We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
8
Melatonin's optimized dosage improves sleep
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
We explored the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD). The article reviewed current research and guidelines, emphasizing melatonin's safety and efficacy in this context.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
Read More
Most Useful Reviews
7.5
Helps with insomnia
4 people found this helpful
It suited me perfectly; it helps to cope with insomnia.
Read More
9
Aids post-COVID sleep
3 people found this helpful
These chewable melatonin tablets taste great and work effectively. They have significantly helped me sleep better after experiencing long-term insomnia following my COVID infection.
Read More
9
Improves sleep quality
2 people found this helpful
Excellent! It helps to improve sleep and relieve insomnia, especially for those who dislike pills or capsules.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
9
Melatonin's Potential in Insomnia Treatment
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Read More
9
Melatonin enhances sleep and heart health
Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.
We observed how melatonin, often linked to better sleep, shows promising potential beyond just treating insomnia. Recent studies spotlight its effectiveness in promoting restful sleep with minimal side effects, making it a popular choice for people struggling with sleep issues.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
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9
Ramelteon as insomnia treatment
Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report.
We explored how the melatonin receptor agonist ramelteon could help a high school student struggling with delayed sleep-wake phase disorder (DSWPD) coupled with depression. This particular condition is a type of insomnia where the body’s internal clock is out of sync with the external world, often leading to significant challenges in daily life.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
Read More
9
Melatonin shows promise for insomnia
Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial.
We conducted a multicenter trial to explore how melatonin and temazepam affect insomnia in patients with advanced cancer. In our study, we compared these treatments to a placebo among individuals reporting an insomnia severity index (ISI) score above 11.
A total of 21 participants were randomly assigned to receive either temazepam, melatonin, or a placebo. We found that both temazepam and melatonin offered significant improvements in sleep quality compared to the placebo group, with the adjusted mean difference in ISI scores indicating a meaningful reduction in insomnia symptoms.
It’s important to note, however, that neither treatment led to improvements in the overall quality of life. Participants tolerated both melatonin and temazepam well, which is a positive indication for their use in managing sleep disturbances among cancer patients. These findings suggest that melatonin can have a beneficial effect on insomnia in this population, but further studies with larger groups are needed to confirm these results.
It suited me perfectly; it helps to cope with insomnia.
Read More
9
Aids post-COVID sleep
3 people found this helpful
These chewable melatonin tablets taste great and work effectively. They have significantly helped me sleep better after experiencing long-term insomnia following my COVID infection.
Read More
9
Improves sleep quality
2 people found this helpful
Excellent! It helps to improve sleep and relieve insomnia, especially for those who dislike pills or capsules.
Read More
10
Tremendous effect
1 people found this helpful
AMAZING PRODUCT!!! 5mg of Melatonin with a delightful mint flavour helps me fall asleep quickly. Despite struggling with insomnia due to COVID-19 symptoms, one tablet worked remarkably well. I highly recommend it.
Read More
7.5
Effective for insomnia
1 people found this helpful
Recommended by my psychologist for severe insomnia alongside 10mg slow release tablets, this product helps me fall back asleep despite occasionally causing gastric reflux, which I remedy with honey or milk. It's a great alternative since valerian doesn't work for many with severe sleep issues.
Insomnia is a common sleep disorder characterized by the inability to fall asleep, stay asleep, or wake up too early and not be able to go back to sleep. Individuals experiencing insomnia may find that it affects their daytime functioning, leading to issues such as fatigue, mood disturbances, and difficulty concentrating. Insomnia can be classified into two main types: acute insomnia, which lasts for a short period often triggered by stress or life changes, and chronic insomnia, which occurs at least three times a week for three months or longer, and may require more in-depth evaluation and treatment.
