5/30/2025
Last update
5/30/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
9
SPIO improves lymph node detection
We explored the effectiveness of superparamagnetic iron oxide (SPIO) in detecting sentinel lymph nodes in breast cancer patients who had undergone neoadjuvant systemic therapy before surgery. This study included a systematic review of multiple databases and focused on comparing SPIO to the standard methods involving radioisotope and blue dye.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Read More
9
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Read More
8
We explored the potential of folate-decorated molecular spherical nucleic acids (MSNAs) as targeted delivery agents for cancer treatment. The study involved administering these specially formulated MSNAs to mice with breast cancer tumors and observing their biodistribution.
By using advanced imaging techniques, we found that the folate-decorated MSNAs accumulated more in tumors and other organs that express folate receptors (FRs), like the liver and kidneys. This higher concentration was particularly noted for MSNAs with specific backbone structures.
What stands out is how effective folate decoration enhances the targeting of cancer cells. The results suggest a promising avenue for improving the delivery of therapies specifically to FR-overexpressing cancers, while providing a clearer understanding of how folate can play a key role in cancer targeting strategies.
By using advanced imaging techniques, we found that the folate-decorated MSNAs accumulated more in tumors and other organs that express folate receptors (FRs), like the liver and kidneys. This higher concentration was particularly noted for MSNAs with specific backbone structures.
What stands out is how effective folate decoration enhances the targeting of cancer cells. The results suggest a promising avenue for improving the delivery of therapies specifically to FR-overexpressing cancers, while providing a clearer understanding of how folate can play a key role in cancer targeting strategies.
Read More
Most Useful Reviews
9
Stable haemoglobin levels
5 people found this helpful
My mother is undergoing chemotherapy for her ovarian cancer at stage three. After starting this supplement post her second chemotherapy session, she managed to maintain her haemoglobin levels above 10, without any side effects. It has been very convenient for her to use. After her second cycle of chemotherapy, she returned to this product to help stabilise her levels once again. It consistently works.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8.3
- All Researches
9.5
Iron nanoparticles enhance cancer therapy
We explored an innovative approach to battling breast cancer by developing a drug delivery system that uses superparamagnetic iron oxide nanoparticles. These nanoparticles are coated with platelet membranes, allowing them to specifically target tumor sites while harnessing the benefits of magnetic hyperthermia and chemotherapy.
In our study, we found that these platelet membrane-coated nanoparticles facilitated the controlled release of the chemotherapy drug Paclitaxel (PTX). Notably, when the pH shifted to acidic conditions, similar to those found in tumor environments, the release of PTX increased significantly. We observed enhanced cellular uptake of these nanoparticles and remarkable cytotoxic effects against cancer cells, particularly when combined with an alternating magnetic field.
Our results indicated that this combination therapy could inhibit tumor growth effectively, with a rate reaching nearly 92.14%. This suggests a promising pathway to minimize the harmful side effects commonly associated with traditional chemotherapy, maximizing the therapeutic impact by using iron-based nanoparticles to enhance treatment outcomes.
In our study, we found that these platelet membrane-coated nanoparticles facilitated the controlled release of the chemotherapy drug Paclitaxel (PTX). Notably, when the pH shifted to acidic conditions, similar to those found in tumor environments, the release of PTX increased significantly. We observed enhanced cellular uptake of these nanoparticles and remarkable cytotoxic effects against cancer cells, particularly when combined with an alternating magnetic field.
Our results indicated that this combination therapy could inhibit tumor growth effectively, with a rate reaching nearly 92.14%. This suggests a promising pathway to minimize the harmful side effects commonly associated with traditional chemotherapy, maximizing the therapeutic impact by using iron-based nanoparticles to enhance treatment outcomes.
Read More
9
Iron oxide NPs enhance cancer treatment
We delved into how iron oxide nanoparticles (NPs), when enhanced with a special chiral nanopaint, can impact cancer treatment. Our focus was on comparing two forms of these nanoparticles: the d-nanopainted versions and their l-nanopainted counterparts. We discovered that the d-nanopainted iron oxide NPs had over 50% higher cellular uptake by cancer cells. This increase was linked to the way these chiral NPs interacted specifically with receptors on the cell surfaces.
Moreover, in testing on living subjects, the d-nanopainted iron oxide NPs demonstrated a striking four-fold improvement in anticancer efficiency through magnetic hyperthermia. This was attributed to their better ability to adhere to tumor tissues compared to the l-nanopainted version. Thus, we see that the innovative use of chiral nanopaint appears to significantly enhance the effectiveness of iron oxide nanoparticles in cancer treatments, marrying magnetism with chirality for promising biomedical applications.
Moreover, in testing on living subjects, the d-nanopainted iron oxide NPs demonstrated a striking four-fold improvement in anticancer efficiency through magnetic hyperthermia. This was attributed to their better ability to adhere to tumor tissues compared to the l-nanopainted version. Thus, we see that the innovative use of chiral nanopaint appears to significantly enhance the effectiveness of iron oxide nanoparticles in cancer treatments, marrying magnetism with chirality for promising biomedical applications.
