Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
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7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
Read More
5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
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Most Useful Reviews
10
Great for anxiety
41 people found this helpful
Works so well! This substance is a literal gift from God. I previously took antidepressants, but now I take this and absolutely love it. It significantly helps my depression and anxiety without the side effects associated with antidepressants. I certainly notice a difference when I skip it. I highly recommend it, and it doesn't have a bad taste, even if it’s a bit large to swallow.
Read More
10
Life changing
15 people found this helpful
These magnesium capsules have transformed my life! I experienced daily chest pain and nausea due to general anxiety, but after around six weeks of taking them, the pain has vanished. I haven't required prescription anti-anxiety meds for over a month—it's remarkable!
Read More
9
Panic attack reduction
8 people found this helpful
I’m grateful to have found these supplements for my anxiety and panic attacks. After just a few days, I noticed a significant decrease in panic attacks while driving. My sleep has improved, and my energy levels have increased without feeling the need for naps.
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
Read More
8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Read More
8
Magnesium aids post-surgery anxiety
Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
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8
Magnesium reduces anxiety symptoms
Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
Read More
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Works so well! This substance is a literal gift from God. I previously took antidepressants, but now I take this and absolutely love it. It significantly helps my depression and anxiety without the side effects associated with antidepressants. I certainly notice a difference when I skip it. I highly recommend it, and it doesn't have a bad taste, even if it’s a bit large to swallow.
Read More
10
Life changing
15 people found this helpful
These magnesium capsules have transformed my life! I experienced daily chest pain and nausea due to general anxiety, but after around six weeks of taking them, the pain has vanished. I haven't required prescription anti-anxiety meds for over a month—it's remarkable!
Read More
9
Panic attack reduction
8 people found this helpful
I’m grateful to have found these supplements for my anxiety and panic attacks. After just a few days, I noticed a significant decrease in panic attacks while driving. My sleep has improved, and my energy levels have increased without feeling the need for naps.
Read More
9
Reduced anxiety symptoms
1 people found this helpful
Taking magnesium has significantly improved my life. It alleviates nervous tension and has relieved my anxiety, enhancing my overall quality of life. Symptoms like headaches and constant tiredness have lessened considerably. I alternate between different forms of magnesium for better absorption and avoid less effective forms. I take it in the evening, away from calcium, which works well for me. After two years, I can confidently say magnesium has transformed me from feeling perpetually anxious to calmer and balanced.
Read More
9
Calmer mood
Magnesium helps relax muscles and improves sleep. It acts as a natural anti-stress factor, reducing sensitivity to anxiety-inducing stimuli, and the powder form is quickly absorbed. It's best taken with lemon.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been studied for its potential role in alleviating symptoms of anxiety, and some evidence suggests it may be beneficial. Magnesium plays a critical role in brain function and the regulation of neurotransmitters, which are essential for mood stability. Some studies have indicated that low levels of magnesium may be linked to increased anxiety symptoms, and supplementation could work to help improve overall mental health by restoring adequate magnesium levels. While it's not a standalone treatment for anxiety disorders, integrating magnesium into a balanced diet with other treatment modalities could provide additional support.
That said, it's important to approach magnesium supplementation thoughtfully. Overuse can lead to adverse effects, and individual needs may vary widely depending on dietary intake and overall health status. Before starting any new supplement, especially for managing anxiety, consulting with a healthcare professional is advisable to tailor an approach that aligns with your personal health needs. In summary, while magnesium can play a role in supporting anxiety management, it should complement traditional treatments rather than serve as a primary solution.
Based on user reviews, the timeline for seeing results from magnesium supplements can vary significantly among individuals. Some users report noticeable improvements in their anxiety levels and overall well-being after just a couple of weeks of consistent use. For instance, one user stated that magnesium transformed their feelings from chronic anxiety to a state of calmness and balance after two years of regular intake Read Review. Another user mentioned that this supplement significantly alleviated anxiety and improved sleep, indicating tangible benefits after incorporating it into their routine Read Review.
On the other hand, some users mentioned that while they have not definitively noticed a reduction in anxiety for themselves or others after a period of use, they continue to utilize the supplement for its potential benefits Read Review. This suggests that while many experience benefits relatively quickly, others may require a longer duration or may not find it effective for anxiety relief. It is essential to remember that individual responses to magnesium can vary widely, and factors like dosage, form of magnesium taken, and personal health conditions might influence these outcomes.
Recent research indicates that magnesium supplementation may have potential benefits for alleviating anxiety, though results vary across studies. A systematic review explored multiple studies regarding magnesium's impact on anxiety and sleep disorders, revealing that five out of seven studies reported improvements in self-reported anxiety levels among participants [3]. Furthermore, a double-blind controlled trial found that while magnesium combined with probiotics and coenzyme Q10 reduced anxiety symptoms in the short term, these effects did not persist beyond the treatment period [1].
