We explored how the treatment with JB-1—a type of probiotic bacteria—affects anxiety during chronic stress in rats. In our study, half of the twenty rats received JB-1 while the other half got a placebo over eight weeks of stress exposure.
The results were telling! Rats on JB-1 showed less anxiety and were more willing to explore their environment compared to the placebo group, which largely avoided exploration. Additionally, measurements of brain metabolites indicated that JB-1 helped maintain stability in brain chemistry, even in stressful conditions.
This suggests that lactobacillus rhamnosus might play a beneficial role in reducing anxiety during prolonged stress.
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9
Lactobacillus anxiolytic effects proven
[Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia].
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
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8
Probiotics may reduce anxiety
Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood.
We examined how colonizing newborn mice with probiotics, specifically Lactobacillus rhamnosus GG (LGG), influences anxiety in adulthood. By administering live LGG during pregnancy and early life, we observed significant changes to the gut microbiome and protective effects on the intestinal barrier. Notably, the adult mice with LGG colonization showed reduced anxiety-like behaviors in tests designed to measure stress responses. This indicates that early life probiotics could play an important role in regulating the gut-brain axis and improving mental health in later life.
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Most Useful Reviews
7.5
Mood enhancement
33 people found this helpful
After years of taking plexus probio5 and vitalbiome, I realised I needed a higher dosage. I compared probiotics for similar ingredients and found these at better strengths for less. I've been taking them for months, and they significantly improve my mood and anxiety, making me seem much calmer.
Read More
10
Significant anxiety reduction
17 people found this helpful
I buy these from the Vitamin Shoppe, not Amazon. They helped alleviate my anxiety and panic attacks, which I wanted to avoid treating with prescription medications. After a year’s use, I noticed that my symptoms nearly vanished with just one capsule a day. After running out recently, I have been feeling extremely anxious and realised it was due to stopping this supplement. I won’t go without them again; they truly make a difference for me!
Read More
9
Reduced anxious moments
10 people found this helpful
I highly recommend this probiotic which I discovered during my search after being diagnosed with OCD-related anxiety. In just over two months of use, I’ve seen a significant improvement in my anxious moments, alongside better overall health. I’ve noticed the days I forget to take it, the difference is quite evident.
We investigated the impact of Lactobacillus acidophilus and Bifidobacterium adolescentis on anxiety levels in rats facing acute hypoxia. In our study, 64 male Wistar rats were divided into four groups for comparison. The results showed that rats receiving probiotics exhibited lower oxidative stress and anxiety levels compared to those who did not. Notably, those treated with probiotics went through behavioral tests indicating increased exploratory behavior and decreased anxiety. Overall, our findings suggest that these probiotics offer both antioxidant and anxiety-reducing effects in stressful conditions.
Read More
9
Probiotics impact anxiety in AD
Ameliorative effects of probiotics in AlCl-induced mouse model of Alzheimer's disease.
We investigated how probiotics, specifically Lactobacillus rhamnosus and Bifidobacterium BB-12, can affect anxiety in a mouse model of Alzheimer’s disease. In our study, we found that mice treated with these probiotics exhibited significantly reduced anxiety-like behaviors compared to those exposed to aluminum chloride alone.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
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9
Probiotic alleviates IBS-D symptoms
A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.
We conducted a study to assess how well the probiotic CECT 7347 (ES1) and the heat-treated version (HT-ES1) helped alleviate diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms in adults. Over 84 days, participants took either the probiotic, the postbiotic, or a placebo, reporting significant improvement in key measures like symptom severity, quality of life, and even anxiety levels. The results demonstrated a notable reduction in IBS symptoms, making it one of the first trials to show such effectiveness in this area.
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9
Bifidobacterium longum may ease anxiety
Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination.
We examined the impact of a probiotic blend, Bifidobacterium longum strains 1714® and 35642®, on anxiety and irritable bowel syndrome (IBS) symptoms in patients. Over eight weeks, we observed that the treatment helped restore the stress response and improved IBS symptoms and psychometric scores for anxiety and depression.
Interestingly, the benefits continued after stopping treatment, suggesting a lasting positive effect. The findings indicate that managing stress can significantly influence IBS symptoms and associated mood disturbances.
