Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
We explored the effects of a popular supplement called Coenzyme Q10 (CoQ10) on atherosclerosis, specifically how it influences cholesterol levels in macrophages. Through recent research, we found that CoQ10 inhibits c-Jun expression and hinders the activity of a protein complex known as AP-1. This complex typically boosts the production of a microRNA called miR-378.
miR-378 is significant because it directly targets ABCG1, a transporter that helps in the removal of cholesterol from cells. When the suppression of miR-378 is lifted, cholesterol efflux increases, providing a protective effect against atherosclerosis in mice. This study emphasizes the connections between CoQ10, cholesterol management, and overall heart health.
By understanding these connections better, we can appreciate the potential of CoQ10 as a supportive treatment for conditions like atherosclerosis. The findings open up interesting possibilities for future research and practical applications in addressing heart disease.
miR-378 is significant because it directly targets ABCG1, a transporter that helps in the removal of cholesterol from cells. When the suppression of miR-378 is lifted, cholesterol efflux increases, providing a protective effect against atherosclerosis in mice. This study emphasizes the connections between CoQ10, cholesterol management, and overall heart health.
By understanding these connections better, we can appreciate the potential of CoQ10 as a supportive treatment for conditions like atherosclerosis. The findings open up interesting possibilities for future research and practical applications in addressing heart disease.
Read More
9
We investigated the impact of coenzyme Q10 (CoQ10) on arteriosclerosis, particularly its effects on platelets and their behavior in a context of atherosclerosis. Using apolipoprotein E-deficient (ApoE-/-) mice, we fed the animals either a standard diet, a high-fat diet (HFD), or a CoQ10-supplemented HFD for 12 weeks.
The results were promising; CoQ10 supplementation significantly reduced the formation of atherosclerotic lesions induced by the high-fat diet. Furthermore, we observed that CoQ10 diminished platelet hyper-aggregation and granule secretion, which are critical factors in blood clot formation.
Specifically, we noted lower levels of important markers like CD62P, CD63, and CD40 ligand (CD40L) in the platelets. There was also a notable reduction in the release of substances associated with platelet activity, such as platelet factor-4 and CCL5. Additionally, CoQ10 appeared to inhibit the signaling pathways that activate integrin αIIbβ3, which plays a vital role in platelet aggregation.
By down-regulating both inside-out and outside-in signaling pathways, CoQ10 effectively reduced the reactivity of platelets. This suggests that the supplement might play a preventive role against complications like atherothrombosis, an important consideration given the health risks associated with cardiovascular diseases.
The results were promising; CoQ10 supplementation significantly reduced the formation of atherosclerotic lesions induced by the high-fat diet. Furthermore, we observed that CoQ10 diminished platelet hyper-aggregation and granule secretion, which are critical factors in blood clot formation.
Specifically, we noted lower levels of important markers like CD62P, CD63, and CD40 ligand (CD40L) in the platelets. There was also a notable reduction in the release of substances associated with platelet activity, such as platelet factor-4 and CCL5. Additionally, CoQ10 appeared to inhibit the signaling pathways that activate integrin αIIbβ3, which plays a vital role in platelet aggregation.
By down-regulating both inside-out and outside-in signaling pathways, CoQ10 effectively reduced the reactivity of platelets. This suggests that the supplement might play a preventive role against complications like atherothrombosis, an important consideration given the health risks associated with cardiovascular diseases.
Read More
8
We investigated the relationship between coenzyme Q10 (CoQ10) levels and coronary flow reserve (CFR) in patients undergoing chronic hemodialysis. This is particularly important given that accelerated atherosclerosis is a leading cause of death in these individuals. In our study, we included 71 hemodialysis patients and compared them with 65 healthy individuals of similar age and sex.
Through high-performance liquid chromatography, we measured the plasma levels of CoQ10, while CFR was assessed using transthoracic Doppler echocardiography. Our results demonstrated that patients on hemodialysis had significantly lower levels of CoQ10 (1.36 ± 0.43) compared to the healthy controls (2.53 ± 0.55). Similarly, their CFR values were much lower at 1.73 ± 0.11, compared to 2.32 ± 0.28 in the controls.
Importantly, we found a strong positive correlation between CoQ10 levels and CFR, suggesting that lower CoQ10 levels are associated with reduced heart function. The statistical analysis confirmed that CoQ10 levels are an independent predictor of coronary flow reserve in these patients, emphasizing its potential role in assessing heart health and the risk of atherosclerosis in those undergoing hemodialysis.
