Garden of Life B12 Vitamin

Pernicious anemia treatment effectiveness

Based on 19 Researches

Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.

Most Relevant Research

We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.

Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.

This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.

B12 normalised

Most Useful Review

According to the test results, my child was deficient in B12, which I ordered upon the doctor's recommendation. This vitamin is fantastic and has a pleasant taste, so my child takes it willingly. After 14 days, my child's B12 levels were back to normal—what a relief!

Anemia details

Saccharomyces effectively treats anemia

Moderately Effective

Based on 15 Researches

Production of iron-enriched yeast and it's application in the treatment of iron-deficiency anemia.

Most Relevant Research

We aimed to explore whether Saccharomyces cerevisiae, enriched with iron, could serve as a beneficial treatment for iron-deficiency anemia (IDA) in mice. Our study involved dividing 60 mice into groups that received various forms of iron supplements, including the enriched yeast strain.

Remarkably, those treated with the iron-enriched yeast showed significant recovery. Their weights and blood parameters returned to normal, and levels of key antioxidants in their blood improved. This suggests that strain no. F8, which thrives in iron-rich conditions, could be a promising avenue for developing new organic iron supplements.

9.5

Convenient anaemia solution

Most Useful Review

I have a positive impression of these vitamins. The vitamin B12 spray format is convenient for children, avoiding injections or pills. As someone with low hemoglobin and a restricted diet, I find these vitamins helpful. No side effects, and after a month, my hair stopped falling out, and chronic fatigue disappeared.

Chronic Fatigue Syndrome details

Vitamin B12 ineffective for CFS

Based on 9 Researches

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Most Relevant Research

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

9.5

Fatigue improvement

Most Useful Review

I find these vitamins effective. The vitamin B12 spray is convenient for children—no injections or pills needed. As I have low hemoglobin and do not eat meat, I thought these would benefit me. I experienced no allergies or gastrointestinal changes. My hair stopped falling out after a month, and the chronic fatigue syndrome vanished.

Allergies details

Potential asthma management via yeast

Moderately Effective

Based on 4 Researches

Perinatal administration of Saccharomyces cerevisiae UFMG A-905 prevents asthma development in the offspring of mice.

Most Relevant Research

We explored how perinatal administration of Saccharomyces cerevisiae UFMG A-905 could help prevent asthma in mouse offspring. This study involved various groups of mice receiving the yeast at different stages: before conception, during pregnancy, or only during lactation.

Our results showed that those exposed to S. cerevisiae exhibited significantly less airway hyperresponsiveness and lower levels of certain inflammatory markers compared to those that didn’t receive the treatment. Notably, the greatest protection occurred when the yeast was given during lactation.

Overall, it seems that S. cerevisiae UFMG A-905 shows promise in the management of asthma, especially when administered early in the offspring's development.

9.5

No allergies noted

Most Useful Review

The impression of these vitamins is positive. The vitamin B12 comes in a convenient spray format, making it easy to administer to children without injections or pills. As I have low hemoglobin and don't consume meat, I found these vitamins helpful. There were no allergies or gastrointestinal issues, and my hair stopped falling out after a month. Chronic fatigue also disappeared.

Back Pain details

Vitamin B12 aids low back pain

Moderately Effective

Based on 16 Researches

Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.

Most Relevant Research

We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.

By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.

Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.

9.5

Effective B12 treatment

Most Useful Review

Perfectly raises vitamin B12 levels. I was deficient and purchased this spray, which provides 500 mcg per puff under the tongue for better absorption. It effectively boosted my B12, allowing me to quickly recover. Now, for prevention, I take one puff at times and two doses once a month under the tongue.

Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors.

Most Relevant Research

We explored the potential benefits of Japanese sake yeast on anxiety and depression in mice subjected to stress. Over a week, we treated the mice with different doses of sake yeast and assessed its effects on anxiety, mood, and sleep.

Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.

8.8

Quick anxiety relief

Most Useful Review

Fast Relief for your Nerves! My sister mentioned this product to me, and it helps greatly with my nerves and anxiety. A couple of sprays really seems to provide me with more tolerance on those days I feel overwhelmed.

Cold details

Vitamin B12 shows cold pain relief

Based on 2 Researches

The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.

Most Relevant Research

We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.

In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.

As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.

9.5

Immediate cold relief

Most Useful Review

Love this B12! My family is vegan, so we need a B vitamin that is easily processed, vegan, and affordable. We adore this spray. During a period of 1-2 months without it, I noticed a significant change. Oddly, my skin broke out with pimples, I felt exhausted, and I caught 2 colds, which is unusual for me. After just one week of daily use, my skin and energy returned to normal, and the cold vanished! I won't go without it again.

Headache details

Vitamin B12 deficiency linked to migraines

The correlation between vitamin B12 serum levels and migraine: a case-control study.

Most Relevant Research

We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.

We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.

Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.

9.5

Energy and relief

Most Useful Review

My 17-year-old son had fatigue, headaches, and dry lips. After trying this product, I noticed he had more energy and his dry lips improved. He hasn't had any headaches since starting this, so I believe it genuinely works!

Hot Flashes details

Life changing experience

Most Useful Review

As a woman over 50 with typical perimenopausal symptoms, particularly fatigue, mood swings, and hot flashes, trying the Garden of Life B12 spray was life-changing. The difference was so dramatic that my son immediately noticed it and encouraged me to continue. My energy levels returned to normal, and I felt happy again with no mood swings. I take one spray in the morning and another in the afternoon. I’ve tried many supplements before but never had such an obvious improvement—highly recommend this product!

