Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.4
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
8
WIFAS improving folate and hemoglobin
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Read More
Most Useful Reviews
9
Vital for women
1 people found this helpful
After women enter menopause, supplementation with vitamin B complex is essential. Comprising eight water-soluble vitamins (B1, B2, B6, B12, nicotinic acid, biotin, and pantothenic acid), it serves multiple functions. It regulates metabolism, maintains skin and muscle health, promotes cell growth, and assists in the production of red blood cells, thereby preventing anemia. Additionally, it enhances immune and nervous system functions, reduces heart disease risks, and helps stabilise mood.
Read More
9
Treats anemia effectively
An excellent addition for me in treating anemia. All vitamins are in active forms and I experienced no allergies.
Read More
9
Effective for anemia
Vitamins work effectively. This is a good vitamin for treating anemia.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.4
- All Researches
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Read More
9.5
Thiamine resolves rare anemia effectively
In our examination, we focused on thiamine-responsive megaloblastic anemia (TRMA), a rare genetic disorder affecting young individuals. We learned about a young man with diabetes who faced pancytopenia, initially linked to a COVID-19 infection.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Read More
9.5
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Health education improves anemia outcomes
We explored the effectiveness of a family-centered health education intervention aimed at boosting the adherence to iron-folic acid supplements and improving anemia in rural pregnant women.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
Read More
9
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vital for women
1 people found this helpful
After women enter menopause, supplementation with vitamin B complex is essential. Comprising eight water-soluble vitamins (B1, B2, B6, B12, nicotinic acid, biotin, and pantothenic acid), it serves multiple functions. It regulates metabolism, maintains skin and muscle health, promotes cell growth, and assists in the production of red blood cells, thereby preventing anemia. Additionally, it enhances immune and nervous system functions, reduces heart disease risks, and helps stabilise mood.
Read More
9
Treats anemia effectively
An excellent addition for me in treating anemia. All vitamins are in active forms and I experienced no allergies.
Read More
9
Effective for anemia
Vitamins work effectively. This is a good vitamin for treating anemia.
Read More
7.5
B vitamin increase
2 people found this helpful
Confirmed anemia; I was prescribed this to raise the B vitamin levels in my blood.
Read More
6
Supports metabolism
2 people found this helpful
Excellent! After women enter menopause, they need to supplement with vitamin B complex, which comprises eight water-soluble vitamins (B1, B2, B6, B12, nicotinic acid, biotin, and pantothenic acid). This group possesses diverse functions including regulating metabolism, maintaining skin and muscle health, and promoting cell growth. Notably, it aids in the production of red blood cells, thereby preventing anemia. It also helps reduce heart disease risks and manage stress, stabilising mood. If you appreciate this comment, please show your support, thank you.
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Frequently Asked Questions
7.5
Improved anemia condition
My anemia condition improved significantly after taking it for half a year.
7.5
Quick absorption effect
It is well absorbed and quickly effective. I frequently use it in my practice, especially for anemia and neurological issues.
7.5
Effective vitamin complex
An excellent complex of vitamins; I have iron deficiency anemia and frequently take this along with other supplements. It truly has a noticeable effect.
7.5
Improved mood
An excellent vitamin; prior to meeting with my nutritionist, I was unaware that I had not only iron deficiency anaemia but also anaemia related to the B vitamin group. After taking it, I observed an enhancement in my mood.
6
Enhances work efficiency
1 people found this helpful
After breakfast daily, I supplement with this comprehensive vitamin B, which improves my focus at work and elevates my efficiency, helping me avoid the afternoon slump. It replenishes my energy and has a substantial vitamin B content, enhancing nervous system stability, promoting metabolism, and preventing anemia with folic acid. The small particles are easy to swallow.
7.5
Vital for iron support
I really love this brand; vitamin B is essential for supporting iron levels. Sometimes anemia remains untreated until we start taking vitamin B.
7
Supports cardiovascular system
I take this vitamin complex to support both my cardiovascular and nervous systems. It’s well-selected and combined, particularly vitamins B9 (folic acid) and B12 (in methylcobalamin form), which are beneficial for managing anemia.
9
Improved health benefits
Vitamin B12 is crucial as it helps alleviate pain and prevents pernicious anemia, as well as heart attacks and strokes. It aids in treating nervous diseases, anemia, depression, hypertension, and sclerosis. The quality is excellent, with natural ingredients, and I appreciate the packaging and health benefits. The price is particularly appealing, and the overall advantages are remarkable; the size is convenient, and the taste is pleasant.
8
We explored a compelling case of pernicious anemia in a 51-year-old Ugandan man presenting with lower limb weakness. Initially treated for vitamin B12 deficiency years earlier, he experienced similar symptoms once again.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
9.5
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
8
We examined the impact of daily oral iron supplementation on anemia in pregnant women. Our analysis included 57 trials with nearly 49,000 participants.
We found that iron supplementation could significantly reduce maternal anemia and iron deficiency by the end of pregnancy. However, other outcomes showed limited effects, with uncertainty around the benefits for infant health.
Overall, while iron could be beneficial, there's a need for future studies to explore its broader impacts on maternal and child health.
We found that iron supplementation could significantly reduce maternal anemia and iron deficiency by the end of pregnancy. However, other outcomes showed limited effects, with uncertainty around the benefits for infant health.
Overall, while iron could be beneficial, there's a need for future studies to explore its broader impacts on maternal and child health.
8
WIFAS improving folate and hemoglobin
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
References
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. doi:10.1038/s41598-025-87957-x
- Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. doi:10.1186/s13643-024-02726-7
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. doi:10.1177/03795721241304475
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. doi:10.1021/acsami.4c15206
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2024-261435
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. doi:10.1002/14651858.CD004736.pub6
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
