Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
Most Useful Reviews
9
Anxiety improvements
9 people found this helpful
This is my repeat order. It is highly absorbable with no chemical ingredients. I've been taking it for my chronic anxiety and depression, and after three months, my neurological symptoms have greatly improved.
Read More
8
Reduced anxiety levels
4 people found this helpful
As my mother is vegetarian, elderly, and has diabetes, I bought this B12 supplement. She has seen good effects without any signs of anaemia or emotional anxiety and is feeling energetic.
Read More
0
Caused side effects
4 people found this helpful
Initially, I felt more energetic with this B12, as it was more convenient than the vegan lozenge. However, after time, I experienced numerous side effects like anxiety, headaches, acne, and numbness in my leg. The symptoms vanished when I stopped taking it. I will not purchase this again.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Read More
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Anxiety improvements
9 people found this helpful
This is my repeat order. It is highly absorbable with no chemical ingredients. I've been taking it for my chronic anxiety and depression, and after three months, my neurological symptoms have greatly improved.
Read More
8
Reduced anxiety levels
4 people found this helpful
As my mother is vegetarian, elderly, and has diabetes, I bought this B12 supplement. She has seen good effects without any signs of anaemia or emotional anxiety and is feeling energetic.
Read More
0
Caused side effects
4 people found this helpful
Initially, I felt more energetic with this B12, as it was more convenient than the vegan lozenge. However, after time, I experienced numerous side effects like anxiety, headaches, acne, and numbness in my leg. The symptoms vanished when I stopped taking it. I will not purchase this again.
Read More
9
Anxiety relief
3 people found this helpful
Great brand for my mum's B12 supplementation. Her deficiency caused tingling in her feet and anxiety, but after six months of continuous use, she no longer suffers from these negative symptoms.
Read More
9
Improved anxiety
1 people found this helpful
I've been taking this B12 for over a year, and it's one of the best on the market. It aids red blood cell production and significantly reduces my anxiety attacks. The capsules are tiny and easy to swallow.
Read More
Frequently Asked Questions
9
No anxiety issues
1 people found this helpful
I love this product. I noticed improvements in my mood and energy within days, and most importantly, I no longer have anxiety issues.
7.5
Improved anxiety symptoms
16 people found this helpful
Excellent B12 dosage. I had been experiencing numbness in my feet and toes, but after three weeks of use, I feel about 60% better. I've also noticed slight improvements in my anxiety symptoms. I’ll continue monitoring my reactions to this supplement.
9
Anxiety improvements
9 people found this helpful
This is my repeat order. It is highly absorbable with no chemical ingredients. I've been taking it for my chronic anxiety and depression, and after three months, my neurological symptoms have greatly improved.
9
Anxiety relief
3 people found this helpful
Great brand for my mum's B12 supplementation. Her deficiency caused tingling in her feet and anxiety, but after six months of continuous use, she no longer suffers from these negative symptoms.
9
Insomnia gone
After consuming a jar, I felt lighter, my anxiety vanished, and I could finally sleep well. I recommend it to everyone for brain health!
0
Caused side effects
4 people found this helpful
Initially, I felt more energetic with this B12, as it was more convenient than the vegan lozenge. However, after time, I experienced numerous side effects like anxiety, headaches, acne, and numbness in my leg. The symptoms vanished when I stopped taking it. I will not purchase this again.
0
Worsened acne
5 people found this helpful
This did not help my acne at all! Instead, it worsened it and caused cystic acne. I had done research that suggested it might help, but later findings indicated it could actually make things worse. Only take it if advised by your doctor, as it may affect your anxiety but isn't worth it if acute acne results.
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
7
We set out to explore the role of serum vitamin B12 levels in relation to anxiety disorders, using a robust methodology that involved genetic data analysis. By pulling information from large-scale genome-wide association studies, we focused on identifying potential causal relationships between vitamin B12 and anxiety symptoms.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
4
We explored the impact of high-dose Vitamin B6 and B12 supplementation on anxiety in a double-blind study involving 478 young adults. Participants reported their anxiety and depression levels before and after taking the supplements for a month.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
4
We explored the impact of vitamin B12 on anxiety symptoms in adolescents. In a study involving outpatients aged 12 to 18 with anxiety or depressive symptoms, we measured the severity of their conditions and checked various health markers, including serum vitamin B12 and folate levels.
Our findings indicated that lower levels of vitamin B12 were associated with a higher risk of experiencing severe anxiety and depressive symptoms. Interestingly, we also observed that vitamin B12, folate, and total homocysteine levels were interconnected, suggesting that deficiencies in these vitamins might be related.
However, while we found these associations, the correlations between vitamin levels and anxiety symptoms were generally weak.
In summary, while vitamin B12 might play a role in anxiety severity, the relationships are complex and influenced by other factors. Overall, this study underscores the importance of considering nutritional factors in mental health, but we should be cautious not to overstate the benefits of vitamin B12 alone.
Our findings indicated that lower levels of vitamin B12 were associated with a higher risk of experiencing severe anxiety and depressive symptoms. Interestingly, we also observed that vitamin B12, folate, and total homocysteine levels were interconnected, suggesting that deficiencies in these vitamins might be related.
However, while we found these associations, the correlations between vitamin levels and anxiety symptoms were generally weak.
In summary, while vitamin B12 might play a role in anxiety severity, the relationships are complex and influenced by other factors. Overall, this study underscores the importance of considering nutritional factors in mental health, but we should be cautious not to overstate the benefits of vitamin B12 alone.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. doi:10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. doi:10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. doi:10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. doi:10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. doi:10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. doi:10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. doi:10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. doi:10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. doi:10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. doi:10.2147/NDT.S399378
