Last update
5/16/2026
Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
8
CoQ10 boosts motor function in mice
We examined how coenzyme Q10 (CoQ10) treatment impacts age-related motor issues and changes related to Parkinson's disease in mice. Aged mice displayed reduced motor functions and increased levels of a harmful protein, α-synuclein, in their brains compared to younger mice.
By giving aged mice CoQ10 in their drinking water, we found that their motor abilities improved significantly, and the harmful protein levels decreased. These findings suggest that CoQ10 can positively influence motor function and may help address early signs of Parkinson-like changes in the brain.
By giving aged mice CoQ10 in their drinking water, we found that their motor abilities improved significantly, and the harmful protein levels decreased. These findings suggest that CoQ10 can positively influence motor function and may help address early signs of Parkinson-like changes in the brain.
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2
We explored the effects of coenzyme Q10 (CoQ10) on Parkinson's disease through a thorough meta-analysis of randomized controlled trials. By examining data from eight studies with 899 patients, we found that CoQ10 did not significantly improve motor symptoms compared to a placebo.
While participants tolerated CoQ10 well, there was no added benefit in easing PD symptoms, which raises questions about its routine use in treatment. We suggest that CoQ10 therapy is safe, but current evidence does not support its effectiveness for managing Parkinson's disease.
While participants tolerated CoQ10 well, there was no added benefit in easing PD symptoms, which raises questions about its routine use in treatment. We suggest that CoQ10 therapy is safe, but current evidence does not support its effectiveness for managing Parkinson's disease.
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0
We examined the effects of Coenzyme Q10 (CoQ10) on Parkinson's disease through a systematic review of randomized controlled trials. Our analysis included five studies with nearly 1,000 patients, comparing CoQ10 to placebo regarding motor function and quality of life.
Unfortunately, the results showed no significant benefit. CoQ10 did not slow down disease progression or improve symptoms according to various measurements. It appears that while CoQ10 may have some potential, it currently does not offer substantial aid for those dealing with Parkinson's.
Unfortunately, the results showed no significant benefit. CoQ10 did not slow down disease progression or improve symptoms according to various measurements. It appears that while CoQ10 may have some potential, it currently does not offer substantial aid for those dealing with Parkinson's.
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Most Useful Reviews
7
Cognitive improvement
8 people found this helpful
Cognitive improvement with CoQ10. My father has Parkinson's and now dementia, and he was rapidly deteriorating until he began taking CoQ10. His cognition has improved, and it's as if we've got our father back. Even if this product only pauses the process for a short time, we are grateful for this period.
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7
Slow progression
Initially, I experienced heartache, but I have been taking Q10 consistently for three months and noticed an improvement. Recent studies indicate that patients taking Q10 develop Parkinson’s disease more slowly, particularly in activities like eating, dressing, and walking. Q10 also boosts energy levels and is utilised by those with ME, among others.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.7
- All Researches
9
We explored whether a specific method of delivering Coenzyme Q10 could help protect neurons in Parkinson's disease. By injecting it directly into the brain of rats, we found significant improvements. The rats treated in this way showed fewer symptoms of illness and had more healthy neurons compared to untreated rats.
Interestingly, this method was much more effective than the traditional oral form of Coenzyme Q10. These findings suggest that direct injection could be a promising approach for preventing neuron damage in Parkinson's.
Interestingly, this method was much more effective than the traditional oral form of Coenzyme Q10. These findings suggest that direct injection could be a promising approach for preventing neuron damage in Parkinson's.
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We explored a study examining the effects of coenzyme Q10 (CoQ10) and vitamin B complex combined with L-DOPA on Parkinson's disease in a rat model. The rats underwent treatments with various combinations, observing significant improvements in locomotor functions, cognitive abilities, and neurochemical levels.
While results showed that this combination might enhance neuroprotection, especially when paired with cocoa or vinpocetine, the study emphasizes the need for further clinical trials to determine practical benefits for actual Parkinson's patients. Thus, while there's promise here, we remain cautious regarding its effectiveness in human applications.
While results showed that this combination might enhance neuroprotection, especially when paired with cocoa or vinpocetine, the study emphasizes the need for further clinical trials to determine practical benefits for actual Parkinson's patients. Thus, while there's promise here, we remain cautious regarding its effectiveness in human applications.
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8
We examined the effects of coenzyme Q10 (CoQ10) on Parkinson's disease in a rat model, focusing on its interaction with miR-149-5p and matrix metalloproteinases (MMPs).
After inducing Parkinson's, we treated the rats with CoQ10 and a miR-149-5p mimic. Behavioral tests revealed significant improvements in motor functions after treatment. Furthermore, we noted changes in gene expression, including reduced MMP levels and enhanced tyrosine hydroxylase production, suggesting a protective role against nerve damage.
Overall, our findings indicate that CoQ10 could be beneficial for mitigating Parkinson's symptoms and improving neuronal health.
