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SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
9
Coenzyme Q10 aids anemia treatment
The anemia of vitamin E deficiency in swine: an experimental model of the human congenital dyserythropoietic anemias.
Effective treatment via coenzyme Q10
We explored the characteristics of anemia caused by vitamin E deficiency in pigs to see how it might serve as a model for human congenital dyserythropoietic anemia (CDA). In this study, we found that the main issue in these pigs was ineffective erythropoiesis, similar to what some humans experience with CDA.
Strikingly, we observed increases in certain erythrocyte enzymes in these pigs, paralleling changes noted in CDA patients. In the animals, distinctive structural alterations similar to those seen in human cases were present in normoblasts, the precursors to red blood cells.
A notable finding was that administering coenzyme Q10, alongside vitamin E, led to a complete hematologic response in the pigs. This suggests that coenzyme Q10 could play a significant role in addressing anemia related to vitamin E deficiency. However, the partial response noted after adjusting the diet indicates that there may be more factors at play in this disorder’s development.
Overall, coenzyme Q10 appears to have a beneficial impact on treating anemia in this swine model, indicating potential avenues for further research in human applications.
Strikingly, we observed increases in certain erythrocyte enzymes in these pigs, paralleling changes noted in CDA patients. In the animals, distinctive structural alterations similar to those seen in human cases were present in normoblasts, the precursors to red blood cells.
A notable finding was that administering coenzyme Q10, alongside vitamin E, led to a complete hematologic response in the pigs. This suggests that coenzyme Q10 could play a significant role in addressing anemia related to vitamin E deficiency. However, the partial response noted after adjusting the diet indicates that there may be more factors at play in this disorder’s development.
Overall, coenzyme Q10 appears to have a beneficial impact on treating anemia in this swine model, indicating potential avenues for further research in human applications.
Read More
8
Coenzyme Q10 shows promise for anemia
Disruption of mitochondrial energy metabolism is a putative pathogenesis of Diamond-Blackfan anemia.
Study evaluates treatment effects
We explored the effects of coenzyme Q10 on anemia, particularly in the context ofDiamond-Blackfan anemia, a disorder linked to issues with red blood cell production. In our investigation, we examined how mitochondrial energy metabolism plays a critical role in the health of red blood cell progenitors.
Through a primary cell model, we suppressed the mitochondrial oxidative phosphorylation (OXPHOS) pathway, which led to complications in the differentiation of erythroid cells and disrupted ribosome production. Notably, the mutated genes associated with OXPHOS in patients with Diamond-Blackfan anemia contributed to this malfunction.
When we applied coenzyme Q10—known to activate the OXPHOS pathway—we observed significant improvements in the erythroid defects that arose from the suppression. This compound not only helped in rescuing the erythroid development but also boosted the expression of a crucial protein involved in ribosome biogenesis.
Overall, our study points to coenzyme Q10 as a promising candidate for addressing anemia arising from mitochondrial issues, emphasizing its potential therapeutic impact in conditions like Diamond-Blackfan anemia.
Through a primary cell model, we suppressed the mitochondrial oxidative phosphorylation (OXPHOS) pathway, which led to complications in the differentiation of erythroid cells and disrupted ribosome production. Notably, the mutated genes associated with OXPHOS in patients with Diamond-Blackfan anemia contributed to this malfunction.
When we applied coenzyme Q10—known to activate the OXPHOS pathway—we observed significant improvements in the erythroid defects that arose from the suppression. This compound not only helped in rescuing the erythroid development but also boosted the expression of a crucial protein involved in ribosome biogenesis.
Overall, our study points to coenzyme Q10 as a promising candidate for addressing anemia arising from mitochondrial issues, emphasizing its potential therapeutic impact in conditions like Diamond-Blackfan anemia.
Read More
8
Co-Q improves anemia in HAT
Coenzyme Q prevented breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis.
