Doctor's Best MSM with OptiMSM

We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.

Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.

Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.

This suggests that MSM could be a helpful option for those dealing with mild knee pain.

No knee discomfort

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102 people found this helpful

I purchased this item for my mother after she was diagnosed with minor osteoarthritis. She has been taking it for a couple of months and has stopped experiencing discomfort in her knees.

Rash details

Skin improvement noted

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29 people found this helpful

Transforms the skin! Prescribed by a doctor for complex lesions, I take zinc and beta-carotene in the morning, and sulphur MSM for dinner. The rash disappeared and hasn't returned even during critical days. My skin is smooth, pores are narrowed, and makeup is flawless. It's unfortunate that I have to finish the course and take a break. I wish to maintain such skin always. If I could ascertain a prolonged effect, that would be great. I believe my hair has also grown stronger; however, I'm unsure of the source of this improvement. The clarity of my skin is truly delightful!

Cancer details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

MSM anal cancer treatment feasibility

Reynolds CW, Lieb W, Schecter A, Gaisa MM, McGill SK, et al. Piloting of a Screen‑Triage‑Treat Surgical Approach Model for Management of Anal Cancer in Liberia. Ann Glob Health. 2024;90:75. doi:10.5334/aogh.4576

We explored the challenges faced by men who have sex with men (MSM) regarding anal cancer treatment in Liberia. With limited access to screening and care for anal cancers, we aimed to investigate whether a screen-triage-treat approach could effectively help identify and manage anal high-grade squamous intraepithelial lesions (aHSIL) within this vulnerable population.

In our study, we collaborated with local organizations to gather data from MSM and transgender individuals. Participants were recruited and engaged in self-swabbing to test for high-risk human papillomavirus (HPV), alongside HIV testing. Those who tested positive for aHSIL were offered further evaluation and treatment using high-resolution anoscopy and infrared coagulation.

Among 110 participants, a significant number turned out to be living with HIV, and nearly half tested positive for high-risk HPV. This indicates a notable health concern. While 68% of those who tested positive opted for further procedures, we found that this model effectively presented a potential solution for identifying anal cancer risks and can work in a low-resource environment.

Overall, our findings suggest that implementing a screen-triage-treat model shows promise for reducing anal cancer incidence among MSM in Liberia. This approach, previously successful in cervical cancer management, might become a crucial tool in cancer prevention strategies for similar low- and middle-income countries.

Accelerates hair growth

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6 people found this helpful

I absolutely love this product! Since using MSM, my hair and nails have been growing remarkably quickly. I also believe it is excellent for combatting cancer.

Headache details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

MSM linked to lower migraine impact

Seng EK, Robbins MS, Nicholson RA. Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study. Cephalalgia. 2017;37:955. doi:10.1177/0333102416663459

We dived into how adherence to acute migraine medications influences migraine severity and patient satisfaction. Over three months, participants diligently recorded their migraine experiences in daily diaries.

With 337 adults participating, the findings showed that those using migraine-specific medication (MSM), especially when pain was milder, reported the best outcomes. This included less daily disability and greater satisfaction with their medication.

Our results suggest that starting treatment with MSM may lead to a better quality of life for migraine sufferers.

No headaches experienced

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Excellent sulphur supplement that does not cause any adverse effects. The composition is impressive; with 360 capsules included, it arrived promptly. It effectively reduces greasy hair and skin, lasting a long time without any nausea.

Acne details

Effective acne treatment

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11 people found this helpful

Since July 2021, I struggled with acne following a facial massage. Despite treatments, my condition persisted until I began using sulphur capsules. I recall how sulphur helped me previously with acne, and after starting these, my face has completely cleared. I'm also hopeful for improvements in my joint pain.

Arthritis details

SCIENTIFIC SCORE

Possibly Effective

Based on 13 Researches

MSM improves knee osteoarthritis symptoms

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.

We conducted a randomized, double-blind, placebo-controlled trial exploring the effects of methylsulfonylmethane (MSM) on knee osteoarthritis pain. Fifty adults aged 40 to 76 participated, taking either MSM or a placebo for 12 weeks.

While MSM did show improvements in pain and physical function, there was no significant effect on stiffness or overall symptom scores. This means that while MSM might help with certain aspects of osteoarthritis, the overall benefits and long-term safety need more research.

Knees no longer hurt

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16 people found this helpful

It took away so much pain. I used this to manage arthritis and fibromyalgia. My knees used to ache badly in cold weather, and now I can go out with zero problems. It has assisted me in managing my fibromyalgia so I can enjoy life again.