Bifidobacterium lactis Probio-M8 Adjuvant Treatment Confers Added Benefits to Patients with Coronary Artery Disease via Target Modulation of the Gut-Heart/-Brain Axes.
We conducted a thorough investigation into the effects of Bifidobacterium lactis, known as Probio-M8, on anxiety and overall well-being in patients with coronary artery disease (CAD). Over six months, we compared a group receiving the probiotic with a placebo group.
Notably, those in the probiotic group reported significant improvements in anxiety levels and other markers of mental health. This suggests that enhancing gut health can also positively influence our mood and emotional states.
With ongoing research, it’s becoming clearer how beneficial our gut bacteria can be for our overall mental and physical wellness.
After years of taking plexus probio5 and vitalbiome, I realised I needed a higher dosage. I compared probiotics for similar ingredients and found these at better strengths for less. I've been taking them for months, and they significantly improve my mood and anxiety, making me seem much calmer.
Read More
10
Significant anxiety reduction
17 people found this helpful
I buy these from the Vitamin Shoppe, not Amazon. They helped alleviate my anxiety and panic attacks, which I wanted to avoid treating with prescription medications. After a year’s use, I noticed that my symptoms nearly vanished with just one capsule a day. After running out recently, I have been feeling extremely anxious and realised it was due to stopping this supplement. I won’t go without them again; they truly make a difference for me!
Read More
9
Reduced anxious moments
10 people found this helpful
I highly recommend this probiotic which I discovered during my search after being diagnosed with OCD-related anxiety. In just over two months of use, I’ve seen a significant improvement in my anxious moments, alongside better overall health. I’ve noticed the days I forget to take it, the difference is quite evident.
Read More
9
Calms effectively
7 people found this helpful
I had a lot of anxiety, and this has genuinely alleviated it.
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9
Mood balance
1 people found this helpful
I can’t express how this product has helped me! I was unaware that a healthy gut microbiome was linked to mental well-being. I experience general anxiety and non-clinical depression, and this has truly assisted in balancing my mood.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.
Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.
Recent studies have begun to explore the connection between gut health and mental health, suggesting that probiotics may play a role in alleviating anxiety symptoms. The gut-brain axis, a complex communication network linking the gastrointestinal tract and the brain, indicates that the microbiome can influence mood and behavior. Probiotics, which are live bacteria that confer health benefits, may help to balance the gut microbiome, potentially leading to improvements in anxiety levels. Some research has shown that specific strains of probiotics can reduce anxiety and improve emotional well-being, although results can vary from person to person.
While the evidence is promising, it's essential to approach probiotics as a complementary option rather than a standalone treatment for anxiety. Consulting with a healthcare professional is crucial before starting any new supplement, especially for those already taking medication or undergoing therapy for anxiety. Incorporating probiotics into your routine might enhance gut health and contribute to a more balanced emotional state, but it should ideally be part of a holistic approach to mental wellness, including therapy, lifestyle changes, and other proven interventions.
Based on user reviews, individuals taking this probiotic supplement for anxiety often report noticeable improvements within a matter of weeks. For instance, one user mentioned that they experienced positive changes in their mood in just a few weeks after starting the probiotics, highlighting an increase in energy and a reduced susceptibility to stress and anxiety Read Review. Another reviewer noted an improvement in their mood shortly after beginning use, demonstrating that for some users, effects can manifest relatively quickly Read Review.
Moreover, some users have observed more gradual changes, with one individual mentioning noticeable benefits after approximately 45 days of use, including decreased anxiety levels associated with meals Read Review. Overall, while experiences vary, scores of users seem to agree that consistent use of these probiotics can lead to positive changes in mood and anxiety levels, typically ranging from a few weeks to a couple of months.
Probiotics have emerged as a potential solution for managing anxiety, supported by a growing body of research. One notable study involving a multi-strain probiotic E3 formula resulted in significant improvements in anxiety levels among participants experiencing sleep disturbances and mood issues over an eight-week period, indicating a strong link between gut microbiome health and mental well-being [2]. Furthermore, in a randomized trial on hemodialysis patients, those taking synbiotics and probiotics exhibited notable reductions in anxiety and depression scores after 12 weeks compared to a placebo group, although quality of life improvements were not observed [3].