Numerous factors can contribute to insomnia, including stress, anxiety, poor sleep habits, medical conditions, and the use of certain medications. Treatment for insomnia typically involves a combination of lifestyle changes, cognitive behavioral therapy for insomnia (CBT-I), and sometimes medication. Establishing a consistent sleep routine, creating a comfortable sleep environment, and practicing relaxation techniques can help improve sleep quality. If insomnia persists, it is advisable to consult a healthcare professional for proper diagnosis and customized treatment options.
Melatonin is a hormone naturally produced by the pineal gland in the brain, primarily responsible for regulating sleep-wake cycles. It is often referred to as the "sleep hormone" because its levels typically rise in the evening, signaling to your body that it’s time to prepare for sleep. Conversely, melatonin levels tend to drop in the morning, helping to wake you up and feel alert. Factors such as light exposure, age, and lifestyle can affect melatonin production, which is why many people turn to melatonin supplements as a natural remedy for insomnia and sleep disorders.
Melatonin supplements can be particularly useful for those who have disrupted sleep patterns, such as shift workers or travelers experiencing jet lag. Available in various forms, including tablets and gummies, melatonin is widely regarded as a safe option for short-term use. However, it's essential to consult with a healthcare professional before starting any supplement, especially if you're pregnant, nursing, or taking other medications. While melatonin can be effective in promoting sleep, its efficacy can vary between individuals, and establishing good sleep hygiene practices, like maintaining a consistent sleep schedule and creating a comfortable sleep environment, can also significantly contribute to better sleep quality.
Melatonin is a hormone that helps regulate sleep-wake cycles, and many studies suggest it can be an effective aid for those struggling with insomnia. Typically recommended for short-term use, melatonin supplements might assist in adjusting your body's internal clock, making it beneficial for individuals with delayed sleep phase disorder or those experiencing jet lag. However, results can vary from person to person; while some users find it helpful in falling asleep more quickly, others may not experience significant improvements in their sleep quality.
It's important to note that while melatonin can be useful, it’s not a one-size-fits-all solution. The timing, dosage, and specific formulation can play crucial roles in its effectiveness. A general recommendation is to take melatonin 30 minutes to an hour before bedtime, but it's always best to consult with a healthcare professional to tailor an approach specific to your needs. Furthermore, establishing good sleep hygiene practices—like maintaining a consistent sleep schedule and creating a comfortable sleep environment—can complement the use of melatonin and lead to better sleep outcomes.
Based on user reviews, the time it typically takes to see results from melatonin supplements for insomnia can vary. For many users, effects are often reported to be noticeable almost immediately or after the first few doses. One reviewer mentioned that their husband's sleep significantly improved following the first dose Read Review. Others have described falling asleep quicker on the first night or finding it easier to fall asleep with continued use Read Review.
However, some users did note that it may take a few days to experience the full benefits, with one review suggesting that waiting a day or two can reveal a cumulative effect, meaning the body may adapt over time Read Review. For those struggling with more severe insomnia, a reviewer pointed out that effects might be delayed, highlighting the importance of dosage and individual response Read Review. Overall, while many users see improvements quickly, patience and persistence may be key for others.
Scientific research largely supports the use of melatonin as a viable supplement for treating insomnia. A systematic review of 62 studies indicated that prolonged-release melatonin, in particular, demonstrated significant potential for enhancing sleep quality, especially in older populations and those with mood and neurodevelopmental disorders [19]. Furthermore, various studies have shown that melatonin can effectively reduce the time it takes to fall asleep and increase overall sleep duration, thereby serving as a beneficial sleep aid for individuals struggling with insomnia [16]. Notably, melatonin’s mild side effects make it a generally safe option for many users [14].
In addition to its sleep-promoting properties, melatonin was also found to improve sleep parameters in specific populations, including cancer patients and individuals with conditions such as autism spectrum disorder. For instance, melatonin improved sleep quality in children with autism when behavioral therapies proved insufficient [17]. While it shows promise, researchers caution that more large-scale studies are necessary to solidify its effectiveness across diverse demographics [6]. Overall, melatonin may be a valuable tool in managing insomnia, particularly for those who require a natural alternative to traditional sleep aids.
