Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
â€
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
â€
Top Medical Research Studies
8
Q10 reduces heat stress-induced anxiety
We explored the effects of coenzyme Q10 (Q10) on anxiety symptoms caused by heat stress in male mice. The study involved several groups of mice, exposing them to high temperatures while treating them with either Q10, vitamin E, or a combination of both for two weeks. We assessed their mood through various tests that measure anxiety and despair behavior, including the forced swimming test and the elevated plus maze.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
Read More
7
We explored the potential of coenzyme Q10 (Q10) in alleviating anxiety and depression in a mouse model of Alzheimer's disease. The study involved APPswe/PS1dE9 mice that received either Q10 or a combination of Q10 and low-intensity pulsed ultrasound (LIPUS). The latter approach aimed to enhance the delivery of Q10 through the blood-brain barrier, which is crucial since many treatments struggle to reach the brain effectively.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Read More
Most Useful Reviews
10
Increased energy
6 people found this helpful
Energy charge! I bought this dietary supplement to enhance my performance, especially after covid. On the third week, I felt more energetic, waking up easily with one alarm. My productivity improved, and I felt less fatigued. My anxiety diminished and my mood stabilised. My light tachycardia is gone, and my recovery from gym sessions has improved. Q10 is essential for everyone, as its production decreases with age—suggesting it should be supplemented. I hope this review helps!
Read More
9
Anxiety relief
2 people found this helpful
Good stuff! I continue to enjoy good health, with no more anxiety attacks or arrhythmia. I appreciate the veggie caps.
Read More
9
Stronger heart
1 people found this helpful
My mum and I have experienced excellent results. She has a weak heart, and I struggle with anxiety and palpitations. This CoQ10 variant calms me and strengthens my mum’s heart, as confirmed by our specialist. The Bioperine enhances absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Q10 reduces heat stress-induced anxiety
We explored the effects of coenzyme Q10 (Q10) on anxiety symptoms caused by heat stress in male mice. The study involved several groups of mice, exposing them to high temperatures while treating them with either Q10, vitamin E, or a combination of both for two weeks. We assessed their mood through various tests that measure anxiety and despair behavior, including the forced swimming test and the elevated plus maze.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
Read More
7
We explored the potential of coenzyme Q10 (Q10) in alleviating anxiety and depression in a mouse model of Alzheimer's disease. The study involved APPswe/PS1dE9 mice that received either Q10 or a combination of Q10 and low-intensity pulsed ultrasound (LIPUS). The latter approach aimed to enhance the delivery of Q10 through the blood-brain barrier, which is crucial since many treatments struggle to reach the brain effectively.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Increased energy
6 people found this helpful
Energy charge! I bought this dietary supplement to enhance my performance, especially after covid. On the third week, I felt more energetic, waking up easily with one alarm. My productivity improved, and I felt less fatigued. My anxiety diminished and my mood stabilised. My light tachycardia is gone, and my recovery from gym sessions has improved. Q10 is essential for everyone, as its production decreases with age—suggesting it should be supplemented. I hope this review helps!
Read More
9
Anxiety relief
2 people found this helpful
Good stuff! I continue to enjoy good health, with no more anxiety attacks or arrhythmia. I appreciate the veggie caps.
Read More
9
Stronger heart
1 people found this helpful
My mum and I have experienced excellent results. She has a weak heart, and I struggle with anxiety and palpitations. This CoQ10 variant calms me and strengthens my mum’s heart, as confirmed by our specialist. The Bioperine enhances absorption.
Read More
10
Eliminated anxiety
Easy to take with water, this has no taste. I now wake up easily, and my efficiency has improved. I was able to eliminate my anxiety.
Read More
7.5
Reduced headaches
3 people found this helpful
I recommend this product, but only if you truly need it. I felt the effects about a week after starting, taking 100 mg daily. My headaches have lessened, and the spasms in my head have stopped. It positively impacts my cardiovascular system and helps alleviate my anxiety. I suggest taking it in the morning after a meal along with complex vitamins and minerals.
