We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
Read More
7
Elderberry juice boosts immunity
Anti-influenza virus effects of elderberry juice and its fractions.
We evaluated the effectiveness of elderberry juice, specifically concentrated juice (CJ-E), in combating the human influenza A virus (IFV). Our experiments involved administering CJ-E to mice infected with IFV to observe any potential antiviral effects. While we found that CJ-E had a strong impact on the mice, its antiviral action was less impressive when tested in a controlled cell culture environment.
To further assess its effects, we separated CJ-E into different fractions using ultrafiltration and anion-exchange chromatography. We concentrated on the high-molecular-weight fractions of CJ-E, which appeared to significantly suppress viral replication in the mice's bronchoalveolar lavage fluids (BALFs). Moreover, these fractions seemed to boost the production of IFV-specific neutralizing antibodies in the serum, along with increasing secretory IgA levels in BALFs and feces.
Particularly, one fraction, Fr. II from the high-molecular-weight group, which contained acidic polysaccharides, showed notable strength in defending against the flu infection. In conclusion, our findings suggest that CJ-E can stimulate the immune response and may play a preventative role against the influenza virus infection.
Read More
Most Useful Reviews
7.5
Protected from flu
9 people found this helpful
I absolutely love these! They have no taste, are easy to swallow, and help keep my husband and me healthy. All five of my kids had the stomach flu this winter. Despite being around them while they were unwell, my husband and I started taking the elderberry three times a day and felt better. Amazingly, we never got sick!
Read More
9
Fast flu recovery
2 people found this helpful
We swear by elderberry in our home; it's proven effective for us in preventing and speeding up flu recovery. When I caught the flu, I was back to normal in less than a week. My two-year-old daughter had no symptoms for more than one day after using the gummies. We've tried various brands, but we always come back to these capsules for adults; they're easier to swallow and offer more doses for a better price. We'll continue buying from this brand!
Read More
7.5
Alleviates flu symptoms
1 people found this helpful
I chose this black elderberry product after reviewing many options. My holistic doctor recommended it for its effectiveness in combating viruses. Given the current fears regarding the coronavirus, I've been taking one daily to maintain my health. With various viruses and flus circulating, these seem to help alleviate symptoms and reduce recovery time. Highly recommend!
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
Read More
9
Elderberry shows promise for flu relief
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.
We assessed the effectiveness of black elderberry (Sambucus nigra) in treating upper respiratory symptoms, particularly those associated with the flu. The study included 180 participants and examined various factors, such as vaccination status and the underlying causes of symptoms.
Our findings indicated that elderberry supplementation significantly reduced upper respiratory symptoms, offering a promising alternative for those seeking relief without relying on over-the-counter medications or antibiotics. The analysis revealed a strong positive impact, suggesting that elderberry could be particularly beneficial for treating symptoms arising from viral infections.
Overall, this research indicates that elderberry can serve as a safer, effective option for managing flu symptoms and common colds. This could help address concerns about antibiotic misuse and provide a more natural remedy during flu season.
Read More
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry shows limited flu benefits
Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?
We examined how elderberry might impact flu treatment based on several studies. From 1995 to 2013, three clinical trials looked specifically at different elderberry preparations, and all concluded that elderberry could be effective against influenza. However, it's important to note that these studies involved only 77 people, which is quite small for drawing definitive conclusions.
While the potential for elderberry's effectiveness seems promising, the limited sample size means we should be cautious in making broad claims about its benefits. There were no human or animal studies mentioned that specifically researched the safety of elderberry during pregnancy, presenting a gap in knowledge that is concerning for pregnant women considering herbal treatments for flu.
Overall, while elderberry appears effective against the flu based on the small trials, we need much more comprehensive research to better understand its efficacy and safety, particularly for vulnerable populations like pregnant women.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
I absolutely love these! They have no taste, are easy to swallow, and help keep my husband and me healthy. All five of my kids had the stomach flu this winter. Despite being around them while they were unwell, my husband and I started taking the elderberry three times a day and felt better. Amazingly, we never got sick!
Read More
9
Fast flu recovery
2 people found this helpful
We swear by elderberry in our home; it's proven effective for us in preventing and speeding up flu recovery. When I caught the flu, I was back to normal in less than a week. My two-year-old daughter had no symptoms for more than one day after using the gummies. We've tried various brands, but we always come back to these capsules for adults; they're easier to swallow and offer more doses for a better price. We'll continue buying from this brand!
Read More
7.5
Alleviates flu symptoms
1 people found this helpful
I chose this black elderberry product after reviewing many options. My holistic doctor recommended it for its effectiveness in combating viruses. Given the current fears regarding the coronavirus, I've been taking one daily to maintain my health. With various viruses and flus circulating, these seem to help alleviate symptoms and reduce recovery time. Highly recommend!
Read More
9
Prevents winter flu
I haven't caught a cold since using this. I purchased it to prevent the winter flu and colds. Since I started taking it, I've remained well. It's highly concentrated and offers good value for money. I'll buy it again.