Based on user reviews, many individuals have reported significant improvements in their insomnia symptoms after using melatonin supplements. Users frequently note that they fall asleep more quickly and experience better sleep quality overall. For example, one reviewer highlighted that using melatonin helped them cope with insomnia effectively and mentioned that their sleep has improved greatly after struggling with it for years Read Review. Others have echoed similar sentiments, stating that on their first night of use, they found it easier to fall asleep Read Review or noticed an enhancement in their sleep after just one dose Read Review.
While individual results can vary, a consistent theme in the reviews is the effectiveness of melatonin in aiding sleep without causing the usual morning grogginess associated with sleep aids. Some users even described their experience as "life-changing," particularly those overcoming insomnia exacerbated by stress or other health issues Read Review. A reviewer noted that after persisting through initial challenges with the product, they eventually found relief from insomnia and were able to sleep well again Read Review. Overall, the combination of effective sleep support and the pleasant mint flavor has made melatonin a popular choice among those seeking relief from insomnia.
Users have reported varying experiences when combining melatonin with other supplements for managing insomnia. One reviewer mentioned using melatonin alongside 10mg slow-release tablets for severe insomnia, indicating that this combination helped them fall back asleep despite some side effects, such as gastric reflux, which they managed with honey or milk Read Review. This suggests that individualized approaches, alongside professional recommendations, may enhance the supplement's effectiveness for specific cases of insomnia.
Additionally, while some users focused solely on melatonin for insomnia relief and shared their success stories Read Review, others expressed the importance of careful dosage management to avoid adverse reactions, such as drowsiness or ineffective sleep cycles Read Review. Overall, user reviews imply that while melatonin can be powerful on its own, pairing it with other remedies or implementing dosage adjustments might yield better results, particularly for those with severe sleep challenges.
Research indicates that an optimal melatonin dose for treating insomnia lies between 2 mg and 4 mg. In particular, one study found that a higher dose of 4 mg taken around three hours before bedtime can improve sleep outcomes, helping to reduce the time needed to fall asleep while extending total sleep duration [16]. Additionally, prolonged-release dosages of 2 mg have shown effectiveness in alleviating insomnia symptoms [7].
However, dosing may need to be tailored to individual needs, as responses to melatonin can vary widely. For certain groups, especially children or older adults, the starting dose can be lower, around 0.2 mg to 1 mg, taken 30 to 60 minutes before bedtime, while monitoring effects [21]. It's essential to approach melatonin use with careful consideration and perhaps consult with a healthcare professional to determine the best course of action based on personal health circumstances.
7.5
Immediate improvement
I ordered it for my husband, who has suffered from insomnia for a long time. The effect is noticeable after the first dose; his sleep has significantly improved.
9
Faster sleep onset
I have suffered from insomnia for a long time. After taking this melatonin, I fell asleep much quicker on the first night, and it does not cause drowsiness.
7.5
Cumulative effect
It genuinely helps me to fall asleep. If it doesn't work immediately, waiting a day or two reveals a cumulative effect. I dissolve the pill if I think I may have trouble sleeping; this way, my body adapts and forgets the insomnia.
6
Delayed effects
I take it about an hour before bed, and it often works, but in cases of severe insomnia, its effect can be delayed.
9
Improved sleep
This melatonin has been a great help! Insomnia bothered me for many years; now I fall asleep better, and my sleep quality has significantly improved.
10
Tremendous effect
1 people found this helpful
AMAZING PRODUCT!!! 5mg of Melatonin with a delightful mint flavour helps me fall asleep quickly. Despite struggling with insomnia due to COVID-19 symptoms, one tablet worked remarkably well. I highly recommend it.
7.5
Initial issues
At first, this melatonin caused me insomnia instead of sleep, but I persisted and after around 30 days, I'm now sleeping well.
