Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
7
Vitamin B6 effects on psoriasis inflammation
We explored the intriguing connection between vitamin B6 and psoriasis, a skin condition affecting about 3% of people worldwide. This research centers on how vitamin B6 impacts skin inflammation, focusing on its metabolites and their effects on inflammatory markers in psoriasis patients.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Read More
9.5
Vitamin B shows promise for psoriasis
We conducted a study to examine the effectiveness of a vitamin B-containing ointment in treating mild-to-moderate plaque psoriasis compared to a standard glycerol-petrolatum-based emollient cream. The trial was designed thoughtfully, with 24 patients participating in a randomized, controlled, single-blind format. Each patient received the vitamin B ointment on one side of their body and the standard cream on the other side.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Read More
8
Folate's role in psoriasis management
We explored the relationship between homocysteine levels and psoriasis, with particular attention on how folate treatment may influence this chronic skin condition. Recent findings have shown that individuals suffering from psoriasis typically have elevated serum homocysteine levels. This condition, known as hyperhomocysteinaemia, can be associated with deficiencies in essential nutrients like folic acid and vitamin B12.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Read More
Most Useful Reviews
7.5
Decreased psoriasis
4 people found this helpful
These are fantastic, dissolve super fast, taste great, and have improved our health! My husband and I have both felt much better since taking these; his depression has decreased and his psoriasis has lessened, giving us more energy. I highly recommend them!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
- All Researches
9.5
Vitamin B shows promise for psoriasis
We conducted a study to examine the effectiveness of a vitamin B-containing ointment in treating mild-to-moderate plaque psoriasis compared to a standard glycerol-petrolatum-based emollient cream. The trial was designed thoughtfully, with 24 patients participating in a randomized, controlled, single-blind format. Each patient received the vitamin B ointment on one side of their body and the standard cream on the other side.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Over the duration of 12 weeks, we periodically measured the severity of psoriasis using the Psoriasis Area Severity Index (PASI). Our findings revealed that the vitamin B ointment significantly reduced the severity of psoriasis compared to the control cream at various times, particularly showing an impressive average reduction of 87.6% from baseline after 12 weeks.
This evidence suggests that vitamin B ointment not only offers a new treatment avenue for psoriasis but also should be considered in future treatment guidelines. We believe our research underscores the potential benefits of a vitamin B therapy approach in managing this chronic skin condition effectively.
Read More
9
We assessed the effectiveness of a topical herbal preparation called DurrDerma, designed to treat moderate to severe psoriasis. This preparation combines several natural ingredients, including black cumin, olive oil, tea tree oil, cocoa butter, along with vitamins A and B12. The focus was on seeing how well this combination worked in patients who had severe and treatment-resistant cases of psoriasis.
Our case series involved 12 patients, aged between 21 and 86 years, who used the preparation twice daily for 12 weeks. The results were quite promising. Ten out of the twelve patients (about 83%) achieved significant improvement, with a Psoriasis Area and Severity Index (PASI) score reduction of over 75%. However, two patients only had moderate improvements, with a PASI reduction of 50% or less.
Interestingly, while vitamin B12 was part of the treatment mix, we cannot isolate its specific effects on psoriasis due to its combination with other ingredients. Despite the lack of separate assessment of vitamin B12, the overall findings suggest that the antioxidants and anti-inflammatory properties of DurrDerma may provide a beneficial effect. In summary, our findings indicate that this traditional herbal preparation may serve as a complementary approach to psoriasis management.
Our case series involved 12 patients, aged between 21 and 86 years, who used the preparation twice daily for 12 weeks. The results were quite promising. Ten out of the twelve patients (about 83%) achieved significant improvement, with a Psoriasis Area and Severity Index (PASI) score reduction of over 75%. However, two patients only had moderate improvements, with a PASI reduction of 50% or less.
Interestingly, while vitamin B12 was part of the treatment mix, we cannot isolate its specific effects on psoriasis due to its combination with other ingredients. Despite the lack of separate assessment of vitamin B12, the overall findings suggest that the antioxidants and anti-inflammatory properties of DurrDerma may provide a beneficial effect. In summary, our findings indicate that this traditional herbal preparation may serve as a complementary approach to psoriasis management.
Read More
8
Methotrexate toxicity management insights
We examined the challenges associated with methotrexate (MTX) treatment in psoriasis patients, particularly the risk of toxicity from the medication. In this multicentric, retrospective study, we focused on identifying the underlying causes of MTX toxicity and understanding how folate treatment plays a role in managing these cases.
Out of 21 patients treated for MTX toxicity, most experienced significant side effects like mucocutaneous ulcerations and hematological issues. We observed that folinic acid, a form of folate, was used successfully in treating these patients, with a recovery rate of 85% within just 7-14 days. However, this finding primarily highlights folinic acid's role in mitigating toxicity rather than demonstrating a direct benefit of folate on psoriasis itself.
Importantly, the study revealed that overdosing—often due to self-medication—was the leading cause of toxicity, affecting 66% of patients. This underscores the need for thorough counseling regarding MTX use and potential side effects.
Overall, while folate aids in addressing toxicity symptoms, our findings do not suggest that it offers significant benefits for psoriasis treatment itself. It's crucial for patients to seek prompt medical advice if toxicity symptoms arise, ensuring timely and effective management.
