Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Good
Based on 12 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin from culture of Saccharomyces cerevisiae)
1,000 mcg
41667%
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Raw Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus (flower & stem)
20 mg
+
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
Most Useful Reviews
9
Improved haemoglobin
5 people found this helpful
The composition is good, and the product is very beneficial. The doctor prescribed this drug for my B-12 deficiency anaemia, which caused broken nails, dizziness, and shortness of breath. After a three-month course, I experienced a significant improvement; my haemoglobin levels normalised, and I no longer have shortness of breath. I highly recommend this! ❤️
Read More
9
Decreased nervousness
4 people found this helpful
Scientific sources indicate that Vitamin B12 is essential for brain function, the nervous system, and preventing various types of anaemia. Since it’s not synthesised in the body and absorption decreases with age, I take this vitamin. Since I started, I've become less anxious and my sleep has improved. I recommend it.
Read More
7.5
Raised B12 levels
4 people found this helpful
I take this according to my doctor's advice based on my test results. My levels improved from the lowest borderline to normal within a month. I previously had a history of anaemia, numbness, and insomnia, but now I feel much better! This particular drug is great as it contains nutrients from 23 whole fruits and vegetables, with no synthetic ingredients. The only downside is that there are not enough capsules per jar.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
- All Researches
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
9
We explored a case of a 3-year-old girl diagnosed with Imerslund-Gräsbeck syndrome, a condition that causes vitamin B12 malabsorption and leads to anemia. After identifying novel mutations in the AMN gene, we initiated long-term oral vitamin B12 therapy.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved haemoglobin
5 people found this helpful
The composition is good, and the product is very beneficial. The doctor prescribed this drug for my B-12 deficiency anaemia, which caused broken nails, dizziness, and shortness of breath. After a three-month course, I experienced a significant improvement; my haemoglobin levels normalised, and I no longer have shortness of breath. I highly recommend this! ❤️
Read More
9
Decreased nervousness
4 people found this helpful
Scientific sources indicate that Vitamin B12 is essential for brain function, the nervous system, and preventing various types of anaemia. Since it’s not synthesised in the body and absorption decreases with age, I take this vitamin. Since I started, I've become less anxious and my sleep has improved. I recommend it.
Read More
7.5
Raised B12 levels
4 people found this helpful
I take this according to my doctor's advice based on my test results. My levels improved from the lowest borderline to normal within a month. I previously had a history of anaemia, numbness, and insomnia, but now I feel much better! This particular drug is great as it contains nutrients from 23 whole fruits and vegetables, with no synthetic ingredients. The only downside is that there are not enough capsules per jar.
Read More
9
Maintained health
2 people found this helpful
I’m a vegan and take this daily. My blood tests confirm I’m healthy and free of anaemia. You will feel the benefits!
Read More
7.5
Resolved anaemia
2 people found this helpful
I bought this vitamin B12 to resolve an anaemia issue, and it has definitely helped!
Read More
Frequently Asked Questions
7.5
Raised B12 levels
4 people found this helpful
I take this according to my doctor's advice based on my test results. My levels improved from the lowest borderline to normal within a month. I previously had a history of anaemia, numbness, and insomnia, but now I feel much better! This particular drug is great as it contains nutrients from 23 whole fruits and vegetables, with no synthetic ingredients. The only downside is that there are not enough capsules per jar.
9
Significant progress
1 people found this helpful
This product is ideal for those with B12-deficiency anaemia. One jar raised my levels from 340 to 1020 in just a month. The dosage may increase, but it's crucial to maintain proper nutrition alongside taking vitamins.
9
Improved haemoglobin
5 people found this helpful
The composition is good, and the product is very beneficial. The doctor prescribed this drug for my B-12 deficiency anaemia, which caused broken nails, dizziness, and shortness of breath. After a three-month course, I experienced a significant improvement; my haemoglobin levels normalised, and I no longer have shortness of breath. I highly recommend this! ❤️
9
Decreased nervousness
4 people found this helpful
Scientific sources indicate that Vitamin B12 is essential for brain function, the nervous system, and preventing various types of anaemia. Since it’s not synthesised in the body and absorption decreases with age, I take this vitamin. Since I started, I've become less anxious and my sleep has improved. I recommend it.
7.5
Improves forgetfulness
B12 enhances my memory and attention, as well as aiding in the treatment of anemia.
7.5
Aiding anaemia
This natural B12, along with B6 and vitamin C, effectively combats anaemia.
9
Supports healthy metabolism
This product helps with my anemia, maintains a healthy metabolism, and provides essential vitamin B12. It also supports my nervous system. The taste is pleasant, and the packaging is beautiful. Overall, it’s highly effective and of excellent quality, especially with folic acid included.
9
Maintained health
2 people found this helpful
I’m a vegan and take this daily. My blood tests confirm I’m healthy and free of anaemia. You will feel the benefits!
8
This case explores the journey of a 40-year-old woman who suffered from various nonspecific symptoms, mistakenly attributed to other health issues, for ten years. Her vitamin B12 levels were critically low, ultimately diagnosed as pernicious anemia.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
9
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
8
We investigated the prevalence of pernicious anemia (PA) as a cause of cobalamin (vitamin B12) deficiency in patients with megaloblastic anemia in Hainan, China. By testing 90 patients, we found that over 80% were diagnosed with PA.
During the follow-up period, those receiving consistent B12 therapy showed no relapse, while interruptions led to a significant relapse rate. Our findings suggest that screening for PA is crucial and highlight the importance of ongoing B12 supplementation for affected patients.
During the follow-up period, those receiving consistent B12 therapy showed no relapse, while interruptions led to a significant relapse rate. Our findings suggest that screening for PA is crucial and highlight the importance of ongoing B12 supplementation for affected patients.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. doi:10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. doi:10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. doi:10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. doi:10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. doi:10.1007/s12185-024-03759-3
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
