' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 3 Researches
8.7
USERS' SCORE
Very Good
Based on 13 Reviews
8.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9
Nattokinase optimizes cancer therapy
Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor.
Addresses nattokinase's cancer effects
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
8
Nattokinase-heparin benefits cancer therapy
Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis.
Combined treatments show potential
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More
9
Nattokinase improves cancer therapy
Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy.
Highlighted nattokinase's complex effects
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Read More
Top User Reviews
9.5
Cancer cell destruction
I discovered Nattokinase after struggling with thrombosis. It improves oxygen delivery, helps remove toxins, and can destroy cancer cell plaque, allowing immune cells to identify them. The benefits include improved nutrient absorption, reduced joint pain, and better lymphatic drainage. I recommend consulting a physician before use, especially if you take other medications.
Read More
8.8
Promising for cancer
Nattokinase is similar to plasmin, aiding in dissolving fibrin and potentially breaking down cancer cell barriers. It enhances blood fluidity and reduces the risk of clots, which is vital for preventing heart attacks and strokes that can arise from poor circulation. I take one capsule daily, and the health benefits are remarkable.
Read More
8.8
Effective cancer treatment
Nattokinase, found in natto, is a powerful enzyme that offers numerous health benefits, including aiding in cancer treatment by identifying and neutralising cancer cells. It acts as an excellent alternative to aspirin, promoting heart and blood vessel health while supporting metabolic processes. I’ve been taking it for two weeks and feel sharper mentally. Always consult a doctor regarding proper dosage!
Read More
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Medical Researches
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Most Likely Effective
Based on 3 Researches
8.7
9
Nattokinase improves cancer therapy
Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy.
Highlighted nattokinase's complex effects
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Read More
9
Nattokinase optimizes cancer therapy
Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor.
Addresses nattokinase's cancer effects
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
8
Nattokinase-heparin benefits cancer therapy
Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis.
Combined treatments show potential
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 13 Reviews
8.9
9.5
Cancer cell destruction
I discovered Nattokinase after struggling with thrombosis. It improves oxygen delivery, helps remove toxins, and can destroy cancer cell plaque, allowing immune cells to identify them. The benefits include improved nutrient absorption, reduced joint pain, and better lymphatic drainage. I recommend consulting a physician before use, especially if you take other medications.
Read More
8.8
Effective cancer treatment
Nattokinase, found in natto, is a powerful enzyme that offers numerous health benefits, including aiding in cancer treatment by identifying and neutralising cancer cells. It acts as an excellent alternative to aspirin, promoting heart and blood vessel health while supporting metabolic processes. I’ve been taking it for two weeks and feel sharper mentally. Always consult a doctor regarding proper dosage!
Read More
8.8
Promising for cancer
Nattokinase is similar to plasmin, aiding in dissolving fibrin and potentially breaking down cancer cell barriers. It enhances blood fluidity and reduces the risk of clots, which is vital for preventing heart attacks and strokes that can arise from poor circulation. I take one capsule daily, and the health benefits are remarkable.
Read More
8.8
Detoxifying effects
I take Nattokinase two capsules every four hours, reducing the dosage as I improve. The enzyme helps absorb fibrin, reducing the risk of clots and treating conditions like cancer. It enhances oxygen delivery and supports various bodily functions, making it a versatile supplement. However, consult your doctor before starting this.
Read More
8.8
Cancer prevention
I’ve read that Nattokinase can be effective against cancer growth, and I plan to add it to my smoothies. At 72, I’m quite cautious about my health and thoroughly research before purchasing such supplements.
