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Top Medical Research Studies
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
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The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
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Frequently Asked Questions
Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.
Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.
Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.
While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.
Based on user reviews, the timeline for seeing results from this supplement can vary significantly. One user reported experiencing remarkable outcomes after five months of continuous use, including a clean bill of health from their doctor regarding their cancer cell analysis ((Read Review)). However, another user mentioned that their condition remained stable shortly after starting the supplement, implying that benefits may not always be immediately evident but can contribute positively over time ((Read Review)). This suggests that while some users may notice changes within a few months, others may need to continue the supplement for a more extended period to observe any significant effects.
Recent scientific research highlights the potential of nattokinase, a supplement known primarily for its blood clot-dissolving abilities, in enhancing cancer treatments. Studies suggest that nattokinase can modify the tumor microenvironment to improve the efficacy of various treatments, including chemotherapy and radiotherapy. For instance, one study found that intratumoral injections of nattokinase reduced fibronectin levels, which subsequently improved blood flow and oxygen delivery to tumors, thus making chemotherapy more effective and increasing the tumor’s response to radiation therapy [3].
Moreover, combining nattokinase with heparin presented a promising approach for patients suffering from cancer-related thrombosis while enhancing anti-tumor effects of therapies like doxorubicin [2]. There’s also compelling evidence from mouse model studies indicating that nattokinase may improve survival rates and reduce tumor sizes in liver cancer [4]. These findings underscore the significance of nattokinase not just as a supplement, but as a potential aid in cancer treatment, meriting further investigation into its clinical applications.
Many users have reported significant improvements in their symptoms after using the supplement, with some experiencing transformative results. One user shared a particularly striking account of how their long-standing reproductive health issues, including endometriosis, adhesions, cysts, and even HPV, disappeared after just five months of taking the supplement. This individual also received a clean bill of health from their doctor regarding cancer cell analysis, leading them to declare the product a "magic pill" ((Read Review)). Such anecdotal evidence suggests that for some, the supplement can lead to remarkable health improvements.
Conversely, other users report a more gradual stabilization of their conditions rather than outright disappearances of ailments. For example, one individual diagnosed with cancer noted that their condition remained stable after incorporating the supplement along with their existing medications ((Read Review)). This indicates that while some may experience profound changes, others might benefit in ways that promote stability rather than complete resolution of their health issues. It's worth noting that individual results can vary widely depending on personal health circumstances and commitment to the supplement regimen.
Based on user reviews, there is a sense of positive synergy when combining this supplement with others for cancer management. One user, who shared their journey of overcoming various health challenges, specifically highlighted the benefit of adding Nattokinase and Serrapeptase to their regimen, declaring the combination a "magic pill" for their overall health recovery, including a clean bill of health from their cancer analysis ((Read Review)). This suggests that certain combinations with this supplement may contribute effectively to healthier outcomes and symptom relief.
Contrastingly, another user emphasized a more cautious approach, noting that while they continued their supplement regimen alongside various medications, their condition remained stable rather than showing marked improvement ((Read Review)). This indicates that, while combining supplements may be beneficial for some, the results can vastly differ based on individual health conditions and how these supplements interact with existing treatments. Therefore, users should consider their unique health scenarios and consult healthcare professionals when integrating supplements into their cancer management plans.
Users report varying experiences regarding the appropriate dose of Nattokinase for treating cancer, with some suggesting that one capsule taken nightly may be effective. One user noted a positive transformation in their health after taking just one capsule on an empty stomach for three months, leading to no issues in their cancer cell analysis (Read Review). Another user mentioned their doctor's recommendation of Nattokinase as part of their regimen following a cancer diagnosis, indicating that they were pleased with the stability of their condition while combining it with other medications (Read Review). While individual responses may vary, these reviews suggest that users have found success with different dosing approaches.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
References
- Zhang Y, Liu Y, Li T, Yang X, Lang S, et al. Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy. J Control Release. 2024;373:867. doi:10.1016/j.jconrel.2024.07.076
- Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. doi:10.1016/j.lfs.2024.122935
- Zhang Y, Pei P, Zhou H, Xie Y, Yang S, et al. Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor. ACS Nano. 2023;17:7475. doi:10.1021/acsnano.2c12463
- Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. doi:10.4014/jmb.1812.12058