Study indicates significant effects
We examined the effects of Coenzyme Q10 (Co-Q) on anemia in the context of Human African Trypanosomiasis (HAT), a severe illness caused by the parasite T.b.r. Our study involved multiple groups, including a control group, an infected group, and a group treated with Co-Q. The results were quite promising for the Co-Q group.
Specifically, we observed that Co-Q administration significantly mitigated T.b.r-induced microcytic hypochromic anemia. This condition typically leads to low levels of healthy red blood cells, contributing to the fatigue and weakness associated with anemia. Alongside this, Co-Q helped combat thrombocytopenia, a drop in platelet count often linked to such infections.
Furthermore, Co-Q treatment improved the overall health and survival of the infected mice. By preventing the parasite from causing significant changes in the body, including high inflammatory markers and oxidative stress, Co-Q proved to be beneficial. Essentially, we found that using Co-Q might offer a protective effect against the organ damage and severe anemia driven by the parasitic infection.
Overall, our findings suggest that Co-Q could be a valuable addition to therapeutic strategies aimed at not just treating anemia but also managing other severe complications associated with late-stage HAT.
Specifically, we observed that Co-Q administration significantly mitigated T.b.r-induced microcytic hypochromic anemia. This condition typically leads to low levels of healthy red blood cells, contributing to the fatigue and weakness associated with anemia. Alongside this, Co-Q helped combat thrombocytopenia, a drop in platelet count often linked to such infections.
Furthermore, Co-Q treatment improved the overall health and survival of the infected mice. By preventing the parasite from causing significant changes in the body, including high inflammatory markers and oxidative stress, Co-Q proved to be beneficial. Essentially, we found that using Co-Q might offer a protective effect against the organ damage and severe anemia driven by the parasitic infection.
Overall, our findings suggest that Co-Q could be a valuable addition to therapeutic strategies aimed at not just treating anemia but also managing other severe complications associated with late-stage HAT.
Read More
Most Useful Reviews
8.8
Increased energy
Doctors Best High Absorption coQ10 has significantly boosted my energy levels. I have thalassemia anemia, which isn't treatable with medications, but this product is quite affordable and helps me a great deal.
Read More
9.5
Supports heart health
This is my preferred remedy for heart health, significantly aiding my chronic anemia. It provides energy and alleviates chest discomfort. The dosage is ideal, and it represents great value. This is my second purchase of it.
Read More
8.8
Strong heart support
This supplement supports a healthy heart, particularly after my mother suffered from postoperative haemorrhage and anemia. It appears to strengthen heart function effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
9
Coenzyme Q10 aids anemia treatment
The anemia of vitamin E deficiency in swine: an experimental model of the human congenital dyserythropoietic anemias.
Effective treatment via coenzyme Q10
We explored the characteristics of anemia caused by vitamin E deficiency in pigs to see how it might serve as a model for human congenital dyserythropoietic anemia (CDA). In this study, we found that the main issue in these pigs was ineffective erythropoiesis, similar to what some humans experience with CDA.
Strikingly, we observed increases in certain erythrocyte enzymes in these pigs, paralleling changes noted in CDA patients. In the animals, distinctive structural alterations similar to those seen in human cases were present in normoblasts, the precursors to red blood cells.
A notable finding was that administering coenzyme Q10, alongside vitamin E, led to a complete hematologic response in the pigs. This suggests that coenzyme Q10 could play a significant role in addressing anemia related to vitamin E deficiency. However, the partial response noted after adjusting the diet indicates that there may be more factors at play in this disorder’s development.
Overall, coenzyme Q10 appears to have a beneficial impact on treating anemia in this swine model, indicating potential avenues for further research in human applications.
Strikingly, we observed increases in certain erythrocyte enzymes in these pigs, paralleling changes noted in CDA patients. In the animals, distinctive structural alterations similar to those seen in human cases were present in normoblasts, the precursors to red blood cells.
A notable finding was that administering coenzyme Q10, alongside vitamin E, led to a complete hematologic response in the pigs. This suggests that coenzyme Q10 could play a significant role in addressing anemia related to vitamin E deficiency. However, the partial response noted after adjusting the diet indicates that there may be more factors at play in this disorder’s development.
