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Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
The product is found useful for the following medical conditions
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.1
USERS' SCORE
Excellent
Based on 73 Reviews
9
9
Iron supplements reduce donor deferral
Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors.
Most Relevant Research
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
10
Aiding anemia
Most Useful Review
These pills truly work! They have significantly improved my anemia, as my recent blood test numbers show improvement. I still experience coldness, but my doctor confirms my numbers are getting better. I've just started my second bottle, and best of all, there is NO CONSTIPATION whatsoever!
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.8
8
Long-term PPI effects analyzed
Gastric atrophy and intestinal metaplasia in a patient on long-term proton pump inhibitor therapy.
Most Relevant Research
We explored the case of a 74-year-old man who had been taking proton pump inhibitors for 20 years to manage symptoms of gastroesophageal reflux disease. Despite stopping his acid-reducing medications for a month, he showed an unusually high gastric pH level, indicating a significant decrease in stomach acidity. This condition may have led to gastric atrophy and intestinal metaplasia, as revealed through multiple biopsies of his stomach lining. Interestingly, after halting all anti-secretory drugs and starting only prokinetic treatment, the patient reported a significant improvement in heartburn symptoms.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
During follow-up, although he developed symptoms of peripheral neuropathy—which were found to be related to a low level of vitamin B12—prompt treatment with vitamin B12 injections alleviated this issue. However, the correlation between improved heartburn symptoms and the vitamin B12 therapy is difficult to establish because the patient was also on prokinetics, which could have contributed to his symptom relief. Overall, our findings indicate that while vitamin B12 treatment offered benefits in this case, isolating its specific effect on heartburn remains challenging due to the combination therapy involved.
9.5
Significant improvement
Most Useful Review
Great iron supplement! My Ferritin level was extremely low, and after trying another brand that worsened my heartburn, I switched to Garden of Life. In just a few weeks, my Ferritin increased by 10 points! I've had no digestive upset and haven’t taken Zantac in over two months. The addition of a probiotic/enzyme blend seems to have helped as well. I highly recommend this gentle iron supplement, though it’s important to give it time as it contains less iron than some alternatives.
Leg Cramps details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.8
7
Iron treatment improves leg cramps
Iron deficiency associates with deterioration in several symptoms independently from hemoglobin level among chronic hemodialysis patients.
Most Relevant Research
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
Cured leg cramps
Most Useful Review
Excellent product! This is the second time I have ordered it due to severe iron deficiency, which caused me leg cramps during sleep. This natural and safe extract has alleviated the problem. It importantly does not adversely affect my kidneys and does not cause constipation like other iron supplements.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.6
USERS' SCORE
Good
Based on 18 Reviews
8.7
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Increased ferritin levels
Most Useful Review
I had latent iron deficiency anaemia and tried various pharmaceutical iron supplements, but my ferritin level remained low. In desperation, I ordered Iron from Garden of Life, and after three months, my ferritin rose to normal levels. This product works excellently and is gentle on the stomach. I'm feeling stronger, my hair has stopped falling out, and my general well-being has improved. I highly recommend this complex!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Hemoglobin recovery
Most Useful Review
This supplement marked my first experience with iHerb. After an emergency operation in March, I struggled to recover my haemoglobin for two months. Despite various medications failing to raise it even slightly, this product elevated my levels to those of a healthy individual within a month. It feels miraculous. Now, I am also addressing other aspects of my health.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Most Relevant Research
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9.5
Calms digestive issues
Most Useful Review
This iron supplement is remarkable! I have irritable bowel syndrome and most iron products upset my stomach, but this one actually improves and soothes it. With added digestive enzymes, my digestion has significantly improved alongside my low iron levels.
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
9.5
Life-changing iron supplement
Most Useful Review
This product truly saved me. After struggling with anaemia and constant migraines, I began taking these supplements. Instead of stomach issues, I regained energy and clarity. I finished a whole bottle — a first for me! I won’t use any other iron supplement again; this one is exceptional.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Iron improves cold tolerance
Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in .
Most Relevant Research
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
9.5
Cold symptom relief
Most Useful Review
I started taking iron because I was cold all the time, had stubborn dark circles under my eyes, and experienced hair loss. This was alarming. I began taking iron despite my fear of tests and needles, suspecting iron deficiency. Thankfully, my hair has stopped falling out, I’m no longer cold in warm rooms, and the dark circles have significantly improved. Clearly, the raw iron is effective and working wonders!
Bruise details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin B12 benefits thrombocytopenia
Vitamin B12 Deficiency, a Rare Cause of Isolated Thrombocytopenia in Adults.
Most Relevant Research
We examined the case of a 38-year-old male who experienced bruising and fatigue due to isolated thrombocytopenia, a condition marked by a low platelet count. This situation was particularly interesting because the underlying cause turned out to be a significant deficiency in vitamin B12, which is quite rare in adults when it comes to isolated thrombocytopenia. As we explored the case, we found that the patient's vitamin B12 levels were extraordinarily low, prompting treatment with subcutaneous mecobalamin, a form of vitamin B12.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
9.5
Reduced bruising
Most Useful Review
Great product! My doctor recommended this brand for iron, and I’ve been taking it daily with no issues typical of iron supplements. I've noticed fewer bruises since starting.
