Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 17 Reviews
8.1
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Read More
7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
Read More
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
Most Useful Reviews
9
Effective neuropathy relief
4 people found this helpful
I purchased this as a countermeasure for my peripheral neuropathy, which makes my fingertips feel peculiar. It's been about 10 days since I started taking it, and it has worked so well that I've forgotten the discomfort in my fingertips.
Read More
9
High-quality ingredients
Excellent! Really amazing quality with natural ingredients, small packaging, and a pleasant smell. It uses methylcobalamin, which is crucial for the development of myelin that protects nerve fibres. This activated form of vitamin B12 is essential for treating peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis. I highly recommend it to everyone.
Read More
9
Tremendous help
This product has been tremendously helpful. I would recommend Methyl B12 as it aids my neuropathy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
We examined a unique case involving a 33-year-old woman with HIV who experienced sudden vision loss linked to vitamin B12 deficiency. Initially treated with B12 tablets for severe peripheral neuropathy, her condition escalated to optic neuritis. Upon diagnosis, she received prednisolone and daily B12 injections. After five months of this treatment, she reported a significant recovery in her vision. This case highlights the importance of recognizing vitamin B12 deficiency’s potential eye-related symptoms, especially in patients with underlying health conditions like HIV, to ensure timely intervention.
Read More
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Read More
8
We explored the effectiveness of steroid treatment versus vitamin B12 therapy for improving diabetic ocular nerve palsy. Our study involved fifty participants, with half receiving steroids and the other half vitamin B12 injections.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
Read More
8
We explored the connection between nitrous oxide use and vitamin B12 deficiency, specifically focusing on neurological issues like peripheral neuropathy. Through a reported case of nitrous oxide-induced subacute combined degeneration of the spinal cord, we identified a functional B12 deficiency despite normal serum levels.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective neuropathy relief
4 people found this helpful
I purchased this as a countermeasure for my peripheral neuropathy, which makes my fingertips feel peculiar. It's been about 10 days since I started taking it, and it has worked so well that I've forgotten the discomfort in my fingertips.
Read More
9
High-quality ingredients
Excellent! Really amazing quality with natural ingredients, small packaging, and a pleasant smell. It uses methylcobalamin, which is crucial for the development of myelin that protects nerve fibres. This activated form of vitamin B12 is essential for treating peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis. I highly recommend it to everyone.
Read More
9
Tremendous help
This product has been tremendously helpful. I would recommend Methyl B12 as it aids my neuropathy.
Read More
9
Very useful
I find the B12 Methylcobalamin formula very beneficial for the nervous systems of diabetic patients, especially for those suffering from neuropathy. As a diabetic, I regularly take it.
Read More
9
Peripheral neuropathy
This product has significantly helped in the treatment of peripheral neuropathy!
Read More
Frequently Asked Questions
9
Effective neuropathy relief
4 people found this helpful
I purchased this as a countermeasure for my peripheral neuropathy, which makes my fingertips feel peculiar. It's been about 10 days since I started taking it, and it has worked so well that I've forgotten the discomfort in my fingertips.
7.5
Feeling significant improvement
It works! I got this to assist with neuropathy and am feeling a very good improvement.
6
Uncertain effectiveness
I took it to alleviate the neuropathy of my diabetic foot, but I’m unsure if it’s working. For now, I’ll see what happens after using one bottle, so I can’t draw a conclusion yet. It’s a drop type applied under the tongue, but I haven’t noticed any immediate effects. The taste is pleasant, like a tablet confectionery, and there’s no particular issue so far. I might consider using it again later.
9
Tremendous help
This product has been tremendously helpful. I would recommend Methyl B12 as it aids my neuropathy.
9
Peripheral neuropathy
This product has significantly helped in the treatment of peripheral neuropathy!
7.5
Mixed results noted
I started taking B12, ALA, Acetyl-L-Carnitine, Benfotiamine, D3 & K2, CoQ10, and B6 six weeks ago and have found that the mild peripheral neuropathy in my toes has reduced. I combined this with nerve stretching and high-intensity training, making it difficult to pinpoint which part(s) of the regimen are effective. As always with vitamins, results may vary!
6
Reduced polyneuropathy symptoms
It helped, in combination with other group B vitamins, to lessen the manifestations of polyneuropathy.
9
High-quality ingredients
Excellent! Really amazing quality with natural ingredients, small packaging, and a pleasant smell. It uses methylcobalamin, which is crucial for the development of myelin that protects nerve fibres. This activated form of vitamin B12 is essential for treating peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis. I highly recommend it to everyone.
9
Reduces pain
This high-quality vitamin B is essential for nerve health, immunity, and joint function. The amount is appropriate for diabetics and reduces pain in the feet and hands caused by peripheral neuropathy with diabetes.
7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
7
We conducted a cross-sectional study with 130 type-2 diabetic patients to explore the connection between diabetic peripheral neuropathy (DPN) and various micronutrients. Using a well-defined screening tool, we identified 28 patients with DPN.
Our results showed a significant association between DPN and both zinc and vitamin B12 levels. However, there was no significant correlation with copper or magnesium levels. This suggests that while zinc and vitamin B12 may play a role in neuropathy among diabetic patients, other micronutrients do not appear to have the same impact.
Our results showed a significant association between DPN and both zinc and vitamin B12 levels. However, there was no significant correlation with copper or magnesium levels. This suggests that while zinc and vitamin B12 may play a role in neuropathy among diabetic patients, other micronutrients do not appear to have the same impact.
8
B12 contributes to neuropathy improvement
We investigated how a combination of vitamins, minerals, and other compounds influences symptoms of diabetic neuropathy. For six months, 73 participants were evenly split between a treatment or placebo group.
The results highlighted those on the active treatment saw significant improvements in pain and vibration perception, along with increased vitamin B12 levels. This suggests that B12, while part of a broader treatment plan, may play a beneficial role in managing neuropathy. However, the study primarily focuses on the overall combination, with B12 contributing to positive outcomes.
The results highlighted those on the active treatment saw significant improvements in pain and vibration perception, along with increased vitamin B12 levels. This suggests that B12, while part of a broader treatment plan, may play a beneficial role in managing neuropathy. However, the study primarily focuses on the overall combination, with B12 contributing to positive outcomes.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. doi:10.31557/APJCP.2025.26.2.375
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. doi:10.7759/cureus.74383
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. doi:10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. doi:10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. doi:10.7759/cureus.63003
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. doi:10.1097/MD.0000000000037605
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. doi:10.1186/s12883-025-04069-9
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. doi:10.1186/s12883-024-03966-9
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. doi:10.1016/j.vascn.2024.107552
