Last update
8/6/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
8
Sake yeast shows potential for anxiety
We explored the potential benefits of Japanese sake yeast on anxiety and depression in mice subjected to stress. Over a week, we treated the mice with different doses of sake yeast and assessed its effects on anxiety, mood, and sleep.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
Read More
8
Yeast hydrolysate shows anti-anxiety effects
We investigated the anti-stress effects of yeast hydrolysate (YH) in a study involving human subjects over two weeks. Participants who received YH showed improved scores on both the Beck Anxiety Inventory and Beck Depression Inventory, particularly regarding physical symptoms of anxiety. Brain mapping revealed a balanced distribution of theta and alpha waves, suggesting a more stable mental state. Overall, our findings suggest that yeast hydrolysate could be beneficial for reducing anxiety levels and enhancing one's ability to cope with stress.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
Most Useful Reviews
7.5
Quick anxiety relief
4 people found this helpful
Fast Relief for your Nerves! My sister mentioned this product to me, and it helps greatly with my nerves and anxiety. A couple of sprays really seems to provide me with more tolerance on those days I feel overwhelmed.
Read More
9
Enhanced energy levels
14 people found this helpful
Life changing! I have been taking this daily for a month; it has truly transformed my life. Each day, I feel an increase in energy levels and it has notably helped with my anxiety.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.7
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
8
Sake yeast shows potential for anxiety
We explored the potential benefits of Japanese sake yeast on anxiety and depression in mice subjected to stress. Over a week, we treated the mice with different doses of sake yeast and assessed its effects on anxiety, mood, and sleep.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
Our findings indicated that the yeast improved anxiety and antidepressant-like behaviors, particularly at higher doses. It also increased sleep duration and influenced certain brain levels related to mood. However, the overall results suggest that while sake yeast shows promise, it may not significantly alter all biological markers associated with stress.
Read More
8
Yeast hydrolysate shows anti-anxiety effects
We investigated the anti-stress effects of yeast hydrolysate (YH) in a study involving human subjects over two weeks. Participants who received YH showed improved scores on both the Beck Anxiety Inventory and Beck Depression Inventory, particularly regarding physical symptoms of anxiety. Brain mapping revealed a balanced distribution of theta and alpha waves, suggesting a more stable mental state. Overall, our findings suggest that yeast hydrolysate could be beneficial for reducing anxiety levels and enhancing one's ability to cope with stress.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Quick anxiety relief
4 people found this helpful
Fast Relief for your Nerves! My sister mentioned this product to me, and it helps greatly with my nerves and anxiety. A couple of sprays really seems to provide me with more tolerance on those days I feel overwhelmed.
Read More
9
Enhanced energy levels
14 people found this helpful
Life changing! I have been taking this daily for a month; it has truly transformed my life. Each day, I feel an increase in energy levels and it has notably helped with my anxiety.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Bozorgi H, Rashidy-Pour A, Moradikor N, Zamani M, Motaghi E. Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors. Psychopharmacology (Berl). 2024;241:401. 10.1007/s00213-023-06496-3
- Lin YK, Lin YH, Chiang CF, Jingling L. Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. 10.3390/nu15194221
- Lee HS, Jung EY, Suh HJ. Chemical composition and anti-stress effects of yeast hydrolysate. J Med Food. 2009;12:1281. 10.1089/jmf.2009.0098
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