Insomnia details

Vitamin B12 promotes sleep in rats

Based on 7 Researches

Effects of intravenously administered vitamin B12 on sleep in the rat.

Most Relevant Research

We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.

During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.

Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.

9.5

Life-changing sleep

Most Useful Review

This product changed my life. I have various medical conditions that cause insomnia, low energy, and fatigue. Since I started taking this, I've been sleeping better and my energy has increased tremendously. It’s hard to express how grateful I am for this product, which has been working perfectly for nearly four weeks now.

Menopause details

Vitamin B12 may aid menopause relief

Likely Very Effective

Based on 2 Researches

Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.

Most Relevant Research

We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.

After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.

However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.

9.5

Restored energy

Most Useful Review

Game Changer for Female 50+. As a woman over 50, I experienced perimenopause symptoms like fatigue, mood swings, and hot flashes. I tried Garden of Life B12 spray, which transformed my life. This dramatic change led me to write a review! My son noticed the difference immediately. My energy levels returned to normal; I’m happier now with no mood swings. No issues with flavour; I’d use it regardless of taste. This has been truly beneficial.

Blurred Vision details

The condition of my skin, mucous membranes, nails, and hair has improved significantly thanks to this product, often referred to as a “beauty vitamin”. It has had a positive effect on my vision and aids in hemoglobin production. Vitamin B12 (cyanocobalamin), found in meat, offal, eggs, mushrooms, and cabbage, plays a crucial role in red blood cell formation, neuron development, and DNA synthesis. A deficiency can lead to serious issues like blurred vision, neurotoxic build-up, anaemia, loss of balance, limb numbness, fatigue, and memory loss. I’ve noticed indicators such as anaemia, persistent fatigue, weakness, and pale skin, which may signal a lack of this essential vitamin.

Hypothyroidism details

Vitamin B12 and hypothyroid patients

Based on 5 Researches

A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.

Most Relevant Research

We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.

Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.

Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.

9.5

Improvement noticed

Most Useful Review

This supplement worked wonders for my hypothyroidism and B12 deficiency. After a two-month course, my results improved significantly, and my naturopath was pleased. The goitre I thought was normal has reduced, and my husband's levels improved as well. We'll continue taking B12 until it's optimal.

Liver Disease details

Methylcobalamin aids liver health

Based on 14 Researches

Methylcobalamin protects against liver failure via engaging gasdermin E.

Most Relevant Research

We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.

Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.

Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.

9.5

Salvation for deficiency

Most Useful Review

An essential vitamin for the body, especially for those with liver disease. This product provides effective support and can be a real lifesaver!

Pelvic Pain details

This product is excellent for alleviating pelvic pain, especially if you have low levels of vitamin B complex. I frequently purchase vitamin B, but I believe this is one of the best supplements I have bought.

Pneumonia details

Supports pneumonia treatment

Most Useful Review

Only in this form is the drug effective. I have taken vitamin B12 for years; it is the only one that works for me, supports my immune system, and alleviates anaemia. After testing, my levels are normal. I also give it to my husband. The taste is pleasant, and there are no side effects. It's vital for maintaining immunity, especially concerning pneumonia.

Tinnitus details

It's excellent! Although I haven't tested my B12 levels, my tinnitus and tachycardia have diminished. I appreciate the convenient sweet berry spray for taking the vitamin.

Bone Pain details

β-Glucans improve bone health

β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.

Most Relevant Research

We investigated how β-glucans derived from Saccharomyces cerevisiae can impact bone loss and metabolic health. In our study, diabetic rats underwent a treatment regimen of β-glucans for 28 days.

We observed that these glucans significantly reduced the loss of alveolar bone in both diabetic and non-diabetic groups, as well as lowered blood glucose and triglyceride levels. Additionally, they appeared to improve metabolic markers related to inflammation and bone health.

Overall, β-glucans show promise for enhancing both metabolic and periodontal health in diabetic conditions.

8.8

Reduced body pain

Most Useful Review

This is excellent for alleviating bone pain if you have low vitamin B levels. I purchase vitamin B frequently, and I believe this is one of the best I have had.

Heart Disease details

Vitamin B12 helps heart recovery

Based on 4 Researches

Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.

Most Relevant Research

We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.

9.5

Positive heart effects

Most Useful Review

I chose this natural vitamin because of its pleasant raspberry taste. Taking it once a day under the tongue has positively affected my heart muscles, thyroid glands, immunity, and blood pressure, while providing antiallergenic, antitoxic, and antitumour benefits. Despite B12 being poorly absorbed, this form worked well for me, alleviating muscle aches and pains.

Cancer details

Hydrothermal yeast impacts breast cancer

Based on 10 Researches

Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall.

Most Relevant Research

We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.

The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.

This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.

Overall, our findings hint at a promising potential for this approach in cancer therapy development.

1.3

Risky dosage warning

Most Useful Review

20833% RDA is excessive. Such extreme levels in any supplement are unhealthy. Excess vitamin B12 may increase cancer risk, according to studies. A headache soon after taking it can indicate the body struggles to cope with such large amounts. Manufacturers promote high dosages since they are inexpensive to produce, but this does not ensure efficacy. It’s advisable to use only a small amount daily to gain benefits without the undesirable risks and side effects.

Sore Throat details

Ineffective treatment

Most Useful Review

Doesn't work. Don't waste your money. My throat was sore, and despite the positive reviews, it didn't help me at all. I attempted to return the product, but I received NO REFUND. This product was a disappointment, so avoid wasting your money or time on this ineffective spray.

Heart Attack details