We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Rare genetic defect in B12 transport
Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
8
WIFAS improving folate and hemoglobin
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
Read More
Most Useful Reviews
9
Energy boost
36 people found this helpful
I’m pleased with this complex, as it truly provides energy. On a stressful day, I doubled my intake and felt revitalised. The whole family uses it, and we all appreciate the wonderful results, especially regarding my husband's and my assistance in treating our anemia.
Read More
9
Reduced headaches
15 people found this helpful
This glass jar contains a rich mix of organic fruits and vegetables, probiotics, and enzymes. The complex is natural and not synthetic. I’ve experienced fewer headaches and improved blood circulation since using it, which has been beneficial for my anaemia.
Read More
9
Improved condition
8 people found this helpful
A wonderful complex, well-packaged with a protective membrane. B vitamins are vital during stress, helping with the immune system, protein synthesis, and managing hormonal balance. My husband and I took this for a month on a nutritionist's advice. His condition improved significantly, aiding in his recovery from anaemia.
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Read More
9.5
Thiamine resolves rare anemia effectively
Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia.
In our examination, we focused on thiamine-responsive megaloblastic anemia (TRMA), a rare genetic disorder affecting young individuals. We learned about a young man with diabetes who faced pancytopenia, initially linked to a COVID-19 infection.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Read More
9.5
Case study: Vitamin B12 efficacy
Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy.
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Health education improves anemia outcomes
Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study.
We explored the effectiveness of a family-centered health education intervention aimed at boosting the adherence to iron-folic acid supplements and improving anemia in rural pregnant women.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
Read More
9
Rare genetic defect in B12 transport
Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
I’m pleased with this complex, as it truly provides energy. On a stressful day, I doubled my intake and felt revitalised. The whole family uses it, and we all appreciate the wonderful results, especially regarding my husband's and my assistance in treating our anemia.
Read More
9
Reduced headaches
15 people found this helpful
This glass jar contains a rich mix of organic fruits and vegetables, probiotics, and enzymes. The complex is natural and not synthetic. I’ve experienced fewer headaches and improved blood circulation since using it, which has been beneficial for my anaemia.
Read More
9
Improved condition
8 people found this helpful
A wonderful complex, well-packaged with a protective membrane. B vitamins are vital during stress, helping with the immune system, protein synthesis, and managing hormonal balance. My husband and I took this for a month on a nutritionist's advice. His condition improved significantly, aiding in his recovery from anaemia.
Read More
9
Higher energy
I take these vitamins based on a specialist's advice, especially to compensate for my B vitamin deficiencies. The product is of high quality, and I notice a positive change, especially in my energy levels. It also supports treating my anaemia effectively.
Read More
7.5
Headache relief
257 people found this helpful
The complex is aptly named "raw". It consists of a rich blend of fruits, vegetables, probiotics, and enzymes, all derived from unprocessed, organic ingredients. The moderately large, transparent capsules contain sand-coloured powder. I found that the B vitamins have significantly lessened my frequent headaches and tension in my temples, which is essential for treating my anemia.
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Vitamin B Complex can play a significant role in managing certain types of anemia, particularly those related to deficiencies in specific B vitamins, such as B12 and folate. Vitamin B12 is essential for the production of red blood cells and effective functioning of the nervous system. A deficiency in B12 can lead to pernicious anemia, characterized by the production of large, ineffective red blood cells, which can result in fatigue and weakness. Similarly, folate (B9) is crucial for DNA synthesis and cell division, and its deficiency can lead to megaloblastic anemia, where the bone marrow produces oversized and dysfunctional red blood cells.
However, it's important to note that not all types of anemia are related to B vitamin deficiencies. For instance, iron deficiency anemia is the most common form and would require iron supplementation instead. If you're considering taking a B Complex vitamin to address symptoms of anemia, it’s advisable to consult a healthcare provider first. They can recommend appropriate testing and determine whether a B vitamin deficiency is contributing to your anemia and help you identify the right treatment plan tailored to your needs.
Based on user reviews, those taking this B vitamin complex for anemia typically start noticing results after several weeks. For instance, one user mentioned they observed significant improvement in their husband's condition after a month of use, which highlights the importance of consistency in supplementation Read Review. Another user emphasized a positive change in energy levels and overall health after a few weeks of regular intake Read Review.
Additionally, several users note that combining the B vitamin complex with iron supplements enhances their effectiveness in managing anemia. One user pointed out the supplement's beneficial impact on alleviating symptoms related to anemia, implying that users often experience improvements as they follow their healthcare provider's recommendations Read Review. Overall, while individual results may vary, a timeframe of approximately 4 to 6 weeks seems common for users to start feeling the benefits of this supplement in relation to anemia.
The effectiveness of various supplements in treating anemia is well-supported by scientific research. For instance, a study focused on the impact of iron-folic acid supplementation combined with nutrition education showed a significant reduction in anemia rates among pregnant women in Ethiopia, dropping from 27.8% to 7.2% [2]. Furthermore, an analysis of daily oral iron supplements during pregnancy indicated that such supplementation can significantly reduce maternal anemia and iron deficiency [10]. These studies suggest that iron and folic acid are crucial in combating anemia, particularly in vulnerable populations like pregnant women.
Additionally, vitamin B12 plays a vital role in addressing certain types of anemia. Research involving pernicious anemia highlighted the improvement in symptoms following the administration of parenteral methylcobalamin therapy [1]. This emphasizes the importance of diagnosing and treating vitamin B12 deficiencies, which can significantly impact overall health. Overall, the evidence strongly supports the effectiveness of specific supplements, particularly iron, folic acid, and vitamin B12, in managing anemia across various populations and conditions.
