Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 68 Reviews
8.2
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
8
DHA improves milk and reduces anxiety
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Read More
7
We investigated the effects of docosahexaenoic acid (DHA) on anxiety and other health aspects following long-term antibiotic treatment using an azithromycin mouse model. In our research, we divided thirty specific-pathogen-free BALB/c mice into three distinct groups: a control group, a group recovering naturally from azithromycin treatment, and a group receiving DHA.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
Read More
9
We investigated the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on anxiety-like behaviors in juvenile mice subjected to a stress model. By exposing one-month-old C57/BL6 mice to alternating ultrasound frequencies designed to induce stress, we could observe the behavioral changes that occurred.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Read More
Most Useful Reviews
10
Remarkable mood enhancement
45 people found this helpful
After two months of daily use, ashwagandha reduced my stress and anxiety significantly, improving my mood and overall stamina. It also increased my sense of enjoyment in life and my sexual desire. Highly recommend based on my positive experience.
Read More
9
Improved mood
21 people found this helpful
Especially at work, where I previously disliked interacting with customers in person, I can personally affirm the effectiveness of this product. Two weeks after adding Ashwagandha to my diet, I've noticed significant enhancements in my mood and energy levels. I battled fatigue from my busy schedule, with long days of work and school, and even caffeine couldn't help. Ashwagandha aids my body in recovering from daily fatigue, keeping me motivated and energised throughout the day, while allowing for relaxation in the evenings. My mood has improved in social settings, which is beneficial since I have social anxiety. I feel uplifted and conversational now; I recommend this product to others in similar situations.
Read More
9
Phobia relief
13 people found this helpful
After three weeks, I noticed significant improvement in my anxiety and phobias. I began with one pill a day but adjusted to half a pill, feeling much better. I recommend starting with lower doses to avoid allergic reactions. I plan to continue for a month, then reassess.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
- All Researches
9
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Read More
9
We investigated the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on anxiety-like behaviors in juvenile mice subjected to a stress model. By exposing one-month-old C57/BL6 mice to alternating ultrasound frequencies designed to induce stress, we could observe the behavioral changes that occurred.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Read More
9
We examined the effects of docosahexaenoic acid (DHA), found in fish oil, on anxiety and mood in mice fed a high-fat diet. In our study, male C57Bl/6J mice were divided into groups, with some receiving a standard diet and others consuming a saturated high-fat diet (HFD) for 20 weeks. Over the last five weeks, half of the mice received daily doses of fish oil, while the others received a control corn oil.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
Read More
8
We explored the effects of docosahexaenoic acid (DHA), a key omega-3 fatty acid, on anxiety-like behavior in both adult and aged rats. This study utilized a carefully designed methodology with control groups and various treatment combinations including exercise and different doses of omega-3 supplementation.
Our findings revealed that aging adversely affects locomotor and exploratory activities in rats. Specifically, we observed that in adult rats, a lower dose of omega-3 FA seemed to decrease locomotor activity when combined with exercise. However, a higher dose of omega-3s, especially when paired with exercise, appeared to lessen anxiety-like behavior and enhance recognition memory.
This suggests a complex interplay between omega-3 fatty acids and exercise, indicating that while omega-3s can impact anxiety, the effects can vary based on dosage and additional factors like physical activity. Overall, our study emphasizes the need for further investigation to fully understand the cognitive benefits of omega-3s in relation to anxiety, especially as it relates to the aging process.
Our findings revealed that aging adversely affects locomotor and exploratory activities in rats. Specifically, we observed that in adult rats, a lower dose of omega-3 FA seemed to decrease locomotor activity when combined with exercise. However, a higher dose of omega-3s, especially when paired with exercise, appeared to lessen anxiety-like behavior and enhance recognition memory.
This suggests a complex interplay between omega-3 fatty acids and exercise, indicating that while omega-3s can impact anxiety, the effects can vary based on dosage and additional factors like physical activity. Overall, our study emphasizes the need for further investigation to fully understand the cognitive benefits of omega-3s in relation to anxiety, especially as it relates to the aging process.
Read More
8
DHA's potential in anxiety treatment
We examined how docosahexaenoic acid (DHA) affects anxiety in rats suffering from chronic sleep deprivation. In a study involving male Wistar rats, researchers divided them into multiple groups, some receiving a combination of a melatonin receptor agonist called ramelteon (RMT) and DHA. When the rats were subjected to anxiety-inducing tests, it became clear that while the paired RMT and DHA treatment was beneficial, the specific effects of DHA alone on anxiety could not be entirely isolated due to the combination treatment.
