Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 23 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
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7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
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9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
Most Useful Reviews
10
Miraculous cat recovery
7 people found this helpful
This worked wonders for my diabetic cat, whose neuropathy made him visibly pained in his feet. After reading about the Methyl form of B12, I tried it, and within two days, he went from hobbling to chasing toys. I give him one capsule twice a day mixed with food, and the price is excellent, especially with a subscription.
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9
Affordable and effective
4 people found this helpful
Affordable and effective. I feel revitalised with these; do not waste time or money on other brands like I did for the past two years. I have chemotherapy-induced peripheral neuropathy and these are very effective and affordable—a necessity for me. I’m grateful to have found them after much trial and error. Five stars.
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9
Cat's mobility improved
3 people found this helpful
I bought methylcobalamin for my diabetic cat suffering from hind limb neuropathy. He had a wobbly gait and struggled to walk normally. After four months on B12 and methylfolate, I noticed significant improvement after about a month, and his condition continues to get better. I will keep purchasing this supplement.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
We examined a unique case involving a 33-year-old woman with HIV who experienced sudden vision loss linked to vitamin B12 deficiency. Initially treated with B12 tablets for severe peripheral neuropathy, her condition escalated to optic neuritis. Upon diagnosis, she received prednisolone and daily B12 injections. After five months of this treatment, she reported a significant recovery in her vision. This case highlights the importance of recognizing vitamin B12 deficiency’s potential eye-related symptoms, especially in patients with underlying health conditions like HIV, to ensure timely intervention.
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9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Read More
8
We explored the effectiveness of steroid treatment versus vitamin B12 therapy for improving diabetic ocular nerve palsy. Our study involved fifty participants, with half receiving steroids and the other half vitamin B12 injections.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
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8
We explored the connection between nitrous oxide use and vitamin B12 deficiency, specifically focusing on neurological issues like peripheral neuropathy. Through a reported case of nitrous oxide-induced subacute combined degeneration of the spinal cord, we identified a functional B12 deficiency despite normal serum levels.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Miraculous cat recovery
7 people found this helpful
This worked wonders for my diabetic cat, whose neuropathy made him visibly pained in his feet. After reading about the Methyl form of B12, I tried it, and within two days, he went from hobbling to chasing toys. I give him one capsule twice a day mixed with food, and the price is excellent, especially with a subscription.
Read More
9
Affordable and effective
4 people found this helpful
Affordable and effective. I feel revitalised with these; do not waste time or money on other brands like I did for the past two years. I have chemotherapy-induced peripheral neuropathy and these are very effective and affordable—a necessity for me. I’m grateful to have found them after much trial and error. Five stars.
Read More
9
Cat's mobility improved
3 people found this helpful
I bought methylcobalamin for my diabetic cat suffering from hind limb neuropathy. He had a wobbly gait and struggled to walk normally. After four months on B12 and methylfolate, I noticed significant improvement after about a month, and his condition continues to get better. I will keep purchasing this supplement.
Read More
9
Pain relief effective
1 people found this helpful
I take B12 for peripheral neuropathy and find Doctor's Best the most reliable brand. This supplement reduces neuropathy-related pain and 'electric shock' sensations effectively. The quality of their products is consistently high, and I appreciate the convenient flip lid on their containers.
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9
Tremendous help noted
1 people found this helpful
I love this vitamin brand, which has helped my neuropathy tremendously. However, one of the two recently ordered bottles arrived with tampering signs. Despite that, it doesn’t deter me from future purchases, as I can easily exchange the problematic bottle.
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Frequently Asked Questions
7.5
Fingertip numbness regained
1 people found this helpful
Used in conjunction with a lozenge for peripheral neuropathy, I had numbness in my fingertips but noticed significant improvement within ten days. It no longer bothers me.
9
Cat's mobility improved
3 people found this helpful
I bought methylcobalamin for my diabetic cat suffering from hind limb neuropathy. He had a wobbly gait and struggled to walk normally. After four months on B12 and methylfolate, I noticed significant improvement after about a month, and his condition continues to get better. I will keep purchasing this supplement.
9
Pain relief effective
1 people found this helpful
I take B12 for peripheral neuropathy and find Doctor's Best the most reliable brand. This supplement reduces neuropathy-related pain and 'electric shock' sensations effectively. The quality of their products is consistently high, and I appreciate the convenient flip lid on their containers.
9
Foot neuropathy support
I use this for neuropathy in my feet, and it indeed helps. I take two capsules daily under my doctor's advice.
7.5
Preventive Measure
A great product and very effective. I give it to my diabetic cat to prevent neuropathy, and I take it as well. The capsules are small and easily swallowed. Highly recommended!
7.5
Improved memory
5 people found this helpful
I wish you health! I regularly order quality chelated vitamin B12, which is efficiently absorbed. It boosts my energy levels and improves my nervous system while reducing diabetic polyneuropathy symptoms. Combined with DHA-500, it enhances memory and concentration. I recommend this quality B12.
7.5
Ears and stress relief
2 people found this helpful
B12 aids the ears and peripheral nervous system issues. I've been taking it with a B group supplement after learning its benefits for neuropathy. The small, pink tablets are easy to take, and I have one in the morning and one at night. If you're stressed and have neuralgia, I recommend trying B12.
7.5
Improved tinnitus
6 people found this helpful
For improving blood flow and chronic illness, I began taking vitamin B12 regularly from iHerb for neuropathy and circulation issues. While I also purchase Solger's Vitamin B12 occasionally due to its better ingredient profile and affordability, I feel B12 is effective for my tinnitus and hearing difficulties. My eye condition has not deteriorated either. In addition, I take lutein, astaxanthin, vitamin E, and other supplements daily, which I plan to continue.
7.5
Works Well
Using this for neuropathy, it's a very small pill containing 1500mcg of methylcobalamin. It works well.
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
8
B12 contributes to neuropathy improvement
We investigated how a combination of vitamins, minerals, and other compounds influences symptoms of diabetic neuropathy. For six months, 73 participants were evenly split between a treatment or placebo group.
The results highlighted those on the active treatment saw significant improvements in pain and vibration perception, along with increased vitamin B12 levels. This suggests that B12, while part of a broader treatment plan, may play a beneficial role in managing neuropathy. However, the study primarily focuses on the overall combination, with B12 contributing to positive outcomes.
The results highlighted those on the active treatment saw significant improvements in pain and vibration perception, along with increased vitamin B12 levels. This suggests that B12, while part of a broader treatment plan, may play a beneficial role in managing neuropathy. However, the study primarily focuses on the overall combination, with B12 contributing to positive outcomes.
4
Vitamin B12's limited neuropathy effects
We explored the impact of vitamin B12 on neuropathy in the context of a unique case presenting with symptoms resembling POEMS syndrome. The patient, a man in his 40s, initially showed signs such as fatigue, imbalance, and painful numbness, which led to a diagnosis focused on vitamin B12 deficiency after initial evaluations.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. doi:10.31557/APJCP.2025.26.2.375
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. doi:10.7759/cureus.74383
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. doi:10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. doi:10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. doi:10.7759/cureus.63003
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. doi:10.1097/MD.0000000000037605
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. doi:10.1186/s12883-025-04069-9
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. doi:10.1186/s12883-024-03966-9
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. doi:10.1016/j.vascn.2024.107552