Overall, coenzyme Q10 appears to have a beneficial impact on treating anemia in this swine model, indicating potential avenues for further research in human applications.
Read More
8
Coenzyme Q10 shows promise for anemia
Disruption of mitochondrial energy metabolism is a putative pathogenesis of Diamond-Blackfan anemia.
Study evaluates treatment effects
We explored the effects of coenzyme Q10 on anemia, particularly in the context ofDiamond-Blackfan anemia, a disorder linked to issues with red blood cell production. In our investigation, we examined how mitochondrial energy metabolism plays a critical role in the health of red blood cell progenitors.
Through a primary cell model, we suppressed the mitochondrial oxidative phosphorylation (OXPHOS) pathway, which led to complications in the differentiation of erythroid cells and disrupted ribosome production. Notably, the mutated genes associated with OXPHOS in patients with Diamond-Blackfan anemia contributed to this malfunction.
When we applied coenzyme Q10—known to activate the OXPHOS pathway—we observed significant improvements in the erythroid defects that arose from the suppression. This compound not only helped in rescuing the erythroid development but also boosted the expression of a crucial protein involved in ribosome biogenesis.
Overall, our study points to coenzyme Q10 as a promising candidate for addressing anemia arising from mitochondrial issues, emphasizing its potential therapeutic impact in conditions like Diamond-Blackfan anemia.
Through a primary cell model, we suppressed the mitochondrial oxidative phosphorylation (OXPHOS) pathway, which led to complications in the differentiation of erythroid cells and disrupted ribosome production. Notably, the mutated genes associated with OXPHOS in patients with Diamond-Blackfan anemia contributed to this malfunction.
When we applied coenzyme Q10—known to activate the OXPHOS pathway—we observed significant improvements in the erythroid defects that arose from the suppression. This compound not only helped in rescuing the erythroid development but also boosted the expression of a crucial protein involved in ribosome biogenesis.
Overall, our study points to coenzyme Q10 as a promising candidate for addressing anemia arising from mitochondrial issues, emphasizing its potential therapeutic impact in conditions like Diamond-Blackfan anemia.
Read More
8
Co-Q improves anemia in HAT
Coenzyme Q prevented breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis.
Study indicates significant effects
We examined the effects of Coenzyme Q10 (Co-Q) on anemia in the context of Human African Trypanosomiasis (HAT), a severe illness caused by the parasite T.b.r. Our study involved multiple groups, including a control group, an infected group, and a group treated with Co-Q. The results were quite promising for the Co-Q group.
Specifically, we observed that Co-Q administration significantly mitigated T.b.r-induced microcytic hypochromic anemia. This condition typically leads to low levels of healthy red blood cells, contributing to the fatigue and weakness associated with anemia. Alongside this, Co-Q helped combat thrombocytopenia, a drop in platelet count often linked to such infections.
Furthermore, Co-Q treatment improved the overall health and survival of the infected mice. By preventing the parasite from causing significant changes in the body, including high inflammatory markers and oxidative stress, Co-Q proved to be beneficial. Essentially, we found that using Co-Q might offer a protective effect against the organ damage and severe anemia driven by the parasitic infection.
Overall, our findings suggest that Co-Q could be a valuable addition to therapeutic strategies aimed at not just treating anemia but also managing other severe complications associated with late-stage HAT.
Specifically, we observed that Co-Q administration significantly mitigated T.b.r-induced microcytic hypochromic anemia. This condition typically leads to low levels of healthy red blood cells, contributing to the fatigue and weakness associated with anemia. Alongside this, Co-Q helped combat thrombocytopenia, a drop in platelet count often linked to such infections.
Furthermore, Co-Q treatment improved the overall health and survival of the infected mice. By preventing the parasite from causing significant changes in the body, including high inflammatory markers and oxidative stress, Co-Q proved to be beneficial. Essentially, we found that using Co-Q might offer a protective effect against the organ damage and severe anemia driven by the parasitic infection.
