Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
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7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
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5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
Read More
Most Useful Reviews
7.5
Reduced anxiety
478 people found this helpful
Magnesium citrate calms me effectively and helps soften stools. I take one tablet before bedtime, and my constipation has vanished, leaving me feeling much calmer. I highly recommend it!
Read More
9
Alleviated anxiety
207 people found this helpful
This magnesium is very affordable and has greatly improved my overall wellbeing. It helps with stool improvement, headaches, and anxiety. My sleep has improved significantly; I now fall asleep quickly and wake up refreshed. I recommend it to everyone!
Read More
9
Improved wellbeing
179 people found this helpful
Magnesium has transformed my life for the better. Recognising symptoms of magnesium deficiency led me to supplement. After two years of consistent use, my anxiety has lessened, and I no longer suffer from fatigue or headaches. I feel balanced and healthy!
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
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8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Read More
8
Magnesium aids post-surgery anxiety
Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
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8
Magnesium reduces anxiety symptoms
Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
Read More
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Magnesium citrate calms me effectively and helps soften stools. I take one tablet before bedtime, and my constipation has vanished, leaving me feeling much calmer. I highly recommend it!
Read More
9
Alleviated anxiety
207 people found this helpful
This magnesium is very affordable and has greatly improved my overall wellbeing. It helps with stool improvement, headaches, and anxiety. My sleep has improved significantly; I now fall asleep quickly and wake up refreshed. I recommend it to everyone!
Read More
9
Improved wellbeing
179 people found this helpful
Magnesium has transformed my life for the better. Recognising symptoms of magnesium deficiency led me to supplement. After two years of consistent use, my anxiety has lessened, and I no longer suffer from fatigue or headaches. I feel balanced and healthy!
Read More
7.5
Calmed nerves
61 people found this helpful
I purchased magnesium during a stressful time for my family. Initially prescribed for my son’s anxiety, I discovered my own magnesium deficiency. After consistent use, both our anxiety reduced significantly, and sleep quality improved. I highly recommend it!
Read More
9
Improved sleep
18 people found this helpful
This magnesium is fantastic for anxiety and enhancing sleep quality. Highly recommended!
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been studied for its potential role in alleviating symptoms of anxiety, and some evidence suggests it may be beneficial. Magnesium plays a critical role in brain function and the regulation of neurotransmitters, which are essential for mood stability. Some studies have indicated that low levels of magnesium may be linked to increased anxiety symptoms, and supplementation could work to help improve overall mental health by restoring adequate magnesium levels. While it's not a standalone treatment for anxiety disorders, integrating magnesium into a balanced diet with other treatment modalities could provide additional support.
That said, it's important to approach magnesium supplementation thoughtfully. Overuse can lead to adverse effects, and individual needs may vary widely depending on dietary intake and overall health status. Before starting any new supplement, especially for managing anxiety, consulting with a healthcare professional is advisable to tailor an approach that aligns with your personal health needs. In summary, while magnesium can play a role in supporting anxiety management, it should complement traditional treatments rather than serve as a primary solution.
Based on user reviews, the timeline for experiencing results from magnesium supplementation for anxiety varies among individuals but generally falls within a few weeks to a couple of months. Several users have reported noticeable improvements in their anxiety levels after just a couple of weeks of consistent use. For instance, one user mentioned feeling calmer and experiencing improved sleep after two weeks of taking magnesium Read Review. Another user highlighted that their anxiety significantly decreased after about a month of use Read Review.
Others noted a more extended period of use, with an overall improvement in anxiety taking about two years of consistent supplementation Read Review. Ultimately, it seems that regular and continuous use is key, with many users advising others to give it some time to fully appreciate the benefits Read Review. While individual experiences may vary, the consensus leans toward a gradual improvement over weeks to months.
The scientific research surrounding magnesium as a supplement for anxiety presents a mixed but generally positive picture. Studies have indicated that magnesium may offer some benefits in reducing anxiety, particularly in specific contexts. For instance, a systematic review of 15 studies suggested that magnesium supplementation can lead to improvements in anxiety levels, especially among individuals with initially low magnesium levels ([3]). Furthermore, some recent trials have shown significant short-term alleviation of anxiety symptoms in various populations, including pregnant women and individuals experiencing chronic stress ([4], [9]).
However, the evidence comes with caveats; many studies report short-lived effects, and variations in dosage and formulation complicate determining magnesium's precise efficacy ([3]). Moreover, one study highlighted that while magnesium has the potential to help with anxiety, it may not be as impactful as established treatments like diazepam when compared directly ([6]). Overall, while magnesium supplements could be a useful addition for those with mild anxiety or deficiencies, more robust and larger-scale trials are needed to solidify its role and effectiveness in treating anxiety disorders long-term.
Based on user reviews, many individuals report marked improvements in anxiety levels, sleep quality, and overall well-being after incorporating magnesium citrate into their daily regimen. For instance, one user highlighted experiencing diminished feelings of anxiety and improved sleep after just two weeks of consistent supplementation Read Review. Another review noted that after a month of use, significant reductions in anxiety were observed, which greatly enhanced their quality of life Read Review.
Moreover, long-term users reported transformative benefits, with comments extending to improved muscle recovery and reduced fatigue as well Read Review. Several users corroborated that magnesium effectively alleviated muscle tension and cramps, contributing to an overall sense of calm and relaxation Read Review. While individual results can vary, a consensus among users suggests that magnesium citrate is a beneficial supplement for managing anxiety, enhancing sleep quality, and improving overall health when taken consistently.
