Last update
4/11/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
8
We analyzed data from two clinical trials involving 579 individuals with Irritable Bowel Syndrome (IBS) to determine how CNCM I-3856 affects symptoms like bloating.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Read More
7
We examined how sourdough baked goods affect bloating and other gastrointestinal symptoms in healthy adults. Using a double-blind, randomized crossover method, we served participants either sourdough or brewer's yeast croissants and monitored gastric emptying and hydrogen production.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
Read More
7
Yeast treatment shows mixed results
We investigated the effects of EpiCor fermentate on gastrointestinal discomfort and constipation, focusing on bloating. In a randomized double-blind trial, eighty participants tracked their symptoms over six weeks, comparing a yeast-based treatment to a placebo. While the results showed that EpiCor could positively influence gut microbiome composition and improve constipation symptoms, there was no significant direct benefit reported for bloating relief. So, while EpiCor can help with certain bowel issues, its effectiveness may not extend to all gastrointestinal discomforts.
Read More
Most Useful Reviews
10
Bloating eliminated
I like this drug. I took it during a body cleansing protocol, and the effect was good. The bloating of my intestines has gone, and I appreciate this manufacturer.
Read More
10
Bloating relief
The drug worked well for me; the swelling and bloating disappeared. I took it alongside homeopathy.
Read More
9
Reduced swelling
Great! I used it in a liver detoxification regimen. The product worked remarkably well; both swelling and bloating disappeared, and it had a positive effect on my skin. I took it alongside homeopathy.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
- All Researches
8
We analyzed data from two clinical trials involving 579 individuals with Irritable Bowel Syndrome (IBS) to determine how CNCM I-3856 affects symptoms like bloating.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Read More
8
We analyzed the effectiveness of sacrosidase from Saccharomyces cerevisiae in reducing gastrointestinal symptoms, including bloating, in children with congenital sucrase-isomaltase deficiency (CSID).
In a randomized, double-blind trial involving 28 children, results indicated that sacrosidase effectively minimized diarrhea, abdominal cramps, gas, and bloating, particularly when consumed alongside a regular diet.
By measuring symptoms and daily stool counts over several phases, we found sacrosidase to be a safe and effective option for managing CSID symptoms.
In a randomized, double-blind trial involving 28 children, results indicated that sacrosidase effectively minimized diarrhea, abdominal cramps, gas, and bloating, particularly when consumed alongside a regular diet.
By measuring symptoms and daily stool counts over several phases, we found sacrosidase to be a safe and effective option for managing CSID symptoms.
Read More
7
We examined how sourdough baked goods affect bloating and other gastrointestinal symptoms in healthy adults. Using a double-blind, randomized crossover method, we served participants either sourdough or brewer's yeast croissants and monitored gastric emptying and hydrogen production.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
Read More
7
Yeast treatment shows mixed results
We investigated the effects of EpiCor fermentate on gastrointestinal discomfort and constipation, focusing on bloating. In a randomized double-blind trial, eighty participants tracked their symptoms over six weeks, comparing a yeast-based treatment to a placebo. While the results showed that EpiCor could positively influence gut microbiome composition and improve constipation symptoms, there was no significant direct benefit reported for bloating relief. So, while EpiCor can help with certain bowel issues, its effectiveness may not extend to all gastrointestinal discomforts.
Read More
7
Saccharomyces cerevisiae shows potential
We conducted a randomized, double-blind, placebo-controlled trial with 379 individuals diagnosed with irritable bowel syndrome (IBS) to investigate the effects of Saccharomyces cerevisiae (S. cerevisiae) on bloating and other symptoms.
Although the overall results showed no significant improvement in intestinal pain or discomfort for all IBS patients, we observed promising results in those with constipation. This subgroup experienced notable relief from bloating and abdominal pain, highlighting the need for further research in this area.
Although the overall results showed no significant improvement in intestinal pain or discomfort for all IBS patients, we observed promising results in those with constipation. This subgroup experienced notable relief from bloating and abdominal pain, highlighting the need for further research in this area.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Bloating eliminated
I like this drug. I took it during a body cleansing protocol, and the effect was good. The bloating of my intestines has gone, and I appreciate this manufacturer.
Read More
10
Bloating relief
The drug worked well for me; the swelling and bloating disappeared. I took it alongside homeopathy.
Read More
9
Reduced swelling
Great! I used it in a liver detoxification regimen. The product worked remarkably well; both swelling and bloating disappeared, and it had a positive effect on my skin. I took it alongside homeopathy.