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
Most Relevant Research
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
8.8
Reduced chest pain
Most Useful Review
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 24 Reviews
8.6
9
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
10
Normalised levels
Most Useful Review
I had low haemoglobin and iron, which caused constant fatigue and dizziness. After taking Solgar and Garden life supplements, everything returned to normal. I recommend these products for anyone facing similar issues.
Gastritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Iron treatment impacts gastritis
Iron Pill-Induced Gastritis in a Pediatric Patient Taking Ferrous Sulfate Tablets.
Most Relevant Research
We examined a case involving an 11-year-old male who experienced adverse effects from taking oral ferrous sulfate tablets to treat iron deficiency anemia. Over two months of treatment, he developed gastritis, which was confirmed through histological analysis during an endoscopy.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
8.8
No stomach issues
Most Useful Review
Very good iron preparation. I took my teenage daughter to boost her hemoglobin levels. I was concerned about potential reactions to iron due to her gastritis. Her haemoglobin is now around 150, and thankfully, there have been no negative stomach reactions!
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Iron treatment in menopause study
Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
Most Relevant Research
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
9.5
Anemia alleviated
Most Useful Review
This version of iron has been excellent for those with sensitive stomachs. After being diagnosed as anaemic, I've taken it for years and have not been anaemic since. It digests easily, with no stomach issues, and I will continue using it even though I'm now in menopause and don't experience the monthly issues that caused my anaemia.
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Most Relevant Research
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
9.5
Magical results
Most Useful Review
I rarely review products but felt compelled to share my experience. Suffering from very low ferritin and numerous symptoms of anaemia, I struggled to find an iron supplement that didn't bloat me. This product has been life-changing; after a week, my iron levels significantly improved. I previously experienced hair loss and felt cold all the time, but this supplement helped immensely.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Allergy management in iron treatments
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.
Most Relevant Research
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
7.5
Effective, minor issues
Most Useful Review
I've been taking it for two weeks without nausea or allergies. Initially, there were minor toilet issues, but now all is normal. It's a good preparation that includes vitamin C for absorption and other beneficial components.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Most Relevant Research
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
8.8
Eased joint pain
Most Useful Review
The smell is quite off-putting, but it has alleviated my joint pain. I previously suffered from bone pain in my legs, and this product has helped ease that pain significantly.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.3
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Most Relevant Research
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
9.5
No pain experienced
Most Useful Review
These are the best iron pills I've used. Most cause headaches or stomach pain, but this one doesn't. I can take it either on an empty stomach or with food without issues. Just remember not to take it with dairy, as it hampers iron absorption.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 13 Reviews
8.3
9
FCH reduces nausea in IDA treatment
A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH.
Most Relevant Research
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
9.5
Nausea-free experience
Most Useful Review
They work well! UPDATE: My teen and I have been using this for low iron, and it works perfectly! It does not constipate us, and we feel better within 20-30 minutes. My iron levels have improved, and neither of us experiences nausea, despite having sensitive stomachs. I'll keep purchasing this!
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.7
USERS' SCORE
Good
Based on 68 Reviews
8.1
9.5
Iron treatment reduces anemia
Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever".
Most Relevant Research
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
8.3
Enhanced wellbeing
Most Useful Review
Perfect iron supplement for the health-conscious. After a diagnosis of iron deficiency anaemia, I was advised to take ferrous sulfate. However, I wanted a high-quality, whole food-based alternative. After finding Garden of Life Vitamin Code Raw Iron, I've noticed an increase in energy and mental clarity. I no longer feel as depressed, and after three months of taking this, I'm pleased to report that I am no longer anemic.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Supports iron levels
Most Useful Review
Garden of Life, Vitamin Code, RAW Iron, 30 Vegan Capsules is excellent for naturally supporting iron levels. Made from high-quality, allergen-free ingredients, it benefits blood and heart health. I've experienced a notable improvement in my iron levels since using it, making it vital for managing heart disease.
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
9.5
Vitamin B12 aids chronic diarrhea
CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.
Most Relevant Research
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
5
No more diarrhea
Most Useful Review
Iron is vital! After a blood test revealed anaemia, I was prescribed iron, but I struggled with stomach pain and nausea. This product, containing iron, vitamins C and B12, folic acid, and probiotics, has worked well. After ten days, I noticed improvements: shortness of breath and chest pain have lessened, my energy has returned, and my complexion improved. I experienced diarrhea only on the first day. Now, my stomach is fine, and I believe the iron is being absorbed properly.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.5
USERS' SCORE
Medium or Average
Based on 25 Reviews
6.7
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Reduced fatigue
Most Useful Review
This complex is remarkable! It not only provides iron but also includes vitamin B12, vitamin C, and probiotics that enhance absorption. I noticed a significant reduction in chronic fatigue syndrome symptoms, with improved mood and energy levels. By the end of the course, my blood tests showed a considerable recovery in iron levels.
