Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 31 Researches
8.2
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
8
Hydrothermal yeast impacts breast cancer
We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
Read More
8
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
Read More
Most Useful Reviews
10
Cancer prevention
17 people found this helpful
Great product! I had stage 4 cancer, and this supplement is essential for helping me stay cancer-free!
Read More
9
Supports recovery efforts
13 people found this helpful
Great stuff. I trust Doctor's Best products and their pricing. Following my recovery from cancer a year and a half ago, my healthcare guru recommended this supplement. She has researched extensively and believes it’s superior to taking glutathione alone, which I now take alongside it.
Read More
9
High-quality supplement
2 people found this helpful
Essential NAC is a powerful antioxidant and detoxifier, neutralising free radicals and eliminating heavy metals like mercury and lead. Its promotion of glutathione synthesis demonstrates both anti-mutagenic and anti-cancer properties. The ingredient quality is high, particularly with the addition of molybdenum, making this supplement very effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 31 Researches
8.2
- All Researches
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
9.5
We investigated the impact of selenium nanoparticles (SeNPs) on enhancing treatment for advanced non-small-cell lung cancer (NSCLC). Our research revealed that selenium deficiency is linked to immune dysfunction in patients, contributing to cancer progression. In experiments with mice, low selenium led to weakened immunity and faster tumor growth.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Read More
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
Read More
9
We synthesized thirty selenium-containing coumarin derivatives and tested their effectiveness against various malignant tumor cell lines. Notably, one compound, referred to as 11i, showed remarkable potency against SK-N-SH neuroblastoma cells, with a low inhibitory concentration of just 2.5 μM.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
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User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cancer prevention
17 people found this helpful
Great product! I had stage 4 cancer, and this supplement is essential for helping me stay cancer-free!
Read More
9
Supports recovery efforts
13 people found this helpful
Great stuff. I trust Doctor's Best products and their pricing. Following my recovery from cancer a year and a half ago, my healthcare guru recommended this supplement. She has researched extensively and believes it’s superior to taking glutathione alone, which I now take alongside it.
Read More
9
High-quality supplement
2 people found this helpful
Essential NAC is a powerful antioxidant and detoxifier, neutralising free radicals and eliminating heavy metals like mercury and lead. Its promotion of glutathione synthesis demonstrates both anti-mutagenic and anti-cancer properties. The ingredient quality is high, particularly with the addition of molybdenum, making this supplement very effective.
Read More
6
Improves fertility
133 people found this helpful
I ordered N-acetyl cysteine several times as it significantly boosts intracellular glutathione, the main antioxidant for fertility and PCOS. Glutathione reduces oxidative stress and protects ovarian cells from damage. It is vital for both male and female fertility, enhancing sperm health and the quality of oocytes, leading to healthier embryos. Studies indicate that glutathione deficiency is linked to premature ovarian ageing and ovarian cancer. Women undergoing IVF have shown improved pregnancy rates with higher glutathione levels. It’s crucial for women with PCOS to improve egg quality and overall chances of conception, as it supports regular ovulation.
Read More
7.5
Endometriosis management
1 people found this helpful
This product helps me as an endometriosis sufferer. My cancer marker decreased after taking it for over six months. However, NAC has been low in supply, and I'm concerned it might not be available in the future.
Read More
Frequently Asked Questions
7.5
Endometriosis management
1 people found this helpful
This product helps me as an endometriosis sufferer. My cancer marker decreased after taking it for over six months. However, NAC has been low in supply, and I'm concerned it might not be available in the future.
6
Post-cancer recovery
8 people found this helpful
After my surgery for early-stage breast cancer, I sought NAC for its antioxidant properties to prevent recurrence. I take one tablet before bed and another on an empty stomach upon waking, coupled with time-release vitamin C. Since starting this regimen, I've improved my sleep quality, and I notice enhanced skin clarity. It's reassuring that it contains molybdenum, and I believe the quality justifies the price.
6
No recurrence noted
I bought this for my husband following his cancer treatment. Although I'm unsure if it truly helped, it's been a year since he had any recurrence.
6
Improves fertility
133 people found this helpful
I ordered N-acetyl cysteine several times as it significantly boosts intracellular glutathione, the main antioxidant for fertility and PCOS. Glutathione reduces oxidative stress and protects ovarian cells from damage. It is vital for both male and female fertility, enhancing sperm health and the quality of oocytes, leading to healthier embryos. Studies indicate that glutathione deficiency is linked to premature ovarian ageing and ovarian cancer. Women undergoing IVF have shown improved pregnancy rates with higher glutathione levels. It’s crucial for women with PCOS to improve egg quality and overall chances of conception, as it supports regular ovulation.