Out of 21 patients treated for MTX toxicity, most experienced significant side effects like mucocutaneous ulcerations and hematological issues. We observed that folinic acid, a form of folate, was used successfully in treating these patients, with a recovery rate of 85% within just 7-14 days. However, this finding primarily highlights folinic acid's role in mitigating toxicity rather than demonstrating a direct benefit of folate on psoriasis itself.
Importantly, the study revealed that overdosing—often due to self-medication—was the leading cause of toxicity, affecting 66% of patients. This underscores the need for thorough counseling regarding MTX use and potential side effects.
Overall, while folate aids in addressing toxicity symptoms, our findings do not suggest that it offers significant benefits for psoriasis treatment itself. It's crucial for patients to seek prompt medical advice if toxicity symptoms arise, ensuring timely and effective management.
Read More
8
Folate's role in psoriasis management
We explored the relationship between homocysteine levels and psoriasis, with particular attention on how folate treatment may influence this chronic skin condition. Recent findings have shown that individuals suffering from psoriasis typically have elevated serum homocysteine levels. This condition, known as hyperhomocysteinaemia, can be associated with deficiencies in essential nutrients like folic acid and vitamin B12.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Our investigation highlighted the potential role of homocysteine in exacerbating the inflammatory processes underlying psoriasis, by activating certain immune cells while hindering the activity of regulatory T cells. Importantly, increasing folate intake through systemic folinate calcium has been noted to provide effective treatment results.
Topical vitamin B12 has also shown promise. The growing body of evidence points to the idea that addressing deficiencies in these vitamins could help manage symptoms of psoriasis more effectively. It seems clear that optimizing folate levels might play a vital role in improving patients' conditions.
Read More
7
Vitamin B6 effects on psoriasis inflammation
We explored the intriguing connection between vitamin B6 and psoriasis, a skin condition affecting about 3% of people worldwide. This research centers on how vitamin B6 impacts skin inflammation, focusing on its metabolites and their effects on inflammatory markers in psoriasis patients.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Decreased psoriasis
4 people found this helpful
These are fantastic, dissolve super fast, taste great, and have improved our health! My husband and I have both felt much better since taking these; his depression has decreased and his psoriasis has lessened, giving us more energy. I highly recommend them!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Martínez-Navarro FJ, Martínez-Morcillo FJ, López-Muñoz A, Pardo-Sánchez I, Martínez-Menchón T, et al. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. Dev Comp Immunol. 2020;108:103666. doi:10.1016/j.dci.2020.103666
- Erduran F, Emre S, Hayran Y, Adışen E, Polat AK, et al. Analysis of factors influencing target PASI responses and side effects of methotrexate monotherapy in plaque psoriasis: a multicenter study of 1521 patients. Arch Dermatol Res. 2024;316:278. doi:10.1007/s00403-024-03066-1
- Singh GK, Sapra D, Bahuguna A, Das P. Methotrexate toxicity in psoriasis-A multicentric retrospective study. Dermatol Ther. 2022;35:e15765. doi:10.1111/dth.15765
- Zhang Q, Lin J, Zhang Z, Han L, Huang Q, et al. MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate. J Clin Med. 2022;11. doi:10.3390/jcm11154580
- Bruins FM, Van Acht MR, Bronckers IMGJ, Groenewoud HMM, De Jong EMGJ, et al. Real-world Methotrexate Use in a Prospective Cohort of Paediatric Patients with Plaque Psoriasis: Effectiveness, Adverse Events and Folic Acid Regimen. Acta Derm Venereol. 2022;102:adv00745. doi:10.2340/actadv.v102.1000
- Grželj J, Mlinarič-Raščan I, Marko PB, Marovt M, Gmeiner T, et al. Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis. Biomed Pharmacother. 2021;138:111456. doi:10.1016/j.biopha.2021.111456
- Lin X, Meng X, Song Z. Homocysteine and psoriasis. Biosci Rep. 2019;39. doi:10.1042/BSR20190867
- Yousefkhani L, Rafiei R, Darjani A, Alizadeh N, Eftekhari H, et al. Evaluation of serum folate level before and after bath PUVA therapy in patients referred to Razi Hospital, Rasht, Iran. Dermatol Ther. 2019;32:e13000. doi:10.1111/dth.13000
- Kim BR, Lee DH, Shim HI, Kim JW, Park S, et al. Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study. Ann Dermatol. 2022;34:191. doi:10.5021/ad.2022.34.3.191
- Beranek M, Malkova A, Fiala Z, Kremlacek J, Hamakova K, et al. Goeckerman Therapy of Psoriasis: Genotoxicity, Dietary Micronutrients, Homocysteine, and Gene Polymorphisms. Int J Mol Sci. 2019;20. doi:10.3390/ijms20081908
- Del Duca E, Farnetani F, De Carvalho N, Bottoni U, Pellacani G, et al. Superiority of a vitamin B-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis. Int J Immunopathol Pharmacol. 2017;30:439. doi:10.1177/0394632017736674
- Michalsen A, Eddin O, Salama A. A case series of the effects of a novel composition of a traditional natural preparation for the treatment of psoriasis. J Tradit Complement Med. 2016;6:395.
- Liu W, Xuan M, Xue F, Yang R. [Acquired coagulation factor X deficiency: three cases report and literature review]. Zhonghua Xue Ye Xue Za Zhi. 2014;35:633. doi:10.3760/cma.j.issn.0253-2727.2014.07.014