Read More
9
No more colds
The best! I haven't caught a cold or the flu since I started taking these supplements.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Sambucus elderberry is often touted as a natural remedy for flu and cold symptoms. Some studies suggest that elderberry extract may help reduce the duration and severity of flu symptoms by enhancing immune response and inhibiting the replication of certain strains of the influenza virus. The compounds in elderberry, such as flavonoids and phenolic acids, are believed to have anti-inflammatory and antioxidant properties, which can support your immune system during bouts of illness.
However, while elderberry may offer some benefits, it should not be relied upon as a substitute for medical treatment or preventive measures such as vaccinations. It's essential to consult with a healthcare professional for appropriate advice, particularly for managing flu symptoms or for individuals with underlying health conditions. Always choose a high-quality elderberry product and follow the recommended dosages for safety and efficacy.
Based on user reviews, the time it takes to see results from taking this elderberry supplement for flu varies among individuals. Some users report an immediate boost in their immune response when taking the supplement at the first sign of a cold or flu. For instance, one reviewer mentions that they experience quicker recoveries from illnesses when starting the supplement early Read Review. Other users indicate that consistent use over a period of about two weeks can lead to noticeable improvements, with one user specifically stating they began recovering from symptoms two weeks after starting the supplement Read Review.
Overall, while some users may notice immediate benefits, others suggest that maintaining a regular intake during the flu season might provide the best defense against illness. Several reviews emphasize the importance of using it proactively to lessen the chances of getting sick, indicating the supplement is most effective when taken consistently rather than reactively Read Review.
Scientific research has indicated that elderberry, particularly the European black elderberry, may offer some supportive benefits for combating influenza. Studies highlight that elderberry extracts can enhance immune responses, such as boosting dendritic cells and T cell activity, which play crucial roles in responding to viral infections like the flu [1]. Moreover, systematic reviews suggest that while the evidence is not definitive, elderberry may reduce the duration and severity of flu symptoms, with some studies hinting at its effectiveness when compared to conventional antiviral treatments like oseltamivir [2].
Further investigations have revealed that elderberry can exhibit significant antiviral properties against various strains of the flu virus, including H1N1. Research shows that elderberry juice can inhibit viral replication and stimulate immune responses [6][8]. However, it's important to note that the overall conclusions from these studies remain somewhat inconclusive, and many recommend further research to solidify elderberry's effectiveness against flu. Ultimately, while elderberry appears to be a promising natural option for flu support, consumers should approach its use with cautious optimism and an understanding of the ongoing research in this area.
Users have reported several notable improvements in symptoms after incorporating this elderberry supplement into their wellness routines. Many have shared their positive experiences, indicating that consistent use has helped them avoid colds and flu altogether. For instance, one user mentioned, "I haven’t caught a cold since using this," emphasizing its preventive benefits Read Review. Similarly, another reviewer declared, "I haven’t caught a cold or the flu since I started taking these supplements," illustrating the supplement's effectiveness in keeping illness at bay Read Review.
In terms of symptomatic relief, users report quicker recoveries when the supplement is taken at the first sign of illness. For example, a reviewer mentioned that starting the supplement led to quicker recoveries from symptoms Read Review. Another user highlighted a dramatic reduction in the duration of their flu, asserting that it "helps prevent illness and dramatically reduces how long the flu lasts" Read Review. Overall, while individual results can vary, the general consensus is that this elderberry supplement has achieved significant positive effects in user experiences, particularly in immune support and flu prevention.
Users report positive experiences when combining this elderberry supplement with other supplements, particularly Vitamin C. One user highlighted that their husband took the elderberry alongside Vitamin C and managed to remain well despite the rest of the family catching the flu Read Review. This indicates a potentially beneficial synergy between elderberry and Vitamin C in supporting immune health during flu season.
Additionally, many users attest to using elderberry as a part of their larger wellness routine, especially at the first sign of illness, which can maximize its effectiveness. For instance, one user reported taking the supplement at the first symptoms of a cold, leading to quicker recoveries Read Review. The collective testimonials suggest that while elderberry can be effective on its own, its role may be enhanced when taken with complementary supplements, reinforcing overall immune support and potentially aiding in flu prevention and recovery.
The optimal dose of elderberry (Sambucus nigra) for treating flu symptoms appears to be around 40 to 80 μg/mL. Research indicates that within this concentration range, elderberry extract significantly reduces viral activity and helps improve the immune response against influenza. Specifically, the polysaccharides in the elderberry extracts enhance dendritic cell maturation, subsequently supporting T cell stimulation, which is vital in fighting off viral infections like influenza [1].
Furthermore, a systematic review highlighted elderberry's potential to shorten the duration of flu symptoms, although the certainty of these benefits varies across studies [2]. While lower doses may not effectively inhibit viral replication, higher concentrations have demonstrated notable antiviral properties, suggesting that dosing is key to maximizing elderberry’s efficacy against the flu [4]. Although the current evidence supports elderberry's use as a natural remedy for flu symptoms, further research is needed to solidify the recommended dosage and confirm its overall effectiveness.
7.5
Quick flu relief
I always take this supplement at the first sign of a cold or flu, resulting in quicker recovery from illnesses.