However, while some studies have shown promising results, findings are not universally strong or conclusive. For example, research involving Lactobacillus acidophilus demonstrated reduced anxiety-like behaviors in animal models but revealed limited efficacy in humans experiencing generalized anxiety disorder [5]. Similarly, while participants taking probiotics showed improvements in anxiety symptoms, the overall effect compared to placebo groups often lacked significant distinction, indicating a need for further investigation [1]. In summary, while there is encouraging evidence that probiotics may support anxiety management, especially through their influence on the gut-brain axis, more rigorous and larger-scale studies are required to establish definitive benefits.
Based on user reviews, many individuals report significant improvements in their symptoms related to anxiety and mood after using these probiotics. One user highlighted a remarkable transformation, stating that the product has helped balance their mood and alleviate feelings of general anxiety and non-clinical depression, which underscores the connection between gut health and mental well-being Read Review. Another reviewer echoed this sentiment, expressing that they noticed a positive shift in their mood shortly after starting the probiotics, leading to a more energetic and balanced state Read Review.
In addition to fast-acting results, some users observed gradual changes, with one individual indicating an improvement in anxiety levels after about 45 days of use, particularly with anxiety associated with meals Read Review. Others have mentioned that these probiotics not only help with digestion but also assist in reducing stress and anxiety overall, demonstrating that consistent use can yield positive effects over time Read Review. While experiences can vary, many users appear to have benefitted from the calming effects of these probiotics, often citing specific ingredients like ashwagandha as key components in this positive experience Read Review.
Based on user reviews, many individuals have reported positive experiences when combining this probiotic supplement with other supplements for handling anxiety. One reviewer expressed particular appreciation for the inclusion of ashwagandha in the mood variant, noting its calming and anti-stress properties as beneficial for anxiety reduction Read Review. Another user emphasized the significant mood shifts alongside better digestive health, highlighting the role probiotics play in enhancing emotional and mental well-being Read Review.
Furthermore, several users shared that these probiotics helped alleviate anxiety symptoms, with one individual noting a decrease in anxiety provoked by meals after a month and a half of use Read Review. Many have found that the combination of probiotics with other supportive ingredients enhances their effectiveness, contributing to a more balanced mood and improved overall mental health Read Review. Overall, the integration of such supplements has resonated positively among users seeking to manage anxiety.
Based on user reviews, many individuals report positive experiences with probiotics in alleviating anxiety, but specific dosing recommendations vary. Users generally found relief with a typical dosage of two capsules taken on an empty stomach each morning. For instance, one reviewer mentioned this regimen as ideal for better gut absorption, while others confirmed improvements in mood and anxiety symptoms with regular use of the probiotics Read Review.
Moreover, several users highlighted the benefits of combined ingredients like ashwagandha, which is found in some variants, further emphasizing its calming properties. Reviews indicate that users perceive noticeable changes in their anxiety levels and overall mental well-being within a few weeks of consistent use Read Review. Overall, while personal experiences vary, the included evidence points toward a favorable response to a dosage of two capsules daily for managing anxiety.
9
Reduced anxiety
I recently started using Garden of Life probiotics and am impressed with the results! These probiotics not only support digestive health but also enhance mood, with noticeable positive changes in just weeks. The capsules contain various probiotic strains aimed at supporting the gut microbiome. I now feel more energetic and balanced. Each convenient serving is vegetarian and I've experienced no side effects. I've noticed I'm less susceptible to stress and anxiety, which has significantly improved my overall mood and quality of life. Highly recommend trying these probiotics!
7.5
Notable improvement
3 people found this helpful
Great! I purchased this hoping it would help with anxiety and depression. I noticed an improvement in my mood shortly after using this probiotic. It came highly recommended by my nutritionist, and I would definitely repurchase if I feel the need in the future.
7.5
Digestive improvement
1 people found this helpful
Evaluation after 45 days of use: I have noticed an improvement in my digestive system with less inflammation and spasms, as well as a decrease in meals provoking anxiety.
