5/11/2025
Last update
5/11/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 210 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic Acid
600 mg
†
Top Medical Research Studies
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
3
We investigated whether alpha-lipoic acid (ALA) could improve symptoms of diabetic peripheral neuropathy (DPN). Our review included three randomized trials with over 800 participants, with treatment durations ranging from six to 48 months.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Read More
Most Useful Reviews
9
Good dosage
33 people found this helpful
I bought this for my wife, and it helps her significantly with polyneuropathy. The dosage is commendable, and it works well.
Read More
10
Significant pain relief
21 people found this helpful
I bought this in hopes of relieving my neuropathy, and it truly exceeded my expectations! My pain levels decreased from 8 or 9 to around 3-4. I recommend giving it a try if you're struggling.
Read More
9
Improved sleep quality
17 people found this helpful
EXCELLENT SUPPLEMENTAL RELIEF OF DIABETIC NEUROPATHY. This works well for my husband, who suffers from severe diabetic neuropathy in his legs and feet. Even with gabapentin, the pain was excruciating and disrupted his sleep. After adding alpha-lipoic acid to his regimen for just a few days, the pain significantly subsided, enabling him to sleep better.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
8
We explored the impact of genome sequencing on diagnosing and treating SLC5A6-related neuropathy. In this study, we observed that thirteen individuals with specific genetic variants experienced various symptoms, including childhood-onset peripheral motor neuropathy.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Read More
User Reviews
USERS' SCORE
Good
Based on 210 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Good dosage
33 people found this helpful
I bought this for my wife, and it helps her significantly with polyneuropathy. The dosage is commendable, and it works well.
Read More
10
Significant pain relief
21 people found this helpful
I bought this in hopes of relieving my neuropathy, and it truly exceeded my expectations! My pain levels decreased from 8 or 9 to around 3-4. I recommend giving it a try if you're struggling.
Read More
9
Improved sleep quality
17 people found this helpful
EXCELLENT SUPPLEMENTAL RELIEF OF DIABETIC NEUROPATHY. This works well for my husband, who suffers from severe diabetic neuropathy in his legs and feet. Even with gabapentin, the pain was excruciating and disrupted his sleep. After adding alpha-lipoic acid to his regimen for just a few days, the pain significantly subsided, enabling him to sleep better.
Read More
9
Miracle improvement!
15 people found this helpful
It really works! Six months ago, I experienced unpleasant sensations in my legs like itching and sensory disturbances, diagnosed as neuropathy. I reduced my carb intake and began taking alpha-lipoic acid. After two to three months, I barely remembered the disease! I wholeheartedly recommend it!
Read More
9
Numbing discomfort subsides
15 people found this helpful
My primary reason for taking this supplement is for diabetic neuropathy. I experienced a numbing discomfort in my thighs, particularly my right one. After taking ALA daily for 6-8 months, the sensation diminished. Now, after a year, this issue has resolved. While results may vary for others, I firmly believe it has benefitted me.
Read More
Frequently Asked Questions
9
Significant pain relief
10 people found this helpful
After nearly a week of taking these 600MG capsules, I’ve noticed a tremendous improvement in the numbness in my feet caused by diabetic neuropathy. I wish I had started using this product sooner as it has substantially reduced my pain from an 8 or 9 down to a manageable 3-4. I'm genuinely grateful!
9
Miracle improvement!
15 people found this helpful
It really works! Six months ago, I experienced unpleasant sensations in my legs like itching and sensory disturbances, diagnosed as neuropathy. I reduced my carb intake and began taking alpha-lipoic acid. After two to three months, I barely remembered the disease! I wholeheartedly recommend it!
9
Pains resolved
4 people found this helpful
I took Alpha Lipoic Acid for polyneuropathy and carpal tunnel syndrome, combining it with phosphatidylserine. After suffering from severe wrist pain and nerve entrapment, I took it for around six months, and now the pain has resolved. A dosage of 600mg has worked wonders for me; I’m very pleased with my purchase.
7.5
Improved sleep noted
8 people found this helpful
This amino acid is a must for individuals with nervous disorders, especially diabetics. My mother began sleeping better and her neuropathy lessened after about two months of use. I’m committed to continuing this for my health as well due to multiple sclerosis, where it's crucial for myelin repair. We both intend to keep using it. Thanks to the manufacturers for this product!
10
Neuropathy reversal
5 people found this helpful
This product, alongside befothiamine, has successfully reversed my diabetic neuropathy.
9
Effective neuropathy relief
3 people found this helpful
Alpha lipoic acid is essential. This compound (4-600 mg capsules/day) has been crucial in my anti-oxidant supplements to alleviate my peripheral neuropathy caused by cancer treatments and excessive vitamin D therapy. Combined with fast-acting magnesium, it has helped control my systolic blood pressure, allowing me to remain off high blood pressure medication for over five years. I take two capsules each morning and afternoon with magnesium and benfotiamine. Alpha lipoic acid has benefitted me for over a decade, and I trust the quality of this product.
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
7
Alpha-lipoic acid shows promise
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. 10.3390/biomedicines13020438
- Abuali SM, Frasca DJ. Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy. Am Fam Physician. 2025;111:119.
- Walimbe AS, Waskow E, Mackay L, Miller M, Gijavanekar C, et al. Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency. Am J Med Genet A. 2025. 10.1002/ajmg.a.64014
- Hernyák M, Tóth LI, Csiha S, Molnár Á, Lőrincz H, et al. Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy. Int J Mol Sci. 2024;25. 10.3390/ijms252413276
- Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, et al. A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin. J Postgrad Med. 2024;70:191. 10.4103/jpgm.jpgm_310_24
- Wang Q, Xie H, Wang Z, Huang R, Xu M, et al. Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials. Pharm Biol. 2024;62:833. 10.1080/13880209.2024.2422084
- Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. 10.7759/cureus.70299
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Riley LG, Sabui S, Said HM, Niaz A, Girisha KM, et al. Genome sequencing enables diagnosis and treatment of SLC5A6 neuropathy. Eur J Hum Genet. 2024;32:947. 10.1038/s41431-024-01641-8
- Ran GL, Li YP, Lu LC, Lan SH. Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2024;38:108691. 10.1016/j.jdiacomp.2024.108691
- Prado MB, Adiao KJB. Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis. Can J Diabetes. 2024;48:233. 10.1016/j.jcjd.2024.01.007
- Lee DW, Park HC, Kim DH. Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Muscle Nerve. 2024;69:498. 10.1002/mus.28047
- Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206 Suppl 1:110764. 10.1016/j.diabres.2023.110764
- Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024;1:CD012967. 10.1002/14651858.CD012967.pub2
- Li Y, Jia Y. Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy. Cell Mol Biol (Noisy-le-grand). 2023;69:38. 10.14715/cmb/2023.69.12.7
