Doctor&#039;s Best Hyaluronic Acid with Chondroitin Sulfate

Effective, safe pelvic pain treatment

Based on 16 Researches

Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. doi:10.5152/tud.2018.63600

We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.

Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.

Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.

Joint pain relief

Most Useful Review

Excellent! Effective even in advanced cases. I took it to my parents and grandmother, who have suffered from knee joint issues for many years. It's been a month since they forgot about all the ointments and creams. After physical exertion or an active day, there are no problems with their legs. This is very encouraging!

Arthritis details

Hyaluronic acid eases shoulder arthritis

Possibly Effective

Based on 24 Researches

Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. doi:10.4081/reumatismo.2024.1699

We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.

Eliminates arthritis pain

Most Useful Review

Unbelievable! After using this for 30 days, the pain in my hands from arthritis vanished, and I regained 100% use of them. Great stuff!

Flu details

Hirobe S, Azukizawa H, Hanafusa T, Matsuo K, Quan YS, et al. Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. Biomaterials. 2015;57:50. doi:10.1016/j.biomaterials.2015.04.007

Based on 2 Researches

Novel painless flu vaccine method

We investigated a new influenza vaccination method using a dissolving microneedle patch made from hyaluronic acid. This painless transcutaneous immunization (TCI) was tested against traditional subcutaneous injections.

In our study, we compared the immune responses between two groups: one receiving the microneedle patch, and another getting standard injections. Both methods showed similarly strong immune responses against the A/H1N1 and A/H3N2 strains.

Notably, the TCI group exhibited a stronger immune response to the B strain. These findings suggest that this new vaccination approach could be an effective and user-friendly alternative to traditional methods.

9.5

Joint symptoms improved

Most Useful Review

One of the best complexes for joints! It truly enhances joint condition, increases synovial fluid, and provides much more comfort.

Knee Pain details

Hyaluronic acid effectiveness evaluated

Possibly Effective

Based on 15 Researches

Safali S, Ertaş ES, Özdemir A, Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:164. doi:10.1186/s12891-024-07200-y

We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.

Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.

So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.

9.5

Knee pain relief

Most Useful Review

I used to take Doctor's Best, Glucosamine Chondroitin MSM, and I no longer experience knee pain. I bought this product for its hyaluronic acid content, hoping to rejuvenate my skin as well. It's crucial to drink plenty of water while taking hyaluronic acid to ensure effectiveness.

Rheumatoid Arthritis details

Liu L, Ma X, Jia X, Hui JH, Hui M. Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. Clin Case Rep. 2025;13:e70361. doi:10.1002/ccr3.70361

Based on 14 Researches

Hyaluronic acid's role in RA pain

We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.

9.5

Joint pain relief

Most Useful Review

I purchased this supplement as I suffer from rheumatoid arthritis. Initially, I was sceptical about its ability to relieve joint pain, but I was pleasantly surprised by the improvement I experienced in just two months. I hardly recall having any joint pain now and have already ordered more to ensure I don't run out!

Athlete’s Foot details

Very good! After taking Doctor's Best Collagen for five months, my foot joints feel much more relaxed. I will be 67 years old in 2022. After years of working in a container terminal, my foot joints would make a "clucking" sound when cycling there. Standing for prolonged periods would cause discomfort. Since I retired and began using Doctor's Best collagen, my feet feel significantly lighter.

Autoimmune Disorder details

Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073

Based on 16 Researches

Hyaluronic acid shows promise

We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.

9.5

Elastic skin boost

Most Useful Review

Following my beautician's advice, I began a regimen of collagen and hyaluronic acid. My skin was extremely dry from hard water, but now it feels smooth and elastic. After initially taking a break, I resumed with great results - my skin has improved significantly.

Bone Pain details

Polynucleotide sodium reduces knee pain

Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. doi:10.3390/jcm10051138

We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

9.5

Skin improvement

Most Useful Review

I bought this based on feedback and have no regrets. After a few days, I noticed an improvement in my skin and mobility. My legs no longer hurt as they used to; it’s remarkable!