Based on user reviews, many individuals report significant improvements in their symptoms related to anemia after using this B vitamin complex. Users have experienced heightened energy levels, a reduction in headaches, and overall better circulation, contributing to better management of their anemia. For instance, one user noted feeling revitalized enough to double their intake on stressful days, leading them to appreciate the benefits across their family, particularly for their husband's anemia Read Review. Another user highlighted a noticeable decline in headaches and tension while concurrently addressing their anemia with this supplement Read Review.
Additionally, numerous reviews emphasize the importance of these vitamins in enhancing iron absorption and overall metabolic health, suggesting a strong relationship between B vitamin intake and improved symptoms of anemia Read Review. Users have also mentioned their positive experiences in following medical advice regarding their supplementation regimen, confirming that consistent intake over time has yielded beneficial results for their anemia management Read Review. While individual results can vary, these anecdotal experiences provide encouraging insights into the potential effectiveness of this B vitamin complex for improving anemia symptoms.
Users have reported positive outcomes when combining this B vitamin complex with other supplements, particularly iron. Several reviews indicate that individuals taking this complex alongside iron supplements have experienced significant improvements in their symptoms of anemia. One user mentioned taking the complex with iron and noting that it provided a good dosage of B vitamins that proved beneficial for recovery from anemia Read Review. Similarly, another user highlighted that their journey with long-term anemia management has been supported effectively by this vitamin complex in conjunction with iron supplements Read Review.
Additionally, many users emphasized the importance of seeking professional advice when combining supplements. One reviewer noted that following their nutritionist's guidance on pairing these B vitamins with iron helped restore their iron levels and effectively treat their anemia Read Review. This suggests a consensus among users that a tailored approach, ideally guided by a health professional, can enhance the benefits of the B vitamin complex in managing anemia when used alongside iron supplements.
Based on user reviews, there seems to be a consensus that Vitamin B Complex plays a significant role in managing and treating anemia, particularly when taken in alignment with professional advice. Users report positive outcomes from following dosages recommended by healthcare professionals, often highlighting that they experienced improved energy levels and overall well-being after consistent use. For example, one user noted that they were taking the complex "based on a specialist's advice," which notably aided in the effective treatment of their anemia and improved energy levels Read Review.
Additionally, users have mentioned taking these B vitamins alongside iron supplements, suggesting that this combination may enhance recovery from anemia. One user emphasized that the complex "offers a good dosage of B vitamins," proving beneficial when taken with iron Read Review. Overall, while specific dosages may vary, it’s clear that individual experiences lean heavily on professional recommendations, which users have found to yield significant improvements in their anemia symptoms.
9
Improved condition
8 people found this helpful
A wonderful complex, well-packaged with a protective membrane. B vitamins are vital during stress, helping with the immune system, protein synthesis, and managing hormonal balance. My husband and I took this for a month on a nutritionist's advice. His condition improved significantly, aiding in his recovery from anaemia.
9
Higher energy
I take these vitamins based on a specialist's advice, especially to compensate for my B vitamin deficiencies. The product is of high quality, and I notice a positive change, especially in my energy levels. It also supports treating my anaemia effectively.
7.5
Anemia management
Since discovering I had anaemia, I took this complex alongside iron supplements. It offers a good dosage of B vitamins, proving beneficial for my recovery.
9
Energy boost
36 people found this helpful
I’m pleased with this complex, as it truly provides energy. On a stressful day, I doubled my intake and felt revitalised. The whole family uses it, and we all appreciate the wonderful results, especially regarding my husband's and my assistance in treating our anemia.
7.5
Less headaches
247 people found this helpful
The glass jar is well-packaged and protects its rich contents. The "raw" components from natural vegetables and fruits are impressive. I noticed that the B vitamins have greatly improved my frequent headaches and tension in my temples, leading to fewer occurrences, which is important for managing my anemia. I highly recommend it!
8
Essential B vitamins
48 people found this helpful
I like much about Garden of Life's philosophy, especially regarding their Raw line, which maintains the natural origin of B vitamins without artificial additives. Remarkably, these vitamins support iron absorption and reduce anemia risk. The importance of these vitamins cannot be overstated, particularly B12 for the elderly.
7.5
Supports anaemia treatment
I take this B vitamin complex alongside iron for my long-term anaemia. It supports my health effectively.
6
Supports treatment
Following my nutritionist’s advice, I've found this B vitamin complex invaluable for restoring my iron levels and treating anaemia. The pure composition without unnecessary additives is reassuring.
9.5
Nutrition education reduces anemia prevalence
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
We examined the impact of daily oral iron supplementation on anemia in pregnant women. Our analysis included 57 trials with nearly 49,000 participants.
We found that iron supplementation could significantly reduce maternal anemia and iron deficiency by the end of pregnancy. However, other outcomes showed limited effects, with uncertainty around the benefits for infant health.
Overall, while iron could be beneficial, there's a need for future studies to explore its broader impacts on maternal and child health.
8
Pernicious anemia case highlights treatment
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We explored a compelling case of pernicious anemia in a 51-year-old Ugandan man presenting with lower limb weakness. Initially treated for vitamin B12 deficiency years earlier, he experienced similar symptoms once again.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
References
Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. doi:10.1038/s41598-025-87957-x
Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. doi:10.1186/s13643-024-02726-7
Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. doi:10.1177/03795721241304475
Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. doi:10.1021/acsami.4c15206
Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2024-261435
Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. doi:10.1002/14651858.CD004736.pub6
Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7