Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.
We conducted a study to see if a fermented dairy product with Bifidobacterium lactis DN-173 010 could help reduce bloating in patients with irritable bowel syndrome (IBS) and constipation. In a controlled trial with 34 participants over four weeks, we found that this probiotic significantly decreased abdominal girth and improved gastrointestinal transit times.
Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.
Read More
9
Lactobacillus improves bloating symptoms
Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study.
We conducted a double-blind, placebo-controlled trial to assess how Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 affect bloating in patients with functional bowel disorders.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Read More
9
Lactobacillus acidophilus reduces bloating
[Lactobacilli in the treatment of dyspepsia due to dysmicrobia of various causes].
We examined how Lactobacillus acidophilus can help treat bloating in patients with dyspepsia due to imbalances in gut bacteria. In a study involving 30 participants, symptoms such as pain, pressure, and bloating were self-reported while objective measures like bowel movements and weight changes were also tracked.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Read More
Most Useful Reviews
9
Constipation relieved
6 people found this helpful
These probiotics are excellent for pregnant women, significantly aiding digestion and alleviating constipation. I initially struggled with digestive issues, but now I only take them on an empty stomach or before bed and have noticed a remarkable reduction in bloating and gas.
Read More
9
Bloating lessened
4 people found this helpful
Recommended by my gynaecologist, this probiotic noticeably improved my stool consistency and resolved my issues with flatulence and bloating. It is the only product that made a difference for me.
Read More
10
No bloating relief
3 people found this helpful
These probiotics have made a significant difference! When I discovered I was pregnant, I wanted to enjoy dairy again. I have Coeliac Disease, making me sensitive to dairy. After taking these probiotics for a month, I tried dairy once more and experienced no gas, bloating, pain, or diarrhoea. I feel so much better overall and haven't caught a cold since starting them, even while pregnant. Now nursing, I will continue taking them. I genuinely believe they have improved my mood as well. I highly recommend this product!
Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study.
We conducted a double-blind, placebo-controlled trial to assess how Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 affect bloating in patients with functional bowel disorders.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Read More
9
SCM-III improves IBS symptoms
Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome.
We conducted a study examining the effects of a novel symbiotic treatment, SCM-III, on patients with irritable bowel syndrome (IBS). Sixty-eight adults were divided into two groups—one received SCM-III and the other a heat-inactivated version, both for 12 weeks.
Our findings showed that most patients reported significant improvements in bloating and abdominal pain compared to a control group. Over 80% felt the treatment was effective, while less than 5% labelled it ineffective.
Overall, this suggests that certain IBS patients could greatly benefit from symbiotic treatments like SCM-III, though it may require a cyclic use for best results.
Read More
9
Lactobacillus acidophilus reduces bloating
[Lactobacilli in the treatment of dyspepsia due to dysmicrobia of various causes].
We examined how Lactobacillus acidophilus can help treat bloating in patients with dyspepsia due to imbalances in gut bacteria. In a study involving 30 participants, symptoms such as pain, pressure, and bloating were self-reported while objective measures like bowel movements and weight changes were also tracked.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Read More
9
Probiotics improve allergy symptoms
[The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy].
We evaluated the effects of a combined probiotic treatment on food allergies in children aged 4 to 5. In our study, 92 children participated, where one group took probiotics containing Lactobacillus rhamnosus GG for 21 days, while the other group did not.
The children on probiotics experienced significant improvements in skin and gastrointestinal symptoms, including a decrease in bloating. Their IgE levels also dropped notably, suggesting an overall healthier immune response. The control group showed no significant changes.
Overall, lactobacillus rhamnosus proved beneficial for reducing allergy symptoms and improving gut health.
Read More
9
Lactobacillus rhamnosus reduces bloating
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
We investigated how a combination of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001, along with vitamin B6, affects bloating in patients with irritable bowel syndrome (IBS). In a well-structured crossover trial involving 25 IBS patients, we found that this formula significantly reduced bloating by about 36% compared to a placebo. Additionally, patients experienced reduced abdominal pain and improved gut health. Overall, this treatment shows promise for alleviating IBS symptoms and enhancing gut health.
These probiotics are excellent for pregnant women, significantly aiding digestion and alleviating constipation. I initially struggled with digestive issues, but now I only take them on an empty stomach or before bed and have noticed a remarkable reduction in bloating and gas.
