Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8.3
USERS' SCORE
Good
Based on 36 Reviews
8.1
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
Most Useful Reviews
9
Convenient anaemia solution
196 people found this helpful
I have a positive impression of these vitamins. The vitamin B12 spray format is convenient for children, avoiding injections or pills. As someone with low hemoglobin and a restricted diet, I find these vitamins helpful. No side effects, and after a month, my hair stopped falling out, and chronic fatigue disappeared.
Read More
9
Boosts energy levels
28 people found this helpful
A very good form of vitamin B12. I take it for anaemia, and it works effectively. It’s pleasant tasting and well absorbed, providing a surge of energy.
Read More
9
Improved cognition
14 people found this helpful
Saved me from pernicious anemia. I struggled to obtain injectable B-12 due to high prices and poor health insurance. My doctor's office no longer offers B-12 shots. I started experiencing severe memory problems and cognitive issues. After taking this B-12, I noticed improvement within three days, and now, weeks later, I feel much better. It has greatly boosted my energy and diminished my brain fog. I'm genuinely grateful for this product. Also, it tastes pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8.3
- All Researches
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
9
We explored a case of a 3-year-old girl diagnosed with Imerslund-Gräsbeck syndrome, a condition that causes vitamin B12 malabsorption and leads to anemia. After identifying novel mutations in the AMN gene, we initiated long-term oral vitamin B12 therapy.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Convenient anaemia solution
196 people found this helpful
I have a positive impression of these vitamins. The vitamin B12 spray format is convenient for children, avoiding injections or pills. As someone with low hemoglobin and a restricted diet, I find these vitamins helpful. No side effects, and after a month, my hair stopped falling out, and chronic fatigue disappeared.
Read More
9
Boosts energy levels
28 people found this helpful
A very good form of vitamin B12. I take it for anaemia, and it works effectively. It’s pleasant tasting and well absorbed, providing a surge of energy.
Read More
9
Improved cognition
14 people found this helpful
Saved me from pernicious anemia. I struggled to obtain injectable B-12 due to high prices and poor health insurance. My doctor's office no longer offers B-12 shots. I started experiencing severe memory problems and cognitive issues. After taking this B-12, I noticed improvement within three days, and now, weeks later, I feel much better. It has greatly boosted my energy and diminished my brain fog. I'm genuinely grateful for this product. Also, it tastes pleasant.
Read More
9
Child's anaemia improved
9 people found this helpful
Recommended by a hematologist for my daughter and me, this vitamin is easy to use. The child readily accepts it, and it has improved our blood counts. It provides significant energy, making it essential for managing anaemia.
Read More
7.5
Noticeable energy boost
4 people found this helpful
I purchased this for my child to prevent anaemia. The spray form allows for better absorption, and he enjoys the taste. After using it, he became more active, exhibiting significant energy improvements. We're continuing with it and noticing positive changes.
Read More
Frequently Asked Questions
7.5
Pleasant flavour
2 people found this helpful
I've been a vegetarian for 1.5 years and experienced a vitamin B12 deficiency resembling anaemia. This sublingual spray has the best flavour I've tried, and I noticed positive effects in just a week and a half.
9
Raised haemoglobin
2 people found this helpful
Raised my haemoglobin after being diagnosed with anaemia. It normalised in two months and is comfortable to take with a pleasant taste.
9
Family-friendly solution
1 people found this helpful
As a vegetarian family, this is the perfect solution for our severe B12 deficiency and haemoglobin levels. After a month, my levels improved. This spray is essential for healthy nervous system functioning.
9
Convenient anaemia solution
196 people found this helpful
I have a positive impression of these vitamins. The vitamin B12 spray format is convenient for children, avoiding injections or pills. As someone with low hemoglobin and a restricted diet, I find these vitamins helpful. No side effects, and after a month, my hair stopped falling out, and chronic fatigue disappeared.
9
Child's anaemia improved
9 people found this helpful
Recommended by a hematologist for my daughter and me, this vitamin is easy to use. The child readily accepts it, and it has improved our blood counts. It provides significant energy, making it essential for managing anaemia.
7.5
Noticeable energy boost
4 people found this helpful
I purchased this for my child to prevent anaemia. The spray form allows for better absorption, and he enjoys the taste. After using it, he became more active, exhibiting significant energy improvements. We're continuing with it and noticing positive changes.
