We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
Most Useful Reviews
9
Stops flu outbreaks
This product has significantly helped curb the constant bouts of flu in our household. Everyone feels fantastic, and even our nails look great! It's a perfect size and offers excellent value for money. Plus, it tastes lovely.
Read More
9
Boosts immune system
Black elderberry is a top product for enhancing immunity, offering antiviral, anti-inflammatory, and bactericidal effects, making it ideal for cold and viral disease prevention. It serves as an SOS remedy at the first signs of illness, reducing symptoms and accelerating recovery by providing natural immune support. Its high antioxidant content significantly aids in combating cold and flu durations. Plus, it tastes great!
Read More
9
Healthy choice
I loved…!!! Its flavour is delicious. A practical way to consume the supplement at any time without worrying. A quality product with organic ingredients helping improve our health. My family has been better since my son started taking the elderberry gummies, even after catching flu at kindergarten. I bought liquid for him and gummies for us, so far we are doing well, and I hope to continue taking them for better results.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
9
Zinc and flavonoids combat flu
Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions.
We investigated the potential of zinc in combination with herbal polyphenols and copper to reduce the infectivity of respiratory RNA viruses, including the flu. This study is particularly timely due to the ongoing challenges posed by viruses like SARS-CoV-2, highlighting the need for effective therapeutic solutions.
Zinc ions are known to play a role in modulating viral RNA replication, which makes them an appealing option for decreasing viral loads and infectivity. However, a significant challenge is that the natural concentration of zinc in our cells is often too low for effective results. To tackle this, we combined zinc picolinate, a form of zinc that’s easier for the body to absorb, with a range of flavonoids—natural compounds renowned for their antioxidant properties and existing antiviral effects.
We ensured that these combinations were safe by assessing their impact on cultured cells, confirming that they didn’t harm cell viability. When tested further, our results revealed an impressive 50-95% reduction in viral genome replication levels across a variety of respiratory RNA viruses, including the flu virus, which suggests that this combination therapy could be promising in the fight against such illnesses.
Overall, our findings highlight an innovative approach to treating viral infections that is non-toxic, derived from nature, and may remain effective against emerging viral strains.
Read More
9
Elderberry enhances immune response
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
Read More
9
Elderberry shows promise for flu relief
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.
We assessed the effectiveness of black elderberry (Sambucus nigra) in treating upper respiratory symptoms, particularly those associated with the flu. The study included 180 participants and examined various factors, such as vaccination status and the underlying causes of symptoms.
Our findings indicated that elderberry supplementation significantly reduced upper respiratory symptoms, offering a promising alternative for those seeking relief without relying on over-the-counter medications or antibiotics. The analysis revealed a strong positive impact, suggesting that elderberry could be particularly beneficial for treating symptoms arising from viral infections.
Overall, this research indicates that elderberry can serve as a safer, effective option for managing flu symptoms and common colds. This could help address concerns about antibiotic misuse and provide a more natural remedy during flu season.
Read More
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
This product has significantly helped curb the constant bouts of flu in our household. Everyone feels fantastic, and even our nails look great! It's a perfect size and offers excellent value for money. Plus, it tastes lovely.
Read More
9
Boosts immune system
Black elderberry is a top product for enhancing immunity, offering antiviral, anti-inflammatory, and bactericidal effects, making it ideal for cold and viral disease prevention. It serves as an SOS remedy at the first signs of illness, reducing symptoms and accelerating recovery by providing natural immune support. Its high antioxidant content significantly aids in combating cold and flu durations. Plus, it tastes great!
Read More
9
Healthy choice
I loved…!!! Its flavour is delicious. A practical way to consume the supplement at any time without worrying. A quality product with organic ingredients helping improve our health. My family has been better since my son started taking the elderberry gummies, even after catching flu at kindergarten. I bought liquid for him and gummies for us, so far we are doing well, and I hope to continue taking them for better results.
Read More
7.5
Strong immunomodulatory effect
2 people found this helpful
This elderberry product is fantastic for both children and adults. My child enjoys it immensely! Black elderberry boasts significant medicinal properties, providing robust immune support against colds, flu, and upper respiratory issues. I bought it during the peak SARS season, and it was well-priced! I highly recommend it for children.
Read More
7.5
Almost no colds
2 people found this helpful
A great product at a good price. My husband and I take these daily and have had almost no colds or flu. They’re easy to chew, although they’re becoming harder to find. We used to order from Costco, but prefer this specific brand that has the vital ingredients we need.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Sambucus elderberry is often touted as a natural remedy for flu and cold symptoms. Some studies suggest that elderberry extract may help reduce the duration and severity of flu symptoms by enhancing immune response and inhibiting the replication of certain strains of the influenza virus. The compounds in elderberry, such as flavonoids and phenolic acids, are believed to have anti-inflammatory and antioxidant properties, which can support your immune system during bouts of illness.
