' 
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
0
Nattokinase ineffective for atherosclerosis
Nattokinase atherothrombotic prevention study: A randomized controlled trial.
Focus on nattokinase effects
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Read More
9
Nattokinase may reduce atherosclerosis
[A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia].
Direct evaluation with limitations
We investigated the effects of nattokinase, a natural enzyme, on the progression of atherosclerosis, specifically looking at its ability to reduce disease markers in the carotid arteries while also influencing blood lipid levels. Our study involved 82 patients, who were divided into two groups: one received nattokinase and the other was treated with simvastatin, a commonly prescribed statin.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Read More
Most Useful Reviews
8.8
Preventing vascular disease
I have been using K2 nattokinase for several years now to prevent arteriosclerosis and atherosclerosis. This product helps control calcium buildup and breaks up clots comprised of calcium, protein fragments, and lipoprotein A, potentially preventing and even reversing vascular disease. In fact, scans show that I have no buildup. The capsules are small and easy to take, but I ensure that I don’t eat half an hour before or after taking them, so they can properly dissolve in the intestine without being affected by stomach acid.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.5
- All Researches
9
Nattokinase may reduce atherosclerosis
[A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia].
Direct evaluation with limitations
We investigated the effects of nattokinase, a natural enzyme, on the progression of atherosclerosis, specifically looking at its ability to reduce disease markers in the carotid arteries while also influencing blood lipid levels. Our study involved 82 patients, who were divided into two groups: one received nattokinase and the other was treated with simvastatin, a commonly prescribed statin.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Over 26 weeks, both treatment groups showed reductions in carotid artery thickness and plaque size. Notably, the nattokinase group experienced a remarkable 36.6% reduction in plaque size compared to just 11.5% in the statin group. Both supplements also effectively lower total cholesterol, LDL cholesterol, and triglycerides, but statin treatment was more effective in this regard. Interestingly, we found that nattokinase significantly increased levels of HDL cholesterol, suggesting an additional heart-healthy benefit that statins did not provide.
Our findings point to the potential of daily nattokinase supplementation as a promising approach to managing atherosclerosis progression. Importantly, the way nattokinase worked seems to be separate from how statins influence cholesterol levels, indicating it might serve as an effective alternative for patients concerned about cardiovascular health.
Read More
0
Nattokinase ineffective for atherosclerosis
Nattokinase atherothrombotic prevention study: A randomized controlled trial.
Focus on nattokinase effects
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.
Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Preventing vascular disease
I have been using K2 nattokinase for several years now to prevent arteriosclerosis and atherosclerosis. This product helps control calcium buildup and breaks up clots comprised of calcium, protein fragments, and lipoprotein A, potentially preventing and even reversing vascular disease. In fact, scans show that I have no buildup. The capsules are small and easy to take, but I ensure that I don’t eat half an hour before or after taking them, so they can properly dissolve in the intestine without being affected by stomach acid.
Read More
