Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Read More
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
Read More
5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
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Most Useful Reviews
9
Immediate mood change
706 people found this helpful
Better than I expected! After extensive research, I bought this to manage my anxiety without adverse effects. I have various anxiety symptoms, and after taking my first pill, I immediately noticed a positive change in mood. Anxiety decreased significantly after a few days.
Read More
10
Effective anti-anxiety
575 people found this helpful
FANTASTIC PRODUCT! After researching magnesium types extensively, I found Magnesium Glycinate to be the best. This has effectively calmed my stress and anxiety throughout the day and assisted with insomnia. It truly acts on the entire nervous system, enhancing general relaxation.
Read More
9
Improved self-confidence
257 people found this helpful
Doctor's Best Magnesium is highly absorbable and doesn't upset my stomach. After a course of this magnesium, I've experienced a marked improvement—a calmer demeanour and a notable reduction in anxiety. I plan to continue taking this supplement.
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
Read More
8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Read More
8
Magnesium aids post-surgery anxiety
Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
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8
Magnesium reduces anxiety symptoms
Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
Read More
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Better than I expected! After extensive research, I bought this to manage my anxiety without adverse effects. I have various anxiety symptoms, and after taking my first pill, I immediately noticed a positive change in mood. Anxiety decreased significantly after a few days.
Read More
10
Effective anti-anxiety
575 people found this helpful
FANTASTIC PRODUCT! After researching magnesium types extensively, I found Magnesium Glycinate to be the best. This has effectively calmed my stress and anxiety throughout the day and assisted with insomnia. It truly acts on the entire nervous system, enhancing general relaxation.
Read More
9
Improved self-confidence
257 people found this helpful
Doctor's Best Magnesium is highly absorbable and doesn't upset my stomach. After a course of this magnesium, I've experienced a marked improvement—a calmer demeanour and a notable reduction in anxiety. I plan to continue taking this supplement.
Read More
7.5
Enhanced positivity
194 people found this helpful
I've had a positive experience with this magnesium. It helps with anxiety and muscle relaxation. After a week, I felt a surge of positive energy and improved overall well-being.
Read More
7.5
Headache relief
106 people found this helpful
Alternative pharmacy effectively provided magnesium for my anxiety and headaches. It's pricey, but the results are worth it. I've also added vitamin B6 to my regimen. Magnesium chelate seems to be the best form for absorption. I realised how much it alleviates my anxiety and Other symptoms, including tachycardia. Overall, I'm pleased with the positive effects on my health.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been studied for its potential role in alleviating symptoms of anxiety, and some evidence suggests it may be beneficial. Magnesium plays a critical role in brain function and the regulation of neurotransmitters, which are essential for mood stability. Some studies have indicated that low levels of magnesium may be linked to increased anxiety symptoms, and supplementation could work to help improve overall mental health by restoring adequate magnesium levels. While it's not a standalone treatment for anxiety disorders, integrating magnesium into a balanced diet with other treatment modalities could provide additional support.
That said, it's important to approach magnesium supplementation thoughtfully. Overuse can lead to adverse effects, and individual needs may vary widely depending on dietary intake and overall health status. Before starting any new supplement, especially for managing anxiety, consulting with a healthcare professional is advisable to tailor an approach that aligns with your personal health needs. In summary, while magnesium can play a role in supporting anxiety management, it should complement traditional treatments rather than serve as a primary solution.
Based on user reviews, the time it typically takes to see results from magnesium supplements for anxiety varies among individuals. Many users report experiencing noticeable improvements within a week. For instance, one user mentioned feeling a surge of positive energy and improved overall well-being after just one week of use Read Review. Another reviewer observed a reduction in anxiety and improvements in mood and sleep quality after only two weeks Read Review.
However, some individuals note that it may take longer to feel the full benefits of magnesium. For instance, one user reported significant relief from anxiety after four weeks of taking the supplement Read Review. Overall, while some users see results quite quickly, others find that it may take a few weeks to experience the full effects. It's important to remember that individual responses can vary, and consistency in taking the supplement may play a crucial role in efficacy.
Research indicates that magnesium may play a role in alleviating anxiety, although the evidence is mixed and often context-dependent. A systematic review found that out of 15 studies examined, many reported improvements in anxiety levels among those treated with magnesium, especially in individuals with low magnesium levels to start with [3]. Further studies suggest that magnesium may exert its effects by modulating gut bacteria associated with anxiety, as seen in mouse models, and may also improve anxiety symptoms in certain clinical settings, such as during pregnancy-induced hypertension [2][4].
However, the scientific community advises caution, as the majority of existing studies have variations in dosage, formulation, and duration of treatment which complicates the ability to draw definitive conclusions [3]. While some animal studies and human trials hint at magnesium's anxiolytic potential, they also highlight the need for larger, well-designed trials to thoroughly understand how magnesium supplementation can influence anxiety, particularly in humans. Thus, while magnesium could be a viable supplementary aid for managing anxiety in some cases, more research is necessary to clarify its effectiveness as a standalone treatment.
