Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
8
Bifidobacterium longum shows potential benefits
We investigated whether Bifidobacterium longum XZ01 could affect the progression of colon cancer in a mouse model. The results hinted that this probiotic might enhance immune responses by outcompeting harmful bacteria and protecting macrophages within tumors.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Read More
9
Probiotics show promise against colorectal cancer
This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Read More
9
We investigated whether Lactobacillus acidophilus can help prevent liver cancer associated with non-alcoholic fatty liver disease (NAFLD-HCC).
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Read More
Most Useful Reviews
9
Essential for wellness
10 people found this helpful
BEST ON THE MARKET. My husband and I have been taking this probiotic for over 5 years and have always appreciated its effects. Garden of Life is our go-to for supplements. My husband has stage IV metastatic melanoma, and I have Langerhans Cell Histiocytosis, making our choice of supplement critical. My husband has been cancer-free for over 2 years, and I have been tumour-free for 21 years.
Read More
9
Endured 11 years
7 people found this helpful
I had esophageal cancer 12 years ago and underwent significant treatments, leaving me with 11 years of diarrhoea and drastic weight loss. After using probiotics, I ended my diarrhoea and gained weight back to 209 lbs. My hair and nails are healthier, and I feel much stronger. I’ve had to buy new clothes, a testament to my improved condition.
Read More
7.5
Reduced chemotherapy nausea
9 people found this helpful
Garden of Life Is The Best! I started taking these during chemotherapy for stage 3 breast cancer. The nausea was unbearable, and while this wasn’t a cure-all, it significantly reduced my nausea and boosted my immunity. When I stop taking them, I feel bloated and low on energy. As soon as I resume, my energy returns, and I feel much better overall. It also helps with my digestion.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.9
- All Researches
9.5
Lactobacillus acidophilus improves cancer therapy
We explored how lactobacillus acidophilus can enhance chemodynamic therapy for cancer. By coupling the probiotic with specialized nanosheets loaded with calcium oxide nanoparticles, we observed a notable reduction in tumor size.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
Read More
9
We explored the effects of combined treatments with Lactobacillus acidophilus, calcium citrate, and Moringa oleifera extract on colon cancer induced in rats. The study involved administering a carcinogen, DMH, while observing the impact of these treatments over a four-week period.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
Read More
9
Probiotics show promise against colorectal cancer
This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
Read More
9
We investigated whether Lactobacillus acidophilus can help prevent liver cancer associated with non-alcoholic fatty liver disease (NAFLD-HCC).
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
Read More
9
Lactobacillus acidophilus shows promise
We explored the effect of Lactobacillus acidophilus on non-metastatic rectal cancer by studying its influence on the CYLD protein and signaling pathways. In a randomized trial involving 110 patients, those consuming L. acidophilus showed a significant increase in tumor-suppressing CYLD protein and related genes, alongside a decrease in inflammation-related factors compared to a placebo. Impressively, the probiotic group had a higher survival rate after five years. These findings suggest that L. acidophilus can positively influence cancer by modulating inflammatory pathways.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for wellness
10 people found this helpful
BEST ON THE MARKET. My husband and I have been taking this probiotic for over 5 years and have always appreciated its effects. Garden of Life is our go-to for supplements. My husband has stage IV metastatic melanoma, and I have Langerhans Cell Histiocytosis, making our choice of supplement critical. My husband has been cancer-free for over 2 years, and I have been tumour-free for 21 years.
Read More
9
Endured 11 years
7 people found this helpful
I had esophageal cancer 12 years ago and underwent significant treatments, leaving me with 11 years of diarrhoea and drastic weight loss. After using probiotics, I ended my diarrhoea and gained weight back to 209 lbs. My hair and nails are healthier, and I feel much stronger. I’ve had to buy new clothes, a testament to my improved condition.