Based on user reviews, many individuals have successfully combined magnesium citrate with other supplements to enhance its effects on anxiety. For instance, one user noted that pairing magnesium with a vitamin B complex, calcium, and zinc significantly supported their nervous system and alleviated anxiety during workouts Read Review. Another review mentioned the positive impact of taking magnesium in conjunction with vitamins D3 and K2, which helped improve overall well-being and provided relief from anxiety and sleep issues Read Review.
Overall, users have expressed that combining magnesium with other vitamins not only improved their mental health but also enhanced their sleep quality, overall recovery, and reduced feelings of irritability. For example, one user reported that using magnesium with afobazole led to a more calm and optimistic state, significantly reducing anxiety levels Read Review. Similarly, users frequently reiterated that regular magnesium supplementation alongside other vitamins contributed to a stronger sense of calm and better mental clarity Read Review. While individual experiences may vary, the synergy observed between magnesium and various supplements appears to be beneficial for many seeking relief from anxiety.
Users report a variety of beneficial experiences with magnesium when it comes to treating anxiety, particularly with magnesium citrate. Many users recommend starting with a lower dose, especially to avoid potential digestive issues, as some individuals experienced mild laxative effects. It’s often suggested to take magnesium before bedtime, as this timing seems to enhance its calming effects and improve sleep quality. One user specifically noted that starting with a lower dose helped them avoid digestive discomfort while still reaping the anxiety-relief benefits Read Review.
Overall, users mentioned that consistent use over a period of weeks or months led to a significant reduction in anxiety symptoms and improvements in overall well-being. They found that, alongside enhanced sleep quality, magnesium supported a calmer emotional state Read Review. The general consensus appears to be that magnesium is most effective when incorporated into a nightly routine, allowing its calming effects to build over time Read Review.
9
Anxiety and sleep
1 people found this helpful
Concentrating at work was hard, and sleep was elusive, with anxiety symptoms flaring. After using magnesium for two weeks, I became calmer and my sleep improved significantly.
9
Anxiety reduced
4 people found this helpful
I ordered magnesium citrate for my mother but now wish to try it myself. It normalises blood pressure and alleviates anxiety. After a month, my mother experienced a noticeable reduction in anxiety and sleep issues.
9
Improved wellbeing
179 people found this helpful
Magnesium has transformed my life for the better. Recognising symptoms of magnesium deficiency led me to supplement. After two years of consistent use, my anxiety has lessened, and I no longer suffer from fatigue or headaches. I feel balanced and healthy!
9
Family usage
1 people found this helpful
We've consumed countless cans of this magnesium! It has no side effects and is essential for anxiety, irritability, and insomnia, which are immediately noticeable if we stop taking it. Our anxiety levels have significantly decreased.
7.5
Alleviated anxiety
12 people found this helpful
Magnesium Citrate has helped improve my sleep and muscle recovery, as well as reducing anxiety significantly. I advise taking it with food or before sleep, and starting with a lower dose is wise to prevent digestive discomfort.
7.5
Supports anxiety reduction
2 people found this helpful
I’ve ordered this magnesium multiple times as it works wonders for me. Along with a vitamin B complex, calcium, and zinc, it greatly supports my nervous system and helps alleviate my anxiety. I feel amazing during workouts, and my joints hurt much less.
9
Alleviates anxiety
1 people found this helpful
I ordered this for my mother, who began to sleep poorly and experience anxiety. It relieved her leg pain, and combined with vitamins D3 and K2, it improved her overall wellbeing.
9
Reduced anxiety
1 people found this helpful
I took these magnesium capsules at night, which greatly improved my sleep. After a month, I experienced sound sleep without nightmares and decreased night-time waking. Additionally, I noticed fewer leg cramps and my premenstrual pain vanished. Along with afobazole, I felt more calm and optimistic, and the feeling of anxiety reduced.
7.5
Reduced anxiety
14 people found this helpful
Magnesium Citrate is an excellent dietary supplement. It alleviates muscle cramps and promotes better sleep and reduced anxiety. I recommend starting with a lower dose to avoid digestive issues; it’s best taken with food or before bed.
9
Balanced emotions
1 people found this helpful
My emotional state used to be characterised by anxiety and irritability until I began taking magnesium. Now, with just one tablet at night, I sleep well and no longer feel constantly tense. The calming effect builds over time.
7
Magnesium shows potential for anxiety
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
7
Magnesium may ease anxiety symptoms
Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study.
This study aimed to explore how magnesium, when combined with vitamins and herbs, affects anxiety levels in individuals experiencing chronic stress. In a well-structured, randomized controlled trial, participants were given either a magnesium-rich supplement or a placebo for 28 days.
After conducting functional MRI scans, we noticed significant changes in brain activation patterns related to stress and pain perception in those taking the magnesium supplement. Specifically, over the course of the month, there was a notable reduction in anxiety levels as measured by the Depression Anxiety Stress Scale.
Participants reported feeling less stressed and more resilient in facing daily challenges. Our findings suggest that magnesium supplementation may offer a complementary approach to managing anxiety, particularly for those suffering from chronic stress.
5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
References
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. doi:10.3390/microorganisms12071429
Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. doi:10.7759/cureus.59317
Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. doi:10.5152/alphapsychiatry.2024.231342
Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. doi:10.23736/S0375-9393.24.17868-6
Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. doi:10.1080/01616412.2024.2352234
Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. doi:10.3390/life14030306
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. doi:10.1038/s41591-023-02705-w
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. doi:10.3389/fnut.2023.1211321
Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. doi:10.1080/1354750X.2023.2246104
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. doi:10.3390/metabo13010073