Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 77 Researches
7.7
USERS' SCORE
Good
Based on 44 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Colon Care BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221), Bifidobacterium lactis (SD-5674), Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk) Concentrate, ^Eastern European Wild Kefir Culture containing Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum, Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris, Streptococcus thermophilus, Lactobacillus kefir, Lactobacillus parakefir, Lactobacillus plantarum, Lactococcus lactis biovar diacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromyces marxianus, Brettanomyces anomalus, Debaryomyces hansenii, Saccharomyces unisporus, Saccharomyces turicensis, Saccharomyces cerevisiae, Saccharomyces exiguus, Torulaspora delbrueckii
50 Billion CFU¹
+
Colon Transit Support Enzyme BlendAmylase, Protease, Lactase, Glucoamylase, alpha-Galactosidase, Lipase, Pectinase, Peptidase, Bromelain, Phytase, Hemicellulase, beta-Glucanase, Papain, Cellulase, Xylanase, Diastase, Invertase
50 mg
+
Eastern European Raw Fruit & Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
9
We explored the impact of Bifidobacterium lactis BLa80 on constipation using mice that were induced with functional constipation through loperamide treatment. In our study, we compared BLa80 to a blank group and a positive control.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
The results indicated that BLa80 improved intestinal movement, increased fecal moisture, and balanced gut bacteria. It also helped regulate important gut hormones. Overall, BLa80 shows promise as a potential new option for relieving constipation in functional foods.
Read More
9
We investigated the effects of Bifidobacterium lactis subsp. TG11 on loperamide-induced constipation in mice. The mice were grouped into control and treatment categories, receiving different doses of the probiotic.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
After treatment, those receiving TG11 showed improved intestinal motility and maintained better fecal water content. Notably, the probiotic also positively affected gut microbiota, increasing beneficial bacteria and promoting short-chain fatty acid production.
Overall, Bifidobacterium lactis TG11 appears effective in alleviating constipation, potentially by enhancing gut health.
Read More
Most Useful Reviews
9
Homeopathic relief
316 people found this helpful
Diagnosed with gastroparesis, I've faced awful constipation. Prescription laxatives added nausea, so I sought homeopathic remedies. This product, combined with other herbs, has worked wonders. I'm off laxatives and can finally eat easier-digested solid foods.
Read More
9
Resolved constipation
101 people found this helpful
Good probiotic. The product genuinely works. My constipation problem has been resolved.
Read More
9
Eliminated constipation
27 people found this helpful
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 77 Researches
7.7
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Good
Based on 44 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Homeopathic relief
316 people found this helpful
Diagnosed with gastroparesis, I've faced awful constipation. Prescription laxatives added nausea, so I sought homeopathic remedies. This product, combined with other herbs, has worked wonders. I'm off laxatives and can finally eat easier-digested solid foods.
Read More
9
Resolved constipation
101 people found this helpful
Good probiotic. The product genuinely works. My constipation problem has been resolved.
Read More
9
Eliminated constipation
27 people found this helpful
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.
Read More
7.5
Improved bowel regularity
17 people found this helpful
From the 7th month of pregnancy, I suffered from constipation, but once I began using these probiotics, the situation improved almost immediately. After two months of use, I find my bowel movements are regular now. A balanced diet with fruits and vegetables has also contributed to this improvement.
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9
Improved digestion
9 people found this helpful
Microbiome support while taking Upd. After completing the course, my constipation returned. I have dolichocolon, and constipation is frequent for me; I know a lot about it. The packaging is designed for a month's use. It's vital to open the capsule and consume the contents for the drug's effect to be seen—the stool has improved. I take one capsule on an empty stomach. The ingredients are natural, and my digestion has notably improved. The benefits are clear; my intestines have begun functioning well. This is the first time I purchased this brand, and I am pleased with the results.
Read More
Frequently Asked Questions
7.5
Improved bowel regularity
17 people found this helpful
From the 7th month of pregnancy, I suffered from constipation, but once I began using these probiotics, the situation improved almost immediately. After two months of use, I find my bowel movements are regular now. A balanced diet with fruits and vegetables has also contributed to this improvement.
7.5
Constipation relief
1 people found this helpful
This is a super high-quality probiotic essential for healthy microflora. It enhances intestinal function, restores the microbiome, and improves digestion. After a little over a week, I've already noticed positive changes, and the benefits of the product are undeniable. I recommend it.