After inducing Parkinson's, we treated the rats with CoQ10 and a miR-149-5p mimic. Behavioral tests revealed significant improvements in motor functions after treatment. Furthermore, we noted changes in gene expression, including reduced MMP levels and enhanced tyrosine hydroxylase production, suggesting a protective role against nerve damage.
Overall, our findings indicate that CoQ10 could be beneficial for mitigating Parkinson's symptoms and improving neuronal health.
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8
MitoQ's potential in Parkinson's treatment
We explored how MitoQ, a targeted antioxidant, affects dopaminergic neurons in a model of Parkinson's disease. The study showed MitoQ's ability to enhance the fusion of mitochondria by increasing Mfn2 levels, which is crucial for neuron survival.
In both lab-based and animal tests, MitoQ not only improved mitochondrial function but also reduced harmful cellular stress. However, further research is needed to reach definitive conclusions on its effectiveness in treating Parkinson's disease, as this is an ongoing area of study.
In both lab-based and animal tests, MitoQ not only improved mitochondrial function but also reduced harmful cellular stress. However, further research is needed to reach definitive conclusions on its effectiveness in treating Parkinson's disease, as this is an ongoing area of study.
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8
This study tested how coenzyme Q10 (CoQ10) could help in preventing or slowing down Parkinson’s disease. We focused on giving CoQ10 both before and after exposure to a herbicide linked to Parkinson’s. The results were promising, showing that CoQ10 improved behavior and reduced brain damage markers, especially when given before the damaging exposure. It looks like CoQ10 could be a beneficial treatment early in the disease to protect the brain.
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User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7
Cognitive improvement
8 people found this helpful
Cognitive improvement with CoQ10. My father has Parkinson's and now dementia, and he was rapidly deteriorating until he began taking CoQ10. His cognition has improved, and it's as if we've got our father back. Even if this product only pauses the process for a short time, we are grateful for this period.
Read More
7
Slow progression
Initially, I experienced heartache, but I have been taking Q10 consistently for three months and noticed an improvement. Recent studies indicate that patients taking Q10 develop Parkinson’s disease more slowly, particularly in activities like eating, dressing, and walking. Q10 also boosts energy levels and is utilised by those with ME, among others.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Abu-Elfotuh K, Al-Rekabi MD, Abbas AN, Darwish A, Hamdan AME, et al. Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3β/CREB/BDNF and Apoptotic Pathways. Biomed Pharmacother. 2025;186:118011. 10.1016/j.biopha.2025.118011
- Millichap L, Turton N, Damiani E, Marcheggiani F, Orlando P, et al. The Effect of Neuronal CoQ Deficiency and Mitochondrial Dysfunction on a Rotenone-Induced Neuronal Cell Model of Parkinson's Disease. Int J Mol Sci. 2024;25. 10.3390/ijms25126622
- Ghasemloo E, Mostafavi H, Hosseini M, Forouzandeh M, Eskandari M, et al. Neuroprotective effects of coenzyme Q10 in Parkinson's model via a novel Q10/miR-149-5p/MMPs pathway. Metab Brain Dis. 2021;36:2089. 10.1007/s11011-021-00795-4
- Park HW, Park CG, Park M, Lee SH, Park HR, et al. Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model. Sci Rep. 2020;10:9572. 10.1038/s41598-020-66493-w
- Xi Y, Feng D, Tao K, Wang R, Shi Y, et al. MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2859. 10.1016/j.bbadis.2018.05.018
- Mischley LK, Lau RC, Bennett RD. Role of Diet and Nutritional Supplements in Parkinson's Disease Progression. Oxid Med Cell Longev. 2017;2017:6405278. 10.1155/2017/6405278
- Attia HN, Maklad YA. Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals. Behav Pharmacol. 2018;29:79. 10.1097/FBP.0000000000000342
- Gupta BK, Kumar S, Kaur H, Ali J, Baboota S. Attenuation of Oxidative Damage by Coenzyme Q Loaded Nanoemulsion Through Oral Route for the Management of Parkinson's Disease. Rejuvenation Res. 2018;21:232. 10.1089/rej.2017.1959
- Zhu ZG, Sun MX, Zhang WL, Wang WW, Jin YM, et al. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017;38:215. 10.1007/s10072-016-2757-9
- Takahashi K, Ohsawa I, Shirasawa T, Takahashi M. Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol. 2016;81:65. 10.1016/j.exger.2016.04.023
- Negida A, Menshawy A, El Ashal G, Elfouly Y, Hani Y, et al. Coenzyme Q10 for Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis. CNS Neurol Disord Drug Targets. 2016;15:45. PubMed
- Yoritaka A, Kawajiri S, Yamamoto Y, Nakahara T, Ando M, et al. Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease. Parkinsonism Relat Disord. 2015;21:911. 10.1016/j.parkreldis.2015.05.022