Through high-performance liquid chromatography, we measured the plasma levels of CoQ10, while CFR was assessed using transthoracic Doppler echocardiography. Our results demonstrated that patients on hemodialysis had significantly lower levels of CoQ10 (1.36 ± 0.43) compared to the healthy controls (2.53 ± 0.55). Similarly, their CFR values were much lower at 1.73 ± 0.11, compared to 2.32 ± 0.28 in the controls.
Importantly, we found a strong positive correlation between CoQ10 levels and CFR, suggesting that lower CoQ10 levels are associated with reduced heart function. The statistical analysis confirmed that CoQ10 levels are an independent predictor of coronary flow reserve in these patients, emphasizing its potential role in assessing heart health and the risk of atherosclerosis in those undergoing hemodialysis.
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Most Useful Reviews
8.8
Improves circulation
This product has been repurchased for my husband, who suffers from high blood pressure. Coenzyme Q10 can help prevent arteriosclerosis and enhance body circulation.
Read More
8.8
Heart health benefits
Coenzyme Q10 is beneficial for high blood pressure and can positively impact heart health. Some studies indicate that moderate Q10 intake alleviates symptoms in high blood pressure patients. It combats free radicals, reduces inflammation, lowers arteriosclerosis risk, and may slow ageing effects. Additionally, it lessens side effects from statins, which can lower Q10 levels. Thus, combining Q10 supplements with statin therapy can provide therapeutic benefits while minimising adverse effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
- All Researches
9
We investigated the impact of coenzyme Q10 (CoQ10) on arteriosclerosis, particularly its effects on platelets and their behavior in a context of atherosclerosis. Using apolipoprotein E-deficient (ApoE-/-) mice, we fed the animals either a standard diet, a high-fat diet (HFD), or a CoQ10-supplemented HFD for 12 weeks.
The results were promising; CoQ10 supplementation significantly reduced the formation of atherosclerotic lesions induced by the high-fat diet. Furthermore, we observed that CoQ10 diminished platelet hyper-aggregation and granule secretion, which are critical factors in blood clot formation.
Specifically, we noted lower levels of important markers like CD62P, CD63, and CD40 ligand (CD40L) in the platelets. There was also a notable reduction in the release of substances associated with platelet activity, such as platelet factor-4 and CCL5. Additionally, CoQ10 appeared to inhibit the signaling pathways that activate integrin αIIbβ3, which plays a vital role in platelet aggregation.
By down-regulating both inside-out and outside-in signaling pathways, CoQ10 effectively reduced the reactivity of platelets. This suggests that the supplement might play a preventive role against complications like atherothrombosis, an important consideration given the health risks associated with cardiovascular diseases.
The results were promising; CoQ10 supplementation significantly reduced the formation of atherosclerotic lesions induced by the high-fat diet. Furthermore, we observed that CoQ10 diminished platelet hyper-aggregation and granule secretion, which are critical factors in blood clot formation.
Specifically, we noted lower levels of important markers like CD62P, CD63, and CD40 ligand (CD40L) in the platelets. There was also a notable reduction in the release of substances associated with platelet activity, such as platelet factor-4 and CCL5. Additionally, CoQ10 appeared to inhibit the signaling pathways that activate integrin αIIbβ3, which plays a vital role in platelet aggregation.
By down-regulating both inside-out and outside-in signaling pathways, CoQ10 effectively reduced the reactivity of platelets. This suggests that the supplement might play a preventive role against complications like atherothrombosis, an important consideration given the health risks associated with cardiovascular diseases.
Read More
9
Our exploration focused on the potential role of coenzyme Q10 (CoQ10) in tackling arteriosclerosis, particularly when paired with selenium. This study indicates that selenium is crucial for our body as it contributes to the functioning of vital proteins that help combat oxidative stress, which is known to affect heart conditions like ischemic heart disease and heart failure.
We found that many people in Europe might not be getting enough selenium, possibly leading to reduced antioxidant capacity in their bodies. This shortfall in selenium could be a factor influencing the risk and progression of heart diseases, especially atherosclerosis.
Interestingly, we observed that when both selenium and CoQ10 were used in an intervention study among older adults, there were notable improvements. Participants who received both treatments showed reduced cardiovascular mortality and better heart function on echocardiograms, alongside lower levels of NT-proBNP, a biomarker indicating heart stress.
Therefore, while more research is needed to fully understand CoQ10’s individual impact on arteriosclerosis, using it in combination with selenium appears promising in decreasing certain cardiovascular risks.
We found that many people in Europe might not be getting enough selenium, possibly leading to reduced antioxidant capacity in their bodies. This shortfall in selenium could be a factor influencing the risk and progression of heart diseases, especially atherosclerosis.
