Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.6
USERS' SCORE
Good
Based on 13 Reviews
8.3
Supplement Facts
Serving Size: 1 Chewable
Amount Per Serving
%DV
Calories
5
Total Fat
0 g
0%
Sodium
0 mg
0%
Total Carbohydrate
1 g
0%
Total Sugars
less than 1 g
Includes 0 g Added Sugars
0%
Vitamin C*
30 mg
33%
Vitamin D** (as D3)
10 mcg (400 IU)
50%
Kids Probiotic BlendLactobacillus acidophilusLactobacillus gasseriLactobacillus paracaseiLactobacillus plantarumLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus salivariusLactobacillus bulgaricusTotal Lacto Cultures (4 Billion CFU)Bifidobacterium lactisBifidobacterium breveBifidobacterium infantisBifidobacterium bifidumBifidobacterium longumTotal Bifido Cultures (1 Billion CFU)
71 mg
+
Total Probiotic Cultures
5 Billion CFU1
Organic Prebiotic Fiber BlendOrganic Acacia Fiber (A. senegal), Organic Whole Cranberry (Vaccinium macrocarpon) (fruit), Organic Emblic (Amla, Phyllanthus emblica) (fruit) Extract
310 mg
+
Top Medical Research Studies
9.5
Bifidobacterium bifidum improves IBS symptoms
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Read More
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
Most Useful Reviews
9
Improved bowel function
1 people found this helpful
Great probiotics! I purchased these on recommendation and it was a wise choice. My 5-year-old takes them willingly, dissolving 1-2 hours before bed. In two weeks, her bowel movements improved, and the frequent complaints of abdominal pain disappeared. The composition is excellent, featuring 14 different strains often hard to find elsewhere. I highly recommend them for children.
Read More
9
Regulated bowel movement
My son adores these! At six, he’s eager to take one daily, especially enjoying the watermelon flavour. Knowing they are organic reassures me. I’ve noticed they help regulate his bowel movements and although a bit pricey, I choose to give him these.
Read More
9
Restored bowel function
Excellent! I tried it based on reviews and it was worth it! It’s tasty, and I give it 30-40 minutes before breakfast, ensuring it doesn’t cause constipation. I use it to restore intestinal flora and maintain regular bowel movements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.6
- All Researches
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Bifidobacterium bifidum improves IBS symptoms
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Read More
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Lactobacillus drink benefits IBS-C
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved bowel function
1 people found this helpful
Great probiotics! I purchased these on recommendation and it was a wise choice. My 5-year-old takes them willingly, dissolving 1-2 hours before bed. In two weeks, her bowel movements improved, and the frequent complaints of abdominal pain disappeared. The composition is excellent, featuring 14 different strains often hard to find elsewhere. I highly recommend them for children.
Read More
9
Regulated bowel movement
My son adores these! At six, he’s eager to take one daily, especially enjoying the watermelon flavour. Knowing they are organic reassures me. I’ve noticed they help regulate his bowel movements and although a bit pricey, I choose to give him these.
Read More
9
Restored bowel function
Excellent! I tried it based on reviews and it was worth it! It’s tasty, and I give it 30-40 minutes before breakfast, ensuring it doesn’t cause constipation. I use it to restore intestinal flora and maintain regular bowel movements.
Read More
9
Enhanced gut health
My family loves Garden of Life products. This probiotic exceeds expectations, really aiding my children’s gut health. They’re more regular with their bowel movements and seem more focused.
Read More
9
Satisfactory outcome
The watermelon flavour is delightful. Though the price is steep, I am pleased with the purchase since my child has a bowel movement daily, which helps with their irritable bowel syndrome.
Read More
Frequently Asked Questions
9
Improved bowel function
1 people found this helpful
Great probiotics! I purchased these on recommendation and it was a wise choice. My 5-year-old takes them willingly, dissolving 1-2 hours before bed. In two weeks, her bowel movements improved, and the frequent complaints of abdominal pain disappeared. The composition is excellent, featuring 14 different strains often hard to find elsewhere. I highly recommend them for children.