The highlights of the research showed that the combination of RMT and DHA helped alleviate anxiety-like behaviors as observed during elevated plus maze tests. However, it's important to note that the results did not decisively indicate that DHA independently improved anxiety symptoms, meaning more research might be necessary to understand its role better. Overall, this study sheds light on how melatonin and DHA might work together to address anxiety in sleep-deprived conditions, but the distinct influence of DHA may remain elusive.
The highlights of the research showed that the combination of RMT and DHA helped alleviate anxiety-like behaviors as observed during elevated plus maze tests. However, it's important to note that the results did not decisively indicate that DHA independently improved anxiety symptoms, meaning more research might be necessary to understand its role better. Overall, this study sheds light on how melatonin and DHA might work together to address anxiety in sleep-deprived conditions, but the distinct influence of DHA may remain elusive.
Read More
User Reviews
USERS' SCORE
Good
Based on 68 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Remarkable mood enhancement
45 people found this helpful
After two months of daily use, ashwagandha reduced my stress and anxiety significantly, improving my mood and overall stamina. It also increased my sense of enjoyment in life and my sexual desire. Highly recommend based on my positive experience.
Read More
9
Improved mood
21 people found this helpful
Especially at work, where I previously disliked interacting with customers in person, I can personally affirm the effectiveness of this product. Two weeks after adding Ashwagandha to my diet, I've noticed significant enhancements in my mood and energy levels. I battled fatigue from my busy schedule, with long days of work and school, and even caffeine couldn't help. Ashwagandha aids my body in recovering from daily fatigue, keeping me motivated and energised throughout the day, while allowing for relaxation in the evenings. My mood has improved in social settings, which is beneficial since I have social anxiety. I feel uplifted and conversational now; I recommend this product to others in similar situations.
Read More
9
Phobia relief
13 people found this helpful
After three weeks, I noticed significant improvement in my anxiety and phobias. I began with one pill a day but adjusted to half a pill, feeling much better. I recommend starting with lower doses to avoid allergic reactions. I plan to continue for a month, then reassess.
Read More
9
Less irritable
13 people found this helpful
I felt a difference immediately. Suffering from crippling anxiety, I was intrigued when a family member suggested Ashwagandha. I'm amazed by its noticeable effects; I feel less irritable and tired, and more calm. It’s a must-have during stressful times, especially when paired with a glandular adrenal supplement.
Read More
9
Anxiety dropped to zero
9 people found this helpful
Ashwagandha has been life-changing! After trying antidepressants and seeing a psychoanalyst, I found this herb truly helpful—I calmed down and now view life in vibrant colours. My anxiety has diminished to nothing! I wholeheartedly recommend this product!
Read More
Frequently Asked Questions
9
Phobia relief
13 people found this helpful
After three weeks, I noticed significant improvement in my anxiety and phobias. I began with one pill a day but adjusted to half a pill, feeling much better. I recommend starting with lower doses to avoid allergic reactions. I plan to continue for a month, then reassess.
9
Significant improvement
1 people found this helpful
It really works! After taking it for a week, I saw a noticeable improvement in my anxiety. After a month, I felt much more relaxed and energetic. This has been genuinely beneficial for me, though this is purely my own experience.
10
Remarkable mood enhancement
45 people found this helpful
After two months of daily use, ashwagandha reduced my stress and anxiety significantly, improving my mood and overall stamina. It also increased my sense of enjoyment in life and my sexual desire. Highly recommend based on my positive experience.
9
Fast anxiety relief
For me, the most significant benefit of Ashwagandha is its ability to reduce stress and anxiety rapidly and almost magically. Additionally, it offers various other advantages, such as lowering sugar levels, aiding sleep, and decreasing inflammation, although the price of this product is quite high.
9
Lowered anxiety
6 people found this helpful
This supplement is fantastic! I regularly experience high anxiety throughout the day. However, when I take this, my anxiety levels reduce significantly and my energy levels rise—quite the opposite when I don’t take it.
9
Effective for anxiety
2 people found this helpful
Superb quality ashwagandha has greatly reduced my anxiety and panic attacks. I rely on their excellent products, also incorporating other supplements for comprehensive health benefits.
9
Effective for children
3 people found this helpful
I give half a pill to my 7-year-old child with autism to relieve anxiety. It works really well. We administer it alongside other medications prescribed by a geneticist.
7.5
Helps manage anxiety
Ashwagandha is a well-known herb celebrated for its medicinal benefits and has been utilised for centuries in traditional Ayurvedic practices. One of its main applications is to alleviate stress and anxiety. It is believed to lower cortisol levels (the stress hormone) and promote feelings of tranquillity and relaxation. Many individuals use Ashwagandha as a natural approach to address stress-related concerns.