In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.

Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.

However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.

Almost painlessly living

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7 people found this helpful

Works for rheumatoid arthritis! I’ve been diagnosed with rheumatoid arthritis and have been drinking this product. Maybe the immunomodulator isn't effective and should be increased, but thanks to this, I can live almost painlessly! I believe it’s due to this, as it causes pain in 2-3 days if I don't take it and rely solely on the immunomodulator.

Rosacea details

7 people found this helpful

A very good quality product. I have taken MSM before, and this is high quality. I only take one pill a day with lunch, which suffices. This has restored colour to my face and reduced my rosacea to barely noticeable levels.

Sciatica details

3 people found this helpful

I ordered this for my mother, who has been complaining of sciatica. It's excellent, as she feels comfortable since using it. I will definitely purchase it again and the price is excellent. Good luck!

Back Pain details

Joint pain elimination

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8 people found this helpful

If you experience inflammation in your joints, I highly recommend this product. I used to take Aleve daily due to chronic joint pain until I found this miracle. It has significantly reduced the swelling in my knees, wrists, and elbows. I lived in constant pain, but since starting MSM, I no longer need pain medication. My severe pain has vanished, and my body feels normal again. Thank you to whoever created this product; you have truly given me my life back!

Bone Pain details

8 people found this helpful

This product works wonders for my 78-year-old mother's knee pain, which is caused by bone on bone issues. By taking three capsules in the morning and three at night, we manage to keep 80-90% of her pain at bay while she walks. Any further suggestions would be greatly appreciated as well!

Cold Sores details

1 people found this helpful

I experienced soreness in my finger joints. After using this product for a week, I was pleasantly surprised to find I could easily squeeze and unclench my fingers without discomfort.

Cold details

2 people found this helpful

Very effective. I had symptoms of allergies and colds for ages, but they disappeared on a dose of 3 grams. I've also experienced benefits for knee and shoulder pain, plus my nails and hair grow faster than usual. The price is excellent for the quantity; I use three capsules a day.

Fibromyalgia details

Effective anti-inflammatory

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It works very well as an anti-inflammatory and pain reliever. My mother takes it for fibromyalgia.

Flu details

Effective against flu

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5 people found this helpful

I have been using this MSM for many months as an immune support and I believe it is helping. I have not fallen ill this winter season whilst everyone else at my work has. At nearly 63, all my younger colleagues have been sick at least once with colds, flu, and respiratory illnesses. Thank you for a great product!

Frozen Shoulder details

Significant joint improvement

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6 people found this helpful

The product works! I got it on my doctor's advice, who recommends regular sulphur intake unless the dosage changes. My shoulder joints and heels hurt initially, but after two months—one capsule daily with 1000 mg of vitamin C in the first month, and two capsules in the second month—I noticed a remarkable improvement.

Menopause details

Excellent! I occasionally drink this, and it is very beneficial for my immunity and joints, particularly during menopause. It makes me feel better, especially in spring when my knees hurt. I also take vitamin D and glucosamine chondroitin. My skin tone has improved, and hair loss has diminished. I've yet to notice any side effects.

Migraine details

SCIENTIFIC SCORE

Likely Very Effective

Based on 2 Researches

MSM improves migraine management

We aimed to understand how adherence to migraine-specific medications (MSMs) influences migraine-related disability and patient satisfaction. Over three months, 337 participants used daily electronic diaries to track their migraine experiences, including the medications they took and their satisfaction with these treatments.

It was insightful to see that participants took their acute medications on a staggering 96.5% of the days they recorded migraines. Among the medications used, MSMs were the most common at 58%, followed by over-the-counter analgesics and opiates/barbiturates. We found that people tended to reach for medication when their pain was mild most often.

Our analysis showed that when individuals used MSMs during mild pain, they experienced the least daily disability and reported the highest satisfaction with their medications. This implies that using MSMs earlier, especially at the onset of milder symptoms, can significantly improve a patient's overall experience with migraines.

In conclusion, our study highlights the benefits of starting treatment with MSMs for better outcomes in managing migraine-related challenges and achieving greater satisfaction with acute medication usage.

7.5

Effective migraine relief

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My husband and I use it for migraines. This is one of the best brands, and the price is reasonable. We are enjoying it.

Pelvic Pain details

43 people found this helpful

MSM, a natural sulfur compound, is excellent for those with joint pain. It promotes cell renewal and improves digestion, cleansing the joints of excess calcium, thus alleviating discomfort. Since I started taking it alongside treatment for gonarthrosis, my pain has diminished significantly. I wholeheartedly recommend it!