Read More
9
Pain relief
Excellent! A nutritionist recommended it, and I am very pleased. The pain and bloating have vanished; it truly aids in restoring my gastrointestinal tract.
Read More
0
Severe bloating
This product was not for me. I tried it for a month. Bloating started within 3-4 days, and despite continuing to take it, I felt severe bloating with no improvement. The smell was appalling, leading me to discard over 100 capsules. I cannot recommend this product.
Read More
Frequently Asked Questions
0
Severe bloating
This product was not for me. I tried it for a month. Bloating started within 3-4 days, and despite continuing to take it, I felt severe bloating with no improvement. The smell was appalling, leading me to discard over 100 capsules. I cannot recommend this product.
9
Reduced swelling
Great! I used it in a liver detoxification regimen. The product worked remarkably well; both swelling and bloating disappeared, and it had a positive effect on my skin. I took it alongside homeopathy.
2
No effect
I tried this product thoroughly, finishing the whole jar, but there was no effect. Enterosgel worked best for me (in gel form), as it made me feel better immediately, resolving my bloating and stomach pain.
7.5
Improved well-being
Keep eating, and you will feel better! Due to my job requiring overtime, taking NAC with protein enzymes has become my daily morning ritual. It aids my overall well-being and significantly improves my long-standing bloating issue!
7
We examined how sourdough baked goods affect bloating and other gastrointestinal symptoms in healthy adults. Using a double-blind, randomized crossover method, we served participants either sourdough or brewer's yeast croissants and monitored gastric emptying and hydrogen production.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
The results suggested that sourdough may promote better gastrointestinal function and be more tolerable compared to brewer's yeast products. This indicates that switching to sourdough could alleviate some post-meal discomfort, including bloating.
7
Saccharomyces cerevisiae shows potential
We conducted a randomized, double-blind, placebo-controlled trial with 379 individuals diagnosed with irritable bowel syndrome (IBS) to investigate the effects of Saccharomyces cerevisiae (S. cerevisiae) on bloating and other symptoms.
Although the overall results showed no significant improvement in intestinal pain or discomfort for all IBS patients, we observed promising results in those with constipation. This subgroup experienced notable relief from bloating and abdominal pain, highlighting the need for further research in this area.
Although the overall results showed no significant improvement in intestinal pain or discomfort for all IBS patients, we observed promising results in those with constipation. This subgroup experienced notable relief from bloating and abdominal pain, highlighting the need for further research in this area.
7
Yeast treatment shows mixed results
We investigated the effects of EpiCor fermentate on gastrointestinal discomfort and constipation, focusing on bloating. In a randomized double-blind trial, eighty participants tracked their symptoms over six weeks, comparing a yeast-based treatment to a placebo. While the results showed that EpiCor could positively influence gut microbiome composition and improve constipation symptoms, there was no significant direct benefit reported for bloating relief. So, while EpiCor can help with certain bowel issues, its effectiveness may not extend to all gastrointestinal discomforts.
7
We examined the effects of Saccharomyces cerevisiae on bloating in adults with irritable bowel syndrome. In a randomized double-blind study, 179 participants took either 500 mg of the yeast or a placebo for eight weeks.
While Saccharomyces cerevisiae significantly reduced abdominal pain, it showed only a slight non-significant trend in helping with bloating. Overall, participants tolerated the treatment well.
Therefore, while promising for abdominal pain, its impact on bloating remains unclear.
While Saccharomyces cerevisiae significantly reduced abdominal pain, it showed only a slight non-significant trend in helping with bloating. Overall, participants tolerated the treatment well.
Therefore, while promising for abdominal pain, its impact on bloating remains unclear.
References
- Polese B, Nicolai E, Genovese D, Verlezza V, La Sala CN, et al. Postprandial Gastrointestinal Function Differs after Acute Administration of Sourdough Compared with Brewer's Yeast Bakery Products in Healthy Adults. J Nutr. 2018;148:202. 10.1093/jn/nxx049
- Pinheiro I, Robinson L, Verhelst A, Marzorati M, Winkens B, et al. A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med. 2017;17:441. 10.1186/s12906-017-1948-0
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. 10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. 10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. 10.1016/j.dld.2014.11.007
- Moya D, Calsamiglia S, Ferret A, Blanch M, Fandiño JI, et al. Effects of dietary changes and yeast culture (Saccharomyces cerevisiae) on rumen microbial fermentation of Holstein heifers. J Anim Sci. 2009;87:2874. 10.2527/jas.2008-1446
- Treem WR, McAdams L, Stanford L, Kastoff G, Justinich C, et al. Sacrosidase therapy for congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 1999;28:137. PubMed