7.5
Effective for insomnia
1 people found this helpful
Recommended by my psychologist for severe insomnia alongside 10mg slow release tablets, this product helps me fall back asleep despite occasionally causing gastric reflux, which I remedy with honey or milk. It's a great alternative since valerian doesn't work for many with severe sleep issues.
7.5
Effective for insomnia
Excellent! Great for insomnia, but you need to be cautious with the dosages.
8
Prolonged-release melatonin improves insomnia
The use of prolonged-release melatonin in circadian medicine: a systematic review.
We examined 62 studies on prolonged-release melatonin (PRM) and its potential to improve sleep quality, especially in those aged over 55 or experiencing mood and neurodevelopmental disorders.
Results showed notable benefits for primary insomnia, enhancing overall sleep quality. While PRM is promising for various sleep-related issues, additional research is needed for some conditions.
Importantly, PRM is deemed safe with no observed dependence, which positions it as an effective option in managing sleep disorders.
8
Melatonin's optimized dosage improves sleep
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
We analyzed data from 51 randomized controlled trials to explore the effectiveness of over-the-counter products, including melatonin, in treating insomnia. Our findings show that while many participants experienced positive effects on their sleep, the overall results remain inconclusive. Melatonin and valerian were among the most studied and seemed promising. However, future research should include a broader range of real-life products and diverse populations to provide clearer clinical guidance. Overall, the mild and temporary side effects reported were not serious, indicating these products might be safe for many users.
8
Melatonin improves sleep in ASD
Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment.
We explored the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD). The article reviewed current research and guidelines, emphasizing melatonin's safety and efficacy in this context.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
7
Melatonin shows moderate insomnia benefits
Nutritional Supplements for Healthy Aging: A Critical Analysis Review.
We explored the effectiveness of melatonin as a treatment for insomnia, finding that the available evidence supports its use to some degree. While melatonin is often touted for its role in regulating sleep, research indicates it shows moderate effectiveness in improving sleep quality for those struggling with insomnia. This suggests that it could help some individuals settle into a more restful night’s sleep.
Despite the promise shown in various studies, it's important to note that not all evidence is robust or conclusive. Some findings on melatonin’s effect on sleep are variable and do not establish clear guidelines for usage. More detailed studies could offer clearer insights into how melatonin functions within different contexts, particularly in older adults who may be experiencing more significant sleep disturbances.
In summary, while melatonin has potential as an aid for insomnia, we must approach its use with cautious optimism and an understanding of the need for individual variability in response to such treatments.
8
Melatonin's potential in insomnia treatment
Effects of Approved Pharmacological Interventions for Insomnia on Mood Disorders: A Systematic Review.
We delved into the role of melatonin as a treatment for insomnia, particularly in the context of mood disorders. Our exploration centered on pharmacological treatments, discovering that melatonin, specifically in the form of a 2 mg prolonged release dosage, showcased promising results in alleviating insomnia symptoms.
Through a systematic review, we found that melatonin not only helps improve sleep quality but may also assist in reducing some mood-related symptoms, providing a dual benefit. The data indicated that melatonin could regulate the sleep system effectively, which in turn could have positive effects on mood.
Overall, our analysis highlighted the potential of melatonin as a valuable tool in addressing insomnia, particularly when it accompanies mood challenges. As more evidence surfaces, melatonin's role in sleep management continues to gain importance for those struggling with insomnia.
8
Low-dose melatonin for insomnia
European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.
We examined how to effectively manage sleep onset insomnia in typically developing children. The expert panel recommended starting with practical sleep hygiene and behavioral interventions.
When these first steps don’t yield results, low-dose melatonin can be a helpful addition for children over 2 years old, taken 30-60 minutes before bedtime.
Importantly, pediatricians should monitor its use to ensure safety and evaluate its effectiveness. Overall, low-dose melatonin offers a viable option for children struggling with insomnia after standard methods have failed.
