rosa PC, Damaceno-Rodrigues N, et al. Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome. Probiotics Antimicrob Proteins. 2025;17:588. 10.1007/s12602-023-10167-2
- Tan Lim CSC, Sajo MEJV, Orteza KEMP, Fernandez PBA, Vila MJC. Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis. Pediatr Allergy Immunol. 2023;34:e14022. 10.1111/pai.14022
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
- Hou Y, Zheng S, Zou F, Wang D, Da H, et al. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology. 2023;228:152712. 10.1016/j.imbio.2023.152712
- Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. 10.4014/jmb.2301.01028
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- Han K, Xie F, Animasahun O, Nenwani M, Kitamoto S, et al. Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy. Nat Mater. 2024;23:1444. 10.1038/s41563-024-01909-w
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