Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
USERS' SCORE
Good
Based on 61 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Alpha-Lipoic acid
300 mg
†
Benfotiamine
150 mg
†
Top Medical Research Studies
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We conducted a three-week randomized, placebo-controlled pilot study to see how benfotiamine could help patients with diabetic polyneuropathy.
Forty inpatients received either benfotiamine or a placebo, and we found that those taking benfotiamine experienced a significant improvement in neuropathy symptoms, particularly pain reduction.
Although some measures showed no major differences, more individuals in the benfotiamine group felt better overall.
Forty inpatients received either benfotiamine or a placebo, and we found that those taking benfotiamine experienced a significant improvement in neuropathy symptoms, particularly pain reduction.
Although some measures showed no major differences, more individuals in the benfotiamine group felt better overall.
Read More
Most Useful Reviews
9
Relief from symptoms
42 people found this helpful
This is the best mixture for neuropathy (both diabetic and otherwise). I eventually increased to two a day, which made my urine smell, but it relieved 90% of my neuropathy symptoms in my feet. Be consistent and use sensible care practices to regain your feet. It’s the best and least expensive gift I’ve ever given myself.
Read More
9
Quality of life
34 people found this helpful
I experienced eight continuous hours of sleep, which felt miraculous. Initially, I doubted it could help, having tried many remedies before. The only previous relief came from Tramadol, which I wanted to avoid. After reading about ALA, I ordered this product and took it two nights later. This was the first time in almost six months that I slept through the night, and my legs felt significantly better. I've been using it since early November 2015, and it has remarkably improved my quality of life.
Read More
9
Effective for pain
34 people found this helpful
Excellent product. This aids significantly with the pain of peripheral neuropathy, often working as effectively, if not better, than prescription gabapentin.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
- All Researches
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We examined the complexities of diabetic neuropathy and the role of benfotiamine in its management. Recent findings confirm that benfotiamine can inhibit harmful pathways triggered by high blood sugar, thus helping to promote healthier nerve function. Numerous clinical trials worldwide have shown it to be effective.
Furthermore, benfotiamine works alongside other treatments like alpha-lipoic acid to improve symptoms gradually. By focusing on these new therapeutic approaches, we can better address neuropathy and enhance quality of life for those affected.
Furthermore, benfotiamine works alongside other treatments like alpha-lipoic acid to improve symptoms gradually. By focusing on these new therapeutic approaches, we can better address neuropathy and enhance quality of life for those affected.
Read More
8
We examined the effects of benfotiamine, a synthetic derivative of vitamin B1, on neuropathy. This compound increases intracellular thiamine diphosphate, which helps combat advanced glycation end products (AGEs) that contribute to nerve damage, particularly in diabetes.
While benfotiamine shows promise due to its anti-AGE properties and potential benefits for diabetic complications like neuropathy, recent studies offer mixed results regarding its overall effectiveness.
Thus, while it may be helpful in some contexts, the results highlight the need for further investigation to confirm its benefits for neuropathy.
While benfotiamine shows promise due to its anti-AGE properties and potential benefits for diabetic complications like neuropathy, recent studies offer mixed results regarding its overall effectiveness.
Thus, while it may be helpful in some contexts, the results highlight the need for further investigation to confirm its benefits for neuropathy.
Read More
8
We explored the potential of benfotiamine in alleviating inflammatory and neuropathic pain through a detailed study with rats. By inducing pain through specific methods, we noted significant reductions in pain-related behaviors when benfotiamine was administered at varying doses.
The findings suggest that benfotiamine shows promise in reducing pain from different causes, hinting at its potential benefits for humans suffering from nerve pain. While this research is promising, further studies are needed to fully understand its effects in human trials.
The findings suggest that benfotiamine shows promise in reducing pain from different causes, hinting at its potential benefits for humans suffering from nerve pain. While this research is promising, further studies are needed to fully understand its effects in human trials.
Read More
User Reviews
USERS' SCORE
Good
Based on 61 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relief from symptoms
42 people found this helpful
This is the best mixture for neuropathy (both diabetic and otherwise). I eventually increased to two a day, which made my urine smell, but it relieved 90% of my neuropathy symptoms in my feet. Be consistent and use sensible care practices to regain your feet. It’s the best and least expensive gift I’ve ever given myself.
Read More
9
Quality of life
34 people found this helpful
I experienced eight continuous hours of sleep, which felt miraculous. Initially, I doubted it could help, having tried many remedies before. The only previous relief came from Tramadol, which I wanted to avoid. After reading about ALA, I ordered this product and took it two nights later. This was the first time in almost six months that I slept through the night, and my legs felt significantly better. I've been using it since early November 2015, and it has remarkably improved my quality of life.
Read More
9
Effective for pain
34 people found this helpful
Excellent product. This aids significantly with the pain of peripheral neuropathy, often working as effectively, if not better, than prescription gabapentin.
Read More
9
Keeps pain checked
33 people found this helpful
I began using this due to a recent onset of neuropathy pain in my feet from diabetes. Thus far, taking two pills a day has been working excellently for me.
