Last update
5/16/2025
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 14 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**

Top Medical Research Studies

We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Read More
9
Nattokinase optimizes cancer therapy
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.

Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.

Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.

These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.

In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.

Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More

Most Useful Reviews

9
Blood thickness improvement
608 people found this helpful
It's working! My husband has a rare blood cancer (polycythemia vera) that makes his blood too thick. He was having a pint of blood taken every two weeks. I researched options and started him on several supplements. After six weeks, the doctor hasn't had to draw any blood. We'll continue this treatment.
Read More
9
Cancer cell destruction
69 people found this helpful
I discovered Nattokinase after struggling with thrombosis. It improves oxygen delivery, helps remove toxins, and can destroy cancer cell plaque, allowing immune cells to identify them. The benefits include improved nutrient absorption, reduced joint pain, and better lymphatic drainage. I recommend consulting a physician before use, especially if you take other medications.
Read More
7.5
Promising for cancer
9 people found this helpful
Nattokinase is similar to plasmin, aiding in dissolving fibrin and potentially breaking down cancer cell barriers. It enhances blood fluidity and reduces the risk of clots, which is vital for preventing heart attacks and strokes that can arise from poor circulation. I take one capsule daily, and the health benefits are remarkable.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
  • All Researches
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.

The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.

By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.

Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Read More
9
Nattokinase optimizes cancer therapy
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.

Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.

Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.

These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Read More
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.

In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.

Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More

User Reviews

USERS' SCORE
Good
Based on 14 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Blood thickness improvement
608 people found this helpful
It's working! My husband has a rare blood cancer (polycythemia vera) that makes his blood too thick. He was having a pint of blood taken every two weeks. I researched options and started him on several supplements. After six weeks, the doctor hasn't had to draw any blood. We'll continue this treatment.
Read More
9
Cancer cell destruction
69 people found this helpful
I discovered Nattokinase after struggling with thrombosis. It improves oxygen delivery, helps remove toxins, and can destroy cancer cell plaque, allowing immune cells to identify them. The benefits include improved nutrient absorption, reduced joint pain, and better lymphatic drainage. I recommend consulting a physician before use, especially if you take other medications.
Read More
7.5
Promising for cancer
9 people found this helpful
Nattokinase is similar to plasmin, aiding in dissolving fibrin and potentially breaking down cancer cell barriers. It enhances blood fluidity and reduces the risk of clots, which is vital for preventing heart attacks and strokes that can arise from poor circulation. I take one capsule daily, and the health benefits are remarkable.
Read More
7.5
Effective cancer treatment
188 people found this helpful
Nattokinase, found in natto, is a powerful enzyme that offers numerous health benefits, including aiding in cancer treatment by identifying and neutralising cancer cells. It acts as an excellent alternative to aspirin, promoting heart and blood vessel health while supporting metabolic processes. I’ve been taking it for two weeks and feel sharper mentally. Always consult a doctor regarding proper dosage!
Read More
7.5
Detoxifying effects
8 people found this helpful
I take Nattokinase two capsules every four hours, reducing the dosage as I improve. The enzyme helps absorb fibrin, reducing the risk of clots and treating conditions like cancer. It enhances oxygen delivery and supports various bodily functions, making it a versatile supplement. However, consult your doctor before starting this.
Read More

Frequently Asked Questions

7.5
Effective cancer treatment
188 people found this helpful
Nattokinase, found in natto, is a powerful enzyme that offers numerous health benefits, including aiding in cancer treatment by identifying and neutralising cancer cells. It acts as an excellent alternative to aspirin, promoting heart and blood vessel health while supporting metabolic processes. I’ve been taking it for two weeks and feel sharper mentally. Always consult a doctor regarding proper dosage!
7.5
Prostate cancer prevention
2 people found this helpful
This product offers Nattokinase at 2000 FUs, and the price is excellent. My husband has started taking it to lower his PSA count and has successfully lost 35 pounds through diet, exercise, and daily Nattokinase. He’s committed to supplementing healthily to prevent prostate cancer. So far, so good!
9
Cancer cell destruction
69 people found this helpful
I discovered Nattokinase after struggling with thrombosis. It improves oxygen delivery, helps remove toxins, and can destroy cancer cell plaque, allowing immune cells to identify them. The benefits include improved nutrient absorption, reduced joint pain, and better lymphatic drainage. I recommend consulting a physician before use, especially if you take other medications.
7.5
Cancer prevention
2 people found this helpful
I’ve read that Nattokinase can be effective against cancer growth, and I plan to add it to my smoothies. At 72, I’m quite cautious about my health and thoroughly research before purchasing such supplements.
7.5
Supports cancer therapy
1 people found this helpful
Nattokinase quickly absorbs into the blood, improving oxygen delivery and nutrient bioavailability, while enhancing lymphatic drainage and detoxification. It also dissolves fibrin, aiding in cancer treatment by allowing immune cells to penetrate tumours more efficiently.
7.5
Detoxifying effects
8 people found this helpful
I take Nattokinase two capsules every four hours, reducing the dosage as I improve. The enzyme helps absorb fibrin, reducing the risk of clots and treating conditions like cancer. It enhances oxygen delivery and supports various bodily functions, making it a versatile supplement. However, consult your doctor before starting this.
7.5
Promising for cancer
9 people found this helpful
Nattokinase is similar to plasmin, aiding in dissolving fibrin and potentially breaking down cancer cell barriers. It enhances blood fluidity and reduces the risk of clots, which is vital for preventing heart attacks and strokes that can arise from poor circulation. I take one capsule daily, and the health benefits are remarkable.
7.5
Cancer treatment aid
Nattokinase effectively reduces blood viscosity, enhancing oxygen delivery and nutrient bioavailability. It alleviates joint and muscle pain during exertion and improves lymph drainage, cleansing the body of toxins. Additionally, it breaks down fibrin plaques that hinder cancer cell recognition, facilitating the killing of cancer cells. Overall, I feel healthier!
7.5
Natural cancer treatment
1 people found this helpful
Nattokinase is safer and more effective than aspirin; it has no side effects reported over 20 years. This natural alternative has improved my mother's heart condition significantly. However, consulting a doctor is essential to monitor for changes.
9
Nattokinase optimizes cancer therapy
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.

Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.

Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.

These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.

In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.

Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.

The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.

By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.

Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.

References

  1. Zhang Y, Liu Y, Li T, Yang X, Lang S, et al. Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy. J Control Release. 2024;373:867. 10.1016/j.jconrel.2024.07.076
  2. Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. 10.1016/j.lfs.2024.122935
  3. Zhang Y, Pei P, Zhou H, Xie Y, Yang S, et al. Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor. ACS Nano. 2023;17:7475. 10.1021/acsnano.2c12463
  4. Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. 10.4014/jmb.1812.12058
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