9
High-quality supplement
2 people found this helpful
Essential NAC is a powerful antioxidant and detoxifier, neutralising free radicals and eliminating heavy metals like mercury and lead. Its promotion of glutathione synthesis demonstrates both anti-mutagenic and anti-cancer properties. The ingredient quality is high, particularly with the addition of molybdenum, making this supplement very effective.
4
Essential supplement
47 people found this helpful
Very great! This is an essential supplement to keep in stock! I learned from a Spanish medical team that NAC stimulates glutathione production and detoxifies harmful substances, reducing blood clot risk. Spanish researchers claim NAC is more effective than glutathione for absorption, which makes it highly sought-after. I aim to stock it before it becomes classified as a drug by the FDA. The combination of molybdenum and selenium seems to have anti-cancer effects, and I encourage friends to purchase it for detoxification. Its price for 180 tablets is excellent.
7.5
Enhanced recovery noted
I regularly purchase NAC 600, which is N-acetyl-L-cysteine derived from L-cysteine. It acts as a powerful antioxidant, protecting cells from free radicals and slowing premature ageing. It's a preventive agent against cancer and aids in relieving fatigue while accelerating muscle recovery after exercise. NAC also helps dilute phlegm, and combined with selenium and molybdenum, it detoxifies the body, thereby improving quality of life. This supplement is essential for promoting swift recovery during illness and the recovery period afterwards. It's one I would recommend taking continuously.
7.5
Prostate cancer prevention
Must-have dietary supplements for everyone at a great price! This excellent dietary supplement has numerous benefits, including antioxidant effects and potentially lowering DHT to prevent prostate cancer. I definitely recommend it, with an optimal dosage of two capsules daily, but three may yield better results.
8
We explored a new treatment mechanism using a formulation called LYTAC that employs glyco-engineered yeast-derived glycans for targeting cancer cells. This method taps into the body’s natural lysosomal degradation system to remove a protein linked to tumors.
In our study, LYTAC demonstrated the ability to effectively degrade the PD-L1 protein, which is known to inhibit T cell activity against cancer. Not only did it show greater effectiveness compared to traditional treatments, but it also highlights an innovative approach that could play a vital role in advancing cancer therapies.
In our study, LYTAC demonstrated the ability to effectively degrade the PD-L1 protein, which is known to inhibit T cell activity against cancer. Not only did it show greater effectiveness compared to traditional treatments, but it also highlights an innovative approach that could play a vital role in advancing cancer therapies.
8
Hydrothermal yeast impacts breast cancer
We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
9.5
We investigated the impact of selenium nanoparticles (SeNPs) on enhancing treatment for advanced non-small-cell lung cancer (NSCLC). Our research revealed that selenium deficiency is linked to immune dysfunction in patients, contributing to cancer progression. In experiments with mice, low selenium led to weakened immunity and faster tumor growth.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
References
- Kim S, Kang J, An D, Seo J, Oh DB. Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast. Bioconjug Chem. 2025;36:424. 10.1021/acs.bioconjchem.4c00512
- Kitagawa T. Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall. PLoS One. 2025;20:e0313379. 10.1371/journal.pone.0313379
- Wu J, Ji K, Kang G, Zhang M, Wang J, et al. Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis. Pharmacol Res. 2025;213:107642. 10.1016/j.phrs.2025.107642
- Jia D, Chen S. Yeast paves the way for cancer immunotherapy. Cell Chem Biol. 2025;32:9. 10.1016/j.chembiol.2024.12.011
- Li X, Rui W, Shu P, Sun Y, Yang J. Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice. Probiotics Antimicrob Proteins. 2025. 10.1007/s12602-025-10500-x
- Raman S, Kasirajan S, Chinnapandi B, Karthikeyan K, Pandian A, et al. Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health. Luminescence. 2025;40:e70101. 10.1002/bio.70101