Moreover, additional studies in both animal and human models suggest that magnesium may mitigate anxiety through various mechanisms, including reducing oxidative stress and impacting gut bacteria associated with anxiety-like behaviors [2]. An investigation on magnesium sulfate in pregnant women with high blood pressure indicated notable improvements in anxiety levels when combined with other medications [4]. While the preliminary findings are promising, it’s essential to proceed with caution, as many of these studies utilize varying dosages, formulations, and additional treatments, indicating that further rigorous trials are needed to solidify magnesium's efficacy as a standalone treatment for anxiety.
Many users report significant improvements in their symptoms after consistently taking magnesium supplements. For example, one individual noted that after two years of use, magnesium transformed their chronic anxiety into a state of calm, alleviating nervous tension and even reducing symptoms like headaches and fatigue Read Review. Others have found that magnesium helps them relax their muscles, improves sleep quality, and reduces sensitivity to anxiety-inducing stimuli Read Review. Specific formulations, such as chelated magnesium, have been praised for their superior absorption and efficacy in managing stress and anxiety Read Review.
In addition, several users noted that regular consumption of magnesium not only relieved anxiety but also improved overall mood and alleviated muscle cramps Read Review. Many mentioned the necessity of mixing the powder with other beverages to make it more palatable, though the benefits they experienced often outweighed any taste issues Read Review. However, it is important to acknowledge that individual results can vary widely, with some users not experiencing noticeable effects even after prolonged use Read Review. Overall, magnesium supplements seem to enhance well-being for many, especially in reducing anxiety and improving sleep.
Users have reported positive experiences when combining magnesium supplements with other supplements for handling anxiety. For instance, many prefer chelated magnesium, which is noted for its superior absorption and ability to work effectively alongside other compounds like glycine. One user mentioned that this combination helps in protein formation and further relaxes the nervous system, making it an excellent pairing for stress and anxiety relief Read Review. Additionally, several reviews mention that magnesium can complement other stress-relief strategies, enhancing their efficacy without causing gastrointestinal discomfort Read Review.
Moreover, users often note that magnesium works synergistically with other relaxation techniques or supplements to improve mood and sleep quality, thereby tackling anxiety from multiple angles. Many report significant reductions in anxiety symptoms and improved overall well-being when magnesium is included in their routines Read Review. While individual responses vary, combining magnesium with complementary supplements appears to provide additional benefits for those managing anxiety Read Review.
Users report varying experiences with the right dose of magnesium for managing anxiety, with some finding significant relief at different amounts. One user mentioned taking 400 mg daily, highlighting its benefits in alleviating anxiety, headaches, and aiding overall well-being during stressful times Read Review. Others recommend starting with around 200 mg for children or those sensitive to dosage, indicating that individual responses can vary greatly Read Review.
The form of magnesium can also impact its effectiveness; many users agree that chelated magnesium, particularly forms like glycinate, are better absorbed and produce fewer gastrointestinal issues. It’s noted that taking magnesium in the evening, away from calcium, can optimize its calming effects Read Review. However, it’s worth noting that taste can be a significant factor in compliance with magnesium supplementation, with some users suggesting mixing the powder with juice or other flavor enhancers to make it more palatable Read Review.
9
Reduced anxiety symptoms
1 people found this helpful
Taking magnesium has significantly improved my life. It alleviates nervous tension and has relieved my anxiety, enhancing my overall quality of life. Symptoms like headaches and constant tiredness have lessened considerably. I alternate between different forms of magnesium for better absorption and avoid less effective forms. I take it in the evening, away from calcium, which works well for me. After two years, I can confidently say magnesium has transformed me from feeling perpetually anxious to calmer and balanced.
9
Calms anxiety
4 people found this helpful
I regularly take magnesium from this brand. It's a bioavailable chelated form. I bought powder for my mother, who finds it easier to drink than swallow pills. It has significantly reduced her anxiety and improved her sleep.
4
Still anxious
I switched my son to this magnesium powder, giving him 200mg daily. Despite the numerous reviews about its awful taste, I cannot determine if it has noticeably reduced his anxiety.
9
Calmer mood
Magnesium helps relax muscles and improves sleep. It acts as a natural anti-stress factor, reducing sensitivity to anxiety-inducing stimuli, and the powder form is quickly absorbed. It's best taken with lemon.
7.5
Helps with anxiety
1 people found this helpful
I love this high-quality magnesium! With just one ingredient and no fillers, it lasts long. It has alleviated my muscle cramps and anxiety; it's truly a magical mineral.
6
Reduces anxiety
The taste is dreadful, but I manage by mixing it with juice and using a straw. I've been taking magnesium for a long time, and it effectively alleviates muscle cramps and anxiety.
9
Soothes anxiety
1 people found this helpful
This chelated magnesium combines well with glycine, aiding in protein formation and relaxing the nervous system. It's great for managing stress and anxiety without causing bowel issues.
7.5
Reduced anxiety
6 people found this helpful
Soluble magnesium chelate has been beneficial for me. I take 400 mg per day, as magnesium is crucial, especially during stress and anxiety. It assists with headaches and bile flow. I prefer the powder form as it's easier to consume. I dilute it in warm water and highly recommend it!
7
Magnesium shows potential for anxiety
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
7
Magnesium's transient anxiety relief
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.
At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.
Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
References
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073