Read More
9
We explored how iron metabolism in neutrophils can influence cancer treatment, particularly its role in the formation of neutrophil extracellular traps (NETs). These NETs are problematic because they can suppress immune responses within tumors, creating significant hurdles for cancer therapies.
Our approach involved developing a unique peptide-drug conjugate known as a transformable iron nanochelator (TIN). This innovative tool is designed to manage the iron levels in neutrophils, ultimately aiming to inhibit NET formation. We were excited to see that the TIN utilizes a process where it transforms from nanoparticles into nanofibers. These structural changes facilitate precise regulation of iron, effectively reducing NET formation and enhancing immune responses in our model.
Additionally, we found that combining the TIN with other treatments, like protein arginine deiminase 4 inhibitors and anti-PD-L1 therapy, significantly improved therapeutic outcomes. This joint strategy appears promising, opening the door for a new perspective on immune modulation by focusing specifically on iron metabolism in cancer therapy.
Our approach involved developing a unique peptide-drug conjugate known as a transformable iron nanochelator (TIN). This innovative tool is designed to manage the iron levels in neutrophils, ultimately aiming to inhibit NET formation. We were excited to see that the TIN utilizes a process where it transforms from nanoparticles into nanofibers. These structural changes facilitate precise regulation of iron, effectively reducing NET formation and enhancing immune responses in our model.
Additionally, we found that combining the TIN with other treatments, like protein arginine deiminase 4 inhibitors and anti-PD-L1 therapy, significantly improved therapeutic outcomes. This joint strategy appears promising, opening the door for a new perspective on immune modulation by focusing specifically on iron metabolism in cancer therapy.
Read More
9
We explored the effects of iron treatment on cancer, specifically looking at how it influences immune responses in tumor cells. Our focus was on YTHDF1, a protein that plays a key role in tumor cell immune evasion by promoting the degradation of MHC-I molecules, which are crucial for immune recognition.
To tackle this issue, we developed a unique nanoassembly that combines Deferasirox (an FDA-approved iron chelator) with YTHDF1 siRNA. This innovative approach interferes with iron metabolism while simultaneously targeting YTHDF1, leading to cell cycle arrest in tumor cells.
The results were encouraging: knocking down YTHDF1 not only increased MHC-I molecule expression by 2.5 times but also enhanced the overall immune response. This means less degradation of important antigens, which strengthens T cell activity against tumors. Following treatment, we observed a significant increase in CD8 T cells in the tumors and effector memory T cells in the spleen, indicating a robust anti-tumor immune effect.
While the combination of iron regulation with epigenetic modulation was potent, it left us pondering the isolated impact of iron alone in this complex interplay. Nonetheless, these findings demonstrate a promising avenue for improving breast cancer treatment and potentially addressing recurrence and metastasis.
To tackle this issue, we developed a unique nanoassembly that combines Deferasirox (an FDA-approved iron chelator) with YTHDF1 siRNA. This innovative approach interferes with iron metabolism while simultaneously targeting YTHDF1, leading to cell cycle arrest in tumor cells.
The results were encouraging: knocking down YTHDF1 not only increased MHC-I molecule expression by 2.5 times but also enhanced the overall immune response. This means less degradation of important antigens, which strengthens T cell activity against tumors. Following treatment, we observed a significant increase in CD8 T cells in the tumors and effector memory T cells in the spleen, indicating a robust anti-tumor immune effect.
While the combination of iron regulation with epigenetic modulation was potent, it left us pondering the isolated impact of iron alone in this complex interplay. Nonetheless, these findings demonstrate a promising avenue for improving breast cancer treatment and potentially addressing recurrence and metastasis.
