Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9
We examined a promising new probiotic preparation designed to break down gluten and assist people with celiac disease. Our study included a randomized double-blind placebo-controlled trial with 70 volunteers over a 42-day period, where participants consumed increasing amounts of gluten following a gluten-free diet.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Read More
9
We explored the effects of Bacillus subtilis LZU-GM, a probiotic isolated from traditional Pakistani sourdough, on gluten-related issues in celiac disease. Remarkably, this strain degraded 73.7% of gluten in lab tests and showed threefold more gluten breakdown in mice models compared to untreated groups.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
Read More
8
Probiotic shows potential in celiac
We explored whether Acetobacter ghanensis could reduce gliadin-induced toxicity in intestinal cells from celiac disease patients. Using a cell culture model, we found that gliadin disrupts the intestinal barrier and raises inflammatory markers like IL-6 and TNFα. However, when A. ghanensis was introduced, it showed potential in restoring barrier function and digesting gluten peptides. This study highlights A. ghanensis as a promising candidate for improving gut health in those affected by celiac disease, although more research is needed to confirm these findings.
Read More
Most Useful Reviews
7.5
Improved digestion
Happy customer. I have celiac disease and numerous other food allergies. This product has significantly improved my stomach health and has stabilised my condition. I highly recommend it to anyone facing similar issues. The capsules are also quite small and easy to swallow.
Read More
9
Bloating relief
This is the best probiotic I've ever used. Since I started taking it, I no longer experience bloating after consuming gluten products, which had been a problem for me after turning 40. As a pasta lover, I can now enjoy it once again without worry.
Read More
9
Digestive balance
I adore this product! I discovered it nearly a decade ago and have been using it ever since; when I don’t take it, I feel uncomfortable inside. Having celiac disease, I continually strive to maintain balance in my digestive system. This product is fantastic for daily use and fits perfectly within a detox or cleansing regimen. I appreciate the Garden Of Life company and their evolving range of supplements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
- All Researches
9
We examined a promising new probiotic preparation designed to break down gluten and assist people with celiac disease. Our study included a randomized double-blind placebo-controlled trial with 70 volunteers over a 42-day period, where participants consumed increasing amounts of gluten following a gluten-free diet.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Read More
9
We explored the effects of Bacillus subtilis LZU-GM, a probiotic isolated from traditional Pakistani sourdough, on gluten-related issues in celiac disease. Remarkably, this strain degraded 73.7% of gluten in lab tests and showed threefold more gluten breakdown in mice models compared to untreated groups.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
Read More
8
Brazilian cassava cultivars enhance probiotics
We examined the prebiotic effects of Brazilian cassava cultivars on celiac individuals. Focusing on two selected varieties, OUR and UPI, we observed their ability to promote growth in beneficial probiotic strains. This was evident in the increased population of helpful bacteria compared to established prebiotics like fructooligosaccharides. Our findings indicate that these cassava cultivars can positively influence the gut microbiota in celiacs, suggesting their potential use as prebiotic ingredients in functional foods and supplements.
Read More
8
Probiotic shows potential in celiac
We explored whether Acetobacter ghanensis could reduce gliadin-induced toxicity in intestinal cells from celiac disease patients. Using a cell culture model, we found that gliadin disrupts the intestinal barrier and raises inflammatory markers like IL-6 and TNFα. However, when A. ghanensis was introduced, it showed potential in restoring barrier function and digesting gluten peptides. This study highlights A. ghanensis as a promising candidate for improving gut health in those affected by celiac disease, although more research is needed to confirm these findings.
Read More
8
We investigated the effectiveness of the NLS super strain (NLS-SS) probiotic on alleviating gastrointestinal symptoms in patients with celiac disease (CD) who have been on a gluten-free diet for at least two years. Through a carefully designed randomized, double-blind, placebo-controlled trial, we found that those with severe symptoms experienced improved relief from their CD symptoms after taking NLS-SS.
