Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.1
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*

Top Medical Research Studies

8
DHA shows potential for depression
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.

Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.

Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
4
DHA may prevent depression recurrence
We conducted a thorough 52-week study to explore the potential benefits of docosahexaenoic acid (DHA), an omega-3 fatty acid, in preventing depression from returning in elderly patients who are currently stable. In our research, we gathered 39 elderly participants who were in a good mental state and divided them into two groups: one received a specific dose of DHA, while the other group received a placebo.

Throughout the year, we carefully monitored changes in their depressive symptoms and overall mental health at various points, including at the start and every few months afterward. Our analysis revealed a noteworthy finding: those taking DHA experienced a significant reduction in the risk of depression coming back compared to those who did not receive the supplement.

However, when it came to alleviating existing depressive or anxiety symptoms, DHA didn’t show a considerable impact over the placebo. Despite the positive results regarding preventing recurrence, we should keep in mind the study’s limited size, as this could influence the broader applicability of our findings.
Read More
9
DHA beneficial for depression
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.

The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.

Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.

The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More

Most Useful Reviews

9
Increased energy
21 people found this helpful
I was amazed by my personal results. After a week of taking one caplet daily, my energy level noticeably increased, and my long-standing low-grade depression vanished. Research showed it balanced my hormones, and my daughter also experienced emotional stability. I'm 56 and lead a very healthy lifestyle.
Read More
9
Prevented depression
I highly recommend ashwagandha as an excellent adaptogen. It has been instrumental in preventing depression without causing dependency, which is vital in these turbulent times.
Read More
7.5
Normalized mood
14 people found this helpful
After giving birth, I took this for my depression, and my mood normalised; I regained energy and felt much better.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
  • All Researches
9
DHA beneficial for depression
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.

The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.

Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.

The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
We used a unique model to explore how docosahexaenoic acid, an omega-3 fatty acid, may help alleviate symptoms of depression in young mice. By exposing juvenile mice to alternating ultrasound stress frequencies known to induce depressive-like behaviors, we aimed to mimic conditions of juvenile depression.

Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.

Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Read More
9
DHA alleviates epilepsy-related depression
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.

Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.

Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
8
DHA shows potential for depression
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.

Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.

Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
We examined the role of omega-3 fatty acids, particularly focusing on eicosapentaenoic acid (EPA) rather than docosahexaenoic acid (DHA), in depression. A large two-sample Mendelian randomization approach was used, leveraging data from UK Biobank and the Psychiatric Genomics Consortium.

While our findings showed that higher levels of omega-3 fatty acids can lower the odds of major depressive disorder (MDD), the specific effects of DHA were not thoroughly analyzed. Instead, EPA was highlighted as having a notable impact on reducing depression risk.

Despite these insights, it’s important to note that we did not find distinct evidence linking DHA directly to improvements in depression outcomes. This indicates that while omega-3 fatty acids are relevant to depression, caution is warranted when interpreting the effects of individual components like DHA.

Therefore, while there seems to be a connection with omega-3 intake and depression risk, the exact benefits of DHA remain unclear. This raises important questions about how different omega-3s influence mental health and stresses the need for further targeted research to clarify these effects.
Read More

User Reviews

USERS' SCORE
Good
Based on 12 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Increased energy
21 people found this helpful
I was amazed by my personal results. After a week of taking one caplet daily, my energy level noticeably increased, and my long-standing low-grade depression vanished. Research showed it balanced my hormones, and my daughter also experienced emotional stability. I'm 56 and lead a very healthy lifestyle.
Read More
9
Prevented depression
I highly recommend ashwagandha as an excellent adaptogen. It has been instrumental in preventing depression without causing dependency, which is vital in these turbulent times.
Read More
7.5
Normalized mood
14 people found this helpful
After giving birth, I took this for my depression, and my mood normalised; I regained energy and felt much better.
Read More
7.5
Enhanced post-birth energy
12 people found this helpful
I incorporated this adaptogen to combat postpartum depression, noticing results within a month. Taking it on an empty stomach before meals worked wonders as I regained strength and energy to manage responsibilities effectively. Given my current pregnancy, I plan to continue using this supplement.
Read More
8
Decreased fatigue
Ingested for depression as it benefits adrenal fatigue and mental health. I feel reassured taking it, and my fatigue has lessened significantly. My positive feelings have also returned. On difficult nights, I use it as a preventive measure.
Read More