Read More
9
Bloating lessened
4 people found this helpful
Recommended by my gynaecologist, this probiotic noticeably improved my stool consistency and resolved my issues with flatulence and bloating. It is the only product that made a difference for me.
Read More
10
No bloating relief
3 people found this helpful
These probiotics have made a significant difference! When I discovered I was pregnant, I wanted to enjoy dairy again. I have Coeliac Disease, making me sensitive to dairy. After taking these probiotics for a month, I tried dairy once more and experienced no gas, bloating, pain, or diarrhoea. I feel so much better overall and haven't caught a cold since starting them, even while pregnant. Now nursing, I will continue taking them. I genuinely believe they have improved my mood as well. I highly recommend this product!
Read More
9
Bloating addressed
3 people found this helpful
I ordered this probiotic post-childbirth to restore my gastrointestinal function and was pleased with the results within a week. It effectively tackled significant digestive problems including severe bloating, and I believe it also benefited my daughter, who is breastfed. I plan to use a higher dosage in the future.
Read More
7.5
Bloating relief
Excellent for pregnancy! It helps relieve discomfort and bloating in pregnant women, making the experience much more pleasant.
Bloating is a common gastrointestinal condition characterized by a sensation of fullness, tightness, or swelling in the abdomen. It often occurs after eating and can be accompanied by visible distension of the belly. This discomfort may be caused by various factors, including excessive gas production, food intolerances, overeating, or certain medical conditions affecting the digestive system. Many people experience bloating occasionally, but when it becomes chronic, it can significantly impact one's quality of life.
Managing bloating typically involves dietary adjustments, such as identifying and avoiding trigger foods, eating smaller meals, and incorporating more fiber into your diet. Staying hydrated and engaging in regular physical activity can also help alleviate symptoms. If bloating is persistent or accompanied by other troubling symptoms like severe pain or changes in bowel habits, it is advisable to consult a healthcare professional for proper evaluation and guidance.
Pre and post-natal formulas are specialized dietary supplements designed to support the nutritional needs of women during pregnancy and postpartum recovery. Pre-natal formulas typically include a combination of essential vitamins and minerals, such as folic acid, iron, and calcium, to promote the health of both mother and developing baby. These nutrients are crucial for fetal development, reducing the risk of complications, and supporting the overall well-being of expectant mothers.
Post-natal formulas, on the other hand, focus on replenishing nutrients that may have been depleted during pregnancy and childbirth and enhancing recovery after delivery. They often contain additional nutrients to support breastfeeding, such as DHA and omega-3 fatty acids, which are important for infant brain development. Both types of formulas aim to ensure that mothers have the necessary nutrients for their health and their babies' development, making them an essential part of pre and post-natal care.
Pre and postnatal formulas are designed to support the nutritional needs of pregnant and breastfeeding mothers, but their impact on bloating can vary widely from person to person. These formulas typically contain a blend of vitamins, minerals, and sometimes probiotics, which may help with digestive health. Probiotics, in particular, can aid in maintaining a healthy gut flora, potentially alleviating some digestive discomfort, including bloating. However, individual responses to these formulas can differ, and not everyone may experience relief from bloating when using them.
It's important to note that bloating can be caused by a variety of factors, such as dietary choices, hormonal changes during pregnancy, or even lactose intolerance. Consulting with a healthcare provider is recommended to determine the specific cause of bloating and whether a pre or postnatal formula is appropriate. While these products can be beneficial for nutritional support, they should not be seen as a guaranteed solution for digestive issues. Always prioritize seeking professional advice to tailor any supplement use to your personal health needs.
Based on user reviews, those seeking relief from bloating often begin to notice positive effects within a week of consistent use of this probiotic supplement. For instance, one user reported significant improvements in their digestive function and a notable reduction in bloating after just a week of taking the probiotics post-childbirth Read Review. Similarly, another review mentioned that after a week of use, constipation and bloating were greatly alleviated during pregnancy Read Review.
A broader timeline suggests that while some users experience relief in as little as one week, others noted improvements that took about two weeks to manifest. For example, one reviewer mentioned enjoying foods typically problematic for them without experiencing any bloating after two weeks Read Review. Overall, user reviews indicate that individuals can anticipate seeing results within a week to two weeks, depending on their personal digestive health and consistency of use.