Read More
Frequently Asked Questions
7.5
Reduced headaches
3 people found this helpful
I recommend this product, but only if you truly need it. I felt the effects about a week after starting, taking 100 mg daily. My headaches have lessened, and the spasms in my head have stopped. It positively impacts my cardiovascular system and helps alleviate my anxiety. I suggest taking it in the morning after a meal along with complex vitamins and minerals.
10
Increased energy
6 people found this helpful
Energy charge! I bought this dietary supplement to enhance my performance, especially after covid. On the third week, I felt more energetic, waking up easily with one alarm. My productivity improved, and I felt less fatigued. My anxiety diminished and my mood stabilised. My light tachycardia is gone, and my recovery from gym sessions has improved. Q10 is essential for everyone, as its production decreases with age—suggesting it should be supplemented. I hope this review helps!
10
Eliminated anxiety
Easy to take with water, this has no taste. I now wake up easily, and my efficiency has improved. I was able to eliminate my anxiety.
9
Anxiety relief
2 people found this helpful
Good stuff! I continue to enjoy good health, with no more anxiety attacks or arrhythmia. I appreciate the veggie caps.
9
Cardiovascular improvement
This CoQ10 supplement is outstanding. I visited my cardiologist for anxiety related to high blood pressure and was advised to take this and some relaxants. Thanks to Dr. Best's proprietary blend, absorption is enhanced in the vegetable caps. I have observed improvements in my cardiovascular stamina and reduced anxiety.
9
Less nervousness
Excellent! I no longer have irregular heartbeats, and I sleep better, waking up with more energy. It has also reduced my nervousness and anxiety, aiding my immune system overall.
2
No effect
I've been using these for several weeks alongside Ashwagandha and Olive leaf extract but haven't noticed any change in my anxiety or cortisol levels.
9
Stronger heart
1 people found this helpful
My mum and I have experienced excellent results. She has a weak heart, and I struggle with anxiety and palpitations. This CoQ10 variant calms me and strengthens my mum’s heart, as confirmed by our specialist. The Bioperine enhances absorption.
8
Q10 reduces heat stress-induced anxiety
We explored the effects of coenzyme Q10 (Q10) on anxiety symptoms caused by heat stress in male mice. The study involved several groups of mice, exposing them to high temperatures while treating them with either Q10, vitamin E, or a combination of both for two weeks. We assessed their mood through various tests that measure anxiety and despair behavior, including the forced swimming test and the elevated plus maze.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.
In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.
7
We explored the potential of coenzyme Q10 (Q10) in alleviating anxiety and depression in a mouse model of Alzheimer's disease. The study involved APPswe/PS1dE9 mice that received either Q10 or a combination of Q10 and low-intensity pulsed ultrasound (LIPUS). The latter approach aimed to enhance the delivery of Q10 through the blood-brain barrier, which is crucial since many treatments struggle to reach the brain effectively.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
Our findings indicated that combining Q10 with LIPUS significantly improved anxiety-like and depression-like behaviors in these mice compared to Q10 alone. With the optimal intensity of LIPUS, the treatment led to increased levels of serotonin and dopamine in the brain, while also reducing harmful substances like formaldehyde and protein plaques associated with Alzheimer’s.
However, we must note that despite these encouraging results, the effectiveness of the LIPUS treatment, particularly at varying intensities, only partially addressed anxiety and memory issues. Thus, while this combination therapy holds promise, it is clear that more research is necessary to understand how Q10 alone impacts anxiety effectively, especially without the influence of LIPUS.
References
- Luo Q, Ye X, Xu J, Sun Z, Wang P, et al. Low-intensity pulsed ultrasound enhances delivery of 30Â nm Q10 for improving mental and memory disorder in APP/PS1 mice. Drug Deliv Transl Res. 2025. 10.1007/s13346-025-01814-y
- Mahmoudi J, Kazmi S, Vatandoust S, Athari SZ, Sadigh-Eteghad S, et al. Coenzyme Q10 and vitamin E alleviate heat stress-induced mood disturbances in male mice: Modulation of inflammatory pathways and the HPA axis. Behav Brain Res. 2025;476:115259. 10.1016/j.bbr.2024.115259
