Last update
5/24/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 70 Reviews
7.8
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Chloride (from glucosamine hydrochloride potassium sulfate)
170 mg
7%
Sodium (from chondroitin sulfate sodium)
120 mg
5%
Potassium (from glucosamine hydrochloride potassium sulfate)
190 mg
4%
GlucosamineHydrochloride Potassium Sulfate
1500 mg
†
Chondroitin sulfate Sodium
1200 mg
†
MSM (Methylsulfonylmethane)(OptiMSM®)
1000 mg
†
Top Medical Research Studies
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
Most Useful Reviews
9
Enhanced flexibility observed
1 people found this helpful
I bought it for my elder who has osteoporosis and struggles to get up from sitting. After three months of use, he now can easily catch up with his children and move around with greater flexibility.
Read More
7.5
Tangible results noted
1 people found this helpful
I give it to my 70-year-old mother, diagnosed with osteoporosis. After three weeks, she noticed tangible results! She drinks it for two months with a 1-2 month break.
Read More
7.5
Pain relief experienced
1 people found this helpful
A good drug for osteoporosis that helps with knee and joint pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 70 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced flexibility observed
1 people found this helpful
I bought it for my elder who has osteoporosis and struggles to get up from sitting. After three months of use, he now can easily catch up with his children and move around with greater flexibility.
Read More
7.5
Tangible results noted
1 people found this helpful
I give it to my 70-year-old mother, diagnosed with osteoporosis. After three weeks, she noticed tangible results! She drinks it for two months with a 1-2 month break.
Read More
7.5
Pain relief experienced
1 people found this helpful
A good drug for osteoporosis that helps with knee and joint pain.
Read More
10
Pain gone
This is a truly effective drug. The pain from osteoporosis has disappeared.
Read More
9
Reduced joint pain
I’m 53 and have had Osteoporosis since I was 20, causing me to experience joint pain that made sleep and daily activities difficult. Following my doctor’s advice, I’ve been taking glucosamine for 3-6 months. After starting it, I noticed a significant reduction in joint pain, reduced swelling, and improved sleep quality.
Read More
Frequently Asked Questions
7.5
Tangible results noted
1 people found this helpful
I give it to my 70-year-old mother, diagnosed with osteoporosis. After three weeks, she noticed tangible results! She drinks it for two months with a 1-2 month break.
4
No noticeable improvement
I ordered this product for my mother, who has osteoporosis. Unfortunately, due to the seriousness of her condition, there hasn't been any noticeable improvement.
9
Enhanced flexibility observed
1 people found this helpful
I bought it for my elder who has osteoporosis and struggles to get up from sitting. After three months of use, he now can easily catch up with his children and move around with greater flexibility.
9
Improved health noted
Irreplaceable for osteoporosis + D3 helped my mother greatly. Instead of pharmaceutical drugs with side effects, we opted for this combined with vitamin D3 and K2. She feels much better now!
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
References
- Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. 10.3892/mmr.2016.5274