References
Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. doi:10.1016/j.ijbiomac.2025.140500
Quera-Salva MA, Hartley S, Uscamaita K. Circadian rhythm disorders in the blind. Handb Clin Neurol. 2025;206:113. doi:10.1016/B978-0-323-90918-1.00007-1
Li Z, Shu Y, Liu Q, Liu D, Xie S, et al. Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia. Neurosci Lett. 2025;848:138091. doi:10.1016/j.neulet.2024.138091
Said A, Shah D, Shah P, Singh B, Anamika F, et al. Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System. Cardiol Rev. 2024. doi:10.1097/CRD.0000000000000822
Kaufman MW, DeParis S, Oppezzo M, Mah C, Roche M, et al. Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Am J Lifestyle Med. 2024. doi:10.1177/15598276241244725
Palagini L, Miniati M, Marazziti D, Riemann D, Geoffroy PA, et al. Effects of Approved Pharmacological Interventions for Insomnia on Mood Disorders: A Systematic Review. Clin Neuropsychiatry. 2024;21:385. doi:10.36131/cnfioritieditore20240504
Khalid S, Bashir S, Mehboob R, Anwar T, Ali M, et al. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. Front Endocrinol (Lausanne). 2024;15:1370733. doi:10.3389/fendo.2024.1370733
Kim P, Garner N, Tatkovic A, Parsons R, Chunduri P, et al. Melatonin's role in the timing of sleep onset is conserved in nocturnal mice. NPJ Biol Timing Sleep. 2024;1:13. doi:10.1038/s44323-024-00013-1
Matsumoto S, Ohama R, Hoei T, Tojo R, Nakamura T. Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report. Cureus. 2024;16:e68311. doi:10.7759/cureus.68311
Mendis R, Wong A, Frenkel S, Southcott AM, Selman CJ, et al. Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial. J Palliat Med. 2024;27:1368. doi:10.1089/jpm.2024.0151
Terribili R, Vallifuoco G, Bardelli M, Frediani B, Gentileschi S. A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16162785
Huang X, Li R, Zhang S, Liu K, Shen L, et al. Effects of integrative therapy with Du Meridian moxibustion, ear acupuncture, and alprazolam on cardiac function and neurotransmitter levels in patients with coronary heart disease and insomnia: An observational study. Medicine (Baltimore). 2024;103:e39318. doi:10.1097/MD.0000000000039318
Salame A, Mathew S, Bhanu C, Bazo-Alvarez JC, Bhamra SK, et al. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Sleep Med. 2025;129:219. doi:10.1016/j.sleep.2025.02.027
Frost R, Mathew S, Thomas V, Uddin S, Salame A, et al. A scoping review of over-the-counter products for depression, anxiety and insomnia in older people. BMC Complement Med Ther. 2024;24:275. doi:10.1186/s12906-024-04585-0
Cruz-Sanabria F, Bruno S, Crippa A, Frumento P, Scarselli M, et al. Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis. J Pineal Res. 2024;76:e12985. doi:10.1111/jpi.12985
Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. doi:10.1016/j.sleep.2024.05.046
Nissen ER, Neumann H, Knutzen SM, Henriksen EN, Amidi A, et al. Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis. JNCI Cancer Spectr. 2024;8. doi:10.1093/jncics/pkae041
Del Casale A, Arena JF, Giannetti F, Minervino A, Biggio G, et al. The use of prolonged-release melatonin in circadian medicine: a systematic review. Minerva Med. 2024;115:125. doi:10.23736/S0026-4806.24.09303-0
Ren H, Kong X, Zhang Y, Deng F, Li J, et al. The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics techniques. J Ethnopharmacol. 2024;330:118255. doi:10.1016/j.jep.2024.118255
Bruni O, Breda M, Nobili L, Fietze I, Capdevila ORS, et al. European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children. Eur J Pediatr. 2024;183:2955. doi:10.1007/s00431-024-05556-w
Vecchierini MF, Léger D. [Pharmacotherapies for insomnia]. Rev Prat. 2024;74:297.
De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. doi:10.3390/medsci12010002