Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 81 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Chewable
Amount Per Serving
%DV
Calories
5
Total Fat
0 g
0%
Sodium
0 mg
0%
Total Carbohydrate
1 g
0%
Total Sugars
less than 1 g
Includes 0 g Added Sugars
0%
Vitamin C*
30 mg
33%
Vitamin D** (as D3)
10 mcg (400 IU)
50%
Kids Probiotic BlendLactobacillus acidophilusLactobacillus gasseriLactobacillus paracaseiLactobacillus plantarumLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus salivariusLactobacillus bulgaricusTotal Lacto Cultures (4 Billion CFU)Bifidobacterium lactisBifidobacterium breveBifidobacterium infantisBifidobacterium bifidumBifidobacterium longumTotal Bifido Cultures (1 Billion CFU)
71 mg
+
Total Probiotic Cultures
5 Billion CFU1
Organic Prebiotic Fiber BlendOrganic Acacia Fiber (A. senegal), Organic Whole Cranberry (Vaccinium macrocarpon) (fruit), Organic Emblic (Amla, Phyllanthus emblica) (fruit) Extract
310 mg
+
Top Medical Research Studies
9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
9
We explored the impact of Lactobacillus salivarius SNK-6 on treating and preventing diarrhea in pigeons. In our research, we compared healthy pigeons with those infected with specific strains of E. coli known to cause diarrhea. After administering L. salivarius SNK-6, we observed a notable reduction in diarrhea among treated pigeons, while control pigeons still experienced a 10% incidence of diarrhea. This suggests that boosting levels of Lactobacillus can help maintain a healthy balance in the gut, potentially preventing diarrhea in the future.
Read More
9.5
Probiotics improve H. pylori treatments
We analyzed various studies on incorporating probiotics into treatments for Helicobacter pylori (H. pylori) infection. Our findings revealed that adding probiotics like Bifidobacterium longum improved the eradication rate significantly.
Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Read More
Most Useful Reviews
9
Prevents diarrhea
After my son began kindergarten, he frequently fell ill and ended up needing antibiotics, sometimes leading to diarrhoea. This prebiotic was recommended alongside the antibiotics, and thankfully, he did not experience any diarrhoea. I will use it again for his next illness.
Read More
7.5
Best for kids
This is one of the best products for bowel issues and diarrhoea for children. I bought it for my daughter, especially when she’s on antibiotics. Although she dislikes the chewable taste and texture, it’s worth it. A bit pricey, but truly exceptional.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 81 Researches
8
- All Researches
9.5
We explored the impact of Lactobacillus acidophilus and L. plantarum on patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded clinical trial of 100 patients, some received standard IBS treatment alone while others added probiotics to their therapy.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
Read More
9.5
We explored the impact of Lactobacillus acidophilus and L. plantarum on patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded clinical trial of 100 patients, some received standard IBS treatment alone while others added probiotics to their therapy.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
Read More
9.5
Lactobacillus shows promise for diarrhea
We aimed to explore how Lactobacillus acidophilus can help relieve diarrhea symptoms associated with irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).
In a study with 54 patients, those taking the probiotic Neobiotic Lactobalance® for 21 days saw significant reductions in diarrhea severity and abdominal pain, with scores dropping impressively on the Gastrointestinal Symptom Rating Scale.
Fecal analysis indicated improved intestinal health, highlighting Lactobacillus's potential benefits for those struggling with these conditions.
In a study with 54 patients, those taking the probiotic Neobiotic Lactobalance® for 21 days saw significant reductions in diarrhea severity and abdominal pain, with scores dropping impressively on the Gastrointestinal Symptom Rating Scale.
Fecal analysis indicated improved intestinal health, highlighting Lactobacillus's potential benefits for those struggling with these conditions.
Read More
9.5
Probiotics improve H. pylori treatments
We analyzed various studies on incorporating probiotics into treatments for Helicobacter pylori (H. pylori) infection. Our findings revealed that adding probiotics like Bifidobacterium longum improved the eradication rate significantly.
Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Read More
9.5
We conducted a randomized double-blind, placebo-controlled trial with 200 participants to see how well the probiotic CECT 7347 (ES1) and its heat-treated version (HT-ES1) could help those suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). After 12 weeks of treatment, both ES1 and HT-ES1 showed significant improvements in symptom severity, with marked reductions in IBS-SSS scores compared to the placebo.
Secondary benefits included better stool consistency and quality of life, making these treatments promising options for managing IBS-D symptoms. These findings reflect meaningful advancements in probiotic and postbiotic solutions.
Secondary benefits included better stool consistency and quality of life, making these treatments promising options for managing IBS-D symptoms. These findings reflect meaningful advancements in probiotic and postbiotic solutions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevents diarrhea
After my son began kindergarten, he frequently fell ill and ended up needing antibiotics, sometimes leading to diarrhoea. This prebiotic was recommended alongside the antibiotics, and thankfully, he did not experience any diarrhoea. I will use it again for his next illness.
Read More
7.5
Best for kids
This is one of the best products for bowel issues and diarrhoea for children. I bought it for my daughter, especially when she’s on antibiotics. Although she dislikes the chewable taste and texture, it’s worth it. A bit pricey, but truly exceptional.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Li S, Lu T, Lin Z, Zhang Y, Zhou X, et al. Supplementation with probiotics co-cultivation improves the reproductive performance in a sow-piglet model by mother-infant microbiota transmission and placental mTOR signaling. World J Microbiol Biotechnol. 2024;41:13. doi:10.1007/s11274-024-04222-5
- Hashem B, Gaston M, Carlisle JD, Van Wick P. COMPARISON OF HAND-REARED PRONGHORN () MILK REPLACER COMPOSITIONS AND GROWTH RATES. J Zoo Wildl Med. 2024;55:1056. doi:10.1638/2023-0112
- Wei Q, Song LY, Rao R, Yang HW, Wen YP, et al. The Impact of Combined Therapy with Lactobacillus acidophilus and Montmorillonite Powder on the Inflammatory Response in Pediatric Rotavirus Enteritis. Int Arch Allergy Immunol. 2024. doi:10.1159/000542593
- Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10232-4
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
- Miranda-Yuquilema J, Taboada J, Once V, Coyago M, Briñez W. Effect of Agroindustrial Waste Substrate Fermented with Lactic Acid Bacteria and Yeast on Changes in the Gut Microbiota of Guinea Pigs. Microorganisms. 2024;12. doi:10.3390/microorganisms12010133
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233.
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233.
- Higuchi T, Furuichi M, Maeda N, Tsugawa T, Ito K. Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan. J Infect Chemother. 2024;30:337. doi:10.1016/j.jiac.2023.11.005
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. doi:10.1001/jamapediatrics.2022.1973
- Huang R, Xing HY, Liu HJ, Chen ZF, Tang BB. Efficacy of probiotics in the treatment of acute diarrhea in children: a systematic review and meta-analysis of clinical trials. Transl Pediatr. 2021;10:3248. doi:10.21037/tp-21-511
- Gandhar JS, De UK, Kala A, Malik YS, Yadav S, et al. Efficacy of Microencapsulated Probiotic as Adjunct Therapy on Resolution of Diarrhea, Copper-Zinc Homeostasis, Immunoglobulins, and Inflammatory Markers in Serum of Spontaneous Rotavirus-Infected Diarrhoetic Calves. Probiotics Antimicrob Proteins. 2022;14:1054. doi:10.1007/s12602-021-09862-9