This probiotic also influenced gut microbiota diversity in these patients without significant side effects. While promising, more extensive studies are necessary to fully validate these results.
This probiotic also influenced gut microbiota diversity in these patients without significant side effects. While promising, more extensive studies are necessary to fully validate these results.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved digestion
Happy customer. I have celiac disease and numerous other food allergies. This product has significantly improved my stomach health and has stabilised my condition. I highly recommend it to anyone facing similar issues. The capsules are also quite small and easy to swallow.
Read More
9
Bloating relief
This is the best probiotic I've ever used. Since I started taking it, I no longer experience bloating after consuming gluten products, which had been a problem for me after turning 40. As a pasta lover, I can now enjoy it once again without worry.
Read More
9
Digestive balance
I adore this product! I discovered it nearly a decade ago and have been using it ever since; when I don’t take it, I feel uncomfortable inside. Having celiac disease, I continually strive to maintain balance in my digestive system. This product is fantastic for daily use and fits perfectly within a detox or cleansing regimen. I appreciate the Garden Of Life company and their evolving range of supplements.
Read More
Frequently Asked Questions
9
Bloating relief
This is the best probiotic I've ever used. Since I started taking it, I no longer experience bloating after consuming gluten products, which had been a problem for me after turning 40. As a pasta lover, I can now enjoy it once again without worry.
7.5
Improved digestion
Happy customer. I have celiac disease and numerous other food allergies. This product has significantly improved my stomach health and has stabilised my condition. I highly recommend it to anyone facing similar issues. The capsules are also quite small and easy to swallow.
9
Digestive balance
I adore this product! I discovered it nearly a decade ago and have been using it ever since; when I don’t take it, I feel uncomfortable inside. Having celiac disease, I continually strive to maintain balance in my digestive system. This product is fantastic for daily use and fits perfectly within a detox or cleansing regimen. I appreciate the Garden Of Life company and their evolving range of supplements.
9
We explored the effects of Bacillus subtilis LZU-GM, a probiotic isolated from traditional Pakistani sourdough, on gluten-related issues in celiac disease. Remarkably, this strain degraded 73.7% of gluten in lab tests and showed threefold more gluten breakdown in mice models compared to untreated groups.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
9
We examined a promising new probiotic preparation designed to break down gluten and assist people with celiac disease. Our study included a randomized double-blind placebo-controlled trial with 70 volunteers over a 42-day period, where participants consumed increasing amounts of gluten following a gluten-free diet.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
7
We investigated whether probiotics could help improve gastrointestinal symptoms and quality of life for individuals with celiac disease. By reviewing randomized controlled trials, we focused on data from 279 participants.
Our findings showed that while probiotics did lead to a reduction in certain gastrointestinal symptoms, the overall evidence was not strong enough to draw firm conclusions. Importantly, we found no significant improvements in quality of life or adverse events compared with placebo groups.
This indicates that while there is some promise in probiotic treatment, further high-quality studies are necessary to validate these results.
Our findings showed that while probiotics did lead to a reduction in certain gastrointestinal symptoms, the overall evidence was not strong enough to draw firm conclusions. Importantly, we found no significant improvements in quality of life or adverse events compared with placebo groups.
This indicates that while there is some promise in probiotic treatment, further high-quality studies are necessary to validate these results.
7
We dove into research to explore what role probiotics might play in celiac disease (CD). While the gut microbiome impacts gluten metabolism and the immune response, the evidence on probiotics is mixed.
Some studies hint that probiotics could ease CD symptoms and tweak the immune response. However, human trials are limited and inconsistent.
Importantly, no proof exists suggesting that probiotics can prevent CD from developing. This area holds potential for future research to clarify how probiotics could fit into CD treatment.
Some studies hint that probiotics could ease CD symptoms and tweak the immune response. However, human trials are limited and inconsistent.
Importantly, no proof exists suggesting that probiotics can prevent CD from developing. This area holds potential for future research to clarify how probiotics could fit into CD treatment.