Read More
7.5
Quick recovery
31 people found this helpful
After breaking my ankle at 62, I began feeling tingling in my foot about 1.5 years later, assuming it was scar tissue affecting a nerve. Within two weeks of using this product, my symptoms improved remarkably. It's commonly used for diabetic peripheral neuropathy, but I find it also helps with my sciatic flare-ups. A great product!
Read More
Frequently Asked Questions
7.5
Marked symptom reduction
8 people found this helpful
I purchased Doctor's Best Benfotiamine and Alpha-Lipoic Acid due to my neuropathy in both feet. Remarkably, within just a couple of days, I noticed a significant reduction in my symptoms. Taking one capsule in the morning and evening has proven effective for me.
9
Pain alleviation
7 people found this helpful
This product greatly alleviates the burning sensation in my feet due to neuropathy. Alongside a low-carb diet, it has helped control my blood sugar, allowing me to stop taking Metformin. Although it doesn’t work immediately—benefits started showing by the third week—I'm extremely thankful for its effectiveness in my case.
7.5
Noticeable improvement
I take this product to alleviate my foot neuropathy symptoms. I’ve noticed that if I miss a few days, the difference is quite evident, affirming its effectiveness.
9
Neuropathy relief
16 people found this helpful
This is a miracle supplement! After years of battling with neuropathy, it became increasingly difficult to stand. I also suffered from restless leg syndrome that disrupted my sleep. After switching from Gabapentin to this supplement, my symptoms have decreased significantly to almost 98% gone; I only experience slight numbness now, which I can manage.
9
Numbness reduction
11 people found this helpful
For about seven years, I have been taking Doctors Best Benfotiamine with Alpha Lipoic Acid for my blood sugar issues and neuropathy in my hands and feet. Since I started, the numbness and white discoloration in my toes and fingers are barely noticeable. I can't imagine adapting without this product.
9
Mood improvement
Well tolerated. This excellent form of benfotiamine and alpha lipoic acid has helped with my neuropathy and improved my mood, along with other vitamins and coenzyme Q10.
7.5
Improved well-being
2 people found this helpful
I take this vitamin to enhance the functioning of my peripheral nervous system. I have polyneuropathy affecting my lower limbs, which means nerve impulses do not always travel effectively, leaving me with weakness in my legs. With this antioxidant, these episodes occur less frequently. It works well for me, and in combination with other vitamins, I’ve managed to improve my well-being and stabilise my blood pressure. I take this vitamin intermittently.
7.5
Stabilised sugar levels
36 people found this helpful
I've tried various dosages of ALA and Benfotiamine for over a year, as both my mum and I have neuropathy due to diabetes. We found that taking two capsules, one in the morning and one at night, works better than higher doses. Initially, higher dosages caused my blood sugar to rise, but since reducing my intake, our sugar levels stabilised and the burning pains in our feet have lessened. A low-carb, sugar-free diet and exercise also help. I hope this will guide someone in choosing the right mix for their peripheral pain.
We investigated the impact of daily thiamine (vitamin B1) supplementation on individuals with Charcot-Marie-Tooth (CMT) neuropathy. Our pilot study observed improvements in hand grip strength among patients taking 100 mg of thiamine. Additionally, we explored molecular changes related to thiamine coenzyme levels, noting differences in enzyme regulation between CMT patients and healthy controls.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
While we found promising benefits for thiamine, including increased grip strength, we also noted unusual decreases in an enzyme related to thiamine, indicating that the effects can vary widely among patients.
7
We examined the role of benfotiamine as a treatment option for diabetic peripheral neuropathy (DPN), which affects many people with diabetes. The existing management strategies often fall short due to limited efficacy and side effects. Over recent years, looking at preclinical studies and various trials has given us hope, showing that benfotiamine and similar agents can yield positive results. The NATHAN 1 trial specifically noted improvements in neuropathic signs after a four-year period. Still, further long-term studies are needed to solidify these findings and explore optimal treatment combinations.
7
We explored how benfotiamine interacts with pain relief when combined with a common opioid, fentanyl, in diabetic mice. By examining four different groups, we found that while benfotiamine did not provide direct pain relief on its own, it significantly enhanced the pain-relieving effects of fentanyl in diabetic subjects. The results suggest that benfotiamine may enhance the analgesic effects of mu-opioid agonists like fentanyl, potentially offering a new avenue for treating neuropathic pain in diabetic patients.
7
We looked into benfotiamine's potential benefits for neuropathy, focusing on its antioxidant properties. In our evaluation, we found that benfotiamine effectively reduces oxidative stress and prevents DNA damage in kidney cells influenced by harmful agents.
This suggests that benfotiamine could play a role in managing diabetic complications, including nerve pain. Overall, the findings indicate that benfotiamine may be a promising treatment option, particularly for those suffering from diabetes-related neuropathy.
This suggests that benfotiamine could play a role in managing diabetic complications, including nerve pain. Overall, the findings indicate that benfotiamine may be a promising treatment option, particularly for those suffering from diabetes-related neuropathy.