Read More
9
SPIO improves lymph node detection
We explored the effectiveness of superparamagnetic iron oxide (SPIO) in detecting sentinel lymph nodes in breast cancer patients who had undergone neoadjuvant systemic therapy before surgery. This study included a systematic review of multiple databases and focused on comparing SPIO to the standard methods involving radioisotope and blue dye.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stable haemoglobin levels
5 people found this helpful
My mother is undergoing chemotherapy for her ovarian cancer at stage three. After starting this supplement post her second chemotherapy session, she managed to maintain her haemoglobin levels above 10, without any side effects. It has been very convenient for her to use. After her second cycle of chemotherapy, she returned to this product to help stabilise her levels once again. It consistently works.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Ye J, Qin Y, Liu H, Xiong H, Zhang H, et al. Inhibiting Neutrophil Extracellular Trap Formation through Iron Regulation for Enhanced Cancer Immunotherapy. ACS Nano. 2025. 10.1021/acsnano.4c18555
- Liu H, Zhang X, Ding F, Pan J, Zhu H, et al. YTHDF1-targeting nanoassembly reverses tumoral immune evasion through epigenetics and cell cycle modulation. J Control Release. 2025. 10.1016/j.jconrel.2025.02.070
- Boland MR, Pantiora E, Rutherford C, Evoy D, Prichard RS, et al. Use of superparamagnetic iron oxide for sentinel lymph node detection following neoadjuvant systemic therapy. A systematic review and meta-analysis. Eur J Surg Oncol. 2025;51:109684. 10.1016/j.ejso.2025.109684
- Li B, Liu S, Zhou X, Hou D, Jia H, et al. Deferasirox Targets TAOK1 to Induce p53-Mediated Apoptosis in Esophageal Squamous Cell Carcinoma. Int J Mol Sci. 2025;26. 10.3390/ijms26041524
- Tavakoli M, Maghsoudian S, Rezaei-Aderiani A, Hajiramezanali M, Fatahi Y, et al. Synergistic effects of paclitaxel and platelet-superparamagnetic iron oxide nanoparticles for targeted chemo-hyperthermia therapy against breast cancer. Colloids Surf B Biointerfaces. 2025;251:114584. 10.1016/j.colsurfb.2025.114584
- Zhang R, Chen M, Zhou H, Liu Y, Wang Y, et al. Eliminating Radioresistance With a Magnetic Ion-Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression. Adv Mater. 2025. 10.1002/adma.202406378
- Zhou G, Zhang Y, Cai Z, Yao H, Liu M, et al. A biomimetic dual-targeting nanomedicine for pancreatic cancer therapy. J Mater Chem B. 2025. 10.1039/d4tb02206h
- Zhang D, Wang T, Zhang X, Xu Y, Ming J, et al. Synchronously Delivering Melittin and Evoking Ferroptosis via Tumor Microenvironment-Triggered Self-Destructive Metal-Organic Frameworks to Boost Cancer Immunotherapy. Adv Healthc Mater. 2025. 10.1002/adhm.202500003
- Yin Y, Wong KH, Wen L, Chen M. Active Iron-Drug Nanocomplexes Improve Photodynamic and Photothermal Cancer Therapy by Mitigating Tumor Hypoxia and Counteracting Tumor Heat Resistance. Adv Healthc Mater. 2025. 10.1002/adhm.202404485
- Kucerova L, Fekiacova A, Udvorkova N, Malcharkova P, Blahova V, et al. Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells. Cells. 2025;14. 10.3390/cells14040287
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- Auchynnikava T, Äärelä A, Moisio O, Liljenbäck H, Andriana P, et al. Biological Evaluation of Molecular Spherical Nucleic Acids: Targeting Tumors via a Hybridization-Based Folate Decoration. ACS Omega. 2025;10:6003. 10.1021/acsomega.4c10047
- Lotter C, Stierli MA, Puligilla RD, Huwyler J. Dual targeted lipid nanoparticles for enhanced DNA delivery and transfection of breast cancer cells. Eur J Pharm Biopharm. 2025. 10.1016/j.ejpb.2025.114674
- Qi P, Chen L, Ma A, Zhang Y, Lin H, et al. Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. Discov Oncol. 2025;16:204. 10.1007/s12672-025-01905-9
- Morshedi B, Esfandyari-Manesh M, Atyabi F, Ghahremani MH, Dinarvand R. Local delivery of ibrutinib by folate receptor-mediated targeting PLGA-PEG nanoparticles to glioblastoma multiform: and studies. J Drug Target. 2025. 10.1080/1061186X.2025.2468749
- Atci MM, Secmeler S, Sakin A, Arici S, Can O, et al. Perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in gastric cancer: Pathological regression grade and its relationship to clinical outcome. Indian J Cancer. 2024;61:714. 10.4103/ijc.IJC_1283_20
- Qin J, Ouyang C, Zhuang X. Association between folate and glutamine metabolism and prognosis of kidney cancer. Front Nutr. 2024;11:1506967. 10.3389/fnut.2024.1506967
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- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. 10.31557/APJCP.2025.26.2.375
- Zhang Y, Xia H, Yang S, Yu W, Liu M, et al. Dietary factors and the risk of gastric and colorectal cancers: A Mendelian randomization study. Medicine (Baltimore). 2025;104:e41610. 10.1097/MD.0000000000041610
- Yang J, Liu Y, Yao H, Sun M, Tong Y, et al. Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology. Integr Cancer Ther. 2025;24:15347354251313524. 10.1177/15347354251313524
- Munteanu C, Mârza SM, Papuc I. The immunomodulatory effects of vitamins in cancer. Front Immunol. 2024;15:1464329. 10.3389/fimmu.2024.1464329
- Tinelli A, Gustapane S, Licchelli M, Coluccia AC, Panese G, et al. Treatment with Epigallocatechin Gallate, Folic Acid, Vitamin B12, and Hyaluronic Acid Decreases HPV Positivity in Women Attending Regional Screening in Puglia. Microorganisms. 2024;12. 10.3390/microorganisms12091897
- Rong YY, Liu PC, Huang XB, Chen GA. Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization. Expert Rev Hematol. 2024;17:833. 10.1080/17474086.2024.2410009