7
We examined the impact of probiotics on patients with celiac disease, whose only established treatment is a strict gluten-free diet. Even with adherence, many struggle with gut microbiota restoration, which is vital for nutrient absorption. Some studies suggest probiotics might help by enhancing gut health and reducing inflammation caused by gluten. Other dietary aids, like prebiotics, also show promise in promoting beneficial bacteria. Nonetheless, evidence supporting routine use of these supplements remains insufficient for clinical practice.
References
- Mafaldo ÍM, Araújo LM, Cabral L, Barão CE, Noronha MF, et al. Cassava (Manihot esculenta) Brazilian cultivars have different chemical compositions, present prebiotic potential, and beneficial effects on the colonic microbiota of celiac individuals. Food Res Int. 2024;195:114909. 10.1016/j.foodres.2024.114909
- Nikoloudaki O, Celano G, Polo A, Cappello C, Granehäll L, et al. Novel probiotic preparation with gluten-degrading activity and potential modulatory effects on the gut microbiota. Microbiol Spectr. 2024;12:e0352423. 10.1128/spectrum.03524-23
- Khan A, Li S, Han H, Jin WL, Ling Z, et al. A gluten degrading probiotic Bacillus subtilis LZU-GM relieve adverse effect of gluten additive food and balances gut microbiota in mice. Food Res Int. 2023;170:112960. 10.1016/j.foodres.2023.112960
- Mozafarybazargany M, Khonsari M, Sokoty L, Ejtahed HS, Qorbani M. The effects of probiotics on gastrointestinal symptoms and microbiota in patients with celiac disease: a systematic review and meta-analysis on clinical trials. Clin Exp Med. 2023;23:2773. 10.1007/s10238-022-00987-x
- Doguer C, Akalan H, Tokatlı Demirok N, Erdal B, Mete R, et al. Protective effects of Acetobacter ghanensis against gliadin toxicity in intestinal epithelial cells with immunoregulatory and gluten-digestive properties. Eur J Nutr. 2023;62:605. 10.1007/s00394-022-03015-6
- Andriulli A, Bevilacqua A, Palmieri O, Latiano A, Fontana R, et al. Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly™ bread in celiac subjects: a randomized, double blind, placebo control study. Food Funct. 2022;13:1299. 10.1039/d1fo00490e
- Jedwab CF, Roston BCMB, Toge ABFS, Echeverria IF, Tavares GOG, et al. The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review. Rev Paul Pediatr. 2021;40:e2020447. 10.1590/1984-0462/2022/40/2020447
- Wei G, Darwish G, Oppenheim FG, Schuppan D, Helmerhorst EJ. Commensal Bacterium Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme. Nutrients. 2020;12. 10.3390/nu12123724
- Smecuol E, Constante M, Temprano MP, Costa AF, Moreno ML, et al. Effect of NLS super strain in symptomatic coeliac disease patients on long-term gluten-free diet - an exploratory study. Benef Microbes. 2020;11:527. 10.3920/BM2020.0016
- Marasco G, Cirota GG, Rossini B, Lungaro L, Di Biase AR, et al. Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients. Nutrients. 2020;12. 10.3390/nu12092674
- Seiler CL, Kiflen M, Stefanolo JP, Bai JC, Bercik P, et al. Probiotics for Celiac Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Gastroenterol. 2020;115:1584. 10.14309/ajg.0000000000000749
- Pecora F, Persico F, Gismondi P, Fornaroli F, Iuliano S, et al. Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics?. Front Immunol. 2020;11:957. 10.3389/fimmu.2020.00957
- de Almeida NEC, Esteves FG, Dos Santos-Pinto JRA, Peres de Paula C, da Cunha AF, et al. Digestion of Intact Gluten Proteins by Species: Reduction of Cytotoxicity and Proinflammatory Responses. J Agric Food Chem. 2020;68:4485. 10.1021/acs.jafc.0c01421