7.5
Eases severe anxiety
4 people found this helpful
I cannot speak to its medical suitability, so please consult a doctor for conflicts with medications. However, my experience has been excellent; it is gentle on the stomach and significantly relieved my severe anxiety and tension. I felt lighter, though I haven't taken it daily.
9
Inner peace
1 people found this helpful
I chose ashwagandha to combat stress during my studies, and its benefits are backed by centuries of use and scientific research. I began taking one tablet each morning, and after a week, my anxiety and irritability vanished. Just be cautious not to take it at night, as it can be invigorating. I'm grateful for the peace it has brought me.
9
Convenient and effective
Relieves anxiety. The form is convenient and well absorbed, with good product quality. My stress level has decreased significantly. Be cautious—do not take more than one tablet!
9
We explored the potential benefits of docosahexaenoic acid (DHA) in reducing anxiety among middle-aged and elderly adults. This was part of a larger study involving over 102,000 participants, where we assessed the impact of various polyunsaturated fatty acids (PUFAs) on mental health conditions, including anxiety and depression.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
Our findings indicated that higher plasma levels of DHA, as well as omega-3 PUFAs in general, were linked to a lower risk of developing anxiety disorders. Specifically, we noted that participants in the highest quartile of PUFA levels, including DHA, showed a 14% reduction in the hazard of incident anxiety compared to those in the lowest quartile.
Further analysis of psychological symptoms revealed that those with elevated omega-3 PUFA levels, prominently DHA, experienced fewer adverse mental health issues. While we also considered white matter microstructures through neuroimaging with a subgroup of participants, the specific mechanisms behind DHA's positive effects on anxiety remain an area for future research.
9
We investigated the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on anxiety-like behaviors in juvenile mice subjected to a stress model. By exposing one-month-old C57/BL6 mice to alternating ultrasound frequencies designed to induce stress, we could observe the behavioral changes that occurred.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
Mice were divided into two groups: one received a food supplement containing DHA and eicosapentaenoic acid (EPA), while the other group was given a placebo. After three weeks, we found that the stressed mice treated with the omega-3 supplement showed significant improvement. They displayed less anxiety-like behavior and did not show the typical signs of depression, such as decreased interest in sweet foods, which reflects anhedonia.
Interestingly, our analysis revealed that omega-3 supplementation seemed to counteract the negative effects induced by stress, likely due to its anti-inflammatory properties. In non-stressed mice, DHA also helped minimize anxiety symptoms, suggesting that these benefits could extend beyond just those experiencing stress. Overall, these findings suggest that omega-3 fatty acids like DHA may hold promise as a treatment approach for anxiety, particularly in vulnerable young individuals.
8
We explored the effects of docosahexaenoic acid (DHA), a key omega-3 fatty acid, on anxiety-like behavior in both adult and aged rats. This study utilized a carefully designed methodology with control groups and various treatment combinations including exercise and different doses of omega-3 supplementation.
Our findings revealed that aging adversely affects locomotor and exploratory activities in rats. Specifically, we observed that in adult rats, a lower dose of omega-3 FA seemed to decrease locomotor activity when combined with exercise. However, a higher dose of omega-3s, especially when paired with exercise, appeared to lessen anxiety-like behavior and enhance recognition memory.
This suggests a complex interplay between omega-3 fatty acids and exercise, indicating that while omega-3s can impact anxiety, the effects can vary based on dosage and additional factors like physical activity. Overall, our study emphasizes the need for further investigation to fully understand the cognitive benefits of omega-3s in relation to anxiety, especially as it relates to the aging process.
Our findings revealed that aging adversely affects locomotor and exploratory activities in rats. Specifically, we observed that in adult rats, a lower dose of omega-3 FA seemed to decrease locomotor activity when combined with exercise. However, a higher dose of omega-3s, especially when paired with exercise, appeared to lessen anxiety-like behavior and enhance recognition memory.
This suggests a complex interplay between omega-3 fatty acids and exercise, indicating that while omega-3s can impact anxiety, the effects can vary based on dosage and additional factors like physical activity. Overall, our study emphasizes the need for further investigation to fully understand the cognitive benefits of omega-3s in relation to anxiety, especially as it relates to the aging process.
