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Top Medical Research Studies
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
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The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
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Frequently Asked Questions
Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.
Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.
Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.
While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.
Based on user reviews, individuals taking Nattokinase for cancer-related purposes report varying timelines for observing benefits. A user noted feeling mentally sharper within two weeks of taking the supplement, implying that some users may start to notice positive effects relatively quickly, around this timeframe (Read Review). Others have expressed confidence in the product's ability to support their health over longer usage periods, with one user highlighting a commitment to health improvements that began with Nattokinase (Read Review).
Furthermore, while many users advocate for its overall health benefits in cancer treatment, they also emphasize the importance of consulting a physician before starting any new supplement regimen. This suggests that personalized medical advice could significantly influence the perception of effectiveness and timeline for results based on individual health conditions (Read Review). Overall, experiences vary between individuals, and for some, noticeable results may occur within a few weeks, while others may require more extended use.
Nattokinase, a supplement known for its ability to dissolve blood clots, is supported by promising scientific research in relation to cancer treatment. Studies have shown that nattokinase can modify the tumor microenvironment, improving the efficacy of various cancer therapies such as chemotherapy and radiotherapy. For instance, one research highlighted that intratumoral injections of nattokinase could reduce tumor stiffness and enhance blood flow, allowing therapeutic agents to reach tumors more effectively, thus boosting treatment outcomes ([3]). Additionally, a combination treatment study with nattokinase and doxorubicin demonstrated enhanced anti-tumor effects while managing cancer-related thrombosis, significantly likely improving quality of life for patients with advanced tumors ([2]).
Further supporting this research, experiments involving nattokinase crude extract in mice with liver cancer showed a notable improvement in survival rates and tumor size reductions ([4]). Another study explored the use of engineered Salmonella to deliver nattokinase in a novel approach to enhance radio-immunotherapy's effectiveness for colon tumors, showing increased immune response and potential long-term effects against tumor recurrence ([1]). Therefore, while more research is needed, current findings suggest that nattokinase has valuable implications for cancer treatment, warranting consideration for its potential use in clinical settings.
Users have reported a variety of improvements in their symptoms after incorporating Nattokinase into their health regimens, although individual results may vary. Many users noted enhancements in general wellbeing, such as improved oxygen delivery, better nutrient absorption, and pain relief. One user mentioned experiencing a mental sharpness within just two weeks of starting the supplement, highlighting an immediate cognitive benefit (Read Review). Other anecdotal experiences include reduced joint pain and improved lymphatic drainage, with one user specifically addressing how the enzyme contributed to lowering their husband’s PSA count, showcasing its potential benefits in cancer-related treatments (Read Review).
In addition to these improvements, users have emphasized the importance of consulting a healthcare professional before starting Nattokinase, especially if they are on other medications, to tailor its use to individual health needs (Read Review). Other reported benefits include enhancing overall body functions, combating cancer cell growth, and promoting heart health (Read Review)(Read Review). Hence, while many users have had positive experiences, it is essential to consider that outcomes may differ from person to person.
Based on user reviews, many individuals report combining Nattokinase with other supplements or health practices to enhance their cancer treatment efforts. Users have highlighted that Nattokinase’s fibrinolytic effects can help break down barriers around cancer cells, facilitating better immune response and potentially improving treatment outcomes. For instance, one user shared that take Nattokinase alongside a healthy diet and exercise has resulted in a significant decrease in his husband’s PSA levels, underscoring its potential benefits when integrated into a broader health regimen (Read Review).
However, a prevalent theme among users is the emphasis on consulting healthcare professionals before starting Nattokinase, especially if they are already on other supplements or medications. Many recommend a cautious approach, highlighting the importance of personalized medical advice to ensure safe and effective use (Read Review). While anecdotal experiences suggest positive effects when combined with other health practices, users generally advise monitoring any potential interactions and adjustments with the help of a healthcare provider to tailor the approach to individual needs.
Based on user reviews, there seems to be a variety of dosing experiences among individuals using Nattokinase for potential cancer treatment. One user reported taking two capsules every four hours, adjusting the dosage as they felt improvements (Read Review). Others have mentioned taking one capsule daily and recognizing remarkable health benefits (Read Review). Most users emphasize the importance of consulting a physician before beginning any supplementation, particularly when addressing health conditions like cancer (Read Review).
It is also noted that Nattokinase is believed to effectively improve various bodily functions and promote better oxygen delivery, which is essential for cancer treatment strategy (Read Review). However, specific standardized dosage guidelines for cancer treatment remain vague in the reviews. Users encourage careful monitoring and professional consultation to tailor the ideal dosage per individual health needs (Read Review).
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
References
- Zhang Y, Liu Y, Li T, Yang X, Lang S, et al. Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy. J Control Release. 2024;373:867. doi:10.1016/j.jconrel.2024.07.076
- Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. doi:10.1016/j.lfs.2024.122935
- Zhang Y, Pei P, Zhou H, Xie Y, Yang S, et al. Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor. ACS Nano. 2023;17:7475. doi:10.1021/acsnano.2c12463
- Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. doi:10.4014/jmb.1812.12058