We explored the safety and effectiveness of a unique seawater solution enhanced with hyaluronic acid, eucalyptus, and copper for treating common cold symptoms, especially nasal congestion. Using an advanced 3D nasal tissue model, the solution showed no negative effects on nasal cell health and improved mucociliary clearance.

Those treated with this solution had better nasal drainage and overall relief from congestion. Though the study was conducted in vitro, these promising results suggest that this seawater solution could be a helpful option for alleviating cold symptoms.

8.8

Improved skin hydration

Most Useful Review

My skin noticeably improved, feeling significantly more hydrated and smoother. Fine wrinkles are less visible, and the dryness and flakiness, which used to be common, have decreased. Additionally, I noticed a positive effect on my joints; after starting hyaluronic acid, my knee discomfort diminished, enhancing my mobility. Overall, I feel better and plan to continue taking the tablets to maintain these results.

Food Poisoning details

At 40, I initially purchased this product but wasn’t consistent until recently. Taking it on an empty stomach before meals has made a remarkable difference! After a few months, the problematic joints that had pained me throughout my life stopped hurting entirely. I'm now more active and engaged in sports, thanks to this product.

Osteoporosis details

BEST supplement for joint pain! I suffer daily with pain from osteoporosis, and this supplement provided relief unlike anything else I’ve tried. Taken in the morning with water on an empty stomach, it's incredibly effective. I even stopped taking it for two days, and the pain returned immediately. I wholeheartedly recommend you try it.

Psoriasis details

I bought this for my skin and joints. While I can't comment on the joints, my skin has significantly improved. Two psoriasis spots I had over the past year have practically "gone", and I haven't applied any special ointments, so I believe their disappearance is due to the hyaluronic acid.

Adenoiditis details

Effective hydration noted

Hyaluronic acid with chondroitin sulfate has been a tremendous help! I noticed that my dry throat issue has gone, and my heels and elbows have become smooth. The crunching in my knees has stopped, and they no longer hurt. I should have taken it for three months as recommended, but I only took it for one. Since the results have been promising, I will continue and order more. I highly recommend it for anyone with similar issues! I give it five stars.

Anxiety details

Improved mood experienced

The supplement has positively influenced my mood, helping to relieve symptoms of anxiety and depression. I now enjoy a general sense of wellbeing that enhances my daily interactions and personal productivity.

Blurred Vision details

Vision improvement experienced

It works! After taking this product for three months, I was amazed that my vision improved. I initially started this supplement for my skin and I am delighted with the results.

Bursitis details

Improved shoulder usability

Retired Doctors cleared up my left shoulder joint to the point that it is now 90% usable. I believe it was very good for bursitis. For arthritis in my lower back, I had to take Flex Comfort from Bio-Tech Laboratories.

Chest Pain details

I’ve been taking this for some time and it greatly alleviates my spinal pain associated with hernia. It has proven effective within three days of starting a course and I usually take it one to two times a year for three months. It requires plenty of water to prevent dehydration, but I haven’t seen any improvements on my skin or nails.

Fibromyalgia details

Dual benefits observed

Incredible! As I approach 30, my skin has struggled, especially after years of smoking. After just a week of this supplement and "schizandra", I can see a noticeable difference. It seems to plump my face perfectly. Even my husband, who rarely notices, has commented. Furthermore, my fibromyalgia has improved; my knee and shoulder pain has lessened significantly when navigating stairs. I wholeheartedly give the Hyaluronic Acid five stars. My mother-in-law takes it now for her thumb issues, which no longer hurt, making me the favourite daughter-in-law!

Gout details

Li L, Wang D, Wang X, Bai R, Wang C, et al. -Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models. Pharm Biol. 2019;57:717. doi:10.1080/13880209.2019.1672755

Based on 5 Researches

BHA shows promise for gout relief

We explored the benefits of butyrylated hyaluronic acid (BHA) in treating gout by examining its effects in specific animal models. Using Wistar rats, we evaluated how BHA can influence inflammation linked with gouty arthritis, specifically by measuring joint swelling and inflammatory markers after injecting monosodium urate crystals.

Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.

This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.