9
Smooth daily stools
The effect on constipation is excellent; I have smooth movements daily, and I will continue to repurchase...
9
Restored bowel function
7 people found this helpful
Excellent probiotics! In the first month, my bowel function was restored, and constipation disappeared. This is my third order, and I am very pleased with the results. I highly recommend them.
9
Resolved constipation
101 people found this helpful
Good probiotic. The product genuinely works. My constipation problem has been resolved.
0
Worsened constipation
The product’s quality is good with clean ingredients, but it is somewhat pricey. However, since starting it, I experienced severe constipation and cramps. The situation worsened, requiring a visit to the doctor, so I am returning it as it did not suit me at all.
9
Regular bowel function
1 people found this helpful
A reliable remedy that I trust due to its high quality. With convenient packaging, my intestines now work like clockwork, increasing microbiome health and reducing constipation. The capsules are flavourless and easily swallowed with water.
2
No more gases
2 people found this helpful
All products from this firm are unique and beneficial. This supplement helped me eliminate gases and enhance my immune system. Thanks to a healthy lifestyle and attention to my intestines, illnesses have become rare over the year. It's wise to increase vegetable intake while using this supplement to nourish the microbiome and prevent constipation.
9
Eliminated constipation
27 people found this helpful
I found this probiotic ideal for restoring intestinal microflora. With 33 strains and 50bn CFU per capsule, it effectively improves colon health and bowel function. It contains a beneficial blend of prebiotics and enzymes. This high-potency formula has noticeably restored gut health and has successfully eliminated constipation for me. I recommend taking one daily.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. doi:10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
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- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
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- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. doi:10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. doi:10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. doi:10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. doi:10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Ito D, Yamamoto Y, Maekita T, Yamagishi N, Kawashima S, et al. Do synbiotics really enhance beneficial synbiotics effect on defecation symptoms in healthy adults?: Randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2022;101:e28858. doi:10.1097/MD.0000000000028858
- Astó E, Huedo P, Altadill T, Aguiló García M, Sticco M, et al. Probiotic Properties of KABP042 and KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants. Front Microbiol. 2021;12:741391. doi:10.3389/fmicb.2021.741391
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. doi:10.1016/j.clnesp.2020.12.025
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. doi:10.1016/j.clnu.2020.01.005
- Zhu S, Guo Z, Liu L, Gao Y, Bai L, et al. Complex Probiotics Relieve Constipation Through Regulation of the Intestinal Microbiota in Kittens. Microorganisms. 2025;13. doi:10.3390/microorganisms13030563
- Zhang Z, Li J, Wan Z, Fang S, Zhao Y, et al. subsp. BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025;16:2347. doi:10.1039/d4fo06350c
- Ma W, Zhao Y, Liu Y, Wang Y, Yu S, et al. subsp. TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota. Front Microbiol. 2025;16:1525887. doi:10.3389/fmicb.2025.1525887
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. doi:10.1039/d4fo04660a
- Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, et al. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study. Benef Microbes. 2024;15:679. doi:10.1163/18762891-bja00038
- Lan W, Yang H, Zhong Z, Luo C, Huang Q, et al. subsp. LPL-RH improves postoperative gastrointestinal symptoms and nutrition indexes by regulating the gut microbiota in patients with valvular heart disease: a randomized controlled trial. Food Funct. 2024;15:7605. doi:10.1039/d4fo01471e
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. doi:10.1007/s00394-024-03398-8
- Lu Y, Zhou X, Wu Y, Cui Q, Tian X, et al. Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway. Mol Nutr Food Res. 2024;68:e2200846. doi:10.1002/mnfr.202200846
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. doi:10.3390/jcm12144838
- Watanabe M, Maruo T, Suzuki T. Effects of intake of subsp. FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study. Int J Food Sci Nutr. 2023;74:695. doi:10.1080/09637486.2023.2236805
- Cui H, Wang Q, Feng C, Guo C, Zhang J, et al. Positive effect of subsp VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Front Microbiol. 2022;13:1040371. doi:10.3389/fmicb.2022.1040371
- van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2022;41:2759. doi:10.1016/j.clnu.2022.10.015
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