Interestingly, we observed that when both selenium and CoQ10 were used in an intervention study among older adults, there were notable improvements. Participants who received both treatments showed reduced cardiovascular mortality and better heart function on echocardiograms, alongside lower levels of NT-proBNP, a biomarker indicating heart stress.
Therefore, while more research is needed to fully understand CoQ10’s individual impact on arteriosclerosis, using it in combination with selenium appears promising in decreasing certain cardiovascular risks.
Read More
9
CoQ10 enhances cholesterol removal
We investigated how coenzyme Q10 (CoQ10) could play a role in reducing arteriosclerosis by promoting the removal of cholesterol in macrophages. This study looked at how CoQ10 treatment can help prevent the formation of foam cells, which are linked to heart disease.
Our findings showed that CoQ10 effectively reduced the buildup of these foam cells by influencing certain cellular mechanisms. Specifically, it impacted the activator protein-1's ability to bind to a gene related to a microRNA called miR-378. By reducing the levels of miR-378, CoQ10 enhanced the function of a protein known as ATP-binding cassette transporter G1, which is crucial for transporting cholesterol out of macrophages.
We confirmed these effects in experiments using macrophages from mice that are genetically predisposed to atherosclerosis. The results revealed that CoQ10 not only encouraged the removal of cholesterol but also helped slow down atherosclerosis progression.
This research highlights the potential of CoQ10 and miR-378 as promising strategies for preventing and treating atherosclerosis, giving us a hopeful perspective on heart health.
Our findings showed that CoQ10 effectively reduced the buildup of these foam cells by influencing certain cellular mechanisms. Specifically, it impacted the activator protein-1's ability to bind to a gene related to a microRNA called miR-378. By reducing the levels of miR-378, CoQ10 enhanced the function of a protein known as ATP-binding cassette transporter G1, which is crucial for transporting cholesterol out of macrophages.
We confirmed these effects in experiments using macrophages from mice that are genetically predisposed to atherosclerosis. The results revealed that CoQ10 not only encouraged the removal of cholesterol but also helped slow down atherosclerosis progression.
This research highlights the potential of CoQ10 and miR-378 as promising strategies for preventing and treating atherosclerosis, giving us a hopeful perspective on heart health.
Read More
8
CoQ10 impacts atherosclerosis treatment
We explored the potential of coenzyme Q10 (CoQ10) in addressing atherosclerosis, a chronic disease particularly affecting older adults and a leading cause of cardiovascular death worldwide. Atherosclerosis is linked to issues such as abnormal lipid transport, impaired blood vessel function, inflammation, and oxidative stress.
CoQ10 is a key antioxidant and plays an essential part in the electron transport chain, which helps produce energy in our cells. Our review highlights how CoQ10 may influence and regulate oxidative stress, inflammation, lipid metabolism, and cellular processes affecting heart health.
Through an examination of various studies, we observed that CoQ10 has beneficial effects on aspects of atherosclerosis. Specifically, it appears to improve lipid transport, reduce inflammation in blood vessels, and address metabolic irregularities. Importantly, combining CoQ10 with other medications has shown to yield better results, suggesting potential for enhanced treatment strategies.
Overall, it seems reasonable to consider CoQ10 as a viable treatment option for cardiovascular diseases stemming from atherosclerosis. However, we acknowledge that more in-depth basic and clinical research is necessary to fully understand its isolated effects.
CoQ10 is a key antioxidant and plays an essential part in the electron transport chain, which helps produce energy in our cells. Our review highlights how CoQ10 may influence and regulate oxidative stress, inflammation, lipid metabolism, and cellular processes affecting heart health.
Through an examination of various studies, we observed that CoQ10 has beneficial effects on aspects of atherosclerosis. Specifically, it appears to improve lipid transport, reduce inflammation in blood vessels, and address metabolic irregularities. Importantly, combining CoQ10 with other medications has shown to yield better results, suggesting potential for enhanced treatment strategies.
Overall, it seems reasonable to consider CoQ10 as a viable treatment option for cardiovascular diseases stemming from atherosclerosis. However, we acknowledge that more in-depth basic and clinical research is necessary to fully understand its isolated effects.
Read More
8
We considered the effectiveness of coenzyme Q10 as part of a multicomponent nutraceutical aimed at addressing markers of dysmetabolism and oxidative stress, particularly its potential impact on arteriosclerosis. In this pilot study, 21 individuals took a daily supplement containing various antioxidants and metabolism regulators, including coenzyme Q10 at 100 mg, over a period of 60 days.
Our key findings revealed significant improvements in some markers associated with atherogenesis and oxidative stress. Specifically, there were notable reductions in total cholesterol and low-density lipoproteins, which are important indicators of cardiovascular risk. However, it's important to mention that while coenzyme Q10 was included, the study did not isolate its specific effects from the other components of the nutraceutical.
