Doctor's Best Glucosamine Chondroitin Msm with OptiMSM

Supplement Facts

Serving Size: 4 capsules

Amount Per Serving

%DV

Chloride (from glucosamine hydrochloride potassium sulfate)

170 mg

Sodium (from chondroitin sulfate sodium)

120 mg

Potassium (from glucosamine hydrochloride potassium sulfate)

190 mg

GlucosamineHydrochloride Potassium Sulfate

1500 mg

†

Chondroitin sulfate Sodium

1200 mg

†

MSM (Methylsulfonylmethane)(OptiMSM®)

1000 mg

†

The product is found useful for the following medical conditions

Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.

Most Relevant Research

In a well-structured randomized, double-blind, placebo-controlled trial, we explored how methylsulfonylmethane (MSM) affects those experiencing mild knee pain. The study involved 88 healthy Japanese participants, split evenly into two groups where one received 200 mg of MSM while the other received a placebo for 12 weeks.

By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.

Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.

9.5

Knee pain relief

Most Useful Review

Mum had severe knee joint pain when walking, and after a month of taking chondroprotectors, the pain disappeared. I ordered different brands, and this one from NOW seemed most effective. For added efficiency, I also got Boswellia extract, which I highly recommend.

Common Cold details

Effective against pain

Most Useful Review

The best! It helped me significantly with joint and back pain. I run daily during warm seasons and even in colder months at my chalet. My knees don't trouble me as they used to, and I take two cans twice a year.

Back Pain details

Effective for pain relief

Most Useful Review

Worthy chondroprotector - recommended by my doctor. After taking these capsules during an arthrosis flare-up, my pain disappeared faster than usual. I've experienced more prolonged remissions since beginning this treatment. I even introduced my wife to it, and she found it effective too. I advise looking at the glucosamine and chondroitin dosage in other chondroprotectors, as this complex has an advantageous formula. I experienced no side effects and believe this product is suitable for ongoing use, especially for athletes and the elderly.

Cancer details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

MSM anal cancer treatment feasibility

Piloting of a Screen‑Triage‑Treat Surgical Approach Model for Management of Anal Cancer in Liberia.

Most Relevant Research

We explored the challenges faced by men who have sex with men (MSM) regarding anal cancer treatment in Liberia. With limited access to screening and care for anal cancers, we aimed to investigate whether a screen-triage-treat approach could effectively help identify and manage anal high-grade squamous intraepithelial lesions (aHSIL) within this vulnerable population.

In our study, we collaborated with local organizations to gather data from MSM and transgender individuals. Participants were recruited and engaged in self-swabbing to test for high-risk human papillomavirus (HPV), alongside HIV testing. Those who tested positive for aHSIL were offered further evaluation and treatment using high-resolution anoscopy and infrared coagulation.

Among 110 participants, a significant number turned out to be living with HIV, and nearly half tested positive for high-risk HPV. This indicates a notable health concern. While 68% of those who tested positive opted for further procedures, we found that this model effectively presented a potential solution for identifying anal cancer risks and can work in a low-resource environment.

Overall, our findings suggest that implementing a screen-triage-treat model shows promise for reducing anal cancer incidence among MSM in Liberia. This approach, previously successful in cervical cancer management, might become a crucial tool in cancer prevention strategies for similar low- and middle-income countries.

9.5

Reduces cancer risk

Most Useful Review

Glucosamine sulfate is a simple sugar that prevents glucose oxidation. The dosage is critical; for an 80 kg person, 2000 mg daily can lead to heart issues and reduced lifespan if taken young. However, studies reveal that for those over 50, glucosamine is linked to a 41% lower risk of mortality from respiratory infections and a significant reduction in lung and colorectal cancer risks. Though I don’t take it as I’m still young, it provides my grandmother with crucial relief for her knees and potentially extends her life.

Bruise details

Effective for injuries

Most Useful Review

Great product! It resolves all issues related to bones, joints, bruises, and fractures exceptionally well! I use it regularly since someone in the family always has a problem. It has never let me down!

Chronic Fatigue Syndrome details

This product is definitely effective. I’ve dealt with meniscus damage, iliotibial band syndrome, and other injuries over the years. It enabled me to run again when walking was difficult due to chondromalacia and tendonitis. I’m unsure of the contributions from MSM, glucosamine, or chondroitin, but my pain has completely vanished, and I've sustained it with MSM. After my positive experience, I bought more to share with family and highly recommend it for anyone with joint pain.

