Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.5
USERS' SCORE
Good
Based on 8 Reviews
8.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
0
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Read More
9
We investigated the effects of nattokinase, a natural enzyme, on the progression of atherosclerosis, specifically looking at its ability to reduce disease markers in the carotid arteries while also influencing blood lipid levels. Our study involved 82 patients, who were divided into two groups: one received nattokinase and the other was treated with simvastatin, a commonly prescribed statin.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Read More
Most Useful Reviews
9
Improves health effectively
3 people found this helpful
Doctors Best Nattokinase, 2,000FU is excellent! I discovered that natto supplements are beneficial for improving arteriosclerosis and maintaining good health, particularly since my blood pressure is high. I found iHerb, where I purchased a large quantity of 270 capsules at a reasonable price nearly a year ago. I've consistently bought in bulk, impressed by the quality and affordability. I owe my gratitude to iHerb for enhancing arterial health and sustaining my wellbeing. This supplement is essential for the elderly, and I plan to continue its use, hoping it remains available at a good price. I appreciate their prompt service.
Read More
9
Supports smooth flow
Natto Kinase promotes smooth blood flow while preventing arteriosclerosis, acne, and atheroma. It is highly effective.
Read More
9
Clears blood vessels
Nattokinase is a traditional Japanese food that effectively removes waste from blood vessels, maintaining their function and reducing the likelihood of myocardial infarction and arteriosclerosis. This product's dosage is adequate, resulting in clearer blood and a boost in energy after a period of consumption.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.5
- All Researches
9
We investigated the effects of nattokinase, a natural enzyme, on the progression of atherosclerosis, specifically looking at its ability to reduce disease markers in the carotid arteries while also influencing blood lipid levels. Our study involved 82 patients, who were divided into two groups: one received nattokinase and the other was treated with simvastatin, a commonly prescribed statin.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Read More
0
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves health effectively
3 people found this helpful
Doctors Best Nattokinase, 2,000FU is excellent! I discovered that natto supplements are beneficial for improving arteriosclerosis and maintaining good health, particularly since my blood pressure is high. I found iHerb, where I purchased a large quantity of 270 capsules at a reasonable price nearly a year ago. I've consistently bought in bulk, impressed by the quality and affordability. I owe my gratitude to iHerb for enhancing arterial health and sustaining my wellbeing. This supplement is essential for the elderly, and I plan to continue its use, hoping it remains available at a good price. I appreciate their prompt service.
Read More
9
Supports smooth flow
Natto Kinase promotes smooth blood flow while preventing arteriosclerosis, acne, and atheroma. It is highly effective.
Read More
9
Clears blood vessels
Nattokinase is a traditional Japanese food that effectively removes waste from blood vessels, maintaining their function and reducing the likelihood of myocardial infarction and arteriosclerosis. This product's dosage is adequate, resulting in clearer blood and a boost in energy after a period of consumption.
Read More
7.5
Preventing vascular disease
11 people found this helpful
I have been using K2 nattokinase for several years now to prevent arteriosclerosis and atherosclerosis. This product helps control calcium buildup and breaks up clots comprised of calcium, protein fragments, and lipoprotein A, potentially preventing and even reversing vascular disease. In fact, scans show that I have no buildup. The capsules are small and easy to take, but I ensure that I don’t eat half an hour before or after taking them, so they can properly dissolve in the intestine without being affected by stomach acid.
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7.5
Lowers blood pressure
1 people found this helpful
After three months of use, I've seen a slight decrease in my blood pressure from taking Nattokinase. It effectively prevents arteriosclerosis and reduces the risk of heart disease. The quality seems good and it has a tolerable taste.
Read More
Frequently Asked Questions
7.5
Lowers blood pressure
1 people found this helpful
After three months of use, I've seen a slight decrease in my blood pressure from taking Nattokinase. It effectively prevents arteriosclerosis and reduces the risk of heart disease. The quality seems good and it has a tolerable taste.
7.5
Promotes cardiovascular health
Natto helps promote cardiovascular health by dissolving blood clots, lowering blood pressure, and reducing arteriosclerosis. It is recommended to consume at least 2000 FU daily, making it convenient with one capsule per day.
9
Clears blood vessels
Nattokinase is a traditional Japanese food that effectively removes waste from blood vessels, maintaining their function and reducing the likelihood of myocardial infarction and arteriosclerosis. This product's dosage is adequate, resulting in clearer blood and a boost in energy after a period of consumption.
9
Supports smooth flow
Natto Kinase promotes smooth blood flow while preventing arteriosclerosis, acne, and atheroma. It is highly effective.
7.5
Convenient daily intake
Nattokinase is rich in vitamin K2, which helps soften blood vessels and prevents calcium buildup, thus averting arteriosclerosis. It's very convenient to take once daily and between meals.
0
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
9
We investigated the effects of nattokinase, a natural enzyme, on the progression of atherosclerosis, specifically looking at its ability to reduce disease markers in the carotid arteries while also influencing blood lipid levels. Our study involved 82 patients, who were divided into two groups: one received nattokinase and the other was treated with simvastatin, a commonly prescribed statin.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
References
- Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. doi:10.3760/cma.j.issn.0376-2491.2017.26.005