Frequently Asked Questions

9
Increased energy
21 people found this helpful
I was amazed by my personal results. After a week of taking one caplet daily, my energy level noticeably increased, and my long-standing low-grade depression vanished. Research showed it balanced my hormones, and my daughter also experienced emotional stability. I'm 56 and lead a very healthy lifestyle.
7.5
Enhanced post-birth energy
12 people found this helpful
I incorporated this adaptogen to combat postpartum depression, noticing results within a month. Taking it on an empty stomach before meals worked wonders as I regained strength and energy to manage responsibilities effectively. Given my current pregnancy, I plan to continue using this supplement.
6
Mild depression relief
I've been taking it for some time, and it has helped with my mild depression, effectively controlling my symptoms.
7.5
Anxiety relief
Ashwagandha is a potent anxiolytic that greatly alleviates my anxiety and depression. However, I advise against prolonged use without breaks, as it can lower cortisol, which is necessary for energy.
9
Prevented depression
I highly recommend ashwagandha as an excellent adaptogen. It has been instrumental in preventing depression without causing dependency, which is vital in these turbulent times.
7.5
Calmer attitude
It has been great for me; it helped manage my anger and made me calmer, while also assisting with my depression. I only wish the dosage were higher than 660 mg.
9
DHA beneficial for depression
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.

The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.

Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.

The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
5
Investigating DHA’s depression treatment
We explored the effectiveness of omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), in treating depression through a meta-analysis of randomized controlled trials. Our investigation included extensive data from 36 studies, offering a comprehensive look at how these fatty acids might influence mental health.

While we found some significant evidence suggesting that omega-3 PUFAs, in general, could be beneficial for people suffering from depression, the specific impact of DHA alone was not isolated. It turned out that there's no stronger effect from omega-3 PUFAs compared to a placebo in terms of response rates, remission, or adverse events. Interestingly, we noted that patients from Asia who experienced mild to moderate depression and took DHA over a period of eight weeks might fare the best if their daily dosage ranged from 1000 to 1500 mg, maintaining a specific ratio of eicosapentaenoic acid (EPA) to DHA.

Overall, we observed that while omega-3s may provide some benefits in treating depression, they do not show superior results compared to a placebo group. This highlights the importance of understanding not just the broader category of omega-3s, but the nuanced roles of individual components like DHA.
8
DHA shows potential for depression
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.

Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.

Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.

References

  1. Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. doi:10.1016/j.jad.2025.03.006
  2. Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. doi:10.1016/j.plefa.2025.102664
  3. Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
  4. Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
  5. Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
  6. Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
  7. Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
  8. Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168675
  9. Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
  10. Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. doi:10.1038/s41398-024-02932-w
  11. Wang M, Yan X, Li Y, Li Q, Xu Y, et al. Association between plasma polyunsaturated fatty acids and depressive among US adults. Front Nutr. 2024;11:1342304. doi:10.3389/fnut.2024.1342304
  12. Chang YY, Ting B, Chen DT, Hsu WT, Lin SC, et al. Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2024;12. doi:10.3390/healthcare12050536
  13. Suneson K, Söderberg Veibäck G, Lindahl J, Tjernberg J, Ståhl D, et al. Omega-3 fatty acids for inflamed depression - A match/mismatch study. Brain Behav Immun. 2024;118:192. doi:10.1016/j.bbi.2024.02.029
  14. Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
  15. Yang Y, Chen L, Zhang N, Zhao Y, Che H, et al. DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12122079
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