9
Mood balance
1 people found this helpful
I can’t express how this product has helped me! I was unaware that a healthy gut microbiome was linked to mental well-being. I experience general anxiety and non-clinical depression, and this has truly assisted in balancing my mood.
6
Stress reduction
These well-formulated probiotics have not only improved my digestion but have also provided benefits in reducing my stress and anxiety.
9
Calming properties
1 people found this helpful
I used Garden of Life probiotics long ago and I adore the brand. I particularly like the mood variant due to its inclusion of ashwagandha, which possesses calming, anti-stress, and anti-inflammatory properties, and is widely used to mitigate anxiety.
7.5
Improved mood
37 people found this helpful
The Best for anxiety and gut health! I usually experience anxiety, but I've noticed a shift in my mood and feel more relaxed and balanced. I previously used another brand of probiotics but discovered this one through an influencer on Instagram. I will definitely continue purchasing from this brand. The inclusion of ashwagandha makes it a perfect combination for emotional well-being and gut health! I take 2 pills on an empty stomach each morning and drink plenty of water, starting my day with a smoothie. You can take it with or without food, but I prefer on an empty stomach for better gut absorption. Please like if you found this helpful!
7
Eased anxiety
This product helps take the edge off my anxiety.
8
Improvement in mental health via probiotics
Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese.
We explored how a novel multi-strain E3 probiotic formula could impact anxiety and other mental health symptoms in a group of 68 individuals with sleep disturbances and mood issues.
Over an 8-week period, participants experienced significant improvements in sleep quality, depressive symptoms, and anxiety levels.
Remarkably, these changes were linked to shifts in their gut microbiome, suggesting that the health of our gut might play a powerful role in our overall mental well-being.
7
Probiotics reduced anxiety, depression
The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial.
This double-blind trial explored how synbiotic and probiotic supplements affect mental health and anemia in hemodialysis patients.
With 75 participants, those receiving synbiotics and probiotics showed a notable decrease in anxiety and depression scores after 12 weeks, compared to a placebo group.
However, there was no meaningful improvement in quality of life reported. Interestingly, the treated group also experienced significant increases in hemoglobin levels, which is beneficial.
7
Probiotics reduced anxiety symptoms
Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial.
We examined the role of probiotics, particularly lactobacillus acidophilus, in alleviating anxiety symptoms among patients with generalized anxiety disorder (GAD). In a double-blind, randomized controlled trial involving drug-free participants, we found that those taking probiotics along with sertraline experienced a notable decrease in anxiety compared to those on sertraline alone.
However, the probiotics did not show a significant impact on improving overall quality of life. While there were encouraging results on anxiety scores, the limited effect on quality of life suggests more research is needed to clarify these findings.
5
Probiotics did not significantly affect anxiety
Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial.
We looked into how combining caloric restriction with probiotics affects anxiety in adult men facing obesity. In a well-structured, double-blind, placebo-controlled study, participants followed a 12-week regimen of caloric restriction while taking a specific blend of probiotics.
While we found that anxiety and depressive symptoms improved within the group taking probiotics, there was no significant difference when compared to those on a placebo. This suggests that further research is necessary to fully understand the relationship between probiotics and anxiety in this context.