Migraine details

SCIENTIFIC SCORE

Likely Very Effective

Based on 2 Researches

MSM improves migraine management

Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study.

Most Relevant Research

We aimed to understand how adherence to migraine-specific medications (MSMs) influences migraine-related disability and patient satisfaction. Over three months, 337 participants used daily electronic diaries to track their migraine experiences, including the medications they took and their satisfaction with these treatments.

It was insightful to see that participants took their acute medications on a staggering 96.5% of the days they recorded migraines. Among the medications used, MSMs were the most common at 58%, followed by over-the-counter analgesics and opiates/barbiturates. We found that people tended to reach for medication when their pain was mild most often.

Our analysis showed that when individuals used MSMs during mild pain, they experienced the least daily disability and reported the highest satisfaction with their medications. This implies that using MSMs earlier, especially at the onset of milder symptoms, can significantly improve a patient's overall experience with migraines.

In conclusion, our study highlights the benefits of starting treatment with MSMs for better outcomes in managing migraine-related challenges and achieving greater satisfaction with acute medication usage.

9.5

Reduces migraine frequency

Most Useful Review

GREAT It normalises sleep with regular intake of 2 capsules. It improves my migraines significantly. When the special effects begin, I take my usual pills, add extra magnesium, and the migraine fades within a couple of hours, compared to the previous half-day disruption. The frequency has also decreased alongside medicinal support. Regular magnesium intake eases PMS and periods, so I remain calmer, and I can even go a day without painkillers. Chronic pain in my nasopharynx hardly worsens. I also take omega-3, serrapeptase, and resveratrol, but I believe magnesium plays a role. Taking magnesium, lecithin, and protein has shown a genuine effect with collagen. I was pleasantly surprised. No allergies, rashes, or digestive issues. Quality is excellent with natural ingredients.

Osteoporosis details

MSM enhances bone cell differentiation

Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells.

Most Relevant Research

We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.

Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.

Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.

9.5

Slows osteoporosis progression

Most Useful Review

Doctor's Best Glucosamine, Chondroitin, and MSM is a remarkable tool for aiding cartilage health. It slows bone resorption and enhances calcium retention, promoting bone tissue repair and inhibiting cartilage degeneration. Its topical application can slow osteoporosis progression and stimulate regeneration in connective tissues. I highly recommend it for managing joint pain and enhancing the normal physiological processes!

Psoriasis details

Psoriasis lesions vanished

Most Useful Review

I have been using it since April this year and am very pleased with the outcome, as my psoriasis lesions have disappeared and my mood has improved. The product's quality is excellent, containing great ingredients, and is gluten, soy, and milk-free, which suits my allergies. I really liked it.

Stroke details

I love this product. Having developed after a stroke, I experience crunchy joints and noticeable stiffness and pain without any treatment. This glucosamine helps significantly; I notice a reduction in stiffness within two or three days of starting it. While the cartilage hasn't reduced, it feels somewhat softer, and the pain is much less pronounced. There are positive changes, including to my collagen.

Toothache details

Прекрасно! Even the toothache is gone! I strongly recommend it!

Anxiety details

MSM reduces anxiety in pregnancy

Effectiveness of the mom supports mom peer support intervention in treating antenatal mental health difficulties in women.

Most Relevant Research

We tested a phone-based peer support program called Mom Supports Mom (MSM) to see how it affects anxiety in pregnant women at risk of mental health issues. A total of 167 women participated in the study and were split into two groups. One group received the MSM intervention, while the other group continued with standard care, which didn’t include psychological support.

After one month, we checked in again on the women’s mental health using various assessment tools. While we found that levels of anxiety significantly dropped in the women who engaged in the MSM program, their depressive symptoms remained unchanged. Specifically, the anxiety levels showed a notable reduction, which suggests that the MSM support could help alleviate some of the stress and anxiety faced during pregnancy.

Additionally, we observed an increase in prenatal attachment among the women who received the peer support. This suggests that while MSM helps reduce anxiety, it may not address depression directly. Overall, the findings show promise for using peer support to aid mental well-being during pregnancy, though depression remains a challenge that needs further attention.

9.5

Manages joint pain

Most Useful Review

These miraculous vitamins, I’m not hesitant to call them that! After about a week of taking them, my knee pain decreased significantly, and my anxiety vanished entirely! I also bought them for my parents, whose joint pain from COVID improved remarkably, along with their anxiety.