7.5
Supports iron absorption
16 people found this helpful
My doctor recommended this vitamin. It's essential to take it after meals, without combining it with iron. Despite having normal hemoglobin, I suffered from anaemia due to iron not reaching the cells. I'm experiencing improvements in my health, and the fruity taste makes it enjoyable.
9
Boosts absorption
1 people found this helpful
This natural B12 spray is the best as it’s absorbed effectively. It helps improve metabolism and energy levels while also assisting iron absorption for those with anaemia. My son enjoys the berry taste.
8
This case explores the journey of a 40-year-old woman who suffered from various nonspecific symptoms, mistakenly attributed to other health issues, for ten years. Her vitamin B12 levels were critically low, ultimately diagnosed as pernicious anemia.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
8
We examined cases of megaloblastic anemia (MA) in children, focusing particularly on the impact of vitamin B12 treatment. Over a span of 42 years, we gathered data on 20 children diagnosed with this rare condition, which primarily arises from deficiencies in vitamin B12 and folic acid.
During our investigation, we found that vitamin B12 related issues played a significant role in various cases. For instance, some children experienced vitamin B12 deficiency due to maternal factors or malnutrition, while others had more specific conditions contributing to their deficiency. Notably, we observed a macrocytic anemia in nearly all cases, underlining the importance of identifying and treating vitamin B12 deficiencies promptly.
Our treatment approaches included not just supplementation with vitamin B12 but also addressing other underlying causes of anemia. While the majority of cases showed a favorable response, we noted some serious outcomes, underscoring that the effectiveness of vitamin B12 treatment can vary greatly depending on the individual situation.
In conclusion, this study highlights the critical role that early diagnosis and targeted therapeutic measures play in improving the long-term neurological outcomes for children suffering from megaloblastic anemia, particularly those with vitamin B12 deficiency.
During our investigation, we found that vitamin B12 related issues played a significant role in various cases. For instance, some children experienced vitamin B12 deficiency due to maternal factors or malnutrition, while others had more specific conditions contributing to their deficiency. Notably, we observed a macrocytic anemia in nearly all cases, underlining the importance of identifying and treating vitamin B12 deficiencies promptly.
Our treatment approaches included not just supplementation with vitamin B12 but also addressing other underlying causes of anemia. While the majority of cases showed a favorable response, we noted some serious outcomes, underscoring that the effectiveness of vitamin B12 treatment can vary greatly depending on the individual situation.
In conclusion, this study highlights the critical role that early diagnosis and targeted therapeutic measures play in improving the long-term neurological outcomes for children suffering from megaloblastic anemia, particularly those with vitamin B12 deficiency.
8
We explored a case involving a 51-year-old Ugandan man who experienced recurring lower limb weakness and was ultimately diagnosed with pernicious anemia. His condition stemmed from vitamin B12 deficiency, confirmed by blood tests showing macrocytic anemia and low cobalamin levels.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
9
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. 10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. 10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. 10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. 10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. 10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. 10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. 10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. 10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. 10.1007/s12185-024-03759-3
- Chen Y, Pang Y, Wan H, Zhou X, Wan M, et al. Production of iron-enriched yeast and it's application in the treatment of iron-deficiency anemia. Biometals. 2024;37:1023. 10.1007/s10534-024-00592-3
- Tafazzoli K, Ghavami M, Khosravi-Darani K. Production of iron enriched Saccharomyces boulardii: impact of process variables. Sci Rep. 2024;14:4844. 10.1038/s41598-024-55433-7
- Zhang XG, Wang N, Ma GD, Liu ZY, Wei GX, et al. Preparation of S-iron-enriched yeast using siderophores and its effect on iron deficiency anemia in rats. Food Chem. 2021;365:130508. 10.1016/j.foodchem.2021.130508
- Zhang XG, Wei GX, Wang WN, Ma GD, Tang P, et al. Effects of Fe-YM1504 on iron deficiency anemia in rats. Food Funct. 2016;7:3184. 10.1039/c6fo00423g
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. 10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. 10.1007/s13668-025-00622-7
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. 10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. 10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. 10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. 10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. 10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. 10.3389/fnut.2024.1493593