Based on user reviews, many individuals have reported significant improvements in their anxiety symptoms after taking magnesium supplements. For example, one user noted a marked improvement in their demeanor and a reduction in anxiety after starting Doctor's Best Magnesium, remarking that they plan to continue with the supplement due to its positive effects Read Review. Another reviewer experienced a similar positive transformation, stating that their social anxiety had remarkably improved, allowing them to navigate crowded places without tension for the first time in years Read Review.
Further, users have reported various additional benefits including better sleep quality and reduced muscle tension. One review mentioned that the magnesium helped to alleviate intercostal neuralgia after a month of use, contributing to a more peaceful nervous system Read Review. Several users expressed how their overall well-being improved, describing feelings of renewed energy and reduced fatigue Read Review. However, it’s important to note that individual results can vary widely based on personal health conditions and responses to supplementation.
According to user reviews, many have found that combining magnesium supplements with other vitamins, such as vitamin B6, can enhance their effectiveness in managing anxiety. One user noted that adding vitamin B6 to their magnesium regimen not only alleviated anxiety but also helped with headaches and tachycardia, highlighting the synergistic benefits of this combination Read Review. This suggests that incorporating additional supplements may provide an added layer of support for individuals dealing with anxiety.
Moreover, some users experienced positive effects from taking magnesium alongside other lifestyle adjustments, such as timing their doses. For instance, a reviewer reported taking two magnesium capsules daily, which significantly improved their mood and tranquillity Read Review. Additionally, individuals who routinely took magnesium in the evening found it beneficial for promoting better sleep and reducing anxiety symptoms Read Review. Overall, user feedback indicates that combining magnesium with other supplements might enhance its effects on anxiety, making it a worthwhile consideration for those seeking comprehensive anxiety management strategies.
Based on user reviews, the right dose of magnesium for treating anxiety appears to vary among individuals, with many users settling on a range between one to two tablets per day. For instance, one user mentioned taking two tablets daily led to significant improvements in anxiety and sleep quality, while another started with two and eventually reduced to one after feeling considerable anxiety relief Read ReviewRead Review. Some reviewers noted specific taking times, with suggestions to take magnesium before meals or before bedtime to enhance relaxation and effectiveness in combating anxiety Read Review.
Users also reported that absorption might differ with magnesium types; many felt that chelated forms led to better outcomes and fewer gastrointestinal issues Read Review. A general sentiment across reviews is that magnesium not only helped manage anxiety but also improved overall well-being when taken consistently over weeks. Importantly, users cautioned about adjusting doses based on personal tolerance and response, emphasizing the importance of monitoring one's feelings and experiences when determining the optimal dose for anxiety relief Read Review.
7.5
Enhanced positivity
194 people found this helpful
I've had a positive experience with this magnesium. It helps with anxiety and muscle relaxation. After a week, I felt a surge of positive energy and improved overall well-being.
9
Reduces anxiety
5 people found this helpful
Excellent! Before taking this magnesium form, I suffered from anxiety and irritability. Now, after two weeks of taking two tablets in the evening, my anxiety has disappeared and my mood has improved. I'm planning to buy more for my husband.
9
Mental relief
95 people found this helpful
After four weeks of taking Vitamin Fusion, I finally found relief from anxiety and chronic fatigue. It has made a significant difference in my mental and physical strength, allowing me to face the day with renewed energy. This supplement has truly changed my quality of life for the better.
9
Improved self-confidence
257 people found this helpful
Doctor's Best Magnesium is highly absorbable and doesn't upset my stomach. After a course of this magnesium, I've experienced a marked improvement—a calmer demeanour and a notable reduction in anxiety. I plan to continue taking this supplement.
10
Social ease
71 people found this helpful
This has alleviated my social anxiety remarkably. I can now navigate crowded places without tension or fear, which is a blessing after living with it since childhood. It has truly transformed my social interactions for the better.
9
Anxiety reduction
35 people found this helpful
This product is fantastic! It helped alleviate anxiety effectively, and after a month of taking two tablets daily, my mother experienced relief from intercostal neuralgia. I would recommend it to anyone seeking support for their nervous system.
7.5
Headache relief
106 people found this helpful
Alternative pharmacy effectively provided magnesium for my anxiety and headaches. It's pricey, but the results are worth it. I've also added vitamin B6 to my regimen. Magnesium chelate seems to be the best form for absorption. I realised how much it alleviates my anxiety and Other symptoms, including tachycardia. Overall, I'm pleased with the positive effects on my health.
7.5
Sleep improvement
4 people found this helpful
This magnesium glycinate has improved my sleep and reduced my anxiety significantly. I take two capsules daily and highly recommend it.
9
Calm nerves
3 people found this helpful
After trying it for a week, I've found it excellent for sleeping and calming my nerves. I take two pills after a meal, ideally three hours before bed.
10
Elevated mood
7 people found this helpful
I love taking this magnesium! Initially, I start with two tablets daily, then reduce to one. It significantly improves my mood, alleviates anxiety, and enhances sleep quality. I highly recommend this supplement.
9
Reduced palpitations
9 people found this helpful
I take one magnesium tablet before breakfast and another before bed. I'm considering increasing to two daily as my stomach sometimes feels unsettled. I've experienced anxiety-driven palpitations, but after taking this magnesium, they seem to have disappeared. I'm eager to continue using it.
7
Magnesium shows potential for anxiety
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
References
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073