However, while elderberry may offer some benefits, it should not be relied upon as a substitute for medical treatment or preventive measures such as vaccinations. It's essential to consult with a healthcare professional for appropriate advice, particularly for managing flu symptoms or for individuals with underlying health conditions. Always choose a high-quality elderberry product and follow the recommended dosages for safety and efficacy.
Based on user reviews, individuals taking elderberry supplements for flu symptoms generally report seeing results fairly quickly, often within a few days. For instance, one user noted feeling better within a couple of days even after falling ill, highlighting how effective the gummies can be during flu season Read Review. Another review cited that after one week of taking the product, they were able to avoid flu-like symptoms entirely Read Review.
Additionally, users have observed enhancements in their overall immunity and a reduction in the duration of their illness. For example, one reviewer mentioned that using elderberry products helped them recover quickly from flu symptoms, contributing to a faster return to health Read Review. Therefore, while individual experiences may vary, many users seem to appreciate the prompt relief and supportive benefits offered by elderberry supplements.
Vitamin C supplementation appears to be supported by scientific research for managing the flu, primarily in terms of reducing the incidence and duration of symptoms. A study indicated that vitamin C can decrease the likelihood of acute respiratory infections, including flu, by about 4% and shorten symptom duration by approximately 9%[1]. Additionally, vitamin C has shown potential in modulating immune responses and enhancing the activity of immune cells, which are vital in combating viral infections like the influenza virus[3].
Further research also suggested that vitamin C might inhibit the activity of neuraminidase, an essential enzyme for the flu virus's lifecycle, although its effectiveness in this capacity is moderate compared to more established antiviral drugs[2]. Additional studies highlight that vitamin C can help reduce inflammation and support immune health in stressful conditions, which may enhance the body's response to flu infections[5]. While these insights position vitamin C as a beneficial supplement for flu management, it is crucial to note that it is not a standalone solution. More research is needed to fully elucidate its potential, especially in the context of broader infection management strategies.
Many users report significant improvements in their symptoms when using elderberry products, particularly for flu and cold prevention. For example, one user noted a marked reduction in flu occurrences within their household and expressed satisfaction with the overall health of their family since taking the supplements Read Review. Others found that starting elderberry supplements at the first signs of illness helped minimize symptoms and speed up recovery. A user specifically highlighted feeling better shortly after developing slight flu symptoms, indicating a quick response from the supplement Read Review.
Additionally, users have mentioned enhanced energy levels and a decrease in the frequency of illnesses. One review noted that after several weeks of consistent use, they felt sick less often and had an overall increase in energy, which can be crucial during peak cold and flu seasons Read Review. While individual results may vary—from one user's experience with enhanced respiratory health Read Review to another's improvements in sore throat and flu symptoms Read Review—the general consensus points to elderberry's efficacy in providing immune support and speeding recovery.
Users frequently report positive experiences when combining elderberry supplements with other vitamins and minerals to enhance their effectiveness against flu symptoms. Many recommend pairing elderberry with vitamin C and zinc, citing that this combination not only boosts immune support but also contributes to an increase in overall energy levels and a decrease in illness frequency. For instance, one user shared that after incorporating Sports Research Organic Elderberry Gummies with vitamin C and zinc, they felt more energetic and had been getting sick less often during the cold and flu season, emphasizing the considerable advantage of this combination Read Review. Another user echoed similar sentiments, noting that taking these gummies along with vitamin C and zinc helped them experience better health outcomes Read Review.
Additionally, users have found that taking elderberry supplements at the first signs of illness, especially when combined with other supportive ingredients, aids in minimizing symptoms and speeding recovery. A user indicated that adding elderberry to their regimen helped them feel better quickly after experiencing slight flu symptoms, demonstrating the potential benefits of such combinations Read Review. Consequently, while individual experiences vary, many users believe that pairing elderberry with additional immune-supporting supplements enhances its efficacy in managing flu symptoms.
Based on user reviews, Elderberry Sambucus products seem to be effective for treating flu, with many users praising the immune-boosting properties of the elderberry extract. Some users noted that taking elderberry at the first signs of flu symptoms aided in symptom reduction and accelerated recovery. For example, one user mentioned, "after one week of taking [elderberry], they have kept me away from any flu-like symptoms" Read Review. Another user described their experience with gummies, stating they “took it at the onset of slight flu symptoms and felt better” Read Review.
While specific dosages were not widely discussed across the reviews, many users pointed out the enjoyable taste, making it easy to incorporate into their daily routine, especially during cold and flu season. Reviews indicate that both liquid forms and gummies are effective; one user mentioned that they bought the liquid for their child and gummies for themselves, noting, "so far we are doing well" Read Review. Overall, users recommend elderberry as a valuable supplement for maintaining wellness during flu season, emphasizing the importance of starting at the onset of symptoms for optimal results.
