Coenzyme Q10 and psoriasis effectsDietary compounds as potential modulators of microRNA expression in psoriasis.
We examined the role of coenzyme Q10 in psoriasis treatment, focusing on its effects on microRNAs. The research highlighted the complex relationship between dietary compounds and the management of psoriasis, particularly through the modulation of specific microRNAs that are known to be implicated in the condition.
Among the findings, it was noted that the expression of miR-125b, which is often downregulated in psoriasis, can be restored by coenzyme Q10. This suggests a potential benefit of coenzyme Q10 in contributing to the overall balance of microRNAs in psoriasis.
However, the evidence remains part of a broader discussion about dietary influences on psoriasis, rather than a definitive conclusion about coenzyme Q10's standalone effectiveness. Therefore, while there is some promising data, we cannot assert that coenzyme Q10 works as a singular treatment for psoriasis without further comprehensive studies.
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CoQ10 improves psoriasis treatment outcomesEffect of CoQ10 Administration to Psoriatic Iraqi Patients on Biological Therapy Upon Severity Index (PASI) and Quality of Life Index (DLQI) Before and After Therapy.
We conducted a clinical study to evaluate the effects of coenzyme Q10 (CoQ10) on psoriasis severity and quality of life among Iraqi patients receiving biological therapy. The study involved 24 participants, who were split into two groups. One group received a biological medication called adalimumab, while the other group received both adalimumab and an additional 100 mg of CoQ10 for a duration of 12 weeks.
Throughout the study, we used the Psoriasis Area Severity Index (PASI) to assess the severity of psoriasis and the Dermatology Life Quality Index (DLQI) to measure the quality of life of the patients. Our findings revealed a significant improvement in both PASI and DLQI scores for patients receiving the combination treatment of adalimumab and CoQ10. The overall improvements demonstrated a strong relationship between the severity of the disease and the quality of life after the 12-week therapy.
After treatment, the average PASI score indicated a notable 67.48% improvement. Likewise, the DLQI scores showed a 56.13% enhancement in quality of life. This suggests that adding CoQ10 to biological treatment can significantly enhance outcomes for psoriasis patients. However, it remains essential to recognize that while CoQ10 appeared to complement the effects of biological therapy, the isolated benefits of CoQ10 on psoriasis were not fully determined in this study.
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