7.5
Normalised bowel function
My child frequently experienced stool issues. This product has helped us normalise bowel function and seems to boost their appetite.
6
Regular bowel movement
My child enjoys these as they taste like watermelon! Previously, their stool resembled rabbit droppings, but now it’s much thicker. The colour is even reminiscent of newborn stool.
9
Satisfactory outcome
The watermelon flavour is delightful. Though the price is steep, I am pleased with the purchase since my child has a bowel movement daily, which helps with their irritable bowel syndrome.
9
Enhanced gut health
My family loves Garden of Life products. This probiotic exceeds expectations, really aiding my children’s gut health. They’re more regular with their bowel movements and seem more focused.
7.5
Supports bowel health
For my daughter, she loved the taste as it was chewy, making it easier for her to take without difficulty. It’s great for immune support and suitable for managing irritable bowel syndrome. Approved, I will buy it more often.
9
Restored bowel function
Excellent! I tried it based on reviews and it was worth it! It’s tasty, and I give it 30-40 minutes before breakfast, ensuring it doesn’t cause constipation. I use it to restore intestinal flora and maintain regular bowel movements.
9
Regulated bowel movement
My son adores these! At six, he’s eager to take one daily, especially enjoying the watermelon flavour. Knowing they are organic reassures me. I’ve noticed they help regulate his bowel movements and although a bit pricey, I choose to give him these.
8
Helps with digestion
I always feed my children this lactic acid bacteria as it tastes nice. They eat it well, and it seems to aid in bowel movements, particularly in relation to managing their irritable bowel syndrome.
9
Lactobacillus drink benefits IBS-C
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
8
We investigated the impact of multispecies probiotics, including Lactobacillus acidophilus, in treating irritable bowel syndrome (IBS). In a randomized, double-blind study with 49 participants, those taking probiotics experienced significantly more symptom relief than those on a placebo after four weeks.
The probiotics not only eased abdominal discomfort and bloating but also positively altered gut bacteria. Our findings suggest that multispecies probiotics could be a valuable option for managing IBS symptoms.
The probiotics not only eased abdominal discomfort and bloating but also positively altered gut bacteria. Our findings suggest that multispecies probiotics could be a valuable option for managing IBS symptoms.
This randomized double-blind placebo-controlled trial investigated how a synbiotic preparation affects adults with diarrhea-predominant irritable bowel syndrome (IBS-D).
Over eight weeks, we found that the synbiotics significantly improved overall IBS symptoms and specific issues like flatulence and bowel habits compared to the placebo.
Participants reported less discomfort such as incomplete bowel movements and fewer diarrheal episodes.
Importantly, the synbiotics were well tolerated, with no significant differences in adverse events between the groups.
Over eight weeks, we found that the synbiotics significantly improved overall IBS symptoms and specific issues like flatulence and bowel habits compared to the placebo.
Participants reported less discomfort such as incomplete bowel movements and fewer diarrheal episodes.
Importantly, the synbiotics were well tolerated, with no significant differences in adverse events between the groups.
References
- Sarkawi M, Raja Ali RA, Abdul Wahab N, Abdul Rathi ND, Mokhtar NM. A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. Sci Rep. 2024;14:9478. doi:10.1038/s41598-024-60029-2
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233.
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233.