Brain Tumor details

Significant pain relief

Most Useful Review

For many years, I endured pain in my back, knees, shoulders, and neck due to posterior cerebral palsy. Various treatments, including Western medicine and acupuncture, had minimal effect and greatly impacted my quality of life. After discovering that glucosamine might enhance joint mobility and reduce pain, I decided to try a well-reviewed product. To my delight, I've experienced seven months of pain relief, with a 90% reduction in knee pain. My shoulder and neck discomfort, which previously affected my brain's nerve function, has also vanished. This affordable solution means I no longer need costly medical treatments, and I highly recommend it to others experiencing similar pain.

Bursitis details

This really helps with tendonitis and bursitis! As a bassist in my late 40s, I began facing tendon and joint issues in my elbows and forearms, worsened by exercise. Following the supplement’s dosage has remarkably reduced soreness and improved my flexibility. I plan to remain a loyal user of this product and have been impressed with all items from this company.

Cardiovascular Disease details

Comprehensive joint care

Most Useful Review

I highly recommend this three-in-one supplement for joint protection. It contains MSM to relieve swelling, chondroitin sulfate for repairing cartilage, and amino sugar to lubricate joints. Made from natural shellfish sources, it is also friendly to cardiovascular health. With 360 capsules in one bottle, it's very cost-effective. For comprehensive care, consider combining it with additional ingredients for enhanced protection.

Chest Pain details

Pain and inflammation reduction

Most Useful Review

I’ve bought this for my sister for 2.5 years. She takes it twice daily alongside vitamin C. After the first course, her knee pain and inflammation improved significantly within three months, enhancing her joint mobility. Following this regimen, there were no side effects, and overall health improved, including nail strength and skin appearance. I definitely recommend this effective product for joint issues.

Dizziness details

I have experienced improvements in my occupation pattern. The dizziness from anaemia has vanished, and my hands no longer ache when I wake up.

Hypothyroidism details

WORK 100%!!! At 50 and on hormone replacement therapy for hypothyroidism, I noticed significant pain in my legs by the end of the day. The pain felt like a tendon or nerve issue. Osteopathy was discovered through my analysis, revealing a middle stage of osteoporosis. After just one month of taking these supplements, I noticed a significant improvement. I recommend a three-month intake followed by a six-month break, especially for those with osteoporosis. I personally believe these dietary supplements work wonders for bone and joint issues!

Kidney Stones details

I purchased this for my partner’s persistent lower back pain, and within three days, he reported feeling better. I was hopeful for my own knee pain relief as well, and to my delight, he mentioned his knee also felt improved. Despite my aversion to medication, I've remained diligent in taking these daily, and I am pleased with the results.

Liver Disease details

This product effectively addresses various musculoskeletal pathologies and offers a good preventive effect. Chondroitin and glucosamine are well absorbed. Part of it is metabolised in the liver, but most reaches its intended site. MSM enhances cell membrane permeability, improving cellular nutrition and preventing catabolic reactions of muscle and bone tissue. The recommended daily doses for these substances vary. I initially bought this for prophylaxis but experienced an exacerbation of inflammation in my knee joint upon arrival. Relief came after three weeks of taking two capsules twice daily, allowing me to eventually reduce to one capsule twice daily. I have nearly forgotten about my knee pain and feel very satisfied.

Reflux details

So glad I found this brand. Excellent quality, very agreeable with my particular system and no acid reflux. Easy to ingest, and I am starting to feel better. Quality makes a difference; these are affordable. Also on auto-ship, which is really convenient, and I will continue with it.

Tinnitus details

This was effective for tinnitus. A physician informed me that chondroitin can help with tinnitus and hearing loss, prompting me to purchase it for a trial. I take 2 capsules in the morning and 2 in the evening. After 2 weeks, I hardly notice my tinnitus! It hasn't completely vanished, but it has lessened significantly, to the extent that I'm not consciously aware of it. I was initially doubtful, but I'm pleased I gave it a go!

Yeast Infection details

Significant improvement

Most Useful Review

My mother, aged 63, had long suffered from knee pain, making it difficult for her to climb stairs or even stand on a chair. After short walks, she experienced excruciating pain in her knee joints. Previous injections into the joint provided only temporary relief, and she was reluctant to repeat such procedures due to fears of infections. Despite using Terafleks and various ointments, she saw no benefit. However, after she began taking this supplement alongside collagen, Omega, and vitamin D3, she was overjoyed after two months, exclaiming, “I’ve forgotten about the ointment! I can walk and climb stairs again!" Initially sceptical, I decided to try it myself after seeing her results.