Gout attack prevention

Most Useful Review

After suffering from gout for many years and being unable to walk for six weeks at a time, I found prescribed medication ineffective. However, having taken these tablets for 18 months now, I've not had a single gout attack. I recommend these to many others experiencing similar issues. They're excellent!

Hair Loss details

Sun X, Ma Y, Gao Y, Li J, Li Y, et al. Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway. Front Vet Sci. 2025;12:1486201. doi:10.3389/fvets.2025.1486201

Likely Very Effective

Based on 3 Researches

Collagen promotes pet hair health

We explored the effects of specific nutrients on hair loss in pets, particularly focusing on canines and cats. Our research highlighted the Wnt/β-catenin signaling pathway, which is crucial for hair regeneration. We found that collagen, particularly in the form of fish collagen peptides, plays an important role in promoting hair health.

In our study, we noted that keratin hydrolyzed and egg yolk lecithin, along with fish collagen peptides, can significantly boost the movement of β-catenin into the nucleus of skin cells. This process is essential for activating genes that are vital for hair regeneration.

Considering the impact of nutritional balance on pet health, our findings suggest that incorporating these nutrients into a pet's diet could provide an effective strategy for addressing hair loss. By enhancing the expression of target genes linked to hair regeneration, we observed that collagen and other related nutrients may offer a promising avenue for maintaining healthy fur in our furry friends.

9.5

Stops hair loss

Most Useful Review

Good quality product. I took this hyaluronic acid for my father, who has problems with his joints. He is very pleased, especially since his hair loss has stopped.

High Cholesterol details

Amazing skin improvement

I started using this to complement my collagen protocol and have noticed remarkable changes in my skin quality within just weeks. By eight weeks, my knees felt more resilient, and my hair has grown significantly longer. This is an exceptional formulation, and I truly recommend it!

Multiple Sclerosis details

Improved joint function

It assists with my lower back and joint issues. My chiropractor suggested taking Hyaluronic acid and Chondroitin for my lower back. I've been using this product for about three weeks alongside other supplements (vitamin C, MSM, magnesium, D3+K2, multivitamins, and Collagen I&II) and I can feel the difference. Additionally, my skin appears different, and my facial wrinkles have been diminishing.

Cardiovascular Disease details

Knee pain improvement

Chondroitin aids in restoring cartilage and is recommended for joint and spine issues. I purchased it for my friend who has experienced less discomfort in her knees since starting this supplement.

Ear Infection details

Excellent! I felt the positive effects early on, with my knees free of pain. I definitely recommend this product.

Eczema details

Significant skin benefits

This is one of the best products I have bought here; it significantly aids my overall skin health. Alongside cod liver oil, this product has notably helped with my eczema. I will buy it again.

Menopause details

Improved menopause health

Doctor’s Best has consistently delivered top-notch quality, with ingredients that have passed extensive testing. This supplement is an excellent aid for women during menopause, and I've been satisfied with its effectiveness over the years. The packaging lasts a long time, and I plan to continue ordering this product as I've seen improvements in health and wellbeing at any age.

Chronic Cough details

This is remarkable! It’s the first product that has genuinely helped alleviate my chronic neck pain. I have tried numerous alternatives, but this truly delivers results!

Reflux details

Eased reflux symptoms

I regularly consume this product, and although I was diagnosed with reflux esophagitis, I feel my condition has improved. It seems to positively affect the mucous membranes, too. Additionally, I had hip joint pain that caused a limp, but I am now walking comfortably. I've been using it consistently for about a year and can see its effects, despite the cost. I highly recommend it.

Sleep Apnea details

Stable sleep patterns

After taking this, my fine wrinkles became significantly less noticeable, something I couldn't achieve with any cream. My skin is more hydrated, provided I drink enough water to avoid the drying effect of hyaluronic acid. Fine wrinkles have disappeared, fatigue has lessened, and my joints feel more comfortable. Overall, my nervous system is more stable, and my sleep has improved tremendously without any allergic reactions. The quality of this product is excellent and its packaging is convenient. The benefits for my skin and joints are remarkable.