Read More
7.5
Reduced chemotherapy nausea
9 people found this helpful
Garden of Life Is The Best! I started taking these during chemotherapy for stage 3 breast cancer. The nausea was unbearable, and while this wasn’t a cure-all, it significantly reduced my nausea and boosted my immunity. When I stop taking them, I feel bloated and low on energy. As soon as I resume, my energy returns, and I feel much better overall. It also helps with my digestion.
Read More
9
Potential cancer cure
6 people found this helpful
THIS MAY BE THE CURE FOR CANCER! Research has shown probiotics can increase white blood cell levels, including T-Cells and Natural-Killer Cells. Garden of Life Primal Defense Ultra includes strains proven to enhance cancer-fighting cells. Independent lab tests confirm its efficacy, making it a reliable choice for anyone concerned about cancer.
Read More
Frequently Asked Questions
9.5
Lactobacillus acidophilus improves cancer therapy
We explored how lactobacillus acidophilus can enhance chemodynamic therapy for cancer. By coupling the probiotic with specialized nanosheets loaded with calcium oxide nanoparticles, we observed a notable reduction in tumor size.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
8
We explored the effects of Lactobacillus acidophilus on oral squamous cell carcinoma (OSCC), a severely aggressive cancer type. The study examined how this probiotic interacts with OSCC cells, both alone and with Streptococcus mutans.
Our findings indicated that Lactobacillus acidophilus does have the ability to suppress the growth of OSCC cells, likely through a mechanism involving apoptosis. Interestingly, this effect wasn't diminished by the presence of S mutans.
These results suggest there may be potential for Lactobacillus acidophilus in future cancer treatment research.
Our findings indicated that Lactobacillus acidophilus does have the ability to suppress the growth of OSCC cells, likely through a mechanism involving apoptosis. Interestingly, this effect wasn't diminished by the presence of S mutans.
These results suggest there may be potential for Lactobacillus acidophilus in future cancer treatment research.
7
Postbiotics show limited cancer effects
Our research focused on understanding how two types of postbiotics from Lactobacillus acidophilus LA-5, created using different media, could influence cancer cells.
We discovered significant differences in their chemical make-up, with MRS-Pb showing greater cytotoxic effects on HCT-116 intestinal cancer cells compared to W-Pb. However, both postbiotics did not improve cell proliferation or migration.
Ultimately, while these probiotics showed varying effects, no significant cancer-fighting benefits were established.
We discovered significant differences in their chemical make-up, with MRS-Pb showing greater cytotoxic effects on HCT-116 intestinal cancer cells compared to W-Pb. However, both postbiotics did not improve cell proliferation or migration.
Ultimately, while these probiotics showed varying effects, no significant cancer-fighting benefits were established.
8
We explored how probiotics, including Lactobacillus acidophilus, could improve recovery after surgery for distal gastric cancer. In a well-structured study, patients were divided into groups receiving either probiotics or a placebo.
Our findings showed that those taking probiotics had less inflammation and recovered quicker. They also had better nutritional markers and overall health post-surgery. This points to the possibility that probiotics like Lactobacillus acidophilus can play a helpful role in enhancing recovery times for cancer surgery patients.
Our findings showed that those taking probiotics had less inflammation and recovered quicker. They also had better nutritional markers and overall health post-surgery. This points to the possibility that probiotics like Lactobacillus acidophilus can play a helpful role in enhancing recovery times for cancer surgery patients.