References
Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, Alves Carrilho FB, Nakamoto FP, et al. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clin Nutr. 2025;45:234. doi:10.1016/j.clnu.2024.12.031
Chan HHY, Siu PLK, Choy CT, Chan UK, Zhou J, et al. Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese. Nutrients. 2023;15. doi:10.3390/nu15245037
Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. doi:10.4103/ijn.IJN_341_19
Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. doi:10.33029/0042-8833-2021-90-2-63-72
Eskandarzadeh S, Effatpanah M, Khosravi-Darani K, Askari R, Hosseini AF, et al. Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial. Nutr Neurosci. 2021;24:102. doi:10.1080/1028415X.2019.1598669
Feher J, Pinter E, Kovács I, Helyes Z, Kemény A, et al. Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients. Ocul Surf. 2014;12:134. doi:10.1016/j.jtos.2013.09.002
Al Kassaa I, Fuad M. Effects of HN001 on Happiness and Mental Well-Being: Findings from a Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16172936
Ruiz-Gonzalez C, Cardona D, Rueda-Ruzafa L, Rodriguez-Arrastia M, Ropero-Padilla C, et al. Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10315-2
Holcomb M, Marshall A, Flinn H, Lozano M, Soriano S, et al. Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice. Res Sq. 2024. doi:10.21203/rs.3.rs-4196801/v1
Lonstein JS, Meinhardt TA, Pavlidi P, Kokras N, Dalla C, et al. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. 2024;165:107033. doi:10.1016/j.psyneuen.2024.107033
Schmidt NP, Molz P, Fraga BS, Bondarczuk NH, Silveira PD, et al. Effect of Probiotic LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet. Nutrients. 2024;16. doi:10.3390/nu16060879
Schell M, Wardelmann K, Hauffe R, Rath M, Chopra S, et al. Sex-Specifically Attenuates Depressive-like Behavior and Mitigates Metabolic Consequences in Obesity. Biol Psychiatry Glob Open Sci. 2023;3:651. doi:10.1016/j.bpsgos.2023.02.011
Jadhav G, Dudhabhate BB, Kokare DM, Sakharkar AJ. Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety. Mol Neurobiol. 2024;61:9892. doi:10.1007/s12035-023-03697-x
Walden KE, Moon JM, Hagele AM, Allen LE, Gaige CJ, et al. A randomized controlled trial to examine the impact of a multi-strain probiotic on self-reported indicators of depression, anxiety, mood, and associated biomarkers. Front Nutr. 2023;10:1219313. doi:10.3389/fnut.2023.1219313
Hamid M, Zahid S. Ameliorative effects of probiotics in AlCl-induced mouse model of Alzheimer's disease. Appl Microbiol Biotechnol. 2023;107:5803. doi:10.1007/s00253-023-12686-y
Chudzik A, Słowik T, Kochalska K, Pankowska A, Łazorczyk A, et al. Continuous Ingestion of JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats. Int J Mol Sci. 2022;23. doi:10.3390/ijms23095173
Wauters L, Van Oudenhove L, Accarie A, Geboers K, Geysen H, et al. CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial. Gut Microbes. 2022;14:2031695. doi:10.1080/19490976.2022.2031695
Zhou B, Jin G, Pang X, Mo Q, Bao J, et al. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacol Res. 2022;177:106090. doi:10.1016/j.phrs.2022.106090
Liu Y, Sanderson D, Mian MF, McVey Neufeld KA, Forsythe P. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. 2021;195:108682. doi:10.1016/j.neuropharm.2021.108682
Foroozan P, Koushkie Jahromi M, Nemati J, Sepehri H, Safari MA, et al. Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice. Nutrients. 2021;13. doi:10.3390/nu13061762
Quero CD, Manonelles P, Fernández M, Abellán-Aynés O, López-Plaza D, et al. Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study. Nutrients. 2021;13. doi:10.3390/nu13041321
Tamayo M, Agusti A, Molina-Mendoza GV, Rossini V, Frances-Cuesta C, et al. Bifidobacterium longum CECT 30763 improves depressive- and anxiety-like behavior in a social defeat mouse model through the immune and dopaminergic systems. Brain Behav Immun. 2025;125:35. doi:10.1016/j.bbi.2024.12.028
Martin FP, Cominetti O, Berger B, Combremont S, Marquis J, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Gut Microbes. 2024;16:2347715. doi:10.1080/19490976.2024.2347715
Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
Boehme M, Rémond-Derbez N, Lerond C, Lavalle L, Keddani S, et al. subsp. Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15143122
Toh MPS, Yang CY, Lim PC, Loh HLJ, Bergonzelli G, et al. A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial. JMIR Res Protoc. 2023;12:e41751. doi:10.2196/41751