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Cocetta V, Giacomini I, Tinazzi M, Berretta M, Quagliariello V, et al. Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Minerva Pediatr (Torino). 2023. doi:10.23736/S2724-5276.23.07128-8
- Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. doi:10.5056/jnm21202
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. doi:10.3390/nu12071999
- Martoni CJ, Srivastava S, Leyer GJ. DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020;12. doi:10.3390/nu12020363
- Sadrin S, Sennoune S, Gout B, Marque S, Moreau J, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis. 2020;52:534. doi:10.1016/j.dld.2019.12.009
- Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. doi:10.3920/BM2017.0105
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. doi:10.3168/jds.2015-10743
- Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. doi:10.3164/jcbn.15-14
- Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29:52. doi:10.1111/jgh.12322
- Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. doi:10.3390/ijms26062656
- Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, et al. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med. 2024;14. doi:10.3390/jcm14010006
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Zhang L, Ni X, Jiang M, Du M, Zhang S, et al. Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome. Microorganisms. 2024;12. doi:10.3390/microorganisms12061081
- Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
- Ding FCL, Karkhaneh M, Zorzela L, Jou H, Vohra S. Probiotics for paediatric functional abdominal pain disorders: A rapid review. Paediatr Child Health. 2019;24:383. doi:10.1093/pch/pxz036
- Nocerino R, Di Costanzo M, Bedogni G, Cosenza L, Maddalena Y, et al. Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy. J Pediatr. 2019;213:137. doi:10.1016/j.jpeds.2019.06.004
- Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. doi:10.1007/5584_2018_321
- Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. doi:10.1080/19490976.2018.1479625
- Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. doi:10.1097/MCG.0000000000001054
- Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. doi:10.1111/jam.13320
- Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. doi:10.1007/s40272-015-0124-6
- Chung HG, Min YW, Lee C, Hong SN, Won JY, et al. Effects of Novel Probiotics in a Murine Model of Irritable Bowel Syndrome. Korean J Gastroenterol. 2020;75:141. doi:10.4166/kjg.2020.75.3.141
- Ruiz-Sánchez C, Escudero-López B, Fernández-Pachón MS. Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome. Endocrinol Diabetes Nutr (Engl Ed). 2024;71:19. doi:10.1016/j.endien.2024.01.003
- Tomita T, Fukui H, Okugawa T, Nakanishi T, Mieno M, et al. Effect of G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn's Disease: A Prospective Pilot Study. J Clin Med. 2023;12. doi:10.3390/jcm12103368
- Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5:658. doi:10.1016/S2468-1253(20)30056-X
- Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:1123. doi:10.1111/j.1365-2036.2011.04633.x
- Hong KS, Kang HW, Im JP, Ji GE, Kim SG, et al. Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Gut Liver. 2009;3:101. doi:10.5009/gnl.2009.3.2.101
- Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2009;29:97. doi:10.1111/j.1365-2036.2008.03848.x
- Martin FP, Cominetti O, Berger B, Combremont S, Marquis J, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Gut Microbes. 2024;16:2347715. doi:10.1080/19490976.2024.2347715
- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Khoo XH, Chong CW, Talha AM, Philip K, Teh CS, et al. The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. J Gastroenterol Hepatol. 2023;38:1259. doi:10.1111/jgh.16174
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Yakovenko EP, Strokova TV, Ivanov AN, Iakovenko AV, Gioeva IZ, et al. [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Ter Arkh. 2022;94:180. doi:10.26442/00403660.2022.02.201368
- Groeger D, Murphy EF, Tan HTT, Larsen IS, O'Neill I, et al. Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination. Neurogastroenterol Motil. 2023;35:e14477. doi:10.1111/nmo.14477
- Sabaté JM, Iglicki F. Effect of 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol. 2022;28:732. doi:10.3748/wjg.v28.i7.732
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. doi:10.1016/j.clnesp.2020.12.025
- Caviglia GP, Tucci A, Pellicano R, Fagoonee S, Rosso C, et al. Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with ES1 for 8 or 12 Weeks: A Preliminary Report. J Clin Med. 2020;9. doi:10.3390/jcm9082353
- Buhner S, Hahne H, Hartwig K, Li Q, Vignali S, et al. Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients. PLoS One. 2018;13:e0193943. doi:10.1371/journal.pone.0193943
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. doi:10.1007/s00394-024-03398-8
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. doi:10.3390/jcm12144838
- Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, et al. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021;2:691689. doi:10.3389/fpain.2021.691689
- Xu H, Ma C, Zhao F, Chen P, Liu Y, et al. Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome. Eur J Nutr. 2021;60:2553. doi:10.1007/s00394-020-02437-4
- Szajewska H, Hojsak I. Health benefits of GG and subspecies BB-12 in children. Postgrad Med. 2020;132:441. doi:10.1080/00325481.2020.1731214
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