Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 9 Reviews
8.5
Supplement Facts
Serving Size: 1 tsp (1.9 g)
Amount Per Serving
%DV
Calories
5
Total Carbohydrates
1 g
<1%*
Dietary Fiber
<1 g
3%
Calcium
71 mg
5%
Valerian, cut (root)
1.9 g
**
Top Medical Research Studies
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More
Most Useful Reviews
9
Natural anxiety relief
228 people found this helpful
Lay off the Xanax, America. Get back to your roots. This stuff works brilliantly steeped and added to a drink. Just a little for anxiety and about three times that for sleep. Put down the orange bottle and stick it to the man.
Read More
9
Effective for anxiety
6 people found this helpful
Perfectly! Full delight! This is my discovery on iHerb! I had been prescribed valerian throughout my life, but the tablets, capsules and drops did not work on me at all; I have congenital heightened anxiety and panic attacks which started at 40. I decided once more to try valerian and bought these roots. The instructions stated that there was no need to brew it, just fill it with cold water for 8 hours. Finally, I felt valerian's effects, experiencing complete calmness and relaxation—it's brilliant, just use it in the right form!
Read More
8
Great natural helper
4 people found this helpful
Good for sleeping. I've created a tonic blend of Kava Kava and Valerian. It's a brilliant natural sleep aid and really effective for anxiety. For someone with panic attacks or a stressful life, this is a fantastic natural helper to help calm you down.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Natural anxiety relief
228 people found this helpful
Lay off the Xanax, America. Get back to your roots. This stuff works brilliantly steeped and added to a drink. Just a little for anxiety and about three times that for sleep. Put down the orange bottle and stick it to the man.
Read More
9
Effective for anxiety
6 people found this helpful
Perfectly! Full delight! This is my discovery on iHerb! I had been prescribed valerian throughout my life, but the tablets, capsules and drops did not work on me at all; I have congenital heightened anxiety and panic attacks which started at 40. I decided once more to try valerian and bought these roots. The instructions stated that there was no need to brew it, just fill it with cold water for 8 hours. Finally, I felt valerian's effects, experiencing complete calmness and relaxation—it's brilliant, just use it in the right form!
Read More
8
Great natural helper
4 people found this helpful
Good for sleeping. I've created a tonic blend of Kava Kava and Valerian. It's a brilliant natural sleep aid and really effective for anxiety. For someone with panic attacks or a stressful life, this is a fantastic natural helper to help calm you down.
Read More
9
Highly recommended root
Valerian root is excellent. Simply put half a teaspoon of the root in a glass with boiling water, and it works wonders: it relaxes and reduces anxiety. Highly recommended.
Read More
6
Calms nervous system
29 people found this helpful
A potent and pain-relieving herb. This organic valerian root is excellent for alleviating muscle pain, tension, anxiety, and stress. It helps with headaches and insomnia and is nonaddictive. While it has an unpleasant smell, I’m consistently impressed with its effectiveness for my chronic ailments.
Read More
Frequently Asked Questions
9
Effective for anxiety
6 people found this helpful
Perfectly! Full delight! This is my discovery on iHerb! I had been prescribed valerian throughout my life, but the tablets, capsules and drops did not work on me at all; I have congenital heightened anxiety and panic attacks which started at 40. I decided once more to try valerian and bought these roots. The instructions stated that there was no need to brew it, just fill it with cold water for 8 hours. Finally, I felt valerian's effects, experiencing complete calmness and relaxation—it's brilliant, just use it in the right form!
9
Highly recommended root
Valerian root is excellent. Simply put half a teaspoon of the root in a glass with boiling water, and it works wonders: it relaxes and reduces anxiety. Highly recommended.
8
Soothes anxiety effectively
This product helps significantly with anxiety and sleeping problems.
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
References
- Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. 10.1016/j.neuroscience.2025.01.003