Sleep Apnea details

Better sleep achieved

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Taking Doctor’s Best MSM morning and evening, I was pleasantly surprised by my improved sleep quality; I no longer wake up every two hours during the night. At over 70, the pain in my knees has ceased. Bravo to MSM!

Tendonitis details

1 people found this helpful

This product is superb! I have suffered from a shoulder tendon injury for the past two years, and plantar fasciitis for the past year. Six months of physiotherapy had minimal effect, preventing me from running last year due to heel pain. However, within three months of taking this MSM, both conditions have almost completely resolved. I am now running three times a week and participating in two Karate sessions without any shoulder or heel pain. The price of this product is incredible considering the amazing benefits it offers.

Leg Cramps details

Miraculous improvement

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8 people found this helpful

Miracle Remedy!!! I want to express my gratitude for such dietary supplements. I’m 33, my mother is 62, and this truly works. She experienced severe leg cramps, while I have knee pain and back issues. These capsules are miraculous as they relieve pain. I wish I had discovered this sooner. We will definitely continue taking them!

Swollen Lymph Nodes details

6 people found this helpful

After using this MSM product, I feel as though I've received a new knee! As a 35-year-old male with chondromalacia and meniscus damage, even walking was challenging. Taking 3g three times a day alongside vitamin C reduced over 95% of the swelling and pain. I was able to resume running pain-free in less than a month after starting this regimen. After years of treatments that didn’t work, it's miraculous to run again. This product is ideal for those who want effective doses with no unnecessary ingredients.

Asthma details

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Asthma medication boosts lung function

Mortimer KM, Neugebauer R, van der Laan M, Tager IB. An application of model-fitting procedures for marginal structural models. Am J Epidemiol. 2005;162:382.

We explored the effectiveness of asthma rescue medication on lung function through a thorough analysis of data collected during the Fresno Asthmatic Children's Environment Study from 2000 to 2002. Our research utilized a method known as inverse probability of treatment weighting (IPTW) to evaluate treatment effects in an observational study context. This approach helps us account for various confounding factors that might influence the outcomes we observe.

In our findings, traditional regression methods suggested that there was no significant association between medication use and improved lung function. This might seem surprising, as one would intuitively expect that asthma medication helps improve breathing. However, we believed that this outcome was likely influenced by confounders, such as asthma symptoms and severity, which can muddle the clear effects of medication.

When we applied our marginal structural model approach, we discovered a causal link between medication use and a 7% improvement in pulmonary function. This suggests that when we accounted for other influences adequately, asthma rescue medication does indeed have a positive impact, contrary to previous findings.

We hope that our discussion on the importance of proper model selection and fitting procedures encourages more researchers to consider these aspects seriously when evaluating treatment effects. By understanding the subtleties of our methodologies, we can better justify our conclusions in the realm of asthma treatment.

Reduced asthma reliance

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Its anti-inflammatory properties helped me with asthma; I realised I wasn’t using my asthma spray anymore. I also had ongoing neck pain, which has settled down. MSM comes highly recommended by Jason Hommel, who does "The Copper Revolution: Healing with Minerals".

Candidiasis details

Resolved discharge issue

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3 people found this helpful

My Best Friend. I have atopic dermatitis, and MSM helps significantly. My knees also stopped hurting when I walk a lot. The product works!!! I advised my friend, and she also purchased it. She experienced strong discharge due to candidiasis, but after ten days of taking MSM, everything improved. 👍

High Cholesterol details

3 people found this helpful

MSM supplements have significantly improved my life, especially regarding knee and lower back stiffness. After incorporating MSM into my daily life, I've experienced remarkable relief from knee discomfort and increased flexibility. The lack of taste makes it easy to include in my routine. If you are in search of a natural supplement to boost your knee health, I highly recommend MSM, as its positive impacts have truly enhanced my well-being.

Allergies details

SCIENTIFIC SCORE

Likely Very Effective

MSM offers allergy symptom relief

Hewlings S, Kalman DS. Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Res Protoc. 2018;7:e11139. doi:10.2196/11139

We aimed to understand how methylsulfonylmethane (MSM) impacts symptoms of allergic rhinitis through a well-structured randomized, double-blind study.

Participants, who were prone to allergic responses, were tested after taking varying doses of MSM following allergen exposure.

Interestingly, the results showed that MSM significantly eased nasal symptoms and improved airflow, making it a potential alternative to conventional allergy medications.