7.5
Quick recovery
I love buying these during flu season. Even if I fall ill, I feel better within a couple of days. Sometimes, I find it difficult to swallow large capsules, so these gummies are a fantastic alternative.
9
Flu prevention
Tastes like candy, making me want more! They have kept me away from any flu-like symptoms after one week of taking.
7.5
Quick recovery
A delicious nutritional supplement that is light on the stomach and has a berry taste that helped me recover quickly from flu symptoms.
9
Stops flu outbreaks
This product has significantly helped curb the constant bouts of flu in our household. Everyone feels fantastic, and even our nails look great! It's a perfect size and offers excellent value for money. Plus, it tastes lovely.
7.5
Effective for flu
Great taste, good! Easy to chew and tastes nice. My child and I loved it. Took it at the onset of slight flu symptoms and felt better.
7.5
Tasty flu remedy
I recently tried Sports Research Organic Elderberry with Vitamin C and Zinc and I want to share my impressions! The package contains 60 gummies, which is convenient during cold and flu season. They have a pleasant natural berry flavour, making them both healthy and delicious. After several weeks of use, I've noticed I get sick less often and feel more energetic. The gummies are easy to chew and do not leave an unpleasant aftertaste. The price is reasonable for such a quality product. Overall, I was very pleased with the purchase and plan to continue using these gummies.
6
Promotes respiratory health
A good blend of ingredients helps prevent colds and flu. After struggling with a gum abscess, I tried various alternatives without success. By taking zinc, vitamin C, and Echinacea, along with Astragalus, the abscess subsided within two to three days. Elderberries appear to enhance respiratory health and are also high in vitamin C.
7.5
Sore throat relief
It is a great alternative for easing sore throat and flu symptoms. It tastes great!
7.5
Effective flu support
I recently tried Sports Research Organic Elderberry, Vitamin C & Zinc Gummies and absolutely loved them! Not only are these gummies delicious, but they are also incredibly healthy. The combination of elderberry, vitamin C, and zinc is excellent for immune support. Since taking them, I feel more energetic and have been getting sick less often, which is vital during cold and flu season! The natural berry flavour makes taking the supplement enjoyable, and the gummies are soft and easy to chew, making them perfect for kids and adults alike. The 60-gummy package is also a big plus as it lasts a long time. Overall, I highly recommend them to anyone health conscious looking for a tasty way to support their immune system.
9
Healthy choice
I loved…!!! Its flavour is delicious. A practical way to consume the supplement at any time without worrying. A quality product with organic ingredients helping improve our health. My family has been better since my son started taking the elderberry gummies, even after catching flu at kindergarten. I bought liquid for him and gummies for us, so far we are doing well, and I hope to continue taking them for better results.
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149
Muniz FWMG, Casarin M, Pola NM, Rösing CK, Silveira TMD, et al. Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms. PLoS One. 2025;20:e0316807. 10.1371/journal.pone.0316807
Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. 10.21873/invivo.12967
Kreiser T, Zaguri D, Sachdeva S, Zamostiano R, Mograbi J, et al. Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions. Pharmaceuticals (Basel). 2022;15. 10.3390/ph15030377
Nakashima A, Horio Y, Suzuki K, Isegawa Y. Antiviral Activity and Underlying Action Mechanism of Euglena Extract against Influenza Virus. Nutrients. 2021;13. 10.3390/nu13113911
Sadeghsoltani F, Mohammadzadeh I, Safari MM, Hassanpour P, Izadpanah M, et al. Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation. Biol Trace Elem Res. 2022;200:2556. 10.1007/s12011-021-02859-z
Stich L, Plattner S, McDougall G, Austin C, Steinkasserer A. Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses. Int J Mol Sci. 2022;23. 10.3390/ijms23073949
Wieland LS, Piechotta V, Feinberg T, Ludeman E, Hutton B, et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complement Med Ther. 2021;21:112. 10.1186/s12906-021-03283-5
Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361. 10.1016/j.ctim.2018.12.004
Shahsavandi S, Ebrahimi MM, Hasaninejad Farahani A. Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By . Iran J Pharm Res. 2017;16:1147.
Holst L, Havnen GC, Nordeng H. Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?. Front Pharmacol. 2014;5:31. 10.3389/fphar.2014.00031
Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata A. Anti-influenza virus effects of elderberry juice and its fractions. Biosci Biotechnol Biochem. 2012;76:1633.
Krawitz C, Mraheil MA, Stein M, Imirzalioglu C, Domann E, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011;11:16. 10.1186/1472-6882-11-16
Roschek B, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70:1255. 10.1016/j.phytochem.2009.06.003