References
- Mao L, Xarpidin B, Shi R, Lin Y, Hu H, et al. Natural Enzyme-Loaded Polymeric Stealth Coating-Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism-Immuno-Enzyme Dynamic Therapy. Adv Sci (Weinh). 2025. doi:10.1002/advs.202417172
- Nasri F, Alizadeh A, İncili GK, Hayaloğlu AA, Moradi M. Investigating Chemical Composition and Functionality of Lactobacillus acidophilus LA-5 Postbiotics Prepared in Classic and Cheese Whey Media. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10435-9
- Si R, Hu T, Williams GR, Yang Y, Yang S, et al. Coupling Probiotics with CaO Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy. Adv Healthc Mater. 2025;14:e2403373. doi:10.1002/adhm.202403373
- Kumawat M, Une H. Effect of Lactobacillus acidophilus, Calcium, and Moringa oleifera leaves extract co-administration can prevent chemical-induced carcinogenesis. Arab J Gastroenterol. 2024;25:421. doi:10.1016/j.ajg.2024.07.015
- Karim MR, Iqbal S, Mohammad S, Kim JH, Ling L, et al. Upgrading Isoquercitrin Concentration via Submerge Fermentation of Mulberry Fruit Extract with Edible Probiotics to Suppress Gene Targets for Controlling Kidney Cancer and Inflammation. J Microbiol. 2024;62:919. doi:10.1007/s12275-024-00163-8
- Gad AI, Orabi MM, Abou-Taleb KA, Abdelghani DY, Amin SA. In vitro digestive system simulation and anticancer activity of soymilk fermented by probiotics and synbiotics immobilised on agro-industrial residues. Sci Rep. 2024;14:18518. doi:10.1038/s41598-024-68086-3
- Xiong H, He Z, Wei Y, Li Q, Xiao Q, et al. Probiotic Compounds Enhanced Recovery after Surgery for Patients with Distal Gastric Cancer: A Prospective, Controlled Clinical Trial. Ann Surg Oncol. 2024;31:5240. doi:10.1245/s10434-024-15394-7
- Al-Asfour A, Bhardwaj RG, Karched M. Growth Suppression of Oral Squamous Cell Carcinoma Cells by Lactobacillus Acidophilus. Int Dent J. 2024;74:1151. doi:10.1016/j.identj.2024.03.017
- Mirzadeh MA, Eslami M, Ghanbari A, Zarbakhsh S, Yosefi S, et al. Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects. Med Oncol. 2024;41:111. doi:10.1007/s12032-024-02346-0
- Reis SK, Socca EAR, de Souza BR, Genaro SC, Durán N, et al. Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis. Tissue Cell. 2024;87:102293. doi:10.1016/j.tice.2023.102293
- Saffar KN, Larypoor M, Torbati MB. Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines. Mol Biol Rep. 2024;51:122. doi:10.1007/s11033-023-09008-w
- Lau HC, Zhang X, Ji F, Lin Y, Liang W, et al. Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid. EBioMedicine. 2024;100:104952. doi:10.1016/j.ebiom.2023.104952
- Erfanian N, Nasseri S, Miraki Feriz A, Safarpour H, Namaei MH. Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis. Sci Rep. 2023;13:22988. doi:10.1038/s41598-023-50047-x
- Zamani F, Khalighfard S, Kalhori MR, Poorkhani A, Amiriani T, et al. Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients. Med Oncol. 2023;40:302. doi:10.1007/s12032-023-02170-y
- Shen S, Ren F, Qin H, Bukhari I, Yang J, et al. NCFM and Lp-115 inhibit colonization and gastric inflammation in a murine model. Front Cell Infect Microbiol. 2023;13:1196084. doi:10.3389/fcimb.2023.1196084
- Abo-Zaid GA, Kenawy AM, El-Deeb NM, Al-Madboly LA. Improvement and enhancement of oligosaccharide production from Lactobacillus acidophilus using statistical experimental designs and its inhibitory effect on colon cancer. Microb Cell Fact. 2023;22:148. doi:10.1186/s12934-023-02153-8
- Zhang H, Li Y, Li L. Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis. BMC Cancer. 2025;25:368. doi:10.1186/s12885-025-13598-y
- Chen Y, Wu J, Cai K, Xiao X, Chen Y, et al. Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity. Int Immunopharmacol. 2025;150:114283. doi:10.1016/j.intimp.2025.114283