- Kumar M, Kala A, Chaudhary LC, Agarwal N, Kochewad SA. Microencapsulated and Lyophilized Lactobacillus acidophilus Improved Gut Health and Immune Status of Preruminant Calves. Probiotics Antimicrob Proteins. 2022;14:523. doi:10.1007/s12602-021-09821-4
- Chorawala MR, Chauhan S, Patel R, Shah G. Cell Wall Contents of Probiotics (Lactobacillus species) Protect Against Lipopolysaccharide (LPS)-Induced Murine Colitis by Limiting Immuno-inflammation and Oxidative Stress. Probiotics Antimicrob Proteins. 2021;13:1005. doi:10.1007/s12602-020-09738-4
- Gunaratnam S, Diarra C, Paquette PD, Ship N, Millette M, et al. The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291. Probiotics Antimicrob Proteins. 2021;13:949. doi:10.1007/s12602-020-09729-5
- Shin I, Kang Y, Ahn J, Kim Y, Nam J, et al. The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs. J Anim Sci. 2025. doi:10.1093/jas/skaf089
- Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. doi:10.1111/jgh.16809
- Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
- Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. doi:10.1002/mnfr.202400295
- Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. doi:10.1039/d3fo04653b
- Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. doi:10.3345/cep.2023.01340
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. doi:10.1007/s12325-024-02783-3
- Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. doi:10.3390/microorganisms12010198
- Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101878
- Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. doi:10.3389/fonc.2023.1168654
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. doi:10.3389/fphar.2023.1153070
- Niu H, Zhou X, Liu P, Wu Y, Lyu L, et al. Lactobacillus rhamnosus MN-431 Metabolic Tryptophan Alleviates Complementary Food-Induced Diarrhea through PXR-NF-κB Pathway and AHR-Th17 Cell Response Pathways. Mol Nutr Food Res. 2023;67:e2200530. doi:10.1002/mnfr.202200530
- Li J, Li Q, Wu Q, Gao N, Wang Z, et al. Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway. J Anim Sci Biotechnol. 2023;14:23. doi:10.1186/s40104-023-00830-7
- He Q, Lu S, Wang J, Xu C, Qu W, et al. and Berberine Alleviated Yak Calves' Diarrhea via Accommodating Oxidation Resistance, Inflammatory Factors, and Intestinal Microbiota. Animals (Basel). 2024;14. doi:10.3390/ani14162419
- Fan W, Zhu Y, Hou H, Yao J, Zhu L, et al. Treatment and prevention of pigeon diarrhea through the application of Lactobacillus SNK-6. Poult Sci. 2024;103:103476. doi:10.1016/j.psj.2024.103476
- Cuevas-Gómez I, de Andrés J, Cardenas N, Espinosa-Martos I, Jiménez E. Feed supplementation with Ligilactobacillus salivarius PS21603 optimises intestinal morphology and gut microbiota composition in weaned piglets. Benef Microbes. 2024;15:195. doi:10.1163/18762891-bja00001
- Molina RA, Villar MD, Miranda MH, Maldonado NC, Vignolo GM, et al. A multi-strain probiotic promoted recovery of puppies from gastroenteritis in a randomized, double-blind, placebo-controlled study. Can Vet J. 2023;64:666.
- Cuevas-Gómez I, de Andrés J, Cardenas N, Espinosa-Martos I, Jiménez E. Safety assessment and characterisation of PS21603 as potential feed additive for swine. Benef Microbes. 2022;13:397. doi:10.3920/BM2022.0020
- Sun Z, Li H, Li Y, Qiao J. , a Potential Probiotic to Improve the Health of LPS-Challenged Piglet Intestine by Alleviating Inflammation as Well as Oxidative Stress in a Dose-Dependent Manner During Weaning Transition. Front Vet Sci. 2020;7:547425. doi:10.3389/fvets.2020.547425
- Azagra-Boronat I, Massot-Cladera M, Knipping K, Garssen J, Ben Amor K, et al. Strain-Specific Probiotic Properties of Bifidobacteria and Lactobacilli for the Prevention of Diarrhea Caused by Rotavirus in a Preclinical Model. Nutrients. 2020;12. doi:10.3390/nu12020498