The scientific evidence supporting the use of certain probiotics for bloating is promising, especially concerning individuals suffering from irritable bowel syndrome (IBS) and other digestive disorders. Research has indicated that specific strains, such as Lactobacillus acidophilus and Bifidobacterium longum, can help alleviate symptoms associated with bloating. For instance, a study involving Bifidobacterium longum found a significant reduction in bloating among IBS patients, with most participants reporting improvements in their overall symptoms after 8 weeks of treatment [19]. Other studies have highlighted the beneficial impacts of probiotic-rich foods, such as kefir, which have shown to reduce bloating and improve gut health [5].
Furthermore, combinations of probiotics have been demonstrated to be more effective than single strains in managing bloating symptoms. In a comprehensive review, multispecies probiotic blends led to significant decreases in bloating for IBS patients, indicating that a combination approach may yield better results [9]. While it's clear that some probiotic strains hold potential for managing bloating, the results are not uniform; thus, more research is still needed to identify the most effective formulations and understand their mechanisms fully. Overall, probiotics represent a viable supplement for bloating relief, particularly for those with gut-related issues.
Many users have reported a range of positive improvements in their digestive symptoms after starting this probiotic supplement, particularly in terms of reducing bloating and gas. For instance, one user noted a "remarkable reduction in bloating and gas" after incorporating the probiotics into their routine, which they used strategically on an empty stomach or before bedtime Read Review. Another user highlighted their gynecologist's recommendation, expressing satisfaction with improved stool consistency and diminished flatulence Read Review.
Additionally, multiple testimonials suggest users began experiencing relief within a week of use, underlining a common trend of noticeable symptom improvement early on. For example, one reviewer shared that their significant digestive issues, including severe bloating, were effectively addressed in just a week's time post-childbirth Read Review. Others reported similar timelines, with improvements manifesting after one to two weeks, allowing them to enjoy foods they had previously avoided due to digestive discomfort Read Review. Overall, while individual results can vary, user experiences indicate a strong consensus regarding the benefits of these probiotics in alleviating common digestive issues.
Users have reported that combining this probiotic supplement with other digestive aids can enhance the overall effectiveness in managing bloating and other gastrointestinal issues. For instance, one reviewer mentioned that they felt much better after taking the probiotics, particularly when timed after consuming dairy products, suggesting a synergistic effect with dietary management Read Review. Additionally, another user noted that they initially started taking the probiotics for prevention but observed that their bloating issues returned after stopping, indicating an ongoing benefit when continued alongside a balanced diet Read Review.
Moreover, numerous testimonials highlight that taking these probiotics typically leads to noticeable improvements in digestive comfort, particularly in pregnant women. For instance, several users praised their efficacy in alleviating bloating and discomfort, especially during pregnancy, making them a preferred option alongside other prenatal supplements Read Review. Overall, the consensus seems to suggest that this probiotic can be effectively used in conjunction with other supplements or dietary practices to enhance digestive health and mitigate bloating.
Based on user reviews, many women find that dosing the Pre Post Natal Formulas correctly is crucial for effectively treating bloating and enhancing digestive health. Users highlighted that taking the probiotic on an empty stomach or before bed was particularly effective, suggesting that this practice led to significant reductions in bloating and gas (c5f0cce0-6ca8-49c2-9c49-a9385fa721b6). Others experienced success when incorporating it into their routine during specific pregnancy stages, such as the third trimester or postpartum, with improvements often noticed within a week of consistent use (05339207-7bc8-4001-be63-1de74a32a2f3, 0bc38d75-c139-449e-a300-e0157039c322).
Additionally, some users expressed plans to increase their dosage after observing positive effects, indicating that the right dose may vary individually and could require adjustments based on personal digestive responses (05339207-7bc8-4001-be63-1de74a32a2f3). Overall, users report a strong correlation between proper dosing and alleviating digestive discomfort, especially bloating, further reinforcing the idea that personalized dosage may be beneficial for optimal results.
9
Bloating addressed
3 people found this helpful
I ordered this probiotic post-childbirth to restore my gastrointestinal function and was pleased with the results within a week. It effectively tackled significant digestive problems including severe bloating, and I believe it also benefited my daughter, who is breastfed. I plan to use a higher dosage in the future.
9
Constipation relief
Outstanding! I've been taking this probiotic since my 10th week of pregnancy. It has greatly alleviated my constipation and bloating after about a week of use.