We’re excited by the findings, as MSM appeared effective without common side effects associated with typical treatments.

Effective relief

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5 people found this helpful

This product effectively soothes my skin allergies; I genuinely like it!

Blood Clot details

Skin elasticity enhancement

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2 people found this helpful

MSM is a vital trace mineral for the body, imperative for elastic skin and healthy hair. Sulfur is essential for blood clotting and aids in maintaining bile production for digestion. It also combats ageing by shielding the body from environmental effects. My skin has regained elasticity, and I’ve noted fewer breakouts since I began supplementing sulfur.

Brain Tumor details

Joint health improvement

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1 people found this helpful

It's beneficial without side effects, offering numerous advantages of sulfur, notably for joint health and enhancing the skin, hair, and breathing. Additionally, it aids in removing aluminium from the brain, potentially reducing Alzheimer's risk in the future. I will certainly repurchase this product.

Liver Disease details

Good for detoxification

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My mother suffers from bad knees and takes this daily. She asserts it's beneficial for her joints and additionally, it seems to detoxify her liver. I've noticed improvements in my skin as well.

Acne Rosacea details

Potent anti-inflammatory

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When combined with vitamin C, MSM becomes a powerful anti-inflammatory agent. It’s particularly beneficial for treating injuries and acne rosacea, offering significant relief.

Eczema details

Moisturising for eczema

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Excellent! It is moisturising and beneficial for eczema-prone skin. The price is reasonable, it tastes pleasant, and I feel refreshed after use.

Hair Loss details

SCIENTIFIC SCORE

Likely Very Effective

MSM shows promise for hair loss

Hummadi AA, Gany SN, Hadi NR. EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE. Wiad Lek. 2022;75:2744. doi:10.36740/WLek202211206

We explored the potential of Methylsulfonylmethane (MSM) as a treatment to minimize hair loss. In our study, we used twenty male Wister Albino mice, carefully dividing them into four groups to test different treatments: a control group with distilled water, a group treated with Minoxidil, one with MSM, and a group receiving a combination of MSM and Minoxidil.

Over the course of the study, we observed that the mice given MSM experienced notable improvements compared to the control group. Specifically, hair growth increased, and hair follicle numbers were significantly higher in the groups treated with MSM, whether alone or in combination with Minoxidil.

Additionally, we found a reduction in tissue levels of 8-isoprostane—a marker of oxidative stress—in the medicated groups, pointing to MSM’s antioxidant properties. There was also an increase in vascular endothelial growth factor, suggesting enhanced blood supply to the hair follicles.

Our overall conclusion is that MSM shows promise in reducing hair loss through its remarkable antioxidant and anti-inflammatory effects in male mice. This research indicates that MSM could be a valuable ally in the fight against hair loss.

7.5

Reduces postpartum hair loss

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28 people found this helpful

Posting a review from my husband's account. My husband originally bought this to help me get sulfur in my system to ward off mosquitoes, but little did I know this product is fantastic for hair and skin! After seven months postpartum, I was experiencing significant postpartum hair loss, losing handfuls of hair. Fortunately, that has completely slowed down, and my hair is already starting to regrow around the edges. Additionally, the stretch marks on my tummy have tightened a bit. I’ve been taking three a day for two weeks and am excited to continue.

Autoimmune Disorder details

KCNA2 autoimmunity diverse; immunotherapy beneficial

Arlt FA, Miske R, Machule ML, Broegger Christensen P, Mindorf S, et al. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain Behav Immun. 2024;117:399. doi:10.1016/j.bbi.2024.01.220

We analyzed data from 35 patients with KCNA2 IgG autoantibodies linked to various neuropsychiatric issues, including cognitive impairment and seizures. These autoantibodies were notably present in cerebrospinal fluid in some patients and showed different subclasses in serum.

Notably, four patients saw significant improvement with early immunotherapy, particularly those with autoimmune encephalitis. The findings suggest that KCNA2 autoimmunity is varied, indicating the need for more research to clarify its role and therapeutic approaches.

Alleviated discomfort

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2 people found this helpful

This supplement works wonders for joint discomfort. I bought it for my mum after her minor osteoarthritis diagnosis, and now she no longer feels discomfort in her knees. I’ve since ordered a stronger version, 1500 mg, which continues to prove effective.

Osteoporosis details

MSM enhances bone cell differentiation

Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. doi:10.3892/mmr.2016.5274

We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.

Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.

Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.

Joint health support

Most Useful Review

Great product for joint health and osteoporosis support.