Groeger D, Murphy EF, Tan HTT, Larsen IS, O'Neill I, et al. Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination. Neurogastroenterol Motil. 2023;35:e14477. doi:10.1111/nmo.14477
Ma T, Jin H, Kwok LY, Sun Z, Liong MT, et al. Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota. Neurobiol Stress. 2021;14:100294. doi:10.1016/j.ynstr.2021.100294
Inoue T, Kobayashi Y, Mori N, Sakagawa M, Xiao JZ, et al. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018;9:843. doi:10.3920/BM2017.0193
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153:448. doi:10.1053/j.gastro.2017.05.003
Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, et al. Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry. 2016;6:e939. doi:10.1038/tp.2016.191
Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF. Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behav Brain Res. 2015;287:59. doi:10.1016/j.bbr.2015.02.044
Savignac HM, Kiely B, Dinan TG, Cryan JF. Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil. 2014;26:1615. doi:10.1111/nmo.12427
Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil. 2011;23:1132. doi:10.1111/j.1365-2982.2011.01796.x
Freitas SM, Franco B, Saragiotto G, Morais MA, Simabuco FM, et al. Effect of a probiotic fermented milk supplementation on behavior and sleep. Nutr Neurosci. 2024;27:607. doi:10.1080/1028415X.2023.2240990
Dandekar MP, Palepu MSK, Satti S, Jaiswal Y, Singh AA, et al. Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome-Brain Activity in Rats. ACS Chem Neurosci. 2022;13:1948. doi:10.1021/acschemneuro.2c00143
Sun B, Ma T, Li Y, Yang N, Li B, et al. Bifidobacterium lactis Probio-M8 Adjuvant Treatment Confers Added Benefits to Patients with Coronary Artery Disease via Target Modulation of the Gut-Heart/-Brain Axes. mSystems. 2022;7:e0010022. doi:10.1128/msystems.00100-22
Dong W, Wang Y, Liao S, Tang W, Peng L, et al. subsp. BB-12 Improves the State Anxiety and Sports Performance of Young Divers Under Stress Situations: A Single-Arm, Prospective Proof-of-Concept Study. Front Psychol. 2020;11:570298. doi:10.3389/fpsyg.2020.570298
Luang-In V, Katisart T, Konsue A, Nudmamud-Thanoi S, Narbad A, et al. Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model. Food Sci Anim Resour. 2020;40:1014. doi:10.5851/kosfa.2020.e72
Venkataraman R, Madempudi RS, Neelamraju J, Ahire JJ, Vinay HR, et al. Effect of Multi-strain Probiotic Formulation on Students Facing Examination Stress: a Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2021;13:12. doi:10.1007/s12602-020-09681-4
Dawe JP, McCowan LME, Wilson J, Okesene-Gafa KAM, Serlachius AS. Probiotics and Maternal Mental Health: A Randomised Controlled Trial among Pregnant Women with Obesity. Sci Rep. 2020;10:1291. doi:10.1038/s41598-020-58129-w
Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2021;24:490. doi:10.1080/1028415X.2019.1646975
Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
Gajdošová L, Katrenčíková B, Borbélyová V, Muchová J. The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged Rats. Physiol Res. 2024;73:461.
Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, et al. Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome. Food Funct. 2023;14:5977. doi:10.1039/d3fo01452e
Mengelberg A, Leathem J, Podd J, Hill S, Conlon C. The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month randomised controlled trial. Int J Geriatr Psychiatry. 2022;37. doi:10.1002/gps.5707
Zambrano E, Rodríguez-González GL, Reyes-Castro LA, Bautista CJ, Castro-Rodríguez DC, et al. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring. Nutrients. 2021;13. doi:10.3390/nu13124243
Tang Q, Li S, Fang C, Yu H. Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction. Food Chem Toxicol. 2022;159:112699. doi:10.1016/j.fct.2021.112699
Neto J, Jantsch J, de Oliveira S, Braga MF, Castro LFDS, et al. DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr. 2022;128:964. doi:10.1017/S0007114521003998
Ponomarenko AI, Tyrtyshnaia AA, Pislyagin EA, Dyuizen IV, Sultanov RM, et al. N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Sci Rep. 2021;11:756. doi:10.1038/s41598-020-80818-9
Demers G, Roy J, Machuca-Parra AI, Dashtehei Pour Z, Bairamian D, et al. Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. Int J Obes (Lond). 2020;44:1936. doi:10.1038/s41366-020-0623-6