9
Bloating manageable
1 people found this helpful
I've been taking these probiotics for a month and have already reordered. They are very effective; after two weeks, I enjoyed foods like a cabbage pie without experiencing pain or bloating, which is incredible considering my past limitations. Highly recommended.
9
Constipation relieved
6 people found this helpful
These probiotics are excellent for pregnant women, significantly aiding digestion and alleviating constipation. I initially struggled with digestive issues, but now I only take them on an empty stomach or before bed and have noticed a remarkable reduction in bloating and gas.
9
Bloating lessened
4 people found this helpful
Recommended by my gynaecologist, this probiotic noticeably improved my stool consistency and resolved my issues with flatulence and bloating. It is the only product that made a difference for me.
7
Bloating relieved
4 people found this helpful
I suffer from digestive issues, including bloating and indigestion. This product has been highly effective; I felt much better after taking it. For optimal results, I recommend taking it after consuming dairy products.
7.5
Bloating returns
2 people found this helpful
I began taking these capsules in my third trimester, initially for prevention. After finishing the course, I noticed that bloating and gas reappeared, which had been particularly bothersome during pregnancy. I realised their impact only after they were gone. I’ve now reordered them for continued use.
7.5
Bloating relief
Excellent for pregnancy! It helps relieve discomfort and bloating in pregnant women, making the experience much more pleasant.
9
Lactobacillus rhamnosus reduces bloating
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
We investigated how a combination of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001, along with vitamin B6, affects bloating in patients with irritable bowel syndrome (IBS). In a well-structured crossover trial involving 25 IBS patients, we found that this formula significantly reduced bloating by about 36% compared to a placebo. Additionally, patients experienced reduced abdominal pain and improved gut health. Overall, this treatment shows promise for alleviating IBS symptoms and enhancing gut health.
7
Kefir probiotics reduce bloating
Putative Probiotic Strains Isolated from Kefir Improve Gastrointestinal Health Parameters in Adults: a Randomized, Single-Blind, Placebo-Controlled Study.
We explored the effects of probiotic strains from kefir on gastrointestinal health. Fifty-six healthy adults participated in a randomized, single-blind, placebo-controlled study. Over three weeks, those consuming AB-kefir experienced significantly reduced bloating and abdominal pain compared to the control group.
Notably, male participants showed marked improvements, along with shifts in their gut microbiota. This suggests that AB-kefir could be a natural approach to enhance gut health in adults.
8
Probiotics alleviate bloating in IBS
Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
We examined how multispecies probiotics, including Lactobacillus acidophilus, affect bloating in individuals with irritable bowel syndrome (IBS). In a randomized, double-blind trial, 49 IBS patients were split into two groups: one received probiotics and the other a placebo for four weeks.
By the end of the study, we found that 68% of the probiotics group reported significant relief from IBS symptoms, including reduced bloating. Fecal analysis indicated beneficial changes in gut bacteria from the probiotics, highlighting their potential role in improving IBS symptoms.
References
Xie P, Luo M, Deng X, Fan J, Xiong L. Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Nutrients. 2023;15. doi:10.3390/nu15173856
Wagner NRF, Ramos MRZ, de Oliveira Carlos L, da Cruz MRR, Taconeli CA, et al. Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Obes Surg. 2021;31:143. doi:10.1007/s11695-020-04900-x
Maixent JM, Pons O, Sennoune SR, Sadrin S. Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives. Cell Mol Biol (Noisy-le-grand). 2020;66:211.
Sadrin S, Sennoune S, Gout B, Marque S, Moreau J, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis. 2020;52:534. doi:10.1016/j.dld.2019.12.009
Wang MC, Zaydi AI, Lin WH, Lin JS, Liong MT, et al. Putative Probiotic Strains Isolated from Kefir Improve Gastrointestinal Health Parameters in Adults: a Randomized, Single-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020;12:840. doi:10.1007/s12602-019-09615-9
Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. doi:10.3920/BM2018.0163
Georgescu D, Ancusa OE, Georgescu LA, Ionita I, Reisz D. Nonmotor gastrointestinal disorders in older patients with Parkinson's disease: is there hope?. Clin Interv Aging. 2016;11:1601.
