5/5/2025
Last update
5/5/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 57 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Replenish BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221),Lactobacillus paracasei (SD-5218), Bifidobacterium lactis (SD-5220),Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk)Concentrate, ^Eastern European Wild Kefir Culture containingBifidobacterium lactis, Bifidobacterium longum, Lactobacillusacidophilus, Lactobacillus brevis, Lactobacillus bulgaricus,Lactobacillus casei, Lactobacillus fermentum, Lactobacillushelveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum,Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris,Streptococcus thermophilus, Lactobacillus kefir, Lactobacillusparakefir, Lactobacillus plantarum, Lactococcus lactis biovardiacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides,Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromycesmarxianus, Brettanomyces anomalus, Debaryomyces hansenii,Saccharomyces unisporus, Saccharomyces turicensis,Saccharomyces cerevisiae, Saccharomyces exiguus,Torulaspora delbrueckii
100 Billion CFU¹
+
Protein-Digesting Enzyme BlendProtease, Acid Protease, Protease S
50 mg
+
Eastern European Raw Fruit and Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
8
Bifidobacterium longum shows potential benefits
We investigated whether Bifidobacterium longum XZ01 could affect the progression of colon cancer in a mouse model. The results hinted that this probiotic might enhance immune responses by outcompeting harmful bacteria and protecting macrophages within tumors.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Read More
8
Hydrothermal yeast impacts breast cancer
We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
Read More
9
Probiotics show promise against colorectal cancer
This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Read More
Most Useful Reviews
8
Alleviates pain
5 people found this helpful
Works for me. This product came highly recommended by my daughter-in-law, who heard from other cancer patients about its benefits. After trying it for 30 days, I can genuinely say it has made a significant difference. I have not experienced any pain after chemotherapy this time, which has been a blessing, especially since I'd previously suffered terrible pain with any digestive movement.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 57 Researches
8
- All Researches
9.5
Lactobacillus acidophilus improves cancer therapy
We explored how lactobacillus acidophilus can enhance chemodynamic therapy for cancer. By coupling the probiotic with specialized nanosheets loaded with calcium oxide nanoparticles, we observed a notable reduction in tumor size.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
Read More
9
We explored the effects of combined treatments with Lactobacillus acidophilus, calcium citrate, and Moringa oleifera extract on colon cancer induced in rats. The study involved administering a carcinogen, DMH, while observing the impact of these treatments over a four-week period.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Read More
9
Probiotics show promise against colorectal cancer
This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Read More
9
We investigated whether Lactobacillus acidophilus can help prevent liver cancer associated with non-alcoholic fatty liver disease (NAFLD-HCC).
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Read More
9
Lactobacillus acidophilus shows promise
We explored the effect of Lactobacillus acidophilus on non-metastatic rectal cancer by studying its influence on the CYLD protein and signaling pathways. In a randomized trial involving 110 patients, those consuming L. acidophilus showed a significant increase in tumor-suppressing CYLD protein and related genes, alongside a decrease in inflammation-related factors compared to a placebo. Impressively, the probiotic group had a higher survival rate after five years. These findings suggest that L. acidophilus can positively influence cancer by modulating inflammatory pathways.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Alleviates pain
5 people found this helpful
Works for me. This product came highly recommended by my daughter-in-law, who heard from other cancer patients about its benefits. After trying it for 30 days, I can genuinely say it has made a significant difference. I have not experienced any pain after chemotherapy this time, which has been a blessing, especially since I'd previously suffered terrible pain with any digestive movement.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Zamani F, Khalighfard S, Kalhori MR, Poorkhani A, Amiriani T, et al. Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients. Med Oncol. 2023;40:302. 10.1007/s12032-023-02170-y
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- Zhang H, Li Y, Li L. Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis. BMC Cancer. 2025;25:368. 10.1186/s12885-025-13598-y
- Chen Y, Wu J, Cai K, Xiao X, Chen Y, et al. Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity. Int Immunopharmacol. 2025;150:114283. 10.1016/j.intimp.2025.114283
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. 10.1016/j.biomaterials.2025.123117
- Kim MJ, Song MH, Ji YS, Park JW, Shin YK, et al. Cell free supernatants of Bifidobacterium adolescentis and Bifidobacterium longum suppress the tumor growth in colorectal cancer organoid model. Sci Rep. 2025;15:935. 10.1038/s41598-024-83048-5
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- Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. 10.1016/j.clnesp.2024.11.016
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- Fan YL, Jin JX, Zhu J, Ruan HB, Huang JQ. Extracellular vesicles of Bifidobacterium longum reverse the acquired carboplatin resistance in ovarian cancer cells via p53 phosphorylation on Ser15. Kaohsiung J Med Sci. 2024;40:530. 10.1002/kjm2.12837
- Zhang Y, Cao T, Wang Y, Yang R, Han Y, et al. Effects of Viable and Heat-Inactivated D42 on Proliferation and Apoptosis of HT-29 Human Colon Cancer Cells. Foods. 2024;13. 10.3390/foods13060958
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