Urinary Tract Infection details

Effective joint support

Excellent quality and benefits; I have been taking Dr Best's product for the last two years. It aids my fight against osteoarthritis and allergies affecting the mucous membranes. The hyaluronic acid, collagen, and other ingredients hydrate and relieve dryness. My skin has also improved, looking hydrated with visibly softened wrinkles. This top product has an excellent balance of ingredients and is essential for my daily routine, providing protection and reducing signs of aging.

Irritable Bowel Syndrome details

Skin and joint improvement

I experienced a remarkable improvement in my skin with hyaluronic acid—it's now hydrated, smooth, and fine wrinkles have diminished. The dryness and flaking have also decreased markedly. Additionally, my knee discomfort has lessened, particularly after physical activity, which has improved my mobility. Overall, my well-being has enhanced, and I feel my skin is more elastic and less irritable. I'm very satisfied with the results and plan to continue with this supplement.

Cancer details

So far, I’ve had a positive experience with this product, recommended to us by a cancer patient. I had been looking for something to alleviate the discomfort in my right knee that has bothered me intermittently. I’m nearing the end of my first bottle and plan to order another, as I believe it’s making a difference.

Headache details

A very good complex for supporting connective tissue. I specifically chose this due to a severe headache with another product from the same manufacturer. Thankfully, this one did not cause any symptoms. Hyaluronic acid is essential for joint health, and I use it in courses several times a year. When taking hyaluronic acid, staying hydrated is crucial to avoid adhesions in the internal organs. I hope my review helps you. Wishing health to you and your loved ones!

Blood Clot details

Good results! This product has effectively alleviated my joint discomfort and noticeably improved the appearance of my skin. However, caution is warranted for those susceptible to blood clots and vein problems.

Cold Sores details

Great. I am entirely against all types of beauty injections and plastic surgery, except when aimed at eliminating cosmetic defects that diminish quality of life. I purchased this remedy for my mother’s sore joints. At 74, she began to look noticeably better, so I tried it myself. I can confirm this product works remarkably well for skin, hair, joints, and much more.

Nausea details

No nausea experienced

The capsules are easy to swallow, and I experienced no side effects, including nausea.

Allergies details

No allergies reported

After completing the course, the discomfort in my knee disappeared. The product suited me well and did not cause allergies.

Bloating details

Great product! I love it, and my family loves it too. I never thought I would find a shop with all my needs available. iHerb is superb! Fastest shipment ever. My digestion was excellent – no bloating or constipation since I began drinking this. The packaging is excellent, and the product quality is superb. The taste is great as well.

Frozen Shoulder details

No additional benefits from HA injections

Questionable

Based on 16 Researches

Hsieh LF, Hsu WC, Lin YJ, Chang HL, Chen CC, et al. Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:957. doi:10.1016/j.apmr.2012.01.021

We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.

After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.

9.5

Shoulder pain gone

Most Useful Review

Hyaluronic acid earns a 5+ on the Timur scale from me. After a month of use, my shoulder joint stopped hurting. I'm now able to train 100%. I highly recommend it.

Leg Cramps details

After recovering from a mild form of coronavirus, I developed severe hip pain that hindered my movement. Thankfully, I had dietary supplements like hyaluronic acid and other essentials, which I started taking. By the fourth day, I experienced significant relief, and nearly all of my discomfort vanished. These should be staples in one's first-aid kit!

Rash details

Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, et al. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung. 2006;56:230.

Based on 5 Researches

Hyaluronic acid gel shows promise

We examined the effects of a gel containing hyaluronic acid on women experiencing vaginal atrophy symptoms after menopause. The pilot and multicenter studies involved 110 postmenopausal participants using the gel both externally and vaginally. Results showed significant improvements in vaginal dryness, burning, itching, and rash from the first week of treatment, without any reported adverse effects. Overall, the gel was well-accepted and demonstrated promise as a safe alternative to traditional hormone replacement therapies.

9.5

Rash eventually cleared

Most Useful Review

Initially, rashes appeared on my skin when I started taking it, but I continued nonetheless. After a month, the skin changed and the rash disappeared. My complexion now looks healthy and even. I'm pleased with the result and have ordered more.

Acne details