There were no significant changes noted in factors like insulin levels, body weight, or blood pressure over the study duration, and importantly, no adverse side effects were reported. Although the results regarding overall oxidative stress and atherogenesis were promising, we advise caution in attributing these benefits solely to coenzyme Q10 given that it was part of a complex mixture of ingredients.
Our key findings revealed significant improvements in some markers associated with atherogenesis and oxidative stress. Specifically, there were notable reductions in total cholesterol and low-density lipoproteins, which are important indicators of cardiovascular risk. However, it's important to mention that while coenzyme Q10 was included, the study did not isolate its specific effects from the other components of the nutraceutical.
There were no significant changes noted in factors like insulin levels, body weight, or blood pressure over the study duration, and importantly, no adverse side effects were reported. Although the results regarding overall oxidative stress and atherogenesis were promising, we advise caution in attributing these benefits solely to coenzyme Q10 given that it was part of a complex mixture of ingredients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improves circulation
This product has been repurchased for my husband, who suffers from high blood pressure. Coenzyme Q10 can help prevent arteriosclerosis and enhance body circulation.
Read More
8.8
Heart health benefits
Coenzyme Q10 is beneficial for high blood pressure and can positively impact heart health. Some studies indicate that moderate Q10 intake alleviates symptoms in high blood pressure patients. It combats free radicals, reduces inflammation, lowers arteriosclerosis risk, and may slow ageing effects. Additionally, it lessens side effects from statins, which can lower Q10 levels. Thus, combining Q10 supplements with statin therapy can provide therapeutic benefits while minimising adverse effects.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wang W, Yang H, Fan Z, Shi R. NQO1 promotes osteogenesis and suppresses angiogenesis in DPSCs via MAPK pathway modulation. Stem Cell Res Ther. 2024;15:306. doi:10.1186/s13287-024-03929-4
- Liao M, He X, Zhou Y, Peng W, Zhao XM, et al. Coenzyme Q10 in atherosclerosis. Eur J Pharmacol. 2024;970:176481. doi:10.1016/j.ejphar.2024.176481
- Ya F, Xu XR, Tian Z, Gallant RC, Song F, et al. Coenzyme Q10 attenuates platelet integrin αIIbβ3 signaling and platelet hyper-reactivity in ApoE-deficient mice. Food Funct. 2020;11:139. doi:10.1039/c9fo01686d
- Jorat MV, Tabrizi R, Kolahdooz F, Akbari M, Salami M, et al. The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology. 2019;27:233. doi:10.1007/s10787-019-00572-x
- Corsi R, Mosti G, Cavezzi A, Urso SU, Dimitrova G, et al. A Polyphenol-Based Multicomponent Nutraceutical in Dysmetabolism and Oxidative Stress: Results from a Pilot Study. J Diet Suppl. 2018;15:34. doi:10.1080/19390211.2017.1310784
- Sahebkar A, Simental-Mendía LE, Stefanutti C, Pirro M. Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis. Pharmacol Res. 2016;105:198. doi:10.1016/j.phrs.2016.01.030
- Alehagen U, Aaseth J. Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view. J Trace Elem Med Biol. 2015;31:157. doi:10.1016/j.jtemb.2014.11.006
- Allen RM, Vickers KC. Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. Arterioscler Thromb Vasc Biol. 2014;34:1795. doi:10.1161/ATVBAHA.114.303741
- Wang D, Yan X, Xia M, Yang Y, Li D, et al. Coenzyme Q10 promotes macrophage cholesterol efflux by regulation of the activator protein-1/miR-378/ATP-binding cassette transporter G1-signaling pathway. Arterioscler Thromb Vasc Biol. 2014;34:1860. doi:10.1161/ATVBAHA.113.302879
- Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013;12:142. doi:10.1186/1475-2891-12-142
- Macunluoglu B, Kaya Y, Atakan A, Ari E, Kaspar C, et al. Serum coenzyme Q10 levels are associated with coronary flow reserve in hemodialysis patients. Hemodial Int. 2013;17:339. doi:10.1111/hdi.12001
- Lee BJ, Yen CH, Hsu HC, Lin JY, Hsia S, et al. A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease. Nutr Res. 2012;32:751. doi:10.1016/j.nutres.2012.09.003
- Lee BJ, Lin YC, Huang YC, Ko YW, Hsia S, et al. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. ScientificWorldJournal. 2012;2012:792756. doi:10.1100/2012/792756
- Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition. 2012;28:767. doi:10.1016/j.nut.2011.11.008
- Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 2012;28:250. doi:10.1016/j.nut.2011.06.004