7.5
Effective herbal remedy
I have avoided medications for colds and flu after my friend introduced these natural herbal capsules. After using them for two weeks, I started recovering from symptoms. I highly recommend elderberry in winter to keep colds and flu at bay.
7.5
Reduces flu impact
The whole family takes Elderberry to lessen the chances of catching the flu. It works very well and tastes nice.
9
Prevents winter flu
I haven't caught a cold since using this. I purchased it to prevent the winter flu and colds. Since I started taking it, I've remained well. It's highly concentrated and offers good value for money. I'll buy it again.
9
No more colds
The best! I haven't caught a cold or the flu since I started taking these supplements.
7.5
Reduces flu duration
I got this for the upcoming cold and flu season. It helps prevent illness and dramatically reduces how long the flu lasts.
9
Effective supplement
I bought this after learning that elderberry boosts the immune system. Our family caught the flu recently, but my husband took this supplement with Vitamin C, and it helped him remain well. It's great quality, effective, easy to swallow, and tastes pleasant.
9
Elderberry enhances immune response
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
5
Elderberry’s uncertain flu benefits
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
We explored the effectiveness of elderberry in treating and potentially preventing flu-related illness. This involved a systematic review of five randomized trials, which helped us examine whether elderberry could play a beneficial role in combatting viruses like the flu.
The findings suggest that while elderberry might not lower the risk of catching the common cold, it could potentially reduce the duration and severity of cold symptoms. We learned that elderberry may also shorten the duration of influenza, but the certainty of these benefits is still uncertain.
Interestingly, when comparing elderberry to oseltamivir, a common antiviral medication, elderberry appeared linked to a lower risk of influenza complications and side effects. However, we found no substantial evidence connecting elderberry to significant inflammatory outcomes. Some studies hinted that elderberry might influence certain inflammatory markers, but this effect may lessen with prolonged use.
Overall, we did not find strong, clear-cut benefits from elderberry in treating flu, stressing the need for more research to confirm these findings. Though it seems to be a safe option without overstimulating the immune system, the evidence remains inconclusive, and more studies are essential to draw firmer conclusions.
7
Elderberry juice boosts immunity
Anti-influenza virus effects of elderberry juice and its fractions.
We evaluated the effectiveness of elderberry juice, specifically concentrated juice (CJ-E), in combating the human influenza A virus (IFV). Our experiments involved administering CJ-E to mice infected with IFV to observe any potential antiviral effects. While we found that CJ-E had a strong impact on the mice, its antiviral action was less impressive when tested in a controlled cell culture environment.
To further assess its effects, we separated CJ-E into different fractions using ultrafiltration and anion-exchange chromatography. We concentrated on the high-molecular-weight fractions of CJ-E, which appeared to significantly suppress viral replication in the mice's bronchoalveolar lavage fluids (BALFs). Moreover, these fractions seemed to boost the production of IFV-specific neutralizing antibodies in the serum, along with increasing secretory IgA levels in BALFs and feces.
Particularly, one fraction, Fr. II from the high-molecular-weight group, which contained acidic polysaccharides, showed notable strength in defending against the flu infection. In conclusion, our findings suggest that CJ-E can stimulate the immune response and may play a preventative role against the influenza virus infection.
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
7
Elderberry's variable effectiveness against influenza
Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By .
We investigated the effects of elderberry fruit on flu viruses, specifically how it interacts with the H9N2 influenza strain in human epithelial cell cultures. Our approach involved treating the virus and cells with various concentrations of elderberry extract before and after infection to see its influence on virus replication.
During our experiments, we noticed that at lower doses of elderberry extract, the viral activity actually increased. This indicated that the herb didn’t stop the virus from replicating. However, when we applied higher concentrations—specifically 40 and 80 μg/mL—we observed a significant reduction in both the amount of virus present and the production of viral proteins. This suggests elderberry may interfere with how viruses enter cells or how they release from them.
Importantly, the results hint that elderberry's effectiveness might stem from its interaction with lipid rafts in cell membranes. These rafts are crucial for the viruses' fusion and budding processes. Our findings underscore the importance of dosage and timing when using elderberry for treating influenza, highlighting the complexity of herbal treatments.
References
Stich L, Plattner S, McDougall G, Austin C, Steinkasserer A. Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses. Int J Mol Sci. 2022;23. 10.3390/ijms23073949
Wieland LS, Piechotta V, Feinberg T, Ludeman E, Hutton B, et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complement Med Ther. 2021;21:112. 10.1186/s12906-021-03283-5
Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361. 10.1016/j.ctim.2018.12.004
Shahsavandi S, Ebrahimi MM, Hasaninejad Farahani A. Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By . Iran J Pharm Res. 2017;16:1147.
Holst L, Havnen GC, Nordeng H. Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?. Front Pharmacol. 2014;5:31. 10.3389/fphar.2014.00031
Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata A. Anti-influenza virus effects of elderberry juice and its fractions. Biosci Biotechnol Biochem. 2012;76:1633.
Krawitz C, Mraheil MA, Stein M, Imirzalioglu C, Domann E, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011;11:16. 10.1186/1472-6882-11-16
Roschek B, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70:1255. 10.1016/j.phytochem.2009.06.003