7
We explored the effects of docosahexaenoic acid (DHA) supplementation on anxiety among older adults with mild cognitive impairment. In a well-structured 12-month randomized controlled trial, 72 participants aged 60 to 90 from New Zealand received either a daily DHA supplement or a placebo. Throughout the study, we measured various outcomes, including depression and anxiety scores, to gauge the potential benefits of DHA on mental well-being.
While we found no significant improvement in cognitive measures associated with DHA, the results were encouraging for participants who carried the apolipoprotein E (APOE) ɛ4 allele. Specifically, this group experienced notable reductions in their depression and anxiety scores, suggesting that DHA supplements may help alleviate these issues for certain individuals. Additionally, we recorded a positive impact on systolic blood pressure among the participants taking DHA.
It's important to acknowledge that our findings indicate DHA may not be beneficial for everyone, particularly in cognitive enhancement. However, the improvements in anxiety and depression scores for APOE ɛ4 carriers pave the way for further research into DHA's effects on mental health.
While we found no significant improvement in cognitive measures associated with DHA, the results were encouraging for participants who carried the apolipoprotein E (APOE) ɛ4 allele. Specifically, this group experienced notable reductions in their depression and anxiety scores, suggesting that DHA supplements may help alleviate these issues for certain individuals. Additionally, we recorded a positive impact on systolic blood pressure among the participants taking DHA.
It's important to acknowledge that our findings indicate DHA may not be beneficial for everyone, particularly in cognitive enhancement. However, the improvements in anxiety and depression scores for APOE ɛ4 carriers pave the way for further research into DHA's effects on mental health.
7
We investigated the effects of docosahexaenoic acid (DHA) on anxiety and other health aspects following long-term antibiotic treatment using an azithromycin mouse model. In our research, we divided thirty specific-pathogen-free BALB/c mice into three distinct groups: a control group, a group recovering naturally from azithromycin treatment, and a group receiving DHA.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
Using various methods, including high-throughput sequencing and biochemical analysis, we explored how DHA influenced lipid metabolism and anxiety levels in these mice. Through our observations, we noted that prolonged exposure to azithromycin resulted in dyslipidemia and anxiety-like behaviors. Remarkably, DHA treatment significantly improved these anxiety-related symptoms, suggesting potential benefits in managing acute anxiety following antibiotic use.
While DHA did not alter the overall structure of the gut microbiome or bile acids content, it did enhance the levels of a crucial enzyme related to fat metabolism and normalized the expression of other key enzymes linked to lipid processing. This shows that DHA may support overall emotional well-being after antibiotic-induced imbalances, even if it doesn't change the gut microbiome dramatically.
Overall, our findings underscore DHA's promising effects in improving anxiety levels associated with antibiotic treatment, highlighting its potential as a supportive therapeutic approach for individuals experiencing similar health concerns.
9
We examined the effects of docosahexaenoic acid (DHA), found in fish oil, on anxiety and mood in mice fed a high-fat diet. In our study, male C57Bl/6J mice were divided into groups, with some receiving a standard diet and others consuming a saturated high-fat diet (HFD) for 20 weeks. Over the last five weeks, half of the mice received daily doses of fish oil, while the others received a control corn oil.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
What we discovered was quite revealing. The supplementation of fish oil rich in DHA—and another fatty acid, eicosapentaenoic acid (EPA)—not only reduced food intake and corrected glucose intolerance but also significantly improved anxiety and depressive-like behaviors in the mice. This was assessed through various behavioral tests that highlight changes in activity and mood.
Beyond the behavioral improvements, we observed that these dietary changes influenced brain chemistry as well. Fish oil supplementation promoted healthier brain lipid profiles and reduced markers of inflammation and microglial activation, which are known to be linked with a state of anxiety and depression.
These compelling findings suggest that incorporating DHA, alongside EPA, into our diets could potentially provide a natural way to alleviate mood and metabolic disorders triggered by obesity.
References
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
- Gajdošová L, Katrenčíková B, Borbélyová V, Muchová J. The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged Rats. Physiol Res. 2024;73:461.
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
- Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, et al. Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome. Food Funct. 2023;14:5977. doi:10.1039/d3fo01452e
- Mengelberg A, Leathem J, Podd J, Hill S, Conlon C. The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month randomised controlled trial. Int J Geriatr Psychiatry. 2022;37. doi:10.1002/gps.5707
- Zambrano E, Rodríguez-González GL, Reyes-Castro LA, Bautista CJ, Castro-Rodríguez DC, et al. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring. Nutrients. 2021;13. doi:10.3390/nu13124243
- Tang Q, Li S, Fang C, Yu H. Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction. Food Chem Toxicol. 2022;159:112699. doi:10.1016/j.fct.2021.112699
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