- Sayan H, Assavacheep P, Angkanaporn K, Assavacheep A. Effect of Lactobacillus salivarius on growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs challenged with F4+ enterotoxigenic Escherichia coli. Asian-Australas J Anim Sci. 2018;31:1308. doi:10.5713/ajas.17.0746
- Skórka A, Pieścik-Lech M, Kołodziej M, Szajewska H. To add or not to add probiotics to infant formulae? An updated systematic review. Benef Microbes. 2017;8:717. doi:10.3920/BM2016.0233
- Maldonado NC, Chiaraviglio J, Bru E, De Chazal L, Santos V, et al. Effect of Milk Fermented with Lactic Acid Bacteria on Diarrheal Incidence, Growth Performance and Microbiological and Blood Profiles of Newborn Dairy Calves. Probiotics Antimicrob Proteins. 2018;10:668. doi:10.1007/s12602-017-9308-4
- Lomasney KW, Cryan JF, Hyland NP. Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology. Am J Physiol Gastrointest Liver Physiol. 2014;307:G241. doi:10.1152/ajpgi.00401.2013
- Tsai CC, Lin PP, Hsieh YM. Three Lactobacillus strains from healthy infant stool inhibit enterotoxigenic Escherichia coli grown in vitro. Anaerobe. 2008;14:61. doi:10.1016/j.anaerobe.2007.11.003
- Casey PG, Gardiner GE, Casey G, Bradshaw B, Lawlor PG, et al. A five-strain probiotic combination reduces pathogen shedding and alleviates disease signs in pigs challenged with Salmonella enterica Serovar Typhimurium. Appl Environ Microbiol. 2007;73:1858.
- Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol. 2005;21:44.
- Xin H, Zhang X, Li P, Li H, Feng G, et al. Bifidobacterium bifidum supplementation improves ischemic stroke outcomes in elderly patients: A retrospective study. Medicine (Baltimore). 2024;103:e37682. doi:10.1097/MD.0000000000037682
- Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. doi:10.1371/journal.pone.0295998
- Tomita T, Fukui H, Okugawa T, Nakanishi T, Mieno M, et al. Effect of G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn's Disease: A Prospective Pilot Study. J Clin Med. 2023;12. doi:10.3390/jcm12103368
- Yalcin G, Demirbas F, Bacalan F, Toy EB. Evaluation of treatment in acute gastroenteritis: A comparative study. J Pak Med Assoc. 2022;72:2019. doi:10.47391/JPMA.4438
- Kang S, Lin Z, Xu Y, Park M, Ji GE, et al. A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease. Microb Cell Fact. 2022;21:113. doi:10.1186/s12934-022-01840-2
- Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. doi:10.1111/jdi.13698
- Ivashkin V, Fomin V, Moiseev S, Brovko M, Maslennikov R, et al. Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:460. doi:10.1007/s12602-021-09858-5
- Yang B, Huang Z, He Z, Yue Y, Zhou Y, et al. Protective effect of Bifidobacterium bifidum FSDJN7O5 and Bifidobacterium breve FHNFQ23M3 on diarrhea caused by enterotoxigenic Escherichia coli. Food Funct. 2021;12:7271. doi:10.1039/d1fo00504a
- Meskina ER, Tselipanova EE, Khadisova MK, Galkina LA, Stashko TV. [Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period]. Ter Arkh. 2021;93:456. doi:10.26442/00403660.2021.04.200835
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. doi:10.3390/nu12071999
- Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Probiotic Bifidobacterium bifidum G9-1 ameliorates phytohemagglutinin-induced diarrhea caused by intestinal dysbiosis. Microbiol Immunol. 2019;63:481. doi:10.1111/1348-0421.12743
- Renaud DL, Kelton DF, Weese JS, Noble C, Duffield TF. Evaluation of a multispecies probiotic as a supportive treatment for diarrhea in dairy calves: A randomized clinical trial. J Dairy Sci. 2019;102:4498. doi:10.3168/jds.2018-15793
- Huang L, Chiang Chiau JS, Cheng ML, Chan WT, Jiang CB, et al. SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy. Pediatr Neonatol. 2019;60:252. doi:10.1016/j.pedneo.2018.07.007
- Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. doi:10.1016/j.clnesp.2024.11.016