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. doi:10.1016/j.biomaterials.2025.123117
- Kim MJ, Song MH, Ji YS, Park JW, Shin YK, et al. Cell free supernatants of Bifidobacterium adolescentis and Bifidobacterium longum suppress the tumor growth in colorectal cancer organoid model. Sci Rep. 2025;15:935. doi:10.1038/s41598-024-83048-5
- Funayama E, Hosonuma M, Tajima K, Isobe J, Baba Y, et al. Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice. Biomed Pharmacother. 2025;182:117749. doi:10.1016/j.biopha.2024.117749
- Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. doi:10.1016/j.clnesp.2024.11.016
- Jeong S, Liao YT, Tsai MH, Wang YK, Wu IC, et al. Microbiome signatures associated with clinical stages of gastric Cancer: whole metagenome shotgun sequencing study. BMC Microbiol. 2024;24:139. doi:10.1186/s12866-024-03219-2
- Fan YL, Jin JX, Zhu J, Ruan HB, Huang JQ. Extracellular vesicles of Bifidobacterium longum reverse the acquired carboplatin resistance in ovarian cancer cells via p53 phosphorylation on Ser15. Kaohsiung J Med Sci. 2024;40:530. doi:10.1002/kjm2.12837
- Zhang Y, Cao T, Wang Y, Yang R, Han Y, et al. Effects of Viable and Heat-Inactivated D42 on Proliferation and Apoptosis of HT-29 Human Colon Cancer Cells. Foods. 2024;13. doi:10.3390/foods13060958
- Yue F, Zeng X, Wang Y, Fang Y, Yue M, et al. Bifidobacterium longum SX-1326 ameliorates gastrointestinal toxicity after irinotecan chemotherapy via modulating the P53 signaling pathway and brain-gut axis. BMC Microbiol. 2024;24:8. doi:10.1186/s12866-023-03152-w
- Yu J, Zhu P, Shi L, Gao N, Li Y, et al. Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma. Cell Host Microbe. 2024;32:131. doi:10.1016/j.chom.2023.11.011
- Ueki H, Kitagawa K, Kato M, Yanase S, Okamura Y, et al. An oral cancer vaccine using Bifidobacterium vector augments combination of anti-PD-1 and anti-CTLA-4 antibodies in mouse renal cell carcinoma model. Sci Rep. 2023;13:9994. doi:10.1038/s41598-023-37234-6
- Chan YL, Liao JC, Li TL, Wu CJ, Chiu YH. Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions. Appl Microbiol Biotechnol. 2025;109:69. doi:10.1007/s00253-025-13445-x
- Fedosova N, Cheremshenko N, Gogol S, Bezdieniezhnykh N, Tikhonov V, et al. THE INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND LECTIN OF B. SUBTILIS IMV B-7724 ON THE ANTITUMOR IMMUNE RESPONSE OF MICE WITH EHRLICH ADENOCARCINOMA. Exp Oncol. 2024;46:228. doi:10.15407/exp-oncology.2024.03.228
- Yang C, Zha M, Li L, Qiao J, Kwok LY, et al. Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer. J Dairy Sci. 2025;108:1211. doi:10.3168/jds.2024-25614
- Kozak T, Lykhova O, Serhiichuk T, Bezdieniezhnykh N, Chekhun V. OPTIMIZATION OF EXPERIMENTAL MODEL SYSTEMS FOR EVALUATING RECIPROCAL INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND HUMAN BREAST CANCER CELLS IN VITRO. Exp Oncol. 2024;45:504. doi:10.15407/exp-oncology.2023.04.504
- Yang X, Cao Q, Ma B, Xia Y, Liu M, et al. Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition. PLoS One. 2023;18:e0277155. doi:10.1371/journal.pone.0277155
- de Moura NA, Caetano BFR, Bidinotto LT, Rodrigues MAM, Barbisan LF. Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis. Benef Microbes. 2021;12:493. doi:10.3920/BM2020.0209
- Holkem AT, Favaro-Trindade CS, Lacroix M. Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions. Food Res Int. 2020;134:109274. doi:10.1016/j.foodres.2020.109274
- An J, Kim H, Yang KM. An Aqueous Extract of a Species Induces Apoptosis and Inhibits Invasiveness of Non-Small Cell Lung Cancer Cells. J Microbiol Biotechnol. 2020;30:885. doi:10.4014/jmb.1912.12054