Ringel-Kulka T, Goldsmith JR, Carroll IM, Barros SP, Palsson O, et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014;40:200. doi:10.1111/apt.12800
Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29:52. doi:10.1111/jgh.12322
Andresen V, Layer P, Menge D, Keller J. [Efficacy of freeze-dried Lactobacilli in functional diarrhoe: a pilot study]. Dtsch Med Wochenschr. 2012;137:1792. doi:10.1055/s-0032-1305295
Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45:518. doi:10.1097/MCG.0b013e31820ca4d6
Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
Tsuchiya J, Barreto R, Okura R, Kawakita S, Fesce E, et al. Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome. Chin J Dig Dis. 2004;5:169.
Molin G. Probiotics in foods not containing milk or milk constituents, with special reference to Lactobacillus plantarum 299v. Am J Clin Nutr. 2001;73:380S. doi:10.1093/ajcn/73.2.380s
Gaón D, Doweck Y, Gómez Zavaglia A, Ruiz Holgado A, Oliver G. [Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin]. Medicina (B Aires). 1995;55:237.
Kocián J. [Lactobacilli in the treatment of dyspepsia due to dysmicrobia of various causes]. Vnitr Lek. 1994;40:79.
Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. doi:10.33029/0042-8833-2023-92-3-79-86
Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
Lai HH, Chiu CH, Kong MS, Chang CJ, Chen CC. Probiotic : Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers. Nutrients. 2019;11. doi:10.3390/nu11051150
Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
Hayes SR, Vargas AJ. Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea. Explore (NY). 2016;12:463. doi:10.1016/j.explore.2016.08.015
Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
Hauser G, Salkic N, Vukelic K, JajacKnez A, Stimac D. Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2015;94:e685. doi:10.1097/MD.0000000000000685
Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, et al. Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study. Transl Gastroenterol Hepatol. 2018;3:72. doi:10.21037/tgh.2018.09.11
Riezzo G, Orlando A, D'Attoma B, Linsalata M, Martulli M, et al. Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation. Benef Microbes. 2018;9:51. doi:10.3920/BM2017.0049
Weizman Z, Abu-Abed J, Binsztok M. Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, Double-Blind, Placebo-Controlled Trial. J Pediatr. 2016;174:160. doi:10.1016/j.jpeds.2016.04.003
Ruiz-Sánchez C, Escudero-López B, Fernández-Pachón MS. Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome. Endocrinol Diabetes Nutr (Engl Ed). 2024;71:19. doi:10.1016/j.endien.2024.01.003
Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:1123. doi:10.1111/j.1365-2036.2011.04633.x
Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. doi:10.1016/j.clnesp.2024.11.016
Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. doi:10.1016/j.clnu.2020.01.005
Chen JC, Lee WJ, Tsou JJ, Liu TP, Tsai PL. Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial. Surg Obes Relat Dis. 2016;12:57. doi:10.1016/j.soard.2015.07.010
Colecchia A, Vestito A, La Rocca A, Pasqui F, Nikiforaki A, et al. Effect of a symbiotic preparation on the clinical manifestations of irritable bowel syndrome, constipation-variant. Results of an open, uncontrolled multicenter study. Minerva Gastroenterol Dietol. 2006;52:349.
Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. doi:10.1039/d4fo01471e
Şahin K, Şahintürk Y, Köker G, Özçelik Köker G, Bostan F, et al. Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance. Turk J Gastroenterol. 2022;33:925. doi:10.5152/tjg.2022.211063
Shin CM, Choi YJ, Lee DH, Moon JS, Kim TY, et al. Validity and safety of ID-JPL934 in lower gastrointestinal symptom improvement. Sci Rep. 2021;11:13046. doi:10.1038/s41598-021-92007-3
Marteau P, Le Nevé B, Quinquis L, Pichon C, Whorwell PJ, et al. Consumption of a Fermented Milk Product Containing CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity. Nutrients. 2019;11. doi:10.3390/nu11010092
Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. doi:10.5152/tjg.2016.16301
Del Piano M, Carmagnola S, Anderloni A, Andorno S, Ballarè M, et al. The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study. J Clin Gastroenterol. 2010;44 Suppl 1:S30. doi:10.1097/MCG.0b013e3181ee31c3
Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2009;29:104. doi:10.1111/j.1365-2036.2008.03853.x
Guyonnet D, Chassany O, Ducrotte P, Picard C, Mouret M, et al. Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. Aliment Pharmacol Ther. 2007;26:475.