- Moreno-Muñoz JA, Ojeda JD, López JJ. A Probiotic Bacterium with Activity against the Most Frequent Bacteria and Viruses Causing Pediatric Diarrhea: subsp. CECT 7210 ( IM1). Microorganisms. 2024;12. doi:10.3390/microorganisms12061183
- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjunctive efficacy of Lactis XLTG11 for Acute diarrhea in children: A randomized, blinded, placebo-controlled study. Nutrition. 2023;111:112052. doi:10.1016/j.nut.2023.112052
- Li W, Zhang S, Wang Y, Bian H, Yu S, et al. Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Front Microbiol. 2023;14:1156058. doi:10.3389/fmicb.2023.1156058
- Mizutani Y, Kawamoto S, Takahashi M, Doi H, Wakida K, et al. Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study. Intern Med. 2023;62:2949. doi:10.2169/internalmedicine.1314-22
- Li W, Kai L, Jiang Z, He H, Yang M, et al. , and Reversed ETEC-Inducing Intestinal Inflammation in Mice. Microorganisms. 2022;10. doi:10.3390/microorganisms10122350
- Yakovenko EP, Strokova TV, Ivanov AN, Iakovenko AV, Gioeva IZ, et al. [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Ter Arkh. 2022;94:180. doi:10.26442/00403660.2022.02.201368
- Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. doi:10.5056/jnm21202
- Álvarez-Mercado AI, Plaza-Díaz J, de Almagro MC, Gil Á, Moreno-Muñoz JA, et al. subsp. CECT 7210 Reduces Inflammatory Cytokine Secretion in Caco-2 Cells Cultured in the Presence of CECT 515. Int J Mol Sci. 2022;23. doi:10.3390/ijms231810813
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
- Uttarwar RG, Mekonnen SA, Van Beeck W, Wang A, Finnegan P, et al. Effects of Bifidobacterium animalis subsp. lactis BB-12 and yogurt on mice during oral antibiotic administration. Microbiol Res. 2024;286:127794. doi:10.1016/j.micres.2024.127794
- Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024;78:501. doi:10.1038/s41430-024-01428-6
- Pang J, Liu Y, Kang L, Ye H, Zang J, et al. Bifidobacterium animalis Promotes the Growth of Weaning Piglets by Improving Intestinal Development, Enhancing Antioxidant Capacity, and Modulating Gut Microbiota. Appl Environ Microbiol. 2022;88:e0129622. doi:10.1128/aem.01296-22
- Şahin K, Şahintürk Y, Köker G, Özçelik Köker G, Bostan F, et al. Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance. Turk J Gastroenterol. 2022;33:925. doi:10.5152/tjg.2022.211063
- Xu B, Liang S, Zhao J, Li X, Guo J, et al. subsp. XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Funct. 2022;13:6404. doi:10.1039/d1fo04305f
- Liu B, Wang C, Huasai S, Han A, Zhang J, et al. Compound Probiotics Improve the Diarrhea Rate and Intestinal Microbiota of Newborn Calves. Animals (Basel). 2022;12. doi:10.3390/ani12030322
- Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, et al. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:738. doi:10.1007/s12602-021-09900-6
- Cheng J, Laitila A, Ouwehand AC. subsp. HN019 Effects on Gut Health: A Review. Front Nutr. 2021;8:790561. doi:10.3389/fnut.2021.790561
- Li Z, Zhu G, Li C, Lai H, Liu X, et al. Which Probiotic Is the Most Effective for Treating Acute Diarrhea in Children? A Bayesian Network Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13. doi:10.3390/nu13124319
- Guo Y, Li Z, Deng M, Li Y, Liu G, et al. Effects of a multi-strain probiotic on growth, health, and fecal bacterial flora of neonatal dairy calves. Anim Biosci. 2022;35:204. doi:10.5713/ab.21.0084
- Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, et al. subsp. BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients. 2021;13. doi:10.3390/nu13082814
- Kluijfhout S, Trieu TV, Vandenplas Y. Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis. Pediatr Gastroenterol Hepatol Nutr. 2020;23:464. doi:10.5223/pghn.2020.23.5.464