8
We investigated the effectiveness of a combined treatment of Benfotiamine and vitamins B6 and B12 for diabetic polyneuropathy in a double-blind, randomized, controlled study with 24 patients over 12 weeks.
We found a significant improvement in nerve conduction velocity, along with trends suggesting enhanced vibration perception.
Notably, patients did not report adverse effects, and long-term follow-up showed continued benefits.
Our findings suggest that this combination could be an important starting point for managing diabetic neuropathy.
We found a significant improvement in nerve conduction velocity, along with trends suggesting enhanced vibration perception.
Notably, patients did not report adverse effects, and long-term follow-up showed continued benefits.
Our findings suggest that this combination could be an important starting point for managing diabetic neuropathy.
8
We investigated how different doses of benfotiamine could help people with painful diabetic neuropathy. In our study, 36 diabetic patients received either a high dose, a medium dose, or a lower dose of benfotiamine over six weeks. We tracked their pain and sensation improvements at various stages.
What we found was promising: all treatment groups showed noticeable relief, with the highest dose group experiencing the most significant benefits. So, while the high dose was the most effective, even lower doses still made a difference for many.
What we found was promising: all treatment groups showed noticeable relief, with the highest dose group experiencing the most significant benefits. So, while the high dose was the most effective, even lower doses still made a difference for many.
References
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. doi:10.1134/S0006297924070010
- Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206 Suppl 1:110764. doi:10.1016/j.diabres.2023.110764
- Vafadar Ghasemi L, Behnam Rassouli M, Matin MM, Mahdavi-Shahri N. Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats. J Diabetes Metab Disord. 2021;20:21. doi:10.1007/s40200-020-00666-2
- Zhu Z, Varadi G, Carter SG. Pharmacokinetics of the transdermal delivery of benfotiamine. Acta Diabetol. 2016;53:317. doi:10.1007/s00592-015-0776-2
- Nacitarhan C, Minareci E, Sadan G. The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes. Exp Clin Endocrinol Diabetes. 2014;122:173. doi:10.1055/s-0033-1363977
- Winkler G, Kempler P. [Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy]. Orv Hetil. 2010;151:971. doi:10.1556/OH.2010.28898
- Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010;61:482. doi:10.1016/j.phrs.2010.02.008
- Ang CD, Alviar MJ, Dans AL, Bautista-Velez GG, Villaruz-Sulit MV, et al. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst Rev. 2008. doi:10.1002/14651858.CD004573.pub3
- Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008;116:600. doi:10.1055/s-2008-1065351
- Schmid U, Stopper H, Heidland A, Schupp N. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev. 2008;24:371. doi:10.1002/dmrr.860
- Sánchez-Ramírez GM, Caram-Salas NL, Rocha-González HI, Vidal-Cantú GC, Medina-Santillán R, et al. Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006;530:48.
- Cameron NE, Gibson TM, Nangle MR, Cotter MA. Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. Ann N Y Acad Sci. 2005;1043:784.
- Haupt E, Ledermann H, Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005;43:71.
- Karachalias N, Babaei-Jadidi R, Ahmed N, Thornalley PJ. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003;31:1423.
- Winkler G, Pál B, Nagybéganyi E, Ory I, Porochnavec M, et al. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung. 1999;49:220.
- Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104:311.
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Abuali SM, Frasca DJ. Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy. Am Fam Physician. 2025;111:119.
- Walimbe AS, Waskow E, Mackay L, Miller M, Gijavanekar C, et al. Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency. Am J Med Genet A. 2025. doi:10.1002/ajmg.a.64014
- Hernyák M, Tóth LI, Csiha S, Molnár Á, Lőrincz H, et al. Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413276
- Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, et al. A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin. J Postgrad Med. 2024;70:191. doi:10.4103/jpgm.jpgm_310_24
- Wang Q, Xie H, Wang Z, Huang R, Xu M, et al. Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials. Pharm Biol. 2024;62:833. doi:10.1080/13880209.2024.2422084
- Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. doi:10.7759/cureus.70299
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Riley LG, Sabui S, Said HM, Niaz A, Girisha KM, et al. Genome sequencing enables diagnosis and treatment of SLC5A6 neuropathy. Eur J Hum Genet. 2024;32:947. doi:10.1038/s41431-024-01641-8
- Ran GL, Li YP, Lu LC, Lan SH. Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2024;38:108691. doi:10.1016/j.jdiacomp.2024.108691
- Prado MB, Adiao KJB. Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis. Can J Diabetes. 2024;48:233. doi:10.1016/j.jcjd.2024.01.007
- Lee DW, Park HC, Kim DH. Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Muscle Nerve. 2024;69:498. doi:10.1002/mus.28047
- Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024;1:CD012967. doi:10.1002/14651858.CD012967.pub2
- Li Y, Jia Y. Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy. Cell Mol Biol (Noisy-le-grand). 2023;69:38. doi:10.14715/cmb/2023.69.12.7