- Janakiram NB, Mohammed A, Ravillah D, Choi CI, Zhang Y, et al. [Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats. Oncol Rep. 2025;53. 10.3892/or.2025.8877
- Varlamova EG. Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer. J Trace Elem Med Biol. 2025;88:127620. 10.1016/j.jtemb.2025.127620
- Qin X, Guo J, Li H, He H, Cai F, et al. Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy. Adv Sci (Weinh). 2025. 10.1002/advs.202412062
- Yu YH, Kouame KJE, Liu X, Yu X, Jin MY, et al. Preparation, characterization, and induced human colon cancer HCT-116 and HT-29 cell apoptosis performance of selenium nanoparticles stabilized by longan polysaccharides. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.140719
- Yassein AS, Elamary RB, Alwaleed EA. Biogenesis, characterization, and applications of Spirulina selenium nanoparticles. Microb Cell Fact. 2025;24:39. 10.1186/s12934-025-02656-6
- Guo K, Yang X, Wang J, Chang W, Liu S, et al. Synthesis and Bioactivity of Selenium Nanoparticles From Tussilago farfara L. Polysaccharides: Antioxidant Properties and MCF-7 Cell Inhibition. Chem Biodivers. 2025. 10.1002/cbdv.202402677
- Wang M, Xu H, Xiong X, Chang L, Zhang K, et al. Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights. Eur J Med Chem. 2025;286:117322. 10.1016/j.ejmech.2025.117322
- Zakharia Y, Reis RJ, Kroll MR, Rataan AO, Manchkanti S, et al. Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2025. 10.1158/1078-0432.CCR-24-3234
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. 10.1016/j.biomaterials.2025.123117
- Ban B, Yang H, Liu Y, Luo Z. Se-methylselenocysteine Inhibits Migration and Glycolysis in Anaplastic Thyroid Carcinoma Cells via the ERK1/2 Signaling Pathway . Ann Clin Lab Sci. 2024;54:810.
- He L, Zhang L, Peng Y, He Z. Selenium in cancer management: exploring the therapeutic potential. Front Oncol. 2024;14:1490740. 10.3389/fonc.2024.1490740
- Rataan AO, Xu Y, Geary SM, Zakharia Y, Kamel ES, et al. Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential. Cancer Treat Res Commun. 2024;42:100864. 10.1016/j.ctarc.2025.100864
- Ashraf R, Khalid Z, Qin QP, Iqbal MA, Taskin-Tok T, et al. Synthesis of N-heterocyclic carbene‑selenium complexes modulating apoptosis and autophagy in cancer cells: Probing the interactions with biomolecules and enzymes. Bioorg Chem. 2025;160:108435. 10.1016/j.bioorg.2025.108435
- Wei K, Yin X, Chen F, Wang X, Ding W, et al. Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.142791
- Hosseinzadeh Ranjbar M, Einafshar E, Javid H, Jafari N, Sajjadi SS, et al. Enhancing the anticancer effects of rosmarinic acid in PC3 and LNCaP prostate cancer cells using titanium oxide and selenium-doped graphene oxide nanoparticles. Sci Rep. 2025;15:11568. 10.1038/s41598-025-96707-y
- Doostan M, Rahmani Azar A, Maleki H. Selenium nanoparticles and paclitaxel co-delivery by a PCL based nanofibrous scaffold to enhance melanoma therapy. J Biomater Appl. 2025. 10.1177/08853282251330724
- Çiğ B. Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1. Front Pharmacol. 2025;16:1549190. 10.3389/fphar.2025.1549190
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. 10.1016/j.ijbiomac.2025.142352
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. 10.4149/gpb_2024046
- Yu Y, Xie B, Wang J, Luo W, Yang M, et al. Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation. Adv Mater. 2025. 10.1002/adma.202415818
- Wang Y, Du Z, Du H, Zhao J, Duan Y, et al. Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study. Chin Clin Oncol. 2025;14:2. 10.21037/cco-24-83
- Szwiec M, Tomiczek-Szwiec J, Marciniak W, Derkacz R, Huzarski T, et al. The Effect of Blood Selenium Level on the pCR Rate in Breast Cancer Patient Receiving Neoadjuvant Chemotherapy. Cancers (Basel). 2025;17. 10.3390/cancers17050839
- Wen X, Zhou Q, Lin S, Mai H, Zhang L. Selenium-modified hydroxyapatite titanium coating: enhancing osteogenesis and inhibiting cancer in bone invasion by head and neck squamous cell carcinoma. Front Bioeng Biotechnol. 2025;13:1552661. 10.3389/fbioe.2025.1552661
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. 10.3389/fimmu.2025.1530174
- Sun K, Ma L, Hou J, Li Y, Jiang H, et al. Physalis peruviana heteropolysaccharide-conjugated selenium nanoparticles: Preparation, characterization, and promising applications in cancer therapy. Int J Biol Macromol. 2025;306:141639. 10.1016/j.ijbiomac.2025.141639