Joint pain alleviated

Most Useful Review

Eczema details

Skin condition improvement

Most Useful Review

MSM (methylsulfonylmethane) is an organic compound containing sulphur that is often used as a supplement to enhance health. Here are the primary benefits of MSM: 1. Pain and Inflammation Relief: MSM can aid in reducing inflammation and pain, particularly in individuals with arthritis or other inflammatory conditions. 2. Joint Health Support: Taking MSM can enhance joint and ligament health by fostering cartilage repair and alleviating symptoms of osteoarthritis. 3. Skin Health Support: MSM is sometimes employed to enhance skin conditions, including acne and eczema, owing to its anti-inflammatory properties.

Blood Clot details

Heart protection mentioned

Most Useful Review

Glucosamine and chondroitin are essential for cartilage health. Combined with MSM, they enhance joint cartilage repair and mobility, preventing further deterioration. Additionally, this supplement supports heart health by reducing the risk of coronary disease and the formation of blood clots, while also inhibiting atherosclerotic plaques. The capsules are large, white, nearly odourless, and last for a minimum course of treatment.

Gout details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

MSM shows promise for gout treatment

Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.

Most Relevant Research

This study aimed to explore how Modified Simiaowan (MSM), a traditional six-herb formula, can help treat gouty arthritis (GA). We examined its effects on macrophages in the lab, as well as in animal models with induced gout. Using various techniques, we analyzed the inflammation response and the underlying biological pathways affected by MSM.

Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.

Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.

9.5

Knee recovery noted

Most Useful Review

Good super useful food supplement. My father enjoyed it for many years and always uses this brand. His knee, which was damaged by a gout attack and left him unable to walk, fully recovered within a month and has continued to improve since. Now it remains in a normal state.

Allergies details

Relieves skin allergies

Most Useful Review

MSM effectively alleviates pain and is safe for various inflamed conditions, including allergies. Doctors recommend it as a vital nutrient for skin, hair, and nails, and it assists in softening scar tissue and relieving muscle spasms.

Heartburn details

Does not cause heartburn. I bought it for my mother who previously used Teraflex, which caused her heartburn. We switched to Arthra, but it's rather pricey. So, we decided to try this product. We started with a small trial jar (120 tablets) and so far, all is well; the heartburn is gone. I plan to place a second order, this time for a larger quantity. I also took some for myself (as a precaution; I'm 44) – MSM without chondroitin and glucosamine.

Diarrhea details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

MSM risk behaviors linked to diarrhea

Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals.

Most Relevant Research

We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.

In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.

Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.

We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.

9.5

Diarrhea resolved

Most Useful Review

My mother, who has diabetes, suffered from diarrhea and could barely move. After consulting her doctor about the ingredients, he deemed it beneficial. Thankfully, after taking it, her diarrhea resolved, and she returned to her normal self. It's important to check ingredient lists before ordering to avoid allergies and ensure health benefits.

Ear Infection details

I purchased this for my dog who had a joint injury. After consulting our vet, we tried this complex. Within two weeks, her limping significantly improved. There were no allergic reactions, and it worked wonders for her!

Constipation details

The quality of this product is excellent, with great ingredients and an amazing taste. Everything about it is suitable, and I have yet to experience constipation – the intestinal lubrication is superb.

Diabetes details

The effect is noticeable! I ordered it for my mother, and her hip and knee joints began to trouble her much less when used with bosvelia and collagen. However, doctors warn against glucosamine for those with diabetes. Patients with cardiovascular issues, hypertension, or obesity should monitor cholesterol levels regularly while using this treatment.

Acne details

This supplement works wonders! I’ve noticed new hair growth, my skin has thickened, and the acne on my face has completely disappeared; my skin now glows. The visible results started appearing after two weeks, and to maintain these benefits, it’s essential to take it consistently for three months.

Headache details

SCIENTIFIC SCORE

Likely Very Effective

Erenumab reduces migraine medication use

Reduction in acute migraine-specific and non-specific medication use in patients treated with erenumab: post-hoc analyses of episodic and chronic migraine clinical trials.

Most Relevant Research

We explored how erenumab impacts the use of acute headache medication, especially migraine-specific medications (MSM). The study analyzed data from two major clinical trials involving patients with episodic migraine (EM) and chronic migraine (CM). Participants received either erenumab or placebo over a set period, allowing us to compare medication usage accurately.

Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.

Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.

Headaches stopped

Most Useful Review

After a month of taking this product, I found that my headaches stopped completely. I am uncertain whether this is directly linked to MSN, but it was a very pleasant bonus.