Overall, our findings suggest that Co-Q could be a valuable addition to therapeutic strategies aimed at not just treating anemia but also managing other severe complications associated with late-stage HAT.
Read More
8
Ubiquinol supports exercise recovery
Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise.
Ubiquinol reduces exercise-related inflammation.
We set out to explore how ubiquinol, a form of coenzyme Q10, impacts hematological issues and inflammation associated with strenuous exercise. By studying 100 healthy, well-trained firemen, we organized them into two groups: one receiving ubiquinol and the other a placebo.
Participants underwent two challenging exercise tests, with blood samples taken before and after supplementation, as well as after each exercise session. The results were quite revealing. We found that those who took ubiquinol experienced improvements in key blood parameters like red blood cells, hematocrit, and hemoglobin. Additionally, levels of beneficial growth factors and anti-inflammatory substances increased, while some harmful inflammatory markers decreased.
This indicates that ubiquinol might help reduce inflammation and improve blood quality in active individuals, possibly preventing sports-related anemia. Essentially, it appears that ubiquinol can support athletes by enhancing oxygen delivery and providing a protective effect against the negative consequences of intense physical activity.
Participants underwent two challenging exercise tests, with blood samples taken before and after supplementation, as well as after each exercise session. The results were quite revealing. We found that those who took ubiquinol experienced improvements in key blood parameters like red blood cells, hematocrit, and hemoglobin. Additionally, levels of beneficial growth factors and anti-inflammatory substances increased, while some harmful inflammatory markers decreased.
This indicates that ubiquinol might help reduce inflammation and improve blood quality in active individuals, possibly preventing sports-related anemia. Essentially, it appears that ubiquinol can support athletes by enhancing oxygen delivery and providing a protective effect against the negative consequences of intense physical activity.
Read More
8
CoQ10 improves oxidative stress markers
Effect of coenzyme Q10 as an antioxidant in beta-thalassemia/Hb E patients.
Relevant study on anemia treatment
We focused our investigation on the effects of coenzyme Q10, or CoQ10, in patients suffering from beta-thalassemia/Hb E, a genetic disorder that leads to imbalanced globin synthesis and increased oxidative stress. The study aimed to find out whether supplementing with CoQ10 could help alleviate some of the oxidative stress and improve overall health.
Over a period of six months, participants received 100 mg of CoQ10 daily. We observed a notable increase in plasma levels of CoQ10 among the patients. Along with this increase, there was a decrease in oxidative stress, as evidenced by lower levels of malondialdehyde (MDA), a marker of oxidative damage.
Furthermore, the CoQ10 supplementation led to significant improvements in various antioxidant enzymes, suggesting that it helps boost the body’s natural defenses against oxidative damage. These findings indicate that CoQ10 could serve as a beneficial adjunct therapy for individuals with beta-thalassemia, improving their quality of life while managing anemia and oxidative stress.
Over a period of six months, participants received 100 mg of CoQ10 daily. We observed a notable increase in plasma levels of CoQ10 among the patients. Along with this increase, there was a decrease in oxidative stress, as evidenced by lower levels of malondialdehyde (MDA), a marker of oxidative damage.
Furthermore, the CoQ10 supplementation led to significant improvements in various antioxidant enzymes, suggesting that it helps boost the body’s natural defenses against oxidative damage. These findings indicate that CoQ10 could serve as a beneficial adjunct therapy for individuals with beta-thalassemia, improving their quality of life while managing anemia and oxidative stress.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Supports heart health
This is my preferred remedy for heart health, significantly aiding my chronic anemia. It provides energy and alleviates chest discomfort. The dosage is ideal, and it represents great value. This is my second purchase of it.
8.8
Increased energy
Doctors Best High Absorption coQ10 has significantly boosted my energy levels. I have thalassemia anemia, which isn't treatable with medications, but this product is quite affordable and helps me a great deal.
8.8
Strong heart support
This supplement supports a healthy heart, particularly after my mother suffered from postoperative haemorrhage and anemia. It